Yida Huang | Cancer Metabolomics | Research Excellence Award

Published on by Cell Biologist

Dr. Yida Huang | Cancer Metabolomics | Research Excellence Award

Shanghai Jiao Tong University | China

Dr. Yida Huang is an accomplished postdoctoral researcher recognized through highly competitive national talent programs, including the Postdoctoral Innovative Talent Support Program and NSFC Doctor Program. Their research centers on advanced mass spectrometry–based molecular profiling technologies for precision diagnosis and prognosis of diseases, particularly cancer. To date, they have published 28 peer-reviewed articles in leading international journals such as Cell Reports Medicine, Gut, PNAS, and Materials Today Bio, including two ESI Highly Cited Papers. With 588 citations and an h-index of 12, their work demonstrates strong scientific influence. They have led multiple nationally and municipally funded projects and contributed to translational innovation through five invention patents. A major achievement includes developing a nano-solid-phase mass spectrometry platform enabling high-throughput metabolic profiling from diverse biological samples, supporting large-scale cancer biomarker discovery and prognostic modeling with clinical accuracy comparable to conventional staging systems.

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Featured Publications

Hongjin Liu | Cancer Cell Biology | Research Excellence Award

Published on by Cell Biologist

Dr. Hongjin Liu | Cancer Cell Biology | Research Excellence Award

National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College | China

Hongjin Liu is a medical oncologist whose research centers on cancer biology, therapeutic resistance, and tumorigenesis. His work spans molecular oncology, hepatocellular carcinoma, and mechanisms of somatic mutagenesis across human tissues. He has contributed to high-impact studies published in Nature and Signal Transduction and Targeted Therapy, including investigations uncovering the landscape of somatic mutations in normal tissues and the critical role of VAV2 in DNA repair and radiotherapy resistance. His research also explores noncoding RNA–mediated regulatory networks in liver cancer, notably identifying the oncogenic function of ELF3-AS1 through its modulation of the miR-98-5p/CPSF4 axis. Collectively, his publications provide important insights into genomic instability, tumor microenvironment dynamics, and potential molecular targets for improving therapeutic outcomes. His translational research aims to bridge molecular mechanisms with clinical oncology to support precision cancer treatment and advance strategies for overcoming therapy resistance.

Profile: Orcid

Featured Publications: 

1. Ge, P., Niu, S., Fang, M., Xu, Q., Zhang, W., Xu, J., Yang, F., Wang, Y., Shi, T., & Liu, H. (2025). ELF3-AS1 promotes the carcinogenesis of hepatocellular carcinoma cells by inhibiting miR-98-5p/CPSF4 axis. Nucleosides, Nucleotides & Nucleic Acids.

2. Zhang, W., Liu, Z., Liu, H., Huang, Z., Huang, X., Xu, L., Che, X., & Zhan, Z. (2025). The impact of immune checkpoint inhibitors on prognosis in unresectable hepatocellular carcinoma treated with TACE and lenvatinib: A meta-analysis. Frontiers in Immunology.

3. Liu, W., Miao, C., Zhang, S., Liu, Y., Niu, X., Xi, Y., Guo, W., Chu, J., Lin, A., Liu, H., Yang, X., Chen, X., Zhong, C., Ma, Y., Wang, Y., Zhu, S., Liu, S., Tan, W., Lin, D., & Wu, C. (2021). VAV2 is required for DNA repair and implicated in cancer radiotherapy resistance. Signal Transduction and Targeted Therapy, 6(9), 2906–2919.

4. Li, R., Di, L., Li, J., Fan, W., Liu, Y., Guo, W., Liu, W., Liu, L., Li, Q., Chen, L., Chen, Y., Miao, C., Liu, H., Wang, Y., Ma, Y., Xu, D., Lin, D., Huang, Y., Wang, J., Bai, F., & Wu, C. (2021). A body map of somatic mutagenesis in morphologically normal human tissues. Nature, 597(7876), 398–403.

5. Chen, Y., Zeng, Q., Liu, X., Fu, J., Zeng, Z., Zhao, Z., Liu, Z., Bai, W., Dong, Z., & Liu, H. (2018). LINE-1 ORF-1p enhances the transcription factor activity of pregnenolone X receptor and promotes sorafenib resistance in hepatocellular carcinoma cells. Cancer Management and Research, 10, 6345–6358.

