Paitoon Rashatasakhon | Fluorescent Dyes | Innovative Research Award

Innovative Research Award

Paitoon Rashatasakhon
Chulalongkorn University, Thailand

Paitoon Rashatasakhon
Affiliation Chulalongkorn University
Country Thailand
Scopus ID 6603258134
Documents 88
Citations 2,123
h-index 28
Subject Area Fluorescent Dyes
Event World Cell Biologist Awards
ORCID 0000-0002-7993-7968

Paitoon Rashatasakhon is a researcher affiliated with Chulalongkorn University, Thailand, whose scholarly profile includes research associated with fluorescent dyes and related areas of chemical and biological applications. The recognition presented here is associated with the Innovative Research Award under the World Cell Biologist Awards. Bibliographic indicators such as publication counts, citation counts and the h-index are commonly used to describe aspects of a researcher’s scholarly output and citation impact.  [1]

Abstract

Paitoon Rashatasakhon is affiliated with Chulalongkorn University in Thailand and is identified in the supplied research profile with a subject-area focus on fluorescent dyes. The profile records 88 documents, 2,123 citations and an h-index of 28. Fluorescent dyes constitute an important research domain because fluorescent molecules can provide sensitive optical signals for analytical chemistry, molecular recognition, imaging and biological investigation. [2] The Innovative Research Award recognizes research activity presented in the context of the World Cell Biologist Awards, with this profile emphasizing bibliographic output, citation impact and relevance to fluorescence-based research.

Keywords

Innovative Research Award; Paitoon Rashatasakhon; Chulalongkorn University; Fluorescent Dyes; Fluorescence Chemistry; Molecular Probes; Bioimaging; Research Impact

Introduction

Fluorescence-based methods occupy an important position across modern chemical and life-science research. Fluorescent dyes and probes can convert molecular interactions or environmental changes into measurable optical signals, supporting applications that range from chemical sensing to cellular and molecular imaging. [2] The development of fluorescent probes has also contributed to the investigation of biological processes where spatial and temporal information is important.

Research Profile

The supplied profile identifies Paitoon Rashatasakhon as a researcher at Chulalongkorn University, Thailand, with a research focus associated with fluorescent dyes. The stated Scopus record contains 88 documents, 2,123 citations and an h-index of 28. The corresponding Scopus author identifier is 6603258134. [1]

Research Contributions

Research involving fluorescent dyes may contribute to the development of molecules and analytical strategies capable of generating detectable optical responses. Depending on molecular design and application, fluorescent systems can be used to investigate chemical environments, molecular interactions and biological phenomena. [2] Fluorescent probes are also relevant to biological research because appropriately designed fluorophores can provide information about cellular structures, biochemical events and molecular targets. The field therefore intersects chemistry, analytical science, molecular biology and cell biology. [4]

Publications

The supplied profile reports 88 documents indexed in Scopus. [1] A complete publication bibliography should be retrieved directly from the researcher’s current institutional and bibliographic profiles because publication lists, citation counts and indexing records can change over time.

For scholarly evaluation, publications in fluorescent-dye research can encompass synthetic chemistry, photophysical characterization, sensing, molecular recognition, imaging and applications in biological systems. Fluorescent probes have been extensively studied for their ability to provide optical responses to specific chemical or biological conditions. [3]

Research Impact

The supplied bibliometric profile records 2,123 citations and an h-index of 28 across 88 documents. [1] These figures indicate measurable citation activity associated with the indexed publication record. Citation-based indicators are most appropriately considered alongside the quality, originality, relevance and reproducibility of the underlying research.[4]

Research on fluorescent systems may also support the development of probes with improved selectivity, sensitivity and photophysical characteristics. Such advances can be relevant to chemical sensing, molecular diagnostics and imaging-oriented research, depending on the intended application and validation of each system. [5]

Award Suitability

The Innovative Research Award profile is aligned with the supplied research information concerning Paitoon Rashatasakhon, particularly the stated subject area of fluorescent dyes and the documented bibliographic indicators. The relationship between fluorescent-dye chemistry and cell biology provides an interdisciplinary basis for considering research that contributes methods, probes or analytical approaches applicable to biological investigation.

