Ana Estela | Developmental Cell Biology | Women Researcher Award

Published on by Cell Biologist

Dr. Ana Estela | Developmental Cell Biology | Women Researcher Award

UNSE | Argentina

Ana Estela Ledesma is a senior researcher specializing in macromolecules, biomolecular interactions, and nanosystems, combining theoretical calculations with advanced spectroscopic techniques. Her work focuses on elucidating structural and biophysical mechanisms in protein–ligand and protein–surface interactions. She has led and contributed to numerous nationally funded research projects and has an extensive publication record in indexed journals. Her research spans nanoparticles functionalized with natural compounds for medical and agricultural applications, bioactive alkaloids with hypoglycemic effects, oxidative processes in proteins, and the characterization of probiotic and prebiotic biomolecules.

Citation Metrics (Scopus)

700
600
400
200
100
50
0

Citations
613

Documents
38

h-index
15

Citations

Documents

h-index

Featured Publications

Mena Boules | Intestinal Failure | Research Excellence Award

Published on by Cell Biologist

Dr. Mena Boules | Intestinal Failure | Research Excellence Award

Ironwood Pharmaceuticals | United States

A senior medical affairs executive with extensive experience leading global strategies across gastroenterology and rare disease portfolios. Recognized for integrating scientific, clinical, and business insights to position Medical Affairs as a strategic command center focused on patient outcomes. Expertise includes evidence generation, real-world data, publications, scientific communications, field medical operations, and external engagement. Demonstrated track record of translating clinical and analytical data into impactful product and medical strategies, supported by a substantial body of peer-reviewed publications, abstracts, and industry presentations. Active contributor to professional societies and governance committees, with strong leadership in cross-functional execution and stakeholder collaboration.

Citation Metrics (Scopus)

900
700
500
300
100
0

Citations
834

Documents
54

h-index
16

Citations

Documents

h-index

Featured Publications

Long-term Safety and Efficacy of Budesonide Oral Suspension for Eosinophilic Esophagitis:
A 4-Year, Phase 3, Open-Label Study
– Clinical Gastroenterology and Hepatology, 2025
Impaired Health-Related Quality of Life in Patients With Short Bowel Syndrome Dependent on Parenteral Support:
Results From a Multinational Survey
– American Journal of Gastroenterology, 2025
Clinical and Psychological Burden Among Patients With Short Bowel Syndrome Requiring Parenteral Support:
Findings From a Multinational Survey
– American Journal of Gastroenterology, 2025
Once-Weekly Apraglutide Reduces Parenteral Support Volume and Improves Clinical Response Rates:
STARS Extend Trial
– American Journal of Gastroenterology, 2025

Zainab Almansour | Immunology and Molecular Biology | Research Excellence Award

Published on by Cell Biologist

Assoc. Prof. Dr. Zainab Almansour | Immunology and Molecular Biology | Research Excellence Award

King Faisal University | Saudi Arabia

Dr. Zainab H. Almansour is a dynamic academic and researcher with extensive expertise in immunology, antibody engineering, molecular bioscience, and cell biology. With a strong foundation in scientific research and teaching, she demonstrates exceptional analytical, leadership, and communication skills, effectively conveying complex concepts to diverse audiences. Her professional experience spans roles as Associate and Assistant Professor, as well as postdoctoral research, with a focus on fostering student development through innovative teaching methods and virtual enrichment programs. Dr. Almansour has contributed to multiple scientific and administrative initiatives, including curriculum development, accreditation committees, and academic guidance, while maintaining active engagement in laboratory research employing techniques such as phage bio-panning, protein analysis, molecular biology, cell culture, flow cytometry, and bioinformatics. She holds multiple patents and actively pursues professional growth through advanced training in AI applications, data analytics, and drug development, reflecting her commitment to innovation and excellence in research and education.

