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Zhi-Jie Liu is a distinguished scientist specializing in structural biology and human cell signaling. With a Ph.D. in Biophysics from the Chinese Academy of Sciences, he has extensive postdoctoral and research experience in crystallography, biochemistry, and molecular biology. Currently, he leads innovative research at the iHuman Institute, focusing on elucidating the structural and functional mechanisms of human cell signaling and developing novel methods and technologies in structural biology. Recognized for his contributions to science and education, he has received multiple honors, including national awards for excellence in research and mentorship, reflecting his impact on both scientific advancement and talent development.
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Aspiring bioinformatics and molecular biology researcher with a strong foundation in computational drug discovery, genomics, and cancer research. Holds a B.Sc. in Anatomy with upper-class honors, demonstrating expertise in neuroanatomy, genetics, and tissue analysis. Experienced in molecular docking, protein modeling, gene expression studies, and laboratory techniques including PCR and ELISA. Skilled in data analysis using SPSS, GraphPad Prism, and Excel, and proficient in scientific software for drug design. Contributed to multiple peer-reviewed publications and mentored undergraduate students in bioinformatics. Active in teaching, research assistance, and professional scientific organizations, committed to advancing translational research in molecular medicine.
The research focuses on elucidating molecular, epigenetic, and neural circuit mechanisms underlying emotional and cognitive disorders. Key areas include identifying epigenetic modifications associated with behavioral changes in mood disorders, uncovering neural circuit and molecular pathways involved in treatment-resistant depression, and examining neural network mechanisms that regulate motivational behaviors such as reward processing, addiction, sexual behavior, and decision-making. Using an integrative approach combining behavioral neuroscience, molecular pharmacology, and systems and computational neuroscience, the work aims to clarify how chronic stress alters brain function and how resilience or anhedonia emerges, ultimately contributing to the development of novel therapeutic strategies for neuropsychiatric diseases.
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BoNT Injection into Temporomandibular Joint Alleviates TMJ Pain in Forced Mouth Opening Mouse Model
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