Department of Medicine and Aging Science, University of Chieti-Pescara “G. d’Annunzio”Chieti | Italy
Francesca Santilli, MD, PhD, is a leading physician-scientist whose work has substantially advanced the understanding of platelet biology, thrombo-inflammation, and cardio-metabolic disease. Her research focuses on mechanisms of platelet activation, interindividual variability in response to low-dose aspirin, and the interplay between inflammation, oxidative stress, and metabolic dysfunction. She has led major national and international projects, including studies on oxidative stress regulation in aspirin-treated diabetes, peripheral blood megakaryocyte maturation, and the effects of JAK inhibitors on thrombopoiesis in inflammatory disease. Her work has also contributed key insights into biomarkers—such as proteomic signatures, microRNAs, and extracellular vesicles—for cardiovascular and metabolic risk stratification. Additional research explores megakaryocyte biology, accelerated platelet turnover, and the impact of emerging therapies including GLP-1 receptor agonists, SGLT2 inhibitors, and PCSK9 inhibitors. Through extensive collaborations across molecular medicine, proteomics, rheumatology, cardiology, and infectious diseases, she has established interdisciplinary frameworks linking platelet function to diabetes, obesity, MASLD, and vascular disease. With over 160 high-impact publications and leadership roles in several scientific networks, her research continues to inform clinical translation and therapeutic optimization in thrombosis, hemostasis, and metabolic disorders.
Featured Publications:
antilli, F., Vazzana, N., Liani, R., Guagnano, M. T., & Davì, G. (2012). Platelet activation in obesity and metabolic syndrome. Obesity Reviews, 13(1), 27–42.
Santilli, F., Rocca, B., De Cristofaro, R., Lattanzio, S., Pietrangelo, L., Habib, A., & Patrono, C. (2009). Platelet cyclooxygenase inhibition by low-dose aspirin is not reflected consistently by platelet function assays: Implications for aspirin “resistance.” Journal of the American College of Cardiology, 53(8), 667–677.
Rocca, B., Santilli, F., Pitocco, D., Mucci, L., Petrucci, G., Vitacolonna, E., … & Patrono, C. (2012). The recovery of platelet cyclooxygenase activity explains interindividual variability in responsiveness to low-dose aspirin in patients with and without diabetes. Journal of Thrombosis and Haemostasis, 10(7), 1220–1230.
Caricato, A., Conti, G., Della Corte, F., Mancino, A., Santilli, F., Sandroni, C., … & Antonelli, M. (2005). Effects of PEEP on the intracranial system of patients with head injury and subarachnoid hemorrhage: The role of respiratory system compliance. Journal of Trauma and Acute Care Surgery, 58(3), 571–576.
Santilli, F., Vazzana, N., Bucciarelli, L. G., & Davì, G. (2009). Soluble forms of RAGE in human diseases: Clinical and therapeutical implications. Current Medicinal Chemistry, 16(8), 940–952.
Di Castelnuovo, A., Bonaccio, M., Costanzo, S., Gialluisi, A., Antinori, A., … Santilli, F., … & Iacoviello, L. (2020). Common cardiovascular risk factors and in-hospital mortality in 3,894 patients with COVID-19: Survival analysis and machine learning-based findings from the multicentre Italian study. Nutrition, Metabolism and Cardiovascular Diseases, 30(11), 1899–1913.
Vazzana, N., Santilli, F., Cuccurullo, C., & Davì, G. (2009). Soluble RAGE in internal medicine. Internal and Emergency Medicine, 4(5), 389–401.
Davì, G., Santilli, F., & Patrono, C. (2010). Nutraceuticals in diabetes and metabolic syndrome. Cardiovascular Therapeutics, 28(4), 216–226.
Chiarelli, F., Santilli, F., & Mohn, A. (2000). Role of growth factors in the development of diabetic complications. Hormone Research in Paediatrics, 53(2), 53–67.
Davì, G., Chiarelli, F., Santilli, F., Pomilio, M., Vigneri, S., Falco, A., … & Basili, S. (2003). Enhanced lipid peroxidation and platelet activation in the early phase of type 1 diabetes mellitus: Role of interleukin-6 and disease duration. Circulation, 107(25), 3199–3203.
Manigrasso, M. R., Ferroni, P., Santilli, F., Taraborelli, T., Guagnano, M. T., … & Davì, G. (2005). Association between circulating adiponectin and interleukin-10 levels in android obesity: Effects of weight loss. The Journal of Clinical Endocrinology & Metabolism, 90(10), 5876–5879.