Esmaa Bouhamida | Molecular and Cellular Biology | Cell Biology Research Award

Dr. Esmaa Bouhamida | Molecular and Cellular Biology | Cell Biology Research Award

Fondazione Ricerca Biomedica Avanzata (VIMM) | Italy

The candidate’s research centers on understanding how mitochondrial signaling, hypoxia-responsive pathways, and cell-cycle regulatory networks collectively influence cardiac regeneration and cardiovascular disease. Their work investigates how hypoxia-inducible factors, particularly HIF-1α, modulate mitochondrial function during ischemic injury, with the broader goal of identifying mechanisms that could restore or enhance the regenerative potential of adult cardiac tissue. Through advanced molecular and cellular approaches, their studies explore how metabolic rewiring, mitochondrial stress responses, and oxygen-sensing pathways govern cardiomyocyte survival, proliferation, and reprogramming.

Building on expertise in molecular biology, signal transduction, and genetics, the researcher has expanded their focus to include the interplay between mitochondrial homeostasis and protein-quality control mechanisms in muscle tissues. Their postdoctoral work examines signaling pathways that regulate proteostasis and their impact on muscle integrity under physiological and pathological conditions. This integrated approach bridges cardiac regeneration, mitochondrial dynamics, and muscle biology, enabling the identification of therapeutic targets relevant to heart failure, ischemia, and degenerative muscle disorders.

Their long-term vision is to develop interventions that combine mitochondrial modulation, gene therapy, and cellular reprogramming strategies to promote tissue repair and functional recovery in cardiovascular disease. Their contributions have been recognized through competitive scientific evaluations at international cardiovascular and stem-cell research forums.

Profiles: Google Scholar | Scopus | Orcid

Featured Publications:

Bouhamida, E., Vadakke-Madathil, S., Mathiyalagan, P., Ranjan, A. K., Khan, A., Sherman, M. P., & others. (2025). Single nucleus transcriptomics supports a role for CCNA2-induced human adult cardiomyocyte cytokinesis. bioRxiv.

Bouhamida, E., Vadakke-Madathil, S., Mathiyalagan, P., Ranjan, A. K., Sherman, M. P., & others. (2025). Cyclin A2 induces cytokinesis in human adult cardiomyocytes and drives reprogramming in mice. npj Regenerative Medicine, 10(1), 47.

Ibrahim Musa | Molecular Physiology | Best Researcher Award

Dr. Ibrahim Musa | Molecular Physiology | Best Researcher Award

Prince Abubakar Audu University | Nigeria

Dr. Ibrahim Musa is a Molecular Physiologist with a PhD in Molecular Physiology and Biochemistry from the University of Birmingham, UK, where his doctoral research focused on the molecular function and stability of MuRF1 in skeletal muscle using CRISPR/Cas9 and retroviral applications. He has over four years of research experience in ubiquitin biology, target validation, cellular biology, and molecular mechanisms, with expertise in CRISPR/Cas9 gene-editing and primary human skeletal muscle culture. As a Research Assistant at the Cellular Health and Metabolism Facility, University of Birmingham, he screened novel drug compounds for mitochondrial dysfunction and optimized dose-response assays in human myoblasts. Dr. Musa has also served as a Lecturer and Researcher in Human Physiology at Kogi State University, Nigeria, for a decade, where he has designed curricula, delivered undergraduate and MBBS lectures, supervised laboratory sessions, and coordinated departmental seminars. His research contributions are published in reputable journals, with an h-index of X, over Y documents, and more than Z citations indexed in Scopus/Google Scholar. He has been recognized with prestigious awards, including the TETFund Doctoral Scholarship (£99,960) and multiple travel awards from the Physiological Society and University of Birmingham, underscoring his growing impact in molecular physiology and biomedical research.

Profiles: Google Scholar | Orcid

Featured Publications:

Gant, H., Ghimire, N., Min, K., Musa, I., Ashraf, M., & Lawan, A. (2024). Impact of the quadriceps angle on health and injury risk in female athletes. International Journal of Environmental Research and Public Health, 21(12), 1547.

Musa, I., et al. (2025). MuRF1 partners with TRIM72 E3 ligases to impair insulin sensitivity in skeletal muscle. FASEB Journal. (Accepted; preprint available at bioRxiv).

Nishimura, Y., Chunthorng-Orn, J., Lord, S., Musa, I., Dawson, P., Holm, L., & Lai, Y. C. (2022). Ubiquitin E3 ligase Atrogin-1 protein is regulated via the rapamycin-sensitive mTOR-S6K1 signalling pathway in C2C12 muscle cells. American Journal of Physiology-Cell Physiology, 323(1), C215–C225.

Nishimura, Y., Musa, I., Holm, L., & Lai, Y. C. (2021). Recent advances in measuring and understanding the regulation of exercise-mediated protein degradation in skeletal muscle. American Journal of Physiology-Cell Physiology, 321(2), C276–C287.

Seabright, A. P., Fine, N. H. F., Barlow, J. P., Lord, S. O., Musa, I., Gray, A., Bryant, J., Banzhaf, M., Lavery, G. G., Hardie, D. G., Hodson, D. J., Philp, A., & Lai, Y. C. (2020). AMPK activation induces mitophagy and promotes mitochondrial fission while activating TBK1 in a PINK1-Parkin independent manner. The FASEB Journal, 34(11), 14416–14433.