Conclusion

Paitoon Rashatasakhon of Chulalongkorn University, Thailand, is presented in the supplied profile as a researcher working in the area of fluorescent dyes. The profile reports 88 documents, 2,123 citations and an h-index of 28. Fluorescent-dye research occupies an interdisciplinary position connecting chemical design, analytical measurement and biological investigation. [2]

References

  1. Elsevier. (n.d.). Scopus author details: Paitoon Rashatasakhon, Author ID 6603258134. Scopus.
    https://www.scopus.com/pages/authors/6603258134
  2. S Namuangruk, P Rashatasakhon., et al. (2020). Solvatochromic triazaborolopyridinium probes toward ultra-sensitive trace water detection in organic solvents.
    https://www.sciencedirect.com/science/article/pii/S0143720820304654
  3. M Sukwattanasinitt, P Rashatasakhon., et al. (2021). Fluorescent sensor for copper (II) and cyanide ions via the complexation–decomplexation mechanism with di (bissulfonamido) spirobifluorene.
    https://pmc.ncbi.nlm.nih.gov/articles/PMC8246698/
  4. P Rashatasakhon, T Kumchoo, V Promarak, et al. (2010). Dipyrenylcarbazole Derivatives for Blue Organic Light‐Emitting Diodes.
    https://www.academia.edu/download/45727478/asia.20100030420160517-24947-14faydz.pdf
  5. P Chinapang, V Ruangpornvisuti, M Sukwattanasinitt, P Rashatasakhon. (2015). Ferrocenyl derivative of 1, 8-naphthalimide as a new turn-on fluorescent sensor for Au (III) ion.
    https://www.sciencedirect.com/science/article/pii/S0143720814002903

Ana Estela | Developmental Cell Biology | Women Researcher Award

Dr. Ana Estela | Developmental Cell Biology | Women Researcher Award

UNSE | Argentina

Ana Estela Ledesma is a senior researcher specializing in macromolecules, biomolecular interactions, and nanosystems, combining theoretical calculations with advanced spectroscopic techniques. Her work focuses on elucidating structural and biophysical mechanisms in protein–ligand and protein–surface interactions. She has led and contributed to numerous nationally funded research projects and has an extensive publication record in indexed journals. Her research spans nanoparticles functionalized with natural compounds for medical and agricultural applications, bioactive alkaloids with hypoglycemic effects, oxidative processes in proteins, and the characterization of probiotic and prebiotic biomolecules.

Citation Metrics (Scopus)

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613

Documents
38

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15

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Aparna Gunjal | Microbiology and Environmental Science | Research Excellence Award

Prof. Dr. Aparna Gunjal | Microbiology and Environmental Science | Research Excellence Award

Dept of Environmental Science, Dr. D.Y. Patil, Arts, Commerce & Science College, Pimpri, Pune, Maharashtra | India

Dr. Aparna B. Gunjal is an accomplished researcher and educator specializing in Industrial Microbiology, Microbiology, and Environmental Sciences. She earned her Ph.D. in Environmental Sciences from Savitribai Phule Pune University, focusing on microbial enrichment of agro-industrial by-products for soil conditioners, and completed postdoctoral research at Hong Kong Baptist University. Her academic contributions include extensive teaching at the postgraduate level, covering practical and theoretical courses in Environmental Science and Microbiology, with emphasis on industrial wastewater treatment and molecular biology. She has also undergone industry-oriented training at prominent dairy and distillery establishments, reflecting a strong integration of research, teaching, and applied microbiology.

Citation Metrics (Google Scholar)

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360

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255

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Jiangang Zhang | Cell Metabolism | Research Excellence Award

Dr. Jiangang Zhang | Cell Metabolism | Research Excellence Award

School of Basic Medical Sciences, Lanzhou University | China

Dr. Jiangang Zhang. A senior academic and medical professional with extensive leadership in pathology, forensic medicine, and laboratory sciences at Lanzhou University and its affiliated hospitals. Holds multiple directorial roles across pathology departments, forensic appraisal institutes, dental hospitals, and GLP laboratory centers, contributing significantly to clinical diagnostics, forensic evaluation, and translational research. Recognized nationally and provincially as an expert in forensic appraisal, including insurance-related forensic assessments, and plays a key role in expert review and governance bodies. Academic training spans clinical medicine, tissue engineering, and advanced biomedical research, with doctoral-level experience at Peking University. Research expertise includes obesity, nutrition, chronic diseases, skin tissue engineering, and pathology-related biomedical sciences. Has led and completed several major nationally funded research projects, including multiple grants from the National Natural Science Foundation of China and military medical research programs, reflecting sustained contributions to medical science, education, and forensic pathology.

