Xingting Guo | Stem Cell Research | Best Researcher Award

Posted on by sciencefather

Assist. Prof. Dr. Xingting Guo | Stem Cell Research | Best Researcher Award

Assist. Prof. Dr. Xingting Guo , Peking University Third Hospital , China

Dr. Xingting Guo is a dedicated postdoctoral fellow at the National Institute of Biological Sciences (NIBS), Beijing, where she has been working since 2018. With a strong academic foundation in biochemistry and molecular biology, her research delves into stem cell biology, cellular differentiation, and tumorigenesis using Drosophila and mouse models. Her expertise lies in integrating genetics, biochemistry, single-cell sequencing, and bioinformatics to unravel mechanisms of cell fate specification and intestinal homeostasis. Dr. Guo has co-authored several high-impact publications and has presented her research at both national and international conferences. Her contributions have significantly advanced our understanding of enteroendocrine cells (EECs), tissue identity, and inter-organ communication. Passionate and detail-oriented, she is actively contributing to biomedical sciences with a vision to translate fundamental biology into therapeutic insights. Her work is paving the way for novel treatments for metabolic diseases and cancers.

Publication Profile:

Scopus

✅ Strengths for the Award:

  1. Innovative Research Focus: Dr. Guo has made pioneering contributions in stem cell biology, particularly in understanding cell fate specification, enteroendocrine diversity, and tumor suppression using Drosophila and murine models.

  2. Multidisciplinary Skillset: She integrates genetics, high-throughput sequencing, bioinformatics, organoid culture, and in vivo models, showcasing deep technical expertise.

  3. High-Impact Publications: Co-first author in multiple peer-reviewed journals, including Cell Reports, Nature Communications, and FEBS Journal.

  4. Leadership in Research: From graduate researcher to postdoctoral fellow, she has led multiple independent projects, contributing novel findings to developmental and regenerative biology.

  5. International Recognition: Regular presenter at top-tier conferences globally, including the European Drosophila Research Conference and Annual Drosophila Research Conference (USA).

  6. Research Funding: Successfully secured National Natural Science Foundation of China funding, reflecting scientific merit and recognition.

🔍 Areas for Improvement:

  1. Broader Collaboration: Expanding collaborations outside her current institute or internationally may enhance the translational reach and impact of her research.

  2. Mentorship Roles: While her research is strong, formal mentorship roles (e.g., supervising Ph.D. students) or teaching contributions could further demonstrate leadership.

  3. Clinical Translation: Though her mouse model work touches on therapeutic discovery, publishing more translational or clinical-facing studies could boost her impact in applied biomedical research.

🎓 Education:

Dr. Xingting Guo earned her Ph.D. in Biochemistry and Molecular Biology from the College of Life Sciences at Beijing Normal University (2012–2018), where she began her in-depth research on stem cell biology and tissue differentiation in Drosophila. Prior to this, she completed her Bachelor’s degree in Biological Engineering at Nanjing Agricultural University (2008–2012), where she was honored with multiple scholarships for academic excellence. Throughout her education, she developed a robust foundation in molecular biology, genetics, and developmental biology, equipping her with the skills to tackle complex biological questions. Her academic journey has been characterized by continuous academic excellence, curiosity-driven research, and a commitment to uncovering the molecular mechanisms of health and disease. Her education laid the groundwork for her successful transition to cutting-edge postdoctoral research in developmental biology and regenerative medicine.

💼 Experience:

Dr. Guo began her research career at NIBS Beijing as a graduate student in 2012, transitioning into a postdoctoral fellow in 2018 under the mentorship of Dr. Rongwen Xi. Her research primarily uses Drosophila intestinal systems and murine models to explore the regulation of cellular identity, differentiation, and plasticity. She has led multiple projects on tumor suppression, transcriptional regulation, and enteroendocrine diversity using advanced techniques like genetic manipulation, single-cell RNA sequencing, and organoid cultures. Additionally, she contributes to translational research by identifying drug targets for diabetes-related therapy by reprogramming intestinal cells into insulin-producing β-cells. Her interdisciplinary approach and long-standing expertise in stem cell biology highlight her versatility and innovation in research. Her consistent progression from graduate student to independent researcher reflects her strong scientific rigor and leadership in high-impact studies.

