Ann-Kathrin Eisfeld | Molecular Profiles | Best Researcher Award

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Prof. Dr. Ann-Kathrin Eisfeld | Molecular Profiles | Best Researcher Award

The Ohio State University | United States

Dr. Ann-Kathrin Eisfeld is an internationally recognized physician-scientist and Associate Professor with Tenure in the Division of Hematology at The Ohio State University, where she also serves as Director of the Clara D. Bloomfield Center for Leukemia Outcomes Research. Her research focuses on the molecular and genetic underpinnings of acute myeloid leukemia (AML), with a particular emphasis on translational applications that improve patient outcomes. Dr. Eisfeld has published extensively in high-impact journals such as Nature, Leukemia, Blood, and Cell Stem Cell, contributing significantly to our understanding of leukemia biology, clonal evolution, and treatment resistance. she has authored over 100 peer-reviewed scientific publications, with an h-index of 38, more than 6,500 citations, and has led or co-led multiple collaborative studies within national consortia such as the Alliance for Clinical Trials in Oncology. Her work has identified critical biomarkers and therapeutic targets in AML, including insights into TP53 mutations, FLT3 alterations, and resistance mechanisms to venetoclax. Recognized for her integration of clinical insight with cutting-edge genomics, Dr. Eisfeld is a leading voice in precision oncology and leukemia research, shaping the future of individualized treatment strategies through both clinical innovation and scientific discovery.

Profile: Scopus

Featured Publications:

“Highly elevated serum hepcidin in patients with acute myeloid leukemia prior to and after allogeneic hematopoietic cell transplantation: Does this protect from excessive parenchymal iron loading?”

“Heritable polymorphism predisposes to high BAALC expression in acute myeloid leukemia”

“miR-3151 interplays with its host gene BAALC and independently affects outcome of patients with cytogenetically normal acute myeloid leukemia”

“Clinical and pharmacodynamic activity of bortezomib and decitabine in acute myeloid leukemia”

“Kinetics of iron removal by phlebotomy in patients with iron overload after allogeneic hematopoietic cell transplantation”

“inv(16)/t(16;16) acute myeloid leukemia with non-type A CBFB-MYH11 fusions associate with distinct clinical and genetic features and lack KIT mutations”

“Clinical Role of microRNAs in Cytogenetically Normal Acute Myeloid Leukemia: miR-155 Upregulation Independently Identifies High-Risk Patients”

“In rare acute myeloid leukemia patients harboring both RUNX1 and NPM1 mutations, RUNX1 mutations are unusual in structure and present in the germline”

“A stem cell-like gene expression signature associates with inferior outcomes and a distinct microRNA expression profile in adults with primary cytogenetically normal acute myeloid leukemia”

John Carethers | DNA Repair | Best Researcher Award

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Prof. John Carethers | DNA Repair | Best Researcher Award

Prof. John Carethers, UC San Diego, United States

Dr. John M. Carethers is a distinguished academic leader and physician-scientist in the field of gastroenterology and cancer genetics. Serving as Vice Chancellor for Health Sciences at the University of California San Diego, he also holds professorial appointments in both the School of Medicine and the Herbert Wertheim School of Public Health. His extensive contributions to colorectal cancer research, health disparities, and tumor biology have earned him national recognition. Dr. Carethers is renowned for his work on DNA mismatch repair mechanisms and their implications in cancer progression and treatment responsiveness. With a prolific publication record and influential roles in medicine and science policy, he stands as a model for translational research excellence. His commitment to mentorship and health equity further underscores his holistic impact on the field of medicine. Dr. Carethers continues to push scientific boundaries while advocating for inclusive healthcare solutions.

Publication Profile: 

Google Scholar

Scopus

Education:

Dr. Carethers completed his undergraduate education at Wayne State University, earning a B.S. in Biological Sciences with a minor in Chemistry (1981–1985). He graduated with distinction and was a recipient of the Michigan State Competitive Scholarship. He continued at Wayne State University School of Medicine, where he earned his M.D. with High Distinction in 1989. His academic performance was recognized with multiple honors including the Dean’s Academic Achievement Award and awards from the Black Medical Association. Dr. Carethers then completed an internship in Internal Medicine at Massachusetts General Hospital (1989–1990), a prestigious Harvard-affiliated institution, under the guidance of Chief of Medicine Dr. John T. Potts. His medical and research training provided the foundation for a career focused on gastrointestinal disorders, tumor genetics, and health disparities, particularly in colorectal cancer. His formative years reflect academic excellence and an early commitment to advancing medicine through both practice and research.