Citation Metrics (Google Scholar)

6000
4000
2000
200
100
50
0

Citations
5,725

Documents
149

h-index
44

i10-index
96

Citations

Documents

h-index

i10-index

Featured Publications

Shaibal Chandra | Pharmacology | Editorial Board Member

Published on by Cell Biologist

Mr. Shaibal Chandra | Pharmacology | Editorial Board Member

Bengal School of Technology | India

Shaibal Chandra is an Assistant Professor of Pharmacology with strong academic training and research expertise in experimental and translational pharmacology. His teaching portfolio spans core and advanced subjects including Pharmacology, Human Anatomy and Physiology, Pathophysiology, Microbiology, Advanced Pharmacology, and Pharmaceutical Screening Methodology. His research interests focus on phytopharmacology, antioxidant and antiurolithiatic studies, CNS pharmacology, antifertility activity, immunopharmacology, and nano-based therapeutic approaches. He has conducted in vivo pharmacological evaluations using established animal models and possesses hands-on expertise in animal handling, biochemical assays, microscopic techniques, and laboratory instrumentation. His postgraduate research investigated the antiurolithiatic potential of metformin in ethylene glycol-induced renal stone models. He has authored multiple peer-reviewed research and review articles in national and international journals, contributed book chapters published by reputed academic publishers, and holds a published patent related to green nanoparticle synthesis with antioxidant and antibacterial applications. He actively participates in national and international scientific conferences through poster and e-poster presentations, including work on cancer immunotherapy and nanostructure-based drug delivery. He has also served as a reviewer for international journals and supervised undergraduate and postgraduate research projects, reflecting sustained engagement in academic research and mentorship.

Profile: Orcid

Featured Publications:

Chandra, S., & Chowdhury, S. (2025). Systemic effect of different physiological parameters associated with mirror syndrome. Journal of Obstetrics and Gynaecology Research. https://doi.org/10.1111/jog.70062

Chandra, S., Mondal, N., Chatterjee, A., & Tapadar, D. (2025). Exploration of antiurolithiatic properties of methanolic extract of rhizome of Cyperus tegetum Roxb. in ethylene glycol-induced urolithiatic rats. Pharmacological Research – Natural Products, 100181. https://doi.org/10.1016/j.prenap.2025.100181

Chandra, S. (2024). Phytochemical and pharmacological (CNS) screening of alcoholic extract obtained from Melia azedarach (leaf). Bengal School of Technology (A College of Pharmacy).

Kar, D. R., Dutta, A., Chandra, S., Das, P. P., & Paul, D. K. (2023). Evaluation of the antifertility activity of methanolic extract of Melia azedarach and their GC–MS study. International Journal of Pharmaceutical and Phytopharmacological Research, 13, 201–220. https://doi.org/10.51847/bxeo6u8vnk

Chakraborty, M., Das, P. P., Chandra, S., Shaharyar, M. A., Sarkar, N., Mukherjee, S., Paul, S., Bhowmik, R., Haldar, P. K., & Karmakar, S. (2023). Toxicology of nanoformulations and materials in tissue engineering. In Nanostructured materials for tissue engineering. Elsevier. https://doi.org/10.1016/B978-0-323-95134-0.00006-7

Chandra, S. (2023). Antidiabetic activity of exotic Indian spices. In Medicinal spices and herbs from India. Apple Academic Press (CRC Press).

Salam Titinchi | Stem Cell Research | Editorial Board Member

Published on by Cell Biologist

Prof. Dr. Salam Titinchi | Stem Cell Research | Editorial Board Member

University of the Western Cape | South Africa

Professor J.J. Titinchi is an established chemist with extensive expertise in inorganic, organic, and materials chemistry, with a strong emphasis on functional materials and catalytic systems. His research focuses on the design, synthesis, and application of heterogeneous catalysts, nanostructured materials, metal–organic frameworks, and functional inorganic materials for sustainable chemical processes, including green chemistry, energy conversion, and environmental remediation. With over three decades of academic experience, he has made significant contributions to advancing structure–property relationships in catalytic and functional materials and their industrial and environmental applications. His scholarly output reflects consistent impact, with an h-index of 25 (Scopus) and approximately 1,760 citations, underscoring the relevance of his work in materials and chemical sciences. He has supervised a substantial number of postgraduate researchers, contributing to capacity building and knowledge transfer in advanced chemistry research. His international research engagement is reflected through collaborative programs and visiting professorships, particularly in the United States and Europe. In addition, he has played a leading role in shaping the scientific community through organizing and chairing international conferences on functional materials, chemical engineering, and nanotechnology. His sustained research productivity and recognition as an established researcher highlight his significant contribution to contemporary chemical and materials research.