Citation Metrics (Scopus)

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252

Documents
14

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6

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Ji Cao | Macrophage Biology | Research Excellence Award

Prof. Ji Cao | Macrophage Biology | Research Excellence Award

Zhejiang University | China

Ji Cao, Ph.D., is a leading scholar in tumor pharmacology and anticancer drug discovery, internationally recognized as a World’s Top 2% Scientist (Stanford ranking, 2023) and a National Young Top Talent of China. His research integrates tumor pharmacology, chemical biology, and artificial intelligence–driven drug design, with major contributions to targeted protein degradation (PROTACs), ferroptosis regulation, MYC oncoprotein inhibition, and cancer immunotherapy. He has published over 59 peer-reviewed articles in high-impact journals such as Cell Metabolism, Nature Communications, PNAS, and Science Advances, including multiple ESI highly cited papers, accumulating more than 4,000 citations with an h-index of 36. His work has translated into innovation through 18 Chinese patents and one international patent. He has led nationally and provincially funded projects exceeding ¥14 million and has received prestigious science and technology awards for outstanding contributions to biomedical research and translational pharmacology.

Citation Metrics (Scopus)

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Citations
5,725

Documents
149

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44

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Featured Publication

Francesca Santilli | Signal Transduction Mechanisms | Research Excellence Award

Prof. Francesca Santilli | Signal Transduction Mechanisms | Research Excellence Award

Department of Medicine and Aging Science, University of Chieti-Pescara “G. d’Annunzio”Chieti | Italy

Francesca Santilli, MD, PhD, is a leading physician-scientist whose work has substantially advanced the understanding of platelet biology, thrombo-inflammation, and cardio-metabolic disease. Her research focuses on mechanisms of platelet activation, interindividual variability in response to low-dose aspirin, and the interplay between inflammation, oxidative stress, and metabolic dysfunction. She has led major national and international projects, including studies on oxidative stress regulation in aspirin-treated diabetes, peripheral blood megakaryocyte maturation, and the effects of JAK inhibitors on thrombopoiesis in inflammatory disease. Her work has also contributed key insights into biomarkers—such as proteomic signatures, microRNAs, and extracellular vesicles—for cardiovascular and metabolic risk stratification. Additional research explores megakaryocyte biology, accelerated platelet turnover, and the impact of emerging therapies including GLP-1 receptor agonists, SGLT2 inhibitors, and PCSK9 inhibitors. Through extensive collaborations across molecular medicine, proteomics, rheumatology, cardiology, and infectious diseases, she has established interdisciplinary frameworks linking platelet function to diabetes, obesity, MASLD, and vascular disease. With over 160 high-impact publications and leadership roles in several scientific networks, her research continues to inform clinical translation and therapeutic optimization in thrombosis, hemostasis, and metabolic disorders.

Profiles: Google Scholar | Scopus

Featured Publications: 

antilli, F., Vazzana, N., Liani, R., Guagnano, M. T., & Davì, G. (2012). Platelet activation in obesity and metabolic syndrome. Obesity Reviews, 13(1), 27–42.

Santilli, F., Rocca, B., De Cristofaro, R., Lattanzio, S., Pietrangelo, L., Habib, A., & Patrono, C. (2009). Platelet cyclooxygenase inhibition by low-dose aspirin is not reflected consistently by platelet function assays: Implications for aspirin “resistance.” Journal of the American College of Cardiology, 53(8), 667–677.

Rocca, B., Santilli, F., Pitocco, D., Mucci, L., Petrucci, G., Vitacolonna, E., … & Patrono, C. (2012). The recovery of platelet cyclooxygenase activity explains interindividual variability in responsiveness to low-dose aspirin in patients with and without diabetes. Journal of Thrombosis and Haemostasis, 10(7), 1220–1230.

Caricato, A., Conti, G., Della Corte, F., Mancino, A., Santilli, F., Sandroni, C., … & Antonelli, M. (2005). Effects of PEEP on the intracranial system of patients with head injury and subarachnoid hemorrhage: The role of respiratory system compliance. Journal of Trauma and Acute Care Surgery, 58(3), 571–576.