🏆 Awards and Honors:

Dr. Xingting Guo has been recognized for her academic excellence and scientific contributions through numerous honors. During her Ph.D., she was awarded the First Class Academic Scholarship for two consecutive years (2014–2016). As an undergraduate, she earned the prestigious Cyrus Tang Scholarship four times, along with the First Class Scholarship at Nanjing Agricultural University. In recent years, she has taken on the role of a peer reviewer for Bio-protocols, highlighting her engagement with the scientific community. Dr. Guo’s research excellence has led her to represent her work at top-tier conferences, including the Annual Drosophila Research Conference (USA) and the European Drosophila Research Conference (Switzerland). Her contributions were also supported by a grant from the National Natural Science Foundation of China (Grant No. 3210050518), demonstrating her ability to secure competitive funding. These accolades mark her as a rising star in molecular and developmental biology.

🔬 Research Focus:

Dr. Guo’s research focuses on the molecular regulation of stem cell differentiation, cellular identity maintenance, and neuroendocrine cell plasticity using Drosophila and mouse models. She investigates how transcription factors such as ttk69 influence enteroendocrine (EEC) specification, tissue homeostasis, and tumor suppression. Using cutting-edge tools like CRISPR, single-cell transcriptomics, and in vivo lineage tracing, she deciphers how intestinal stem cells differentiate into diverse terminal cell types. Her recent work explores how intestinal EECs regulate systemic physiology via neuropeptides in response to environmental cues like starvation and mating. In parallel, she studies cell-fate reprogramming in mammals to identify potential therapeutic strategies for diabetes by inducing insulin-producing cells in the gut. By bridging basic biology with translational goals, her work contributes to regenerative medicine, oncology, and metabolic disease research.

📚 Publications Top Notes:

  • 🧠 Cell-fate conversion of intestinal cells in adult Drosophila midgut by depleting a single transcription factor, Nature Communications, 2024

  • 🔍 The Specification and Function of Enteroendocrine Cells in Drosophila and Mammals: A Comparative Review, FEBS Journal, 2021

  • 🧬 A Switch in Tissue Stem Cell Identity Causes Neuroendocrine Tumors in Drosophila Gut, Cell Reports, 2020

  • 🧫 The Cellular Diversity and Transcription Factor Code of Drosophila Enteroendocrine Cells, Cell Reports, 2019

  • 🧬 Division of Labor: Roles of Groucho and CtBP in Notch-Mediated Lateral Inhibition, Stem Cell Reports, 2019

  • 📘 Signaling Pathways Regulating Stem Cells, Book Chapter, Springer, 2015

  • 🛑 Ttk69 acts as a master repressor of enteroendocrine cell specification, Development, 2015

  • 🧪 EGFR and Notch signaling regulate gastric stem cells, Cell Research, 2014

  • 🧠 Sox9 Ortholog Regulates Intestinal Homeostasis and Regeneration in Drosophila, Cell Reports, 2020

🧾 Conclusion:

Dr. Xingting Guo is a highly qualified and deserving candidate for the Best Researcher Award. Her exceptional track record in stem cell biology, cellular reprogramming, and disease modeling makes her a rising star in the life sciences. With a unique combination of technical excellence, scientific innovation, and publication strength, she has already made a significant impact on our understanding of intestinal cell biology and endocrine regulation. Addressing a few career development aspects—like expanding collaborative networks and clinical translation—will make her an even more formidable leader in the field. Given her achievements, potential, and contributions, she is strongly recommended for this prestigious honor.

Guangdong Zhou | Evolution of resistive synaptic states in memristors | Best Researcher Award

Posted on by sciencefather

Prof. Guangdong Zhou | Evolution of resistive synaptic states in memristors | Best Researcher Award

Prof. Guangdong Zhou , Southwest university , China

Guangdong Zhou is a distinguished Professor at Southwest University, China, specializing in artificial intelligence and neuromorphic computing. With a Master’s degree in Physics and a Ph.D. in Materials and Energy, he has made significant contributions to advanced computing technologies. Over his academic career, Zhou has published more than 100 peer-reviewed papers and developed innovative technologies, including a groundbreaking photoelectric multi-mode memristor, contributing to advancements in brain-like computing systems. His work is recognized internationally, with several papers included in the ESI 0.1% category, and he has been awarded numerous research grants. Zhou actively collaborates with industry partners to translate his research into practical applications, solidifying his reputation as a leader in his field.

Publication Profile

Scopus

Strengths for the Award

Professor Guangdong Zhou exhibits outstanding academic and research achievements in the field of artificial intelligence and neuromorphic computing. His extensive publication record, with over 100 peer-reviewed papers and high citation metrics (total citations: 4348; H-index: 38), highlights his significant impact on the scientific community. Zhou’s pioneering work on a photoelectric multi-mode memristor and all-hardware artificial vision systems has garnered attention for its innovative integration of image processing functions. His research not only contributes to theoretical advancements but also has practical applications in the post-Moore computing landscape. Furthermore, his active involvement in consultancy and industry projects showcases his commitment to bridging academia with real-world applications.