Profile: Scopus

Featured Publications:

Titinchi, J. J., et al. (2025). C4C recent developments: Carbonaceous-supported catalysts for CO₂ conversion into cyclic carbonates. [Journal name not specified].

Titinchi, J. J., et al. (2024). Overcoming curcumin’s limitations: Synthetic derivatives in diabetes and cancer management. [Journal name not specified].

Titinchi, J. J., et al. (2025). Asymmetrical curcumin derivative: Synthesis, structural exploration, Hirshfeld surface analysis, and computational study. Structural Chemistry.

Titinchi, J. J., et al. (2025). Synthesis, in silico and antimicrobial activity study of substituted aromatic imines and their corresponding amines. Results in Chemistry.

Titinchi, J. J., et al. (2025). Fault seal analysis for geological carbon dioxide storage in the Pletmos Basin, offshore South Africa. Marine Georesources and Geotechnology.

Titinchi, J. J., et al. (2024). Evaluating the therapeutic potential of curcumin and synthetic derivatives: A computational approach to anti-obesity treatments. International Journal of Molecular Sciences.

Titinchi, J. J., et al. (2023). Medicinal chemistry perspectives on the development of piperazine-containing HIV-1 inhibitors. [Journal name not specified].

Titinchi, J. J., et al. (2023). Substituent and solvent effects on UV–visible absorption spectra of chalcone derivatives: Experimental and computational studies. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy.

Titinchi, J. J., et al. (2023). Curcuminoid nanovesicles as advanced therapeutics. [Journal name not specified].

Ji Cao | Macrophage Biology | Research Excellence Award

Published on by Cell Biologist

Prof. Ji Cao | Macrophage Biology | Research Excellence Award

Zhejiang University | China

Ji Cao, Ph.D., is a leading scholar in tumor pharmacology and anticancer drug discovery, internationally recognized as a World’s Top 2% Scientist (Stanford ranking, 2023) and a National Young Top Talent of China. His research integrates tumor pharmacology, chemical biology, and artificial intelligence–driven drug design, with major contributions to targeted protein degradation (PROTACs), ferroptosis regulation, MYC oncoprotein inhibition, and cancer immunotherapy. He has published over 59 peer-reviewed articles in high-impact journals such as Cell Metabolism, Nature Communications, PNAS, and Science Advances, including multiple ESI highly cited papers, accumulating more than 4,000 citations with an h-index of 36. His work has translated into innovation through 18 Chinese patents and one international patent. He has led nationally and provincially funded projects exceeding ¥14 million and has received prestigious science and technology awards for outstanding contributions to biomedical research and translational pharmacology.

Citation Metrics (Scopus)

6000
4000
2000
200
100
50
0

Citations
5,725

Documents
149

h-index
44

Citations

Documents

h-index

Featured Publication

Francesca Santilli | Signal Transduction Mechanisms | Research Excellence Award

Published on by Cell Biologist

Prof. Francesca Santilli | Signal Transduction Mechanisms | Research Excellence Award

Department of Medicine and Aging Science, University of Chieti-Pescara “G. d’Annunzio”Chieti | Italy

Francesca Santilli, MD, PhD, is a leading physician-scientist whose work has substantially advanced the understanding of platelet biology, thrombo-inflammation, and cardio-metabolic disease. Her research focuses on mechanisms of platelet activation, interindividual variability in response to low-dose aspirin, and the interplay between inflammation, oxidative stress, and metabolic dysfunction. She has led major national and international projects, including studies on oxidative stress regulation in aspirin-treated diabetes, peripheral blood megakaryocyte maturation, and the effects of JAK inhibitors on thrombopoiesis in inflammatory disease. Her work has also contributed key insights into biomarkers—such as proteomic signatures, microRNAs, and extracellular vesicles—for cardiovascular and metabolic risk stratification. Additional research explores megakaryocyte biology, accelerated platelet turnover, and the impact of emerging therapies including GLP-1 receptor agonists, SGLT2 inhibitors, and PCSK9 inhibitors. Through extensive collaborations across molecular medicine, proteomics, rheumatology, cardiology, and infectious diseases, she has established interdisciplinary frameworks linking platelet function to diabetes, obesity, MASLD, and vascular disease. With over 160 high-impact publications and leadership roles in several scientific networks, her research continues to inform clinical translation and therapeutic optimization in thrombosis, hemostasis, and metabolic disorders.

