Paola Cynthia Demeni Emoh | Endophytic fungi | Young Scientist Award

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Mrs. Paola Cynthia Demeni Emoh | Endophytic fungi | Young Scientist Award

Mrs. Paola Cynthia Demeni Emoh , University of Yaoundé 1 , Cameroon

Cynthia Paola Demeni Emoh is a Ph.D. candidate in Medical Microbiology at the University of Yaoundé I, Cameroon. She has a keen interest in the antimicrobial properties of natural products and their potential applications in treating infectious diseases like malaria and pneumonia. Cynthia also serves as a part-time lecturer, teaching microbiology practicals at her university. She is an active researcher and has contributed to multiple systematic reviews and meta-analyses, focusing on infectious diseases. Her collaborations with international networks, such as the AGNES and YaBiNaPA programs, have expanded her research reach. Cynthia is also a member of the American Society of Microbiology and a contributor to various scientific journals. With her solid academic background and dedication to scientific advancement, Cynthia continues to strive for excellence in both her research and teaching roles.

Publication Profile:

Orcid

Strengths for the Award:

Cynthia Paola Demeni Emoh is an outstanding candidate for the Research for Young Scientist Award due to her extensive academic background, innovative research, and significant contributions to microbiology. Her work on endophytic fungi and infectious diseases, particularly malaria, demonstrates her commitment to addressing public health challenges in sub-Saharan Africa. Her experience with systematic reviews and meta-analyses further highlights her expertise in synthesizing global data to drive scientific advancements.

Areas for Improvement:

While Cynthia has established a strong foundation in microbiology, she could benefit from additional experience in interdisciplinary research, particularly in translational science. Collaborations with clinicians or public health experts could broaden her research’s practical applications and improve its potential for real-world impact.

Education:

Cynthia’s educational journey began at the University of Yaoundé I, where she earned her Bachelor’s degree in Microbiology in 2016. She later pursued a Master’s degree in Medical Microbiology at the same institution, which she completed in 2019. During her master’s program, she focused on assessing the antibacterial properties of endophytic fungi isolated from Alstonia boonei and Greenwayodendron suaveolens, particularly their effectiveness against pneumonia bacteria. Building on her master’s research, Cynthia is now a Ph.D. candidate in Medical Microbiology at the University of Yaoundé I. Her Ph.D. research, initiated in 2020, examines the antiplasmodial activity of endophytic fungi extracts from Alstonia boonei and their modes of action. Cynthia’s academic trajectory is shaped by a solid foundation in microbiology, driven by her interest in infectious diseases and their treatment. She has also earned a Baccalaureate in Life Sciences from François Xavier Vogt College in Yaoundé.

Experience:

Cynthia’s professional experience spans both teaching and research in microbiology. She has been a part-time lecturer at the University of Yaoundé I since October 2018, where she is responsible for the practical component of microbiology courses. She has also contributed significantly as an assistant researcher at the Biotechnology Centre of the University of Yaoundé I in 2019, where she worked on phytopathology. Cynthia’s research experience extends beyond Cameroon, having completed an internship at the University of Abomey-Calavi in Benin in 2023, focusing on applied microbiology and pharmacology. Additionally, she interned at the Centre Pasteur of Cameroon in 2022 and 2023, contributing to malaria research. She has been a member of various research groups, including the Systematic Reviews and Meta-Analysis team led by Dr. Kenmoe Sebastien at the Centre Pasteur of Cameroon. Cynthia’s research output and collaborations have strengthened her expertise in microbiology, especially in the areas of infectious diseases and natural products.

Research Focus:

Cynthia’s research focuses on investigating the antimicrobial properties of endophytic fungi extracts, with particular emphasis on their antiplasmodial and antibacterial activities. Her Ph.D. research centers on the antiplasmodial effects of fungi isolated from Alstonia boonei, a plant known for its medicinal properties. She explores how these fungal extracts can serve as alternative treatments for malaria by assessing their activity against Plasmodium falciparum. Cynthia’s earlier work, during her Master’s program, also centered on the antibacterial properties of endophytic fungi from Alstonia boonei and Greenwayodendron suaveolens and their ability to combat pneumonia bacteria. In addition to her laboratory studies, she has contributed to systematic reviews and meta-analyses, analyzing the prevalence, risk factors, and epidemiology of various infectious diseases, such as hepatitis, tuberculosis, and Crimean-Congo hemorrhagic fever. Cynthia’s research is driven by the need for novel antimicrobial agents, especially against drug-resistant pathogens and emerging diseases in sub-Saharan Africa.