Santilli, F., Vazzana, N., Bucciarelli, L. G., & Davì, G. (2009). Soluble forms of RAGE in human diseases: Clinical and therapeutical implications. Current Medicinal Chemistry, 16(8), 940–952.

Di Castelnuovo, A., Bonaccio, M., Costanzo, S., Gialluisi, A., Antinori, A., … Santilli, F., … & Iacoviello, L. (2020). Common cardiovascular risk factors and in-hospital mortality in 3,894 patients with COVID-19: Survival analysis and machine learning-based findings from the multicentre Italian study. Nutrition, Metabolism and Cardiovascular Diseases, 30(11), 1899–1913.

Vazzana, N., Santilli, F., Cuccurullo, C., & Davì, G. (2009). Soluble RAGE in internal medicine. Internal and Emergency Medicine, 4(5), 389–401.

Davì, G., Santilli, F., & Patrono, C. (2010). Nutraceuticals in diabetes and metabolic syndrome. Cardiovascular Therapeutics, 28(4), 216–226.

Chiarelli, F., Santilli, F., & Mohn, A. (2000). Role of growth factors in the development of diabetic complications. Hormone Research in Paediatrics, 53(2), 53–67.

Davì, G., Chiarelli, F., Santilli, F., Pomilio, M., Vigneri, S., Falco, A., … & Basili, S. (2003). Enhanced lipid peroxidation and platelet activation in the early phase of type 1 diabetes mellitus: Role of interleukin-6 and disease duration. Circulation, 107(25), 3199–3203.

Manigrasso, M. R., Ferroni, P., Santilli, F., Taraborelli, T., Guagnano, M. T., … & Davì, G. (2005). Association between circulating adiponectin and interleukin-10 levels in android obesity: Effects of weight loss. The Journal of Clinical Endocrinology & Metabolism, 90(10), 5876–5879.

Ahmed Sobhy Abdelrahim Abdallah Darwish | Cell Biology | Research Excellence Award

Dr. Ahmed Sobhy Abdelrahim Abdallah Darwish | Cell Biology | Research Excellence Award

Zagazig University & Egyptian International Pharmaceutical Industries Company, EIPICO | Egypt

Ahmed Sobhy Abdelrahim Abdallah Darwish is a highly accomplished analytical chemist with extensive expertise in analytical methodologies and chemical research. His academic journey demonstrates a consistent commitment to scientific rigor, progressing from a strong foundation in chemistry and physics to advanced studies in analytical chemistry. He has completed a diploma in analytical chemistry with distinction, a pre-master qualification with outstanding performance, and a master’s degree in analytical chemistry. Currently pursuing a Ph.D. in the same field, his research is centered on the development, optimization, and validation of analytical techniques for pharmaceutical and industrial applications. His work emphasizes precision, reliability, and innovation in chemical analysis, including method development for complex matrices, quality control protocols, and instrumental analysis techniques. His contributions aim to enhance the accuracy and efficiency of laboratory workflows, ensuring robust and reproducible results in pharmaceutical and chemical research. Additionally, he demonstrates proficiency in data interpretation, statistical analysis, and experimental design, contributing to high-quality scientific outcomes. His ongoing research reflects a commitment to advancing analytical chemistry through both theoretical insights and practical applications, positioning him as a significant contributor to the field and a strong candidate for recognition in research excellence.

Profiles: Google Scholar | Scopus | Orcid

Featured Publications: 

Ma, J. K., Darwish, A. S., Al Ali, A., Abdelazim, A. M., Darwish, W. S., Li, X., & Huang, X. C. (2025). An ecologically sound HPLC determination of LEVOMENOL in topical therapies using a certified reference material with green properties. Results in Chemistry, 13, 102338.

Alenezi, S. S., Gouda, A. A., El Sheikh, R., Badahdah, N. A., Alzuhiri, M. E., & others. (2025). Environmental sustainability profiles assessment of HPLC stability indicating method for quantitation of piracetam and vincamine in pharmaceutical medications. Talanta Open, 11, 100407.

Darwish, A. S., Zaki, M. S. A., Salih, A. G. K. A., Ellatif, M. A., Patel, A. A., Mallick, A. K., & others. (2025). A simple eco‐friendly stability‐indicating HPLC method for determination of NETILMICIN in bulk and ophthalmic solution. Biomedical Chromatography, 39(8), e70152.