Yanqi Dang | Cancer Cell Biology | Editorial Board Member

Published on by Cell Biologist

Mr. Yanqi Dang | Cancer Cell Biology | Editorial Board Member

Institute of Digestive Diseases, Longhua Hospital, China-Canada Center of Research for Digestive Diseases, Shanghai University of Traditional Chinese Medicine, Shanghai 200032 | China

The researcher focuses on the epigenetic regulation of metabolic diseases and tumorigenesis, with major contributions in colorectal cancer (CRC) diagnostics, mechanisms, and traditional Chinese medicine (TCM)-based interventions. In early CRC detection, the team performed transfer RNA (tRNA) sequencing and identified two key tRFs—tRF-Tyr-GTA-081 (downregulated) and tRF-Ala-AGC-060 (upregulated)—whose combined diagnostic model demonstrated strong performance for colorectal neoplastic lesions and cancer, outperforming traditional markers such as CEA and CA199. Multi-omics analyses of mRNAs, miRNAs and circRNAs identified three circRNAs with predictive value for adenoma–carcinoma transition. Through DNA hydroxymethylation sequencing, ZW10 emerged as a prognostic-related marker, and its circulating hydroxymethylation level showed high accuracy for early CRC detection. Mechanistic studies revealed that METTL3 regulates CRB3 in an m6A-dependent manner to modulate HIPPO signaling, while DNMT3B- and TET2-mediated epigenetic modifications jointly control PGC-1α to promote CRC progression. In therapeutic research, Scutellaria baicalensis Tang, Sijunzi Tang, and related monomers are under investigation for anti-CRC effects. In metabolic disease research, Ling-Gui-Zhu-Gan decoction and cinnamaldehyde were shown to improve steatosis and insulin resistance in NAFLD, supporting the TCM concept of “phlegm-beverage.” Current studies focus on lean NAFLD, demonstrating that METTL14 regulates TIM3 to influence disease development, and that GJLZ decoction alleviates steatosis and inflammation by enhancing this pathway.

Profile: Scopus

Featured Publications:

Ma, J., …, & al. (2025). Regulation of histone H3K27 methylation in inflammation and cancer.

Shaoqing Ai | Cancer | Best Researcher Award

Published on by Cell Biologist

Mr. Shaoqing Ai | Cancer | Best Researcher Award

Xi’an Daxing Hospital | China

Dr. Shaoqing Ai’s research focuses on the clinical application and translational potential of integrated traditional Chinese and Western medicine in oncology, particularly in the management of gastrointestinal tumors, lung cancer, and gynecological malignancies. His work emphasizes optimizing multidisciplinary treatment strategies and improving patient outcomes through precision diagnosis and therapy. As an active contributor to the fields of tumor metastasis and geriatric oncology, he has participated in a research project exploring the molecular mechanisms and clinical management of tumor progression and treatment-related complications. His published studies, including one SCI-indexed paper and two Chinese core journal articles, highlight the therapeutic efficacy of combined treatment approaches in reducing radiotherapy- and chemotherapy-induced hematologic toxicities such as leukopenia and thrombocytopenia. Dr. Ai’s research also aims to refine clinical protocols for mitigating adverse effects while enhancing the overall quality of life for cancer patients. Through his involvement in professional oncology committees and collaborative studies, he continues to advance the integration of evidence-based Chinese medicine with modern oncological practices, contributing to the growing body of knowledge supporting individualized and holistic cancer care.

Profile: Orcid

Featured Publications:

Ai, S., Jun, G., Jia, W., & Jie, L. (2025, October 16). Correlation analysis between frequency of gastrointestinal bleeding episodes and abnormal coagulation indexes in digestive system tumors. Scientific Reports. https://doi.org/10.1038/s41598-025-19012-8

 

 

Waldemar Debinski | Cancer Cell Biology | Best Researcher Award

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Prof. Dr. Waldemar Debinski | Cancer Cell Biology | Best Researcher Award

Wake Forest School of Medicine | United States

Dr. Waldemar Debinski, M.D., Ph.D., is a distinguished neuroscientist and cancer researcher recognized for his pioneering work in brain tumor biology and targeted molecular therapies. His research focuses on understanding the molecular mechanisms that drive the development and progression of malignant brain tumors, with a particular emphasis on gliomas. Dr. Debinski has significantly contributed to the development of novel targeted therapeutics, including receptor-directed cytotoxins and biologics designed to selectively eliminate tumor cells while sparing healthy tissues. His investigations bridge molecular oncology, translational science, and clinical application, aiming to improve therapeutic outcomes for patients with brain cancers. Throughout his career, he has integrated insights from physiology, molecular biology, and pharmacology to develop translational approaches that move from laboratory discovery to clinical implementation. His extensive research has advanced the understanding of tumor-specific receptors and intracellular signaling pathways, contributing to innovative strategies in cancer immunotherapy and precision medicine. Dr. Debinski’s work exemplifies the integration of basic and clinical research toward the development of next-generation treatments for central nervous system malignancies, positioning him as a leading figure in neuro-oncology and translational cancer research.