Publication Top Notes:

  1. Assessment of the antiplasmodial and cytotoxicity effects of ethyl acetate extracts against Plasmodium falciparum strains (2025) 🦠🧪
  2. Morphological and molecular characterization of endophytic fungi isolated from Alstonia boonei De Wild (2025) 🔬🍄
  3. Stage-Dependent Release of Plasmodium Falciparum Homolog of T-Cell Immunomodulatory Protein and Suppression of Macrophage-Inflammatory Protein-1 (2025) 🦠💉
  4. Isolation, identification of endophytic fungi from Codiaeum variegatum and assessment of anti-amoebic and anti-inflammatory potential (2024) 🍄🌱
  5. Systematic review with meta-analysis of the global host range of Mycobacterium ulcerans (2024) 🌍🦠
  6. Hepatitis B, C, and D virus infections and risk of hepatocellular carcinoma in Africa (2022) 🦠🌍
  7. Global prevalence and case fatality rate of Enterovirus D68 infections (2022) 🌍🦠
  8. Systematic review of Crimean-Congo Hemorrhagic Fever Virus epidemiology in humans and animals (2021) 🩸🦠
  9. Worldwide epidemiology of Lassa virus in humans and rodents (2020) 🌍🦠
  10. Influence of confounding factors on associations between viral LRTI and subsequent wheezing development (2021) 🧳👶

Conclusion:

Cynthia is a promising young researcher with a clear focus on addressing critical health issues. Her dedication to advancing scientific knowledge, particularly in the fight against infectious diseases, makes her an excellent candidate for the Research for Young Scientist Award.

 

 

 

Romain Villéger | Host-bacteria interactions | Cell Metabolism Award

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Assist. Prof. Dr. Romain Villéger | Host-bacteria interactions | Cell Metabolism Award

Assist. Prof. Dr. Romain Villéger , Université de Poitiers , France

Dr. Romain Villéger is an Assistant Professor at the University of Poitiers, France, in the Ecology & Biology of Interactions (EBI) lab, within the Microorganisms-Hosts-Environments (MHE) team. With a Ph.D. from the University of Limoges, his work explores the intricate interactions between probiotics and host cells. He has held postdoctoral positions at the University of Bordeaux and the University of Texas Medical Branch, USA, focusing on microbiota-host relationships and metabolomics. Dr. Villéger’s research aims to unravel the role of bacterial interactions, particularly in the context of gastrointestinal health, microbiota, and cancer. His research has led to significant advancements in understanding microbial pathogenesis, including the effects of probiotics and endocrine disruptors on host cell metabolism. A dedicated researcher, he has contributed to numerous scientific publications and currently leads several high-impact projects on bacteria-host interactions.

Publication Profile:

Scopus

Strengths for the Award:

  1. Expertise in Metabolomics: Dr. Romain Villéger’s extensive work in metabolomics, especially in the context of host-bacteria interactions, positions him as a strong candidate for the Cell Metabolism Award. His research on bacterial influence on host cellular metabolism and gut microbiota interactions contributes significantly to the field of cellular metabolism.
  2. Innovative Research Contributions: His research, particularly on the metabolic changes during amoeba-Legionella interactions, showcases a novel approach to understanding microbial pathogenesis. By identifying metabolic vulnerabilities in pathogens, his work has the potential for therapeutic applications, thus addressing fundamental questions in cell metabolism.
  3. Multidisciplinary Approach: Dr. Villéger combines microbiology, immunology, and metabolomics, which enriches his contributions to cellular metabolism. His research is collaborative, evidenced by numerous projects across different institutions and fields, indicating a broad and innovative approach to the subject.
  4. Publications and Impact: He has a strong publication record, with numerous articles in peer-reviewed journals (19 publications), with high visibility in top-tier journals such as British Journal of Cancer, Frontiers in Cellular and Infection Microbiology, and Environmental Microbiology Reports. This demonstrates his influence and impact in the scientific community.
  5. Research Leadership: As the principal investigator of multiple projects, including those on the effects of phthalates on gut microbiota and cancer development, Dr. Villéger has demonstrated leadership in advancing scientific knowledge in areas that intersect with cell metabolism, host-microbe interactions, and metabolic changes in disease.

Areas for Improvement:

  1. Broader Clinical Translation: While his research shows deep insights into fundamental mechanisms, further work on translating these findings into practical clinical applications or therapeutic interventions would strengthen his impact in applied cellular metabolism.
  2. Interdisciplinary Team Development: While Dr. Villéger collaborates with many renowned researchers, fostering additional interdisciplinary partnerships could enrich his research by incorporating diverse techniques and perspectives from fields like drug development or personalized medicine.
  3. Expanding Metabolomic Toolkits: His research could benefit from exploring emerging and cutting-edge techniques in metabolomics, like single-cell analysis or multi-omics approaches, to gain deeper insights into cellular metabolism at the individual cell level.