Professional Experience:

Dr. John M. Carethers currently serves as the Vice Chancellor for Health Sciences at the University of California San Diego. He is also a Distinguished Professor in the Department of Medicine and an Adjunct Professor in the School of Public Health. His career has spanned prestigious academic roles, including clinical and research leadership in gastroenterology, particularly focused on colorectal cancer. A physician-scientist, Dr. Carethers has served in roles that bridge bench science and clinical application, contributing significantly to translational medicine. His academic journey includes mentorship of emerging scientists, leadership in national research initiatives, and board participation in scientific organizations. His experience also encompasses major roles in cancer health disparities research, aiming to close gaps in outcomes across racial and socioeconomic lines. Dr. Carethers is a prolific researcher and thought leader whose experience enhances institutional vision, diversity, and health equity. His impactful career exemplifies a dedication to excellence in science and medicine.

Awards and Honors:

Dr. Carethers has been recognized with numerous academic and professional honors throughout his career. As an undergraduate, he received the Michigan State Competitive Scholarship and was inducted into the Golden Key National Honor Society. During medical school, he earned the Dean’s Academic Achievement Award and awards from the Black Medical Association in 1986 and 1987. Over time, he has been widely honored for his contributions to colorectal cancer research, healthcare leadership, and advocacy for health equity. His published work has been highly cited and influential in advancing our understanding of tumor genetics and mismatch repair. He has received numerous invitations for keynote talks and appointments to national research boards and committees. Dr. Carethers’s career has been marked by his commitment to mentoring, scholarly productivity, and advocacy, positioning him as a leader and role model in academic medicine. These honors underscore his national and global influence in health sciences.

Research Focus:

Dr. John M. Carethers’s research primarily focuses on colorectal cancer, particularly mechanisms of tumor progression, genetic and epigenetic alterations, and mismatch repair (MMR) deficiency. He has deeply explored how MMR status influences treatment responses, especially to chemotherapy agents like 5-fluorouracil. A key aspect of his work includes identifying biomarkers for cancer prognosis and understanding familial cancer syndromes, including Lynch syndrome and polyposis syndromes. His studies also delve into the molecular mechanisms underlying microsatellite instability (MSI) and its role in genomic instability. Importantly, Dr. Carethers is a leading voice in cancer health disparities, examining how social, economic, and biological factors impact outcomes among underrepresented populations. His research bridges basic molecular science with clinical applications, enabling personalized approaches to treatment and surveillance. Through his work, he contributes to reducing cancer burden and mortality while promoting health equity in vulnerable communities—making him a pioneer in both biomedical research and public health.

Publications Top Notes:

  1.  Experimental and clinical observations on frostbite

  2.  The epidemiology of methicillin-resistant Staphylococcus aureus in a burn center

  3.  Extraintestinal Manifestations of Crohn’s Disease

  4.  Human chromosome 3 corrects mismatch repair deficiency in colon tumor cells

  5.  Delayed gastric emptying after laparoscopic vagotomy

  6.  Mismatch repair and the G2 cell cycle checkpoint

  7. In vitro assay for screening hMLH1 and hMSH2 mutations

  8.  Massive secretory diarrhea and pseudo-obstruction in Crohn’s disease

  9.  Mismatch repair blocks clonal expansion after DNA damage

  10.  Localization of Bannayan-Riley-Ruvalcaba syndrome gene to chromosome 10q23

Conclusion:

In conclusion, Dr. John M. Carethers embodies the highest standards of research excellence, leadership, and societal impact. His contributions to colorectal cancer genetics, DNA mismatch repair research, and cancer health disparities are not only scientifically rigorous but also clinically transformative. As a widely respected physician-scientist, educator, and health equity advocate, he represents the ideal blend of scholarly productivity and service to humanity. Despite minor opportunities for expanding the global and technological dimensions of his work, Dr. Carethers’s achievements place him in the top tier of biomedical researchers. His continued dedication to both advancing science and closing health outcome gaps aligns perfectly with the spirit of the Best Researcher Award. He is not only deserving of this honor but also serves as an inspiring model for current and future generations of researchers.