Profile: Scopus

Featured Publications:

Wocial, B., Januszewicz, W., Siedlecki, J., Feltynowski, T., & Debinski, W. (1982). Alterations in plasma dopamine-β-hydroxylase and catecholamine concentrations during surgical removal of pheochromocytoma. Endocrinologie, 79, 131–139.

Debinski, W., & Wocial, B. (1982). Various aspects of sodium metabolism in hypertension [in Polish]. Polski Tygodnik Lekarski, 37, 1339–1342.

Ignatowska-Świtalska, H., Debinski, W., & Chojnowski, K. (1983). The role of certain hormonal factors in arterial hypertension [in Polish]. Materia Medica Polona, 15, 74–86.

Wasawska, T., Feltynowski, T., Majewska, Z., Januszewicz, W., Sobolewska-Karwowska, A., Wocial, B., & Debinski, W. (1984). Pheochromocytoma: Description of two cases with an unusual clinical picture [in Polish]. Polski Tygodnik Lekarski, 39, 261–263.

Czarkowski, M., & Debinski, W. (1984). Sodium and primary arterial hypertension [in Polish] (Review). Kardiologia Polska, 27, 967–976.

Wocial, B., Debinski, W., Jablonska-Skwicinska, E., Feltynowski, T., Chodakowska, J., Kozakowska, E., & Januszewicz, W. (1984). Sodium content of erythrocytes in patients with arterial hypertension [in Polish]. Polski Archiwum Medycyny Wewnetrznej, 72, 167–174.

Garcia, R., Debinski, W., Gutkowska, J., Kuchel, O., Thibault, G., Genest, J., & Cantin, M. (1985). Gluco- and mineralocorticoids may regulate the natriuretic effect and the synthesis and release of atrial natriuretic factor by the rat atria in vivo. Biochemical and Biophysical Research Communications, 131, 806–814.

Debinski, W., Kuchel, O., Garcia, R., Buu, N. T., Racz, K., Cantin, M., & Genest, J. (1986). Atrial natriuretic factor inhibits sympathetic activity in one-kidney, one-clip hypertension in the rat. Proceedings of the Society for Experimental Biology and Medicine, 181, 173–177.

Debinski, W., Kuchel, O., Buu, N. T., Garcia, R., Cantin, M., & Genest, J. (1986). Involvement of the adrenal glands in the action of the atrial natriuretic factor. Proceedings of the Society for Experimental Biology and Medicine, 181, 318–324.

Debinski, W., Gutkowska, J., Kuchel, O., Racz, K., Buu, N. T., Cantin, M., & Genest, J. (1986). ANF-like peptide(s) in the peripheral autonomic nervous system. Biochemical and Biophysical Research Communications, 134, 279–284.

Evgeny Deforzh | Cancer | Best Researcher Award

Published on by Cell Biologist

Dr. Evgeny Deforzh | Cancer | Best Researcher Award

Brigham and Women’s Hospital, Harvard University | United States

Dr. Evgeny Deforzh is a molecular biologist whose work focuses on the regulation of RNA, microRNAs, chromatin dynamics, and their roles in cancer and neurological disease. After earning his B.S. and M.S. in Biology from Saint Petersburg State University and a Ph.D. in Molecular Biology from Paris‑Saclay University, he completed postdoctoral research as a Research Fellow and subsequently served as Instructor in Neurology at Brigham & Women’s Hospital. His peer‑reviewed contributions include insights into how WEE1 regulators switch roles in cell cycle control, protection of cyclin mRNAs from translational repression, the impact of glioblastoma‑derived extracellular vesicles on astrocyte transformation, and the nuclear modulation of splicing by oncogenic microRNAs. More recently, his work has elucidated promoter/enhancer RNA regulation of super‑enhancers, and miRNA pathways as therapeutic targets in gliomas and meningiomas. To date, Dr. Deforzh has published ~15–20 independent original research articles (first‑, co‑first, or senior‑author) with many additional co‐authored papers. His publications have been cited in the literature ~800‑1,200 times, giving him an approximate h‑index of 12–15. His research has advanced understanding of RNA regulatory networks in cancer and offers potential translational pathways for diagnostics and therapy.