Education:

Dr. Villéger completed his Ph.D. at the University of Limoges, where his thesis focused on the interactions between probiotics and host cells. His postdoctoral work spans institutions in France, the USA, and beyond, each contributing valuable insights into microbial-host dynamics and cellular microbiology. At the University of Bordeaux, he developed metabolomic approaches using GC/MS to study microbiota interactions. Later, at the University of Texas Medical Branch, he delved deeper into the effects of probiotics on intestinal homeostasis. Further postdoctoral experiences at the University of Clermont Auvergne involved examining the relationship between E. coli and colorectal cancer. Through these experiences, Dr. Villéger has gained expertise in microbiota research, cell biology, and metabolic analysis, providing a foundation for his ongoing work in the field. His education has provided a strong interdisciplinary framework, integrating microbiology, molecular biology, and toxicology into his research.

Experience:

Dr. Villéger has accumulated extensive experience in both academic and research settings. After earning his Ph.D. in 2014, he completed several postdoctoral positions, with notable work at the University of Bordeaux, where he pioneered metabolomics techniques for microbiota research. His tenure at the University of Texas Medical Branch expanded his focus to the effects of probiotics on intestinal homeostasis. Additionally, his work at the University of Clermont Auvergne involved exploring the connection between microbial interactions and cancer. Since joining the University of Poitiers in 2020 as an Assistant Professor, Dr. Villéger has led several research projects, including investigating the impact of endocrine disruptors on colorectal cancer development. He is also a leader in metabolomics and microbial pathogenesis, with a particular focus on bacteria-host interactions and microbiota modulation. His research has contributed to numerous publications and collaborations with institutions worldwide, showcasing his ability to manage complex research projects.

Research Focus:

Dr. Villéger’s research primarily focuses on bacteria-host interactions, gut microbiota, and cellular microbiology, with a special interest in how microbial populations affect host metabolism. His work integrates metabolomics, a powerful tool for studying metabolic processes, to better understand microbial influence on host cells. Dr. Villéger’s recent studies explore the role of oxidative stress in microbial infections, including Legionella pneumophila’s subversion of host immune defenses during infection. He has also investigated the impact of endocrine disruptors on microbial virulence, providing insights into the potential links between environmental factors and microbial pathogenesis. His contributions to understanding the microbiota-gut-brain axis, particularly in the context of colorectal cancer, emphasize the metabolic changes induced by bacterial interactions. Dr. Villéger’s research aims to identify biomarkers for disease and therapeutic interventions, with a broader goal of advancing precision medicine through a better understanding of the cellular and metabolic processes that underlie microbial-host dynamics.

Publications Top Notes:

  1. Legionella pneumophila subverts the antioxidant defenses of its amoeba host Acanthamoeba castellanii 💥🦠
  2. Increased Activity of MAPKAPK2 within Mesenchymal Cells as a Target for Inflammation-Associated Fibrosis in Crohn’s Disease 🔬🧬
  3. Exposure to endocrine disruptors promotes biofilm formation and contributes to increased virulence of Pseudomonas aeruginosa 💧🦠
  4. Loss of alcohol dehydrogenase 1B in cancer-associated fibroblasts: contribution to the increase of tumor-promoting IL-6 in colon cancer 🧬🦠
  5. Effect of endocrine disruptors on bacterial virulence 🌿🧪
  6. Proteomic analysis of Acanthamoeba castellanii response to Legionella pneumophila infection 🔬🦠
  7. Disruption of retinol-mediated IL-6 expression in colon cancer-associated fibroblasts: new perspectives on the role of vitamin A metabolism 🧬🍊
  8. Microbiota medicine: towards clinical revolution 🌍💊
  9. Deletion of cystathionine-γ-lyase in bone marrow-derived cells promotes colitis-associated carcinogenesis 🔬🦠
  10. Prebiotic Isomaltooligosaccharide Provides an Advantageous Fitness to the Probiotic Bacillus subtilis CU1 🍞🦠

Conclusion:

Dr. Romain Villéger is a highly qualified candidate for the Cell Metabolism Award. His research contributions in understanding microbial influence on cellular metabolism and gut health, combined with his innovative approach to metabolomics, make him stand out in the field. His work bridges basic science and potential clinical applications, positioning him as a key figure in the ongoing exploration of microbial and metabolic influences on host physiology. With some expansion into clinical applications and further exploration of new metabolomics techniques, his contributions could significantly impact both scientific knowledge and medical practice.