Dalia Saleh | Cancer Cell Biology | Innovative Research Award

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Prof. Dalia Saleh | Cancer Cell Biology | Innovative Research Award

Prof. Dalia Saleh, National Research Centre, Egypt

Dr. Dalia Osama Abd El Fattah Saleh is a distinguished pharmacologist and professor at the National Research Centre, Cairo, Egypt. With a career spanning over two decades in academic and pharmaceutical research, she specializes in molecular pharmacology, experimental therapeutics, and drug development. She earned her Ph.D. and M.Sc. in Pharmacology from Cairo University, where she also completed her undergraduate pharmacy degree with honors. Dr. Saleh’s prolific contributions to science are reflected in her extensive publication record, focusing on novel therapeutic strategies against various toxicological, metabolic, and inflammatory disorders. Her collaborative efforts have led to advancements in drug signaling pathways, phytochemical pharmacology, and nanotechnology-based delivery systems. Recognized nationally for her innovation, she has received several prestigious awards. Dr. Saleh continues to shape pharmacological research through her dedication to translational science, mentorship, and participation in international seminars and training programs.

Publication Profile: 

Google Scholar

✅ Strengths for the Award:

  • Extensive Academic Background: Holds a Ph.D., M.Sc., and B.Sc. in Pharmacology from Cairo University, with a clear focus on endocrine and vascular pharmacology from early in her career.

  • Distinguished Research Record: Authored over 25+ high-impact publications in peer-reviewed journals including Scientific Reports, Toxicology Reports, Biochemistry and Cell Biology, and Environmental Science and Pollution Research.

  • Novel Scientific Contributions:

    • Explores molecular pharmacology through cutting-edge therapeutic approaches like AMPK/mTOR signaling, Nrf2/NF-κB modulation, and natural compound pharmacodynamics.

    • Studies involve both synthetic and phytochemical-based interventions, representing a hybrid and innovative research style.

  • Awards and Recognition:

    • National recognition for her research quality and productivity by the National Research Centre, with awards received in 2015 and 2020.

    • Ranked 24th in the institution for publication volume in 2014—an indicator of sustained output.

  • Global Exposure: Participated in professional training programs at King’s College London, enhancing her knowledge in clinical drug development and data management—an asset for interdisciplinary and translational research.

  • Leadership and Longevity: Promoted through all academic ranks at NRC, from Research Assistant to Professor, demonstrating not only competence but leadership and mentorship over time.

Areas for Improvement:

  • Clinical Translation: While the preclinical research is extensive, initiating clinical trials or translational studies would further strengthen the real-world applicability of her findings.

  • Global Visibility: Although trained internationally, more international speaking engagements, keynote invitations, or editorial roles could enhance global recognition.

  • Interdisciplinary Projects: Expanding collaborations across fields such as bioinformatics or biotechnology could amplify the innovation aspect of her work.

🎓 Education:

Dr. Dalia Saleh obtained all her academic degrees from Cairo University’s esteemed Faculty of Pharmacy. She was awarded her Ph.D. in Pharmacology in 2012 for her thesis examining estrogen’s vascular effects in insulin-resistant, ovariectomized rats. Earlier, she earned her M.Sc. in 2009 with research on rosiglitazone’s effects in streptozotocin-induced vascular changes. Her academic journey began with a B.Sc. in Pharmacy in 2002, graduating with distinction and honors. Her strong educational foundation laid the groundwork for her innovative and interdisciplinary research spanning molecular pharmacology, toxicology, and metabolic disorders. Through continuous professional development, including modules at King’s College London, Dr. Saleh stays aligned with global standards in pharmacological science and clinical drug development. Her educational background combines academic excellence with practical research expertise, making her well-equipped to address complex biomedical challenges.