Profiles: Google Scholar | Scopus

Featured Publications: 

antilli, F., Vazzana, N., Liani, R., Guagnano, M. T., & Davì, G. (2012). Platelet activation in obesity and metabolic syndrome. Obesity Reviews, 13(1), 27–42.

Santilli, F., Rocca, B., De Cristofaro, R., Lattanzio, S., Pietrangelo, L., Habib, A., & Patrono, C. (2009). Platelet cyclooxygenase inhibition by low-dose aspirin is not reflected consistently by platelet function assays: Implications for aspirin “resistance.” Journal of the American College of Cardiology, 53(8), 667–677.

Rocca, B., Santilli, F., Pitocco, D., Mucci, L., Petrucci, G., Vitacolonna, E., … & Patrono, C. (2012). The recovery of platelet cyclooxygenase activity explains interindividual variability in responsiveness to low-dose aspirin in patients with and without diabetes. Journal of Thrombosis and Haemostasis, 10(7), 1220–1230.

Caricato, A., Conti, G., Della Corte, F., Mancino, A., Santilli, F., Sandroni, C., … & Antonelli, M. (2005). Effects of PEEP on the intracranial system of patients with head injury and subarachnoid hemorrhage: The role of respiratory system compliance. Journal of Trauma and Acute Care Surgery, 58(3), 571–576.

Santilli, F., Vazzana, N., Bucciarelli, L. G., & Davì, G. (2009). Soluble forms of RAGE in human diseases: Clinical and therapeutical implications. Current Medicinal Chemistry, 16(8), 940–952.

Di Castelnuovo, A., Bonaccio, M., Costanzo, S., Gialluisi, A., Antinori, A., … Santilli, F., … & Iacoviello, L. (2020). Common cardiovascular risk factors and in-hospital mortality in 3,894 patients with COVID-19: Survival analysis and machine learning-based findings from the multicentre Italian study. Nutrition, Metabolism and Cardiovascular Diseases, 30(11), 1899–1913.

Vazzana, N., Santilli, F., Cuccurullo, C., & Davì, G. (2009). Soluble RAGE in internal medicine. Internal and Emergency Medicine, 4(5), 389–401.

Davì, G., Santilli, F., & Patrono, C. (2010). Nutraceuticals in diabetes and metabolic syndrome. Cardiovascular Therapeutics, 28(4), 216–226.

Chiarelli, F., Santilli, F., & Mohn, A. (2000). Role of growth factors in the development of diabetic complications. Hormone Research in Paediatrics, 53(2), 53–67.

Davì, G., Chiarelli, F., Santilli, F., Pomilio, M., Vigneri, S., Falco, A., … & Basili, S. (2003). Enhanced lipid peroxidation and platelet activation in the early phase of type 1 diabetes mellitus: Role of interleukin-6 and disease duration. Circulation, 107(25), 3199–3203.

Manigrasso, M. R., Ferroni, P., Santilli, F., Taraborelli, T., Guagnano, M. T., … & Davì, G. (2005). Association between circulating adiponectin and interleukin-10 levels in android obesity: Effects of weight loss. The Journal of Clinical Endocrinology & Metabolism, 90(10), 5876–5879.

Ilaria Cossu | Immunology Cellular Interactions | Research Excellence Award

Published on by Cell Biologist

Ms. Ilaria Cossu | Immunology Cellular Interactions | Research Excellence Award

University of Sassari | Italy

Ilaria Cossu is a motivated PhD candidate in Life Sciences and Biotechnologies with a specialization in Microbiology and Immunology. Their work focuses on understanding the role of human endogenous retroviruses (HERVs) in cancer, integrating molecular biology, immunology, and virology approaches to explore how retroviral elements may influence tumorigenesis. Their doctoral project involves conducting indirect ELISA assays, maintaining and analyzing cell cultures, processing blood samples, performing RNA extraction and reverse transcription, and carrying out quantitative PCR for gene expression profiling. The researcher is actively engaged in experimental design, data analysis, scientific writing, and collaborative research activities at both national and international levels.

