Dr. Marco Leitzke | immunology | Best Researcher Award
Dr. Marco Leitzke, Helios clinics, Germany
Dr. Marco Leitzke, born in 1970 in Karl-Marx-Stadt, Germany, is a senior anesthesiologist and pioneering researcher in neuromodulation and post-viral syndromes. He has served as Senior Consultant in Anesthesiology and Intensive Care at Helios Clinic Leisnig since 2015 and has extensive experience in pain therapy and palliative medicine. Renowned for his innovative studies on autonomic dysfunction, Dr. Leitzke has published extensively on cholinergic neurotransmission, COVID-19 coagulopathy, and vagus nerve stimulation. His recent focus on Long COVID as a disorder of disrupted acetylcholine signaling has gained significant scientific attention. With a dual career in clinical practice and experimental research, he bridges the gap between bedside and bench. His work earned him accolades, including a Poster Award at the 1st Long COVID Congress in Jena. Passionate about translational medicine, Dr. Leitzke continues to drive forward the understanding and treatment of complex neuroimmune disorders.
Publication Profile:
Education:
Dr. Leitzke’s medical education and specialization reflect a deep commitment to anesthesiology and neurobiological research. He became a board-certified specialist in anesthesiology in 2006 and has built on this foundation with focused training in advanced pain management, ultrasound-guided interventions, and emergency medicine. He undertook specialized pain therapy training in 2015 and interventional pain techniques in 2014. In 2019, he began training as an Antibiotic Stewardship (ABS) expert physician, further demonstrating his holistic approach to patient safety and infection control. He also completed a transthoracic echocardiography course in 2018, showcasing his commitment to continuous learning and cross-disciplinary skills. This diverse academic background provides the basis for his translational research into neuroimmune and autonomic disorders, with a strong emphasis on clinical application. His combination of anesthesiology, ultrasound, pain therapy, and experimental neurobiology positions him as a uniquely skilled researcher bridging clinical practice and neuroscience.
Experience:
Dr. Marco Leitzke brings over two decades of clinical experience, predominantly in anesthesiology, intensive care, pain therapy, and palliative medicine. Since 2015, he has held the position of Senior Consultant at the Helios Clinic in Leisnig, where he leads interdisciplinary efforts in patient care and clinical innovation. Prior to this, he served as Senior Consultant at Asklepios Clinic Weißenfels from 2011 to 2014, while also operating as a freelance physician in Zeitz. His professional focus spans acute and chronic pain, complex anesthesia procedures, and critical care management, underpinned by a solid emergency medicine foundation gained since 2001. His hands-on experience with ultrasound-guided interventions, vagal modulation therapies, and autonomic diagnostics directly informs his research into the pathophysiology of post-viral syndromes. The integration of clinical insight and scientific exploration marks him as a dual-domain expert, fostering new therapeutic approaches rooted in both laboratory evidence and patient outcomes.
Research Focus:
Dr. Leitzke’s research centers on cholinergic neurotransmission and its impairment in acute and chronic post-viral conditions, particularly Long COVID. His central hypothesis suggests that autonomic dysfunction and neuromodulatory imbalance—specifically, disruption of the vagus nerve and acetylcholine pathways—underlie many post-viral symptoms. Through translational models using animal studies and human imaging, he explores therapeutic modulation, including vagal nerve stimulation and nicotine administration, to restore autonomic balance. His research extends to the role of NF-κB activation in COVID-19-associated coagulopathy, suggesting molecular pathways that link inflammation, clotting, and neuroimmune dysfunction. A hallmark of his work is the use of advanced imaging techniques (e.g., PET scans) to quantify cerebral receptor activity, particularly α7 nicotinic acetylcholine receptors. This integrative and experimental approach offers new perspectives on diagnostics and treatment in neuroimmune conditions, making his work highly relevant to both the scientific and medical communities in the era of post-COVID syndromes.
Publications Top Notes:
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📖 Long COVID – A Critical Disruption of Cholinergic Neurotransmission? (Springer Nature, 2025)
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📖 Is the Post-COVID-19 Syndrome a Severe Impairment of Acetylcholine-Orchestrated Neuromodulation That Responds to Nicotine Administration? (Springer Nature, 2023)
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🏅 COVID-19 – The Ultimate NF-κB Rush and the Crucial Importance of Nicotinic Acetylcholine Receptors (Poster Award, Long COVID Congress, 2022)
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🔬 Experimental Design for PET Detection of α7nAChR Under Gastric Vagus Nerve Stimulation in Piglets (DAS PLUS AN SCHUTZ, 2022)
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🧠 The Viral Accelerated NF-κB Pathway and COVID-19-Associated Coagulopathy – A Case Report (Fortune Journals, 2021)
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🧪 Afferent Vagal Stimulation via Gastric Electrical Stimulation Alters Sympathetic-Vagal Balance in Pigs – A Pilot Trial (Journal of Biological Regulators, 2021)
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⚖️ Autonomic Balance Determines the Severity of COVID-19 Courses (Springer Nature, 2020)
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🧮 A Semi-Automated Algorithm for Hypothalamus Volumetry in 3 Tesla MRI (Psychiatry Research: Neuroimaging, 2018)
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🧬 Image-Derived Input Function for (-)-[18F]Flubatine Using a Digital PET System (European Journal of Nuclear Medicine, 2024)
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💊 What Is the Impact of Nicotine on the Post-COVID-19 Syndrome? – A Case Series (Preprint, 2025)
Conclusion:
Dr. Marco Leitzke is a highly deserving candidate for the Best Researcher Award due to his pioneering contributions to understanding and treating Long COVID and neuroimmune disorders. His strong publication record, interdisciplinary approach, and clinical insight mark him as a leading figure in his field. With enhanced international collaboration and clinical validation of his findings, his impact could be even greater. Overall, his research is timely, innovative, and of substantial scientific and societal importance.