Gouda, A. A., Elsheikh, R., Eldien, A. S., & Darwish, A. S. (2025). Development and validation of stability indicating RP-HPLC method for simultaneous determination of simvastatin and fenofibrate in bulk and dosage form. Bulletin of Faculty of Science, Zagazig University, 2025(3), 134–146.

Huang, X. C., Darwish, A. S., Darwish, W. S., Chen, R. M., & Ma, J. K. (2025). Green rapid HPLC method for testing retinol and tocopherol in ophthalmic gels. Talanta Open, 100538.

Darwish, A. S., Gouda, A. A., & Eldien, A. S. (2025). Simple validated approach to quantify valsartan and sacubitril in medications using liquid chromatography. Bulletin of Faculty of Science, Zagazig University, 2025(3), 216–229.

Darwish, W. S. D., Zaki, M. S. A., Salih, A. G. K. A., & others. (2025). Developing a sensitive, ecological, and economic HPLC method for the concurrent quantification of KOLCHICINE and KHELLIN, used in bulk and sachet pharmaceuticals. Microchemical Journal, 114716.

Ma, J. K., Chen, X. Y., Zhang, N., Darwish, A. S., Gouda, A. A., El Sheikh, R., & others. (2025). A straightforward HPLC approach to testing butylated hydroxytoluene, an antioxidant, in pure and topical anti-burn gels; evaluation of greenness, blueness, and whiteness grades. Talanta Open, 100565.

Huang, X. C., Darwish, A. S., Darwish, W. S., Zaki, M. S. A., Lin, Y. T., Liang, N. L., & Ma, J. K. (2025). Ecologically conscious profiles assessments for economic, and concurrent HPLC detection of chlordiazepoxide and clidinium bromide in bulk and tablets solid dosage form. Results in Chemistry, 1, 102739.

Mohamed Dammak | Cell Structure Analysis | Best Academic Researcher Award

Prof. Dr. Mohamed Dammak | Cell Structure Analysis | Best Academic Researcher Award

Faculty of Sciences of Sfax | Tunisia

Professor Mohamed Dammak is a distinguished researcher in the field of chemistry, recognized for his significant contributions to materials science, solid-state chemistry, and nanomaterials. His research primarily focuses on the synthesis, structural characterization, and optical properties of functional materials, including luminescent phosphors, glass ceramics, and doped oxide systems. He has extensively investigated rare-earth-doped materials for photonic and optoelectronic applications, contributing valuable insights into energy transfer mechanisms and material stability under various conditions. Professor Dammak’s scholarly output includes numerous publications in high-impact journals indexed in SCI and Scopus, reflecting his consistent pursuit of scientific excellence. With over 1,100 citations and an h-index of 17, his work has had a measurable influence on contemporary research in materials chemistry. He has also participated in national and international research collaborations, enhancing cross-disciplinary approaches to the development of advanced materials with optical and structural functionalities. Through his academic leadership and commitment to innovation, Professor Dammak continues to advance the understanding and application of inorganic and functional materials, bridging the gap between fundamental research and technological development in the field of chemistry.

Profile: Scopus

Featured Publications:

Dammak, M.*, Abdelmoula, N., Cheikhrouhou-Koubaa, W., & Cheikhrouhou, A. (2021). Short-range magnetic behavior in manganites La₀.₉₃K₀.₀₇Mn₁₋ₓCuₓO₃ (0.0 ≤ x ≤ 0.09) above the Curie temperature. Journal of Physics D: Applied Physics, 54(32), 325002. https://doi.org/10.1088/1361-6463/ac015c

 

Nestor Garcia | Cellular Stress Response | Best Academic Researcher Award

Prof. Dr. Nestor Garcia | Cellular Stress Response | Best Academic Researcher Award