Profiles: Google Scholar | Scopus

Featured Publications:

Zeng, A., Wei, Z., Rabinovsky, R., Jun, H. J., El Fatimy, R., Deforzh, E., & Arora, R. (2020). Glioblastoma-derived extracellular vesicles facilitate transformation of astrocytes via reprogramming oncogenic metabolism. iScience, 23(8), 101420.

Deforzh, E., Uhlmann, E. J., Das, E., Galitsyna, A., Arora, R., Saravanan, H., … (2022). Promoter and enhancer RNAs regulate chromatin reorganization and activation of miR-10b/HOXD locus, and neoplastic transformation in glioma. Molecular Cell, 82(10), 1894–1908.e5.

El Fatimy, R., Zhang, Y., Deforzh, E., Ramadas, M., Saravanan, H., Wei, Z., … (2022). A nuclear function for an oncogenic microRNA as a modulator of snRNA and splicing. Molecular Cancer, 21(1), 17.

Poller, W., Sahoo, S., Hajjar, R., Landmesser, U., & Krichevsky, A. M. (2023). Exploration of the noncoding genome for human-specific therapeutic targets—Recent insights at molecular and cellular level. Cells, 12(22), 2660.

Deforzh, E., Vargas, T. R., Kropp, J., Vandamme, M., Pinna, G., & Polesskaya, A. (2016). IMP-3 protects the mRNAs of cyclins D1 and D3 from GW182/AGO2-dependent translational repression. International Journal of Oncology, 49(6), 2578–2588.

Kratassiouk, G., Pritchard, L. L., Cuvellier, S., Vislovukh, A., Meng, Q., … (2016). The WEE1 regulators CPEB1 and miR-15b switch from inhibitor to activators at G2/M. Cell Cycle, 15(5), 667–677.

Rong Zhong | Cancer Cell Biology | Best Researcher Award

Published on by Cell Biologist

Prof. Rong Zhong | Cancer Cell Biology | Best Researcher Award

Prof. Rong Zhong, Huazhong University of Science and Technology, China

Professor Rong Zhong is an esteemed academic in the field of molecular and cancer epidemiology at Tongji Medical College, Huazhong University of Science and Technology, China. With a PhD in Epidemiology and Biostatistics and postdoctoral training from Harvard Medical School, she has built a distinguished career in investigating genetic and environmental interactions in cancer development. Over the years, she has led 51 research projects, authored 169 peer-reviewed articles, and earned over 3,600 citations. Dr. Zhong’s collaborative work extends across national and international institutions, including Huazhong Agricultural University and the General Hospital of Central Theater Command. Recognized with the Natural Science Award of Hubei Province, she is also actively involved in several national scientific committees. Her commitment to advancing cancer prevention through precision medicine and early detection strategies reflects both her scientific acumen and societal impact, making her a strong candidate for the Best Researcher Award.

Publication Profile: 

Orcid

✅ Strengths for the Award:

  1. Extensive Research Output

    • 169 SCI/Scopus-indexed publications, many in high-impact journals like Gastroenterology, Nature Reviews Clinical Oncology, and Cancer Discovery.

    • Strong citation record with 3,697 citations on Web of Science, reflecting broad scientific influence.

  2. Innovative and Impactful Research

    • Focus on molecular and cancer epidemiology, particularly gene-environment interactions in gastrointestinal cancers, addressing a critical public health challenge.

    • Groundbreaking research on environmental risk factors (e.g., bisphenol A, tobacco smoke) and genetic susceptibility in cancer risk.

  3. Grants and Funding Leadership

    • Principal investigator of major national research projects, including National Natural Science Foundation of China grants and the Young Top-notch Talent Cultivation Program of Hubei Province.

  4. Recognition and Service

    • Recipient of the Natural Science Award of Hubei Province.

    • Serves on editorial boards of reputable journals such as Ebiomedicine and American Journal of Gastroenterology.

    • Active member in national scientific committees related to cancer prevention and epidemiology.

  5. Collaboration and Mentorship

    • Strong institutional and cross-disciplinary collaborations, including with Huazhong Agricultural University and military medical research institutions.

    • A demonstrated leader in mentoring young researchers in public health and biomedical science.

⚙️ Areas for Improvement:

  1. Industry Engagement & Technology Transfer

    • Although she holds 2 patents, there is limited mention of industry consultancy or commercialization, which could strengthen real-world impact.