Prior academic training includes Master’s and Bachelor’s degrees in Biology, each completed with top distinction, and research internships in microbiology, virology, and biochemistry laboratories. These experiences provided hands-on expertise in electrophoretic methods such as cellulose acetate electrophoresis, C-PAGE, fluorescent 2-aminoacridone probe (FACE) analysis, and SDS-PAGE, contributing to a solid foundation in protein and nucleic acid characterization. Their current research aims to advance understanding of retroviral contributions to cancer biology and supports the development of innovative molecular approaches for disease investigation and potential therapeutic insights.

Profile: Scopus

Featured Publications:

Cossu, I., Ruberto, S., Filippi, E., Simula, E. R., Noli, M., Mottula, A., & others. (2025). HERV-K envelope induces a humoral response in Non-Hodgkin lymphoma patients. Current Microbiology, 82(12), 574.

Jasemi, S., Molicotti, P., Fais, M., Cossu, I., Simula, E. R., Sechi, L. A., & others. (2025). Biological mechanisms of enterotoxigenic Bacteroides fragilis toxin: Linking inflammation, colorectal cancer, and clinical implications. Toxins, 17(6), 305.

Simula, E. R., Jasemi, S., Cossu, D., Fais, M., Cossu, I., Chessa, V., & others. (2025). Human endogenous retroviruses as novel therapeutic targets in neurodegenerative disorders. Vaccines, 13(4), 415. h

Ruberto, S., Santovito, A., Caviglia, G. P., Noli, M., Cossu, D., Ribaldone, D. G., & others. (2025). Mycobacterium avium subsp. paratuberculosis and human endogenous retrovirus in Italian patients with inflammatory bowel disease and irritable bowel syndrome. Immunology.

Tong Ming Liu | Stem Cell Research | Best Researcher Award

Published on by Cell Biologist

Dr. Tong Ming Liu |  Stem Cell Research | Best Researcher Award

Institute of Molecular and Cell Biology | Singapore

Dr. Tong Ming Liu’s research focuses on advancing gene and cell therapy through innovative studies on human mesenchymal stem cells (hMSCs) and induced pluripotent stem cells (iPSCs). His work explores the mechanisms governing mesenchymal stem cell stemness, potency, and ageing, with the goal of improving the therapeutic efficacy and manufacturing quality of MSC-based treatments. A central aspect of his research is identifying and characterizing critical quality attributes (CQAs) in MSC manufacturing to ensure consistent and safe clinical applications. Dr. Liu also investigates disease modeling of bone and cartilage disorders using iPSC-derived MSCs to facilitate drug screening and gene correction strategies. His recent projects include the development of optimized media for iPSC, iPSC-MSC, and MSC culture, as well as identifying novel biomarkers to select high-quality MSCs for regenerative medicine. Through his studies, he aims to enhance the scalability, functionality, and translational potential of stem cell therapies. His findings have been recognized in scientific forums such as the EVANTICA Symposium and Singapore Cell and Gene Therapy Conference, underscoring his contribution to the development of efficient MSC-derived extracellular vesicle (MSC-EV) optimization and regenerative therapy innovations.

Profiles: Google Scholar | Scopus | Orcid

Featured Publications:

Liu, T. M.*, Tew, W., Yang, Z., Lim, B., Hui, J. H. P., Lee, E. H., Loh, Y.-H., & Cool, S. (2025). Understanding the molecular basis of mesenchymal stem cell stemness: Implications for clinical applications. Cell Death & Disease, 16(1), 778.

Liu, T. M.* (2025). MSC-EVs: Pioneering the next generation of biomedical applications. World Journal of Stem Cells, 17(6), 108197.

Liu, T. M.*, & Wu, Y. (2023). Advancing gene and cell therapy using human mesenchymal stem cells. Frontiers in Cell and Developmental Biology, 11, 1294460.

Shou, Y., Liu, L., Le, Z., Lee, K. L., Li, X., Koh, D. Z., Wang, Y., Liu, T. M., Yang, Z., Lim, C. T., Cheung, C., & Tay, A. (2023). Mechano-responsive hydrogel for directing stem cell manufacturing and therapy. Bioactive Materials, 24, 387–400.

Liu, T. M.* (2021). Application of mesenchymal stem cells derived from human pluripotent stem cells in regenerative medicine. World Journal of Stem Cells, 13(12), 1826–1844.