CONICET | Argentina

Dr. Néstor Horacio García, MD, PhD, is a physician-scientist specializing in nephrology and vascular research with a strong focus on renal physiology, hypertension, and phosphate homeostasis. He earned his medical and doctoral degrees from the National University of Córdoba, complemented by advanced research training at the Henry Ford Hospital in the United States, where he investigated mechanisms related to hypertension and vascular regulation. His postdoctoral fellowship at the Mayo Foundation in Rochester, Minnesota, further deepened his expertise in phosphate metabolism and kidney function. Dr. García has served as a Research Clinical Associate in the Nephrology Department at Sanatorium Mayo, Córdoba, where he has acted as Principal Investigator for multiple pharmaceutical protocols and clinical studies. He has also contributed to Inspiranox Therapeutics Corporation as a medical scientist and clinical research consultant, engaging in translational and therapeutic innovation. His research explores the pathophysiology of kidney disease, the molecular regulation of blood pressure, and protective mechanisms against diabetic renal dysfunction. Recognized nationally and internationally, Dr. García has received multiple awards for excellence in basic nephrology research, including honors from the Argentine Society of Hypertension and the Latin American Society of Nephrology and Hypertension (SLANH).

Profile: Orcid

Featured Publications:

García, N. H. (2021). An intensive follow-up in subjects with cardiometabolic high-risk. Nutrition, Metabolism and Cardiovascular Diseases.

García, N. H. (2021). Effect of SGLT2 inhibitors on stroke and atrial fibrillation in diabetic kidney disease. Stroke, 52(5), e125–e132.

García, N. H. (2020). Monosialoganglioside GM1 reduces toxicity of Ptx and increases anti-metastatic effect in a murine mammary cancer model. Scientific Reports, 10(1), 10645.

García, N. H. (2020). Ibuprofen, a traditional drug that may impact the course of COVID-19: New effective formulation in nebulizable solution. Medical Hypotheses, 144, 110079.

García, N. H. (2020). Eicosapentaenoic acid prevents salt sensitivity in diabetic rats and decreases oxidative stress. Nutrition, 79–80, 110644.

Willa Hsueh | Immunometabolism | Best Researcher Award

Prof. Willa Hsueh | Immunometabolism | Best Researcher Award

The Ohio State University | United States

Dr. Willa Hsueh is a leading researcher in endocrinology, diabetes, and metabolism, with a career spanning several decades of pioneering contributions to hormone regulation and metabolic disease. Her early research provided key insights into renin biochemistry and aldosterone metabolism, particularly focusing on inactive “big renin” forms and their activation mechanisms in normal and pathological conditions such as diabetic nephropathy. Dr. Hsueh’s investigations have significantly advanced the understanding of the renin-angiotensin-aldosterone system (RAAS) and its role in blood pressure regulation, sodium balance, and endocrine disorders. Her studies explored adrenal physiology, steroid metabolism, and hormonal responses to physiological and pharmacological stimuli, laying the groundwork for later research on cardiovascular and metabolic dysfunctions in diabetes. Through her interdisciplinary approach combining endocrinology, nephrology, and metabolism, she has elucidated biochemical pathways linking hormonal imbalances to metabolic diseases. Dr. Hsueh continues to lead impactful research in diabetes and metabolic regulation, contributing to translational advancements that bridge molecular mechanisms with clinical applications for improved patient outcomes in endocrine and metabolic disorders.

Profiles: Scopus | Orcid

Featured Publications:

Hsueh, W. A., Boonjaren, S., Stein, J., Baehler, H. R., Osgood, R. W., Cohen, S., Yashon, D., & Ferris, T. (1974). Effect of plasma sodium concentration on diluting segment sodium reabsorption. Kidney International, 5(1), 1–11.

Johnson, K. R., Hsueh, W. A., Glusman, S. M., & Arnett, F. C. (1976). Fibrous myopathy: A rheumatic complication of drug abuse. Arthritis & Rheumatism, 19(5), 923–926.

Hsueh, W. A., & Hsu, T. H. (1978). Thyrotoxicosis in a patient with secondary hypothyroidism. Southern Medical Journal, 71(9), 1174–1177.

Hsueh, W. A., Luetscher, J. A., Carlson, E., & Grislis, G. (1978). Big renin in plasma of healthy subjects on high-sodium intake. The Lancet, 1(8077), 1281–1284.

Hsueh, W. A., Hsu, T. H., & Federman, D. D. (1978). Endocrine features of Klinefelter’s syndrome. Medicine, 57(5), 447–461.

Hsueh, W. A., Luetscher, J. A., Carlson, E., Grislis, G., Elbaum, D., & Chavarri, M. (1978). A comparison of cold and acid activation of big renin and of inactive renin in normal plasma. Journal of Clinical Endocrinology and Metabolism, 47(4), 792–799.