Areas for Improvement

While Professor Zhou’s contributions are commendable, there are areas for potential enhancement. Increasing collaboration with interdisciplinary teams could further diversify his research outcomes and expand the applicability of his innovations. Additionally, engaging more with international research networks could increase the visibility of his work globally and attract further funding opportunities. Strengthening mentorship roles for emerging researchers may also amplify his influence in the academic community.

Education

Guangdong Zhou completed his Master’s degree in Physics and Science Technology at Southwest University in 2013. He then pursued a Ph.D. in Materials and Energy at the same institution, graduating in 2018. His doctoral research focused on the development of advanced materials for neuromorphic computing systems. Following his Ph.D., he conducted postdoctoral research in the School of Mathematics and Statistics at Southwest University from 2018 to 2020, where he further honed his expertise in algorithm development and machine learning applications. Zhou’s strong educational foundation has equipped him with a deep understanding of both theoretical and practical aspects of artificial intelligence, neuromorphic systems, and advanced computing technologies. This rigorous academic training has been instrumental in shaping his research direction and innovative contributions to the field.

Experience 

Currently, Professor Guangdong Zhou is a prominent faculty member at the College of Artificial Intelligence, Southwest University, where he leads research projects focused on neuromorphic computing and machine learning algorithms. His postdoctoral experience in the School of Mathematics and Statistics provided him with a strong statistical foundation to support his innovative research. Over the years, Zhou has successfully managed numerous research projects, with 14 completed and 5 ongoing, demonstrating his capacity for leadership in complex scientific endeavors. He has also contributed to consultancy projects that bridge academic research and industry applications, enhancing his practical experience in technology transfer. His editorial appointments in various scientific journals reflect his expertise and recognition within the academic community. Zhou’s extensive collaboration with national and international researchers further amplifies his influence, fostering a dynamic exchange of ideas and methodologies that drive forward the field of neuromorphic computing.

Research Focus 

Professor Guangdong Zhou’s research primarily centers on neuromorphic computing systems, exploring their underlying device theories, mechanisms, and algorithms to advance artificial intelligence technologies. His work emphasizes developing brain-like computing chips and advanced algorithms based on machine learning, which aim to replicate human cognitive functions. Zhou has pioneered the creation of an all-hardware artificial vision system utilizing a photoelectric multi-mode memristor array, successfully integrating multiple image processing functions into a single platform. This innovative approach significantly enhances the efficiency and capability of neuromorphic systems. Additionally, Zhou’s research delves into the design and application of memristors for diverse uses, including logic circuits and biomedical monitoring. His contributions have led to over 100 published papers in esteemed journals, positioning him as a thought leader in the transition toward post-Moore computing paradigms. Through his interdisciplinary approach, Zhou is shaping the future of artificial intelligence and its practical applications.

Publications Top Notes

  1. Blood-based biomemristor for hyperglycemia and hyperlipidemia monitoring 🩸💡
  2. Biomaterial/Organic Heterojunction Based Memristor for Logic Gate Circuit Design, Data Encryption, and Image Reconstruction 🔒📊
  3. A multifunctional memristor with coexistence of NDR and RS behaviors for logic operation and somatosensory temperature sensing applications 🌡️🤖
  4. Coexistence of the Negative Photoconductance Effect and Analogue Switching Memory in the CuPc Organic Memristor for Neuromorphic Vision Computing 👁️🔌
  5. A reversible implantable memristor for health monitoring applications ❤️📈
  6. Conversion between digital and analog resistive switching behaviors and logic display application of photoresponsive ZnO nanorods-based memristor 🖥️🔄
  7. An implantable memristor towards biomedical applications 🏥🔧
  8. Memristor-Based Bionic Tactile Devices: Opening the Door for Next-Generation Artificial Intelligence ✋🤖
  9. Brain-Inspired Recognition System Based on Multimodal In-Memory Computing Framework for Edge AI 🧠🌐
  10. Memristor-Based Neuromorphic Chips 🖥️🔬

Conclusion

Professor Guangdong Zhou’s robust research portfolio and significant contributions to neuromorphic computing position him as an exemplary candidate for the Best Researcher Award. His innovative work, combined with a commitment to advancing artificial intelligence, demonstrates both the depth and breadth of his expertise. Recognizing his achievements through this award would not only honor his individual contributions but also inspire future generations of researchers in the field.