Srinivasan, A., Sathiyanathan, P., Yin, L., Liu, T. M., Lam, A., Ravikumar, M., Smith, R. A. A., Loh, H. P., Zhang, Y., Ling, L., Ng, S. K., Yang, Y. S., Lezhava, A., Hui, J., Oh, S., & Cool, S. M. (2022). Strategies to enhance immunomodulatory properties and reduce heterogeneity in mesenchymal stromal cells during ex vivo expansion. Cytotherapy, 24(5), 456–472.

Liu, T. M.*, Yildirim, E. D., Li, P., Fang, H. T., Denslin, V., Kumar, V., Loh, Y.-H., Lee, E. H., Cool, S. M., Teh, B. T., Hui, J. H., Lim, B., & Shyh-Chang, N. (2020). Ascorbate and iron are required for the specification and long-term self-renewal of human skeletal mesenchymal stromal cells. Stem Cell Reports, 14(2), 210–225.

Arzu Yay | Stem Cell Research | Best Researcher Award

Published on by Cell Biologist

Prof. Dr. Arzu Yay | Stem Cell Research | Best Researcher Award

Erciyes University | Turkey

Prof. Arzu Yay is a distinguished researcher in the Department of Histology and Embryology at Erciyes University, Turkey. Her work focuses on cellular and molecular mechanisms underlying tissue development, injury, and repair, with emphasis on immunohistochemical and ultrastructural analyses. Her M.Sc. research examined E-cadherin expression during renal development in the prenatal period, contributing to the understanding of epithelial differentiation in organogenesis. Her Ph.D. focused on nestin expression across different grades of meningiomas and glioblastomas, highlighting neural stem cell marker dynamics in tumor progression. She has conducted significant studies on oxidative stress, neurobiology, and tissue damage, including investigations into the effects of melatonin and vitamin C on alcohol-induced lung injury and nitric oxide synthase immunoreactivity. Her research has also explored tissue-level alterations in diabetes and the histological impacts of hormonal and anesthetic agents. Prof. Yay’s postdoctoral work at the University of Lübeck, Germany, further advanced her expertise in dermatological histopathology. Her contributions have been recognized through multiple national and international awards for excellence in experimental and translational research, particularly in antioxidant mechanisms and radioprotection. Her body of work reflects a strong integration of histological, molecular, and ultrastructural approaches in biomedical sciences.

Profiles: Google Scholar | Scopus

Featured Publications:

Yıldız, K., Efesoy, S. N., Ozdamar, S., Yay, A., Bicer, C., Aksu, R., & Kılıc, E. (2011). Myotoxic effects of levobupivacaine, bupivacaine and ropivacaine in a rat model. Clinical Investigation in Medicine, 34(5), 273–280.

Sarıozkan, S., Bucak, M. N., Canturk, F., Ozdamar, S., Yay, A., Tuncer, P. B., Ozcan, S., Sorgucu, N., & Caner, Y. (2012). The effects of different sugars on motility, morphology and DNA damage during the liquid storage of rat epididymal sperm at 4°C. Cryobiology, 65(2), 93–97.

Sarıozkan, S., Canturk, F., Yay, A., & Akçay, A. (2012). The effect of different storage temperature on sperm parameters and DNA damage in liquid stored New Zealand rabbit spermatozoa. Kafkas Üniversitesi Veteriner Fakültesi Dergisi, 18(3), 475–480.*

Yay, A., Ozdamar, S., Canoz, O., Tucer, B., & Baran, M. (2013). Nestin expression in meningiomas of different grades. Journal of Neurological Sciences (Turkish), 30, 532–540.

Sarıozkan, S., Türk, G., Canturk, F., Yay, A., Eken, A., & Akçay, A. (2013). The effect of bovine serum albumin and fetal calf serum on sperm quality, DNA fragmentation and lipid peroxidation of liquid stored rabbit semen. Cryobiology, 67(1), 1–6.*

Ernst, N., Yay, A., Bíró, T., Tiede, S., Humphries, M., Paus, R., & Kloepper, J. E. (2013). β1 integrin signaling maintains human epithelial progenitor cell survival in situ and controls proliferation, apoptosis and migration of their progeny. PLoS ONE, 8(12), e84356.*

Yay, A., Ozdamar, S., Canoz, O., Baran, M., Tucer, B., & Sonmez, M. F. (2014). Intermediate filament protein nestin is expressed in developing meninges. Bratislava Medical Journal, 115(11), 718–722.*