👩‍🔬 Experience:

Dr. Dalia Saleh has built a progressive research career at Egypt’s National Research Centre, beginning as a Research Assistant in 2003. Over the years, she rose through the ranks to become a Professor in 2022. She previously held positions as Researcher (2012–2017) and Assistant Professor (2017–2022). Throughout her tenure, she has actively contributed to preclinical pharmacology research, focusing on inflammation, neuroprotection, metabolic diseases, and organ toxicity. Her interdisciplinary approach integrates pharmacodynamics, molecular signaling, and therapeutic intervention studies using both synthetic and natural compounds. She has led numerous studies that explore drug mechanisms at cellular and systemic levels, often employing rodent disease models. Dr. Saleh’s active participation in international training (e.g., at King’s College London) highlights her global engagement and commitment to continuous learning. Her career reflects not only research productivity but also leadership in collaborative scientific initiatives and mentoring of emerging researchers.

🏆 Awards & Honors:

Dr. Dalia Saleh has received multiple accolades that underscore her impact in the field of pharmacology. She was honored with the 2020 Scientific Pioneers Award and the 2015 Scientific Encouragement Award from Egypt’s National Research Centre (NRC), recognizing her outstanding research contributions. In 2014, she received institutional recognition for both her high publication output (ranked 24th NRC-wide) and for publishing in a high-impact journal (impact factor 4.067). These achievements highlight her consistent scientific productivity and influence in biomedical research. Dr. Saleh’s awards reflect a career driven by innovation, rigor, and dedication to solving pressing health issues. Her work continues to be widely cited and applied in translational pharmacology, securing her reputation as a leading figure in her discipline. She remains an inspiration to peers and students alike, with a legacy of both scientific excellence and mentorship.

🔬 Research Focus:

Dr. Dalia Saleh’s research is rooted in experimental pharmacology, with an emphasis on cell signaling pathways, drug discovery, and natural compound pharmacodynamics. She investigates molecular mechanisms underlying chronic diseases such as diabetes, hepatic and renal injury, neurodegeneration, and inflammatory disorders. A recurring theme in her work is the modulation of key signaling axes (e.g., AMPK/mTOR, NF-κB, PI3K/Akt) in mitigating organ toxicity and disease progression. Her recent studies explore the pharmacological potential of phytochemicals, drug hybrids, and nanoformulations in preclinical models. Dr. Saleh also examines gender-specific pathophysiology, as seen in her Ph.D. research on estrogen’s role in vascular dysfunction. She actively integrates biochemical, histological, and behavioral endpoints to ensure translational relevance. By bridging traditional medicine and molecular pharmacology, her work contributes to next-generation therapeutics and precision medicine. Her research has both national and global impact, frequently published in high-tier journals and cited in clinical research discussions.

📚 Publications Top Notes:

  1. 🧬 Eugenol alleviates acrylamide-induced testicular toxicity via AMPK/pAKT/mTOR signaling – Scientific Reports, 2024

  2. 💊 Trimetazidine protects against cisplatin-induced neuropathy via AMPK and Nrf2 pathways – Biochemistry and Cell Biology, 2023

  3. 🧪 Chromone-thiazolopyrimidine hybrids inhibit TNF-α, IL-6, and PGE2 – Polycyclic Aromatic Compounds, 2023

  4. 🧻 Chrysin counters cyclophosphamide-induced cystitis via STAT-3 and NF-κB inhibition – Chemico-Biological Interactions, 2023

  5. 🩺 Linagliptin and L-arginine synergize in hyperacidity via EP4 upregulation – Naunyn-Schmiedeberg’s Archives of Pharmacology, 2023

  6. 🧠 L-arginine protects against hepatic encephalopathy via anti-apoptotic mechanisms – Environmental Science and Pollution Research, 2023

  7. 🌿 Calotropis procera seed oil shows anti-inflammatory and antiparasitic activity – Arabian Journal of Chemistry, 2022

  8. 🧫 Olmesartan mitigates diabetic nephropathy through TLR4/P38-MAPK modulation – European Journal of Pharmacology, 2022

  9. 🌱 Anti-fibrotic activities of Plumbago species in liver fibrosis models – Scientific Reports, 2022

  10. 🐟 Omega-3 fatty acids protect against doxorubicin-induced liver damage – Saudi Journal of Biological Sciences, 2022

Conclusion:

Dr. Dalia O. Saleh is highly suitable for the Best Researcher Award based on her prolific scientific contributions, consistent academic progression, and commitment to impactful pharmacological research. Her strength lies in combining rigorous mechanistic studies with applied therapeutic exploration, especially in inflammation, oxidative stress, and natural product pharmacology.