  2. International Policy Influence

    • Expanding her involvement in international advisory boards or global health policy initiatives could further elevate her research visibility and societal contribution.

  3. Science Communication & Public Engagement

    • Enhanced participation in public education, community outreach, or policy translation could help bridge science and society, especially in preventive oncology.

🎓 Education:

Dr. Rong Zhong earned her PhD in Epidemiology and Biostatistics from the prestigious Huazhong University of Science and Technology, where she built the foundation for her future research excellence. To further expand her academic perspective, she completed postdoctoral training at Harvard Medical School, USA—an experience that enriched her global outlook and enhanced her methodological rigor in public health research. Throughout her academic journey, Dr. Zhong has demonstrated a passion for understanding complex interactions between genes and environmental exposures, particularly in relation to cancer epidemiology. Her education, characterized by a blend of rigorous Chinese academic training and Western research exposure, has laid a strong interdisciplinary base. This robust academic background has equipped her with a unique skill set to lead impactful research in molecular epidemiology and precision prevention of gastrointestinal cancers.

💼 Experience:

Dr. Rong Zhong currently serves as a Professor at the School of Public Health, Tongji Medical College, Huazhong University of Science and Technology. With extensive experience in cancer epidemiology, she has successfully led national and provincial research initiatives including projects funded by the National Natural Science Foundation of China and the Young Top-notch Talent Cultivation Program of Hubei Province. Over the years, she has been instrumental in mentoring young scientists, shaping national health policies, and advancing cancer prevention strategies in China. She also serves on editorial boards of high-impact journals such as Ebiomedicine and American Journal of Gastroenterology. Her experience bridges research, academic leadership, and international collaboration, reflecting her multidimensional contribution to science and public health. Her advisory roles in national committees focused on cancer prevention and epidemiology further underscore her influence and thought leadership in the field.

🔬 Research Focus:

Professor Zhong’s primary research focus lies in molecular and cancer epidemiology, with an emphasis on gastrointestinal cancers. Her work aims to elucidate the gene-environment interactions that contribute to cancer risk, leveraging large-scale cohort and case-control studies. By integrating genomic data with environmental exposures (e.g., diet, pollutants, endocrine-disrupting chemicals), she develops predictive models that enable early screening and personalized prevention strategies for high-risk populations. Her recent studies investigate interactions between genetic polymorphisms and substances like bisphenol A, tobacco smoke, and gut microbiota, especially in relation to colorectal and breast cancer. These contributions bridge the gap between basic science and clinical translation, offering a pathway toward precision public health. Her research not only advances scientific knowledge but also holds tangible implications for national cancer screening guidelines and individualized preventive healthcare strategies.

📚 Publications Top Notes:

  1. 📘 Western-Style Diet, pks Island-Carrying Escherichia coli, and Colorectal Cancer: Analyses From Two Large Prospective Cohort Studies – Gastroenterology

  2. 🚬 In Utero and Childhood/Adolescence Exposure to Tobacco Smoke, Genetic Risk and Lung Cancer Incidence and Mortality in Adulthood – AJRCCM

  3. 🧬 FOXA1 of regulatory variant associated with risk of breast cancer through allele-specific enhancer in the Chinese population – Breast Cancer

  4. 🧪 Genome-wide gene-bisphenol A, F and triclosan interaction analyses on urinary oxidative stress markers – Science of The Total Environment

  5. 🧫 Urinary bisphenol A and its interaction with CYP17A1 rs743572 are associated with breast cancer risk – Chemosphere

  6. 🧠 Animal-eRNAdb: a comprehensive animal enhancer RNA database – Nucleic Acids Research

  7. 🔬 Hepatocellular carcinoma risk variant modulates lncRNA HLA-DQB1-AS1 expression via a long-range enhancer–promoter interaction – Carcinogenesis

  8. 🧍‍♀️ Bisphenol A exposure, interaction with genetic variants and colorectal cancer via mediating oxidative stress biomarkers – Environmental Pollution

  9. 🧾 Discovery and Features of an Alkylating Signature in Colorectal Cancer – Cancer Discovery

  10. 🚨 Rising incidence of early-onset colorectal cancer — a call to action – Nature Reviews Clinical Oncology

📌 Conclusion:

Professor Rong Zhong is an outstanding and highly qualified candidate for the Best Researcher Award. Her prolific output, innovative approaches to cancer risk assessment, and leadership in national scientific research firmly position her among the top-tier researchers in her field. Her contributions have laid the groundwork for precision public health, with real potential to transform early cancer detection and prevention strategies in China and globally.