Maria Andriolo | Host-Pathogen Interactions | Best Innovation Award

Published on by Cell Biologist

Dr. Maria Andriolo | Host-Pathogen Interactions | Best Innovation Award

Dr. Maria Andriolo, ASP CALTANISSETTA, Italy

Maria Andriolo is a dedicated biomedical researcher and clinical biologist with extensive experience in neuroscience, immunology, and post-traumatic disorders. Her multidisciplinary approach has led to impactful contributions in clinical diagnostics, neurorehabilitation, and infectious disease studies. With decades of experience across leading Italian institutions, she combines clinical insight with scientific rigor. She has served in prestigious roles such as a Member of the State Examination Commission and President of Public Selection Committees. Dr. Andriolo is widely published, collaborating on pioneering studies in fields including brain trauma, sepsis diagnostics, and vaccine immunoresponse. Known for her collaborative spirit and leadership, she also contributes as a conference moderator and educator. Her body of work reflects a deep commitment to translational science that benefits patient care and public health.

Publication Profile:

Scopus

✅ Strengths for the Award:

  1. Multidisciplinary Research Impact
    Dr. Andriolo’s work spans key medical research areas including:

    • Neurology (e.g., traumatic brain injury, disorders of consciousness)

    • Clinical Biochemistry (e.g., neuron-specific enolase, BDNF, CSF biomarkers)

    • Microbiology & Infectious Diseases (e.g., antimicrobial resistance, sepsis diagnostics)

    • Immunology & Vaccine Response (e.g., post-COVID vaccine serology in healthcare workers)

  2. Innovation with Real-World Impact
    Her studies focus on biomarkers for rapid diagnosis, rehabilitation outcomes, and immune responses, directly translating into improved patient care, particularly in:

    • Post-traumatic brain disorders

    • Early detection of sepsis

    • Infection control strategies

  3. Collaborative and High-Impact Publications

    • Extensive peer-reviewed articles in PubMed-indexed journals like Journal of Neurotrauma, Brain Sciences, Vaccines, and Science Reports.

    • Publications show collaborations with leading national research teams and hospitals.

  4. Scientific Leadership & Recognition

    • Appointed as President of National Selection Committees and State Examiner for Biologist Certification.

    • Served as Moderator at ECM Conferences, further demonstrating peer trust and scientific communication skills.

⚠️ Areas for Improvement:

  1. Lead Authorship and Project Ownership

    • While her publication record is strong, she is mostly listed as co-author. Clear documentation of principal investigator roles, research grants led, or independent innovation patents would further bolster her candidacy.

  2. International Presence

    • A broader international profile (e.g., global conferences, cross-border collaborative studies, citations from non-EU entities) could elevate her global impact.

  3. Recent Innovation Highlights

    • A focused submission highlighting a single groundbreaking innovation (e.g., biomarker panel for TBI prognosis or rapid sepsis tool) would align more clearly with “Best Innovation” award criteria.

🎓 Education:

While the detailed educational background isn’t listed, Maria Andriolo’s professional and scientific achievements imply a robust academic foundation in Biology, Neuroscience, and Clinical Diagnostics, likely culminating in at least a Master’s or Doctorate-level education in Biomedical Sciences. Her involvement as a State Examiner for Biologist Qualification and leader of academic committees suggests a longstanding connection with university-level institutions, particularly the University of Messina. Given her expertise and publication record, it is evident she has received specialized training in neurobiology, molecular genetics, clinical chemistry, and medical microbiology. She has actively participated in ECM-accredited medical conferences, indicating a commitment to continuing professional development. This mix of structured education and applied training positions her as a highly qualified scientific professional.

💼 Professional Experience:

Maria Andriolo holds significant academic and clinical leadership roles. She was appointed in July 2024 as a Member of the State Examination Commission for Biologists at the University of Messina, overseeing professional certifications. In June 2023, she served as President of the Examination Committee for a public selection competition for C1 research staff. She is frequently invited to act as a moderator at ECM-accredited conferences, underscoring her peer recognition in the field. Her expertise spans biomedical research, academic evaluation, and public health diagnostics. Maria’s ability to combine scientific knowledge with regulatory oversight and teaching makes her a valuable contributor to academia and public institutions. Her leadership and participation in national scientific initiatives demonstrate her commitment to innovation, clinical application, and academic excellence.

🔬 Research Focus:

Maria Andriolo’s research is anchored in neuroscience, post-traumatic disorders, biomarkers, and infectious diseases. Her work often centers on patients with disorders of consciousness following trauma, analyzing biomarkers like BDNF, neurofilaments, and amyloid-beta proteins. She is a leading contributor in understanding the neurochemical pathways associated with brain injury and rehabilitation. Maria has also co-authored influential studies on sepsis diagnostics, immune response to COVID-19 vaccines, and antimicrobial resistance. Her research combines laboratory diagnostics with clinical applications, enabling faster diagnoses and more effective treatment strategies. She is known for utilizing multidisciplinary frameworks, involving neurologists, microbiologists, and clinicians to translate science into solutions. This strong translational impact underscores her candidacy for the Best Innovation Award, as she bridges the gap between research and patient-centered innovation.

📚 Publications Top Notes:

  1. 🧠 Reduced neuron-specific enolase levels in chronic severe traumatic brain injury

  2. 🧬 Multidisciplinary approach for the rapid diagnosis of sepsis

  3. 💉 Serological analysis of humoral immune response in Sicilian HCWs post-COVID vaccination

  4. 🧠 Dissociation of CSF amyloid-beta and tau in post-traumatic consciousness disorders

  5. 💉 Staphylococcus aureus in bloodstream infections: frequency & antimicrobial resistance

  6. 🧠 Serum BDNF levels are reduced in disorders of consciousness

  7. 🧠 Six-month outcomes in traumatic consciousness disorders (hemorrhagic/non-hemorrhagic)

  8. 🧠 BDNF Val66Met polymorphism and post-traumatic vegetative state recovery

  9. 💉 Anaphylaxis to streptomycin

  10. 🧠 Prolonged CSF neurofilament light chain increase in traumatic brain patients

🏁 Conclusion:

Maria Andriolo is a highly suitable and deserving candidate for the Research for Best Innovation Award. Her research demonstrates:

  • Exceptional depth in translational neuroscience and diagnostics

  • A strong commitment to multidisciplinary collaboration

  • A clear track record of innovation that impacts both patient outcomes and healthcare protocols

 

 

 

ASLI CEYLAN | Molecular Mechanisms Signaling | Signal Transduction Award

Published on by Cell Biologist

Prof. Dr. ASLI CEYLAN | Molecular Mechanisms Signaling | Signal Transduction Award

Prof. Dr. ASLI CEYLAN , Ankara Yildirim Beyazit University , Turkey

Dr. Aslı F. Ceylan is an accomplished pharmacologist and academic with a strong foundation in medical pharmacology and translational research. Born in Ankara, Turkey, in 1977, she has dedicated over two decades to advancing our understanding of cellular signaling pathways in disease states. After earning her degrees from Ankara University, she completed a prestigious postdoctoral fellowship at the University of Wyoming, where she began her international research journey. Currently serving at Ankara Yıldırım Beyazıt University School of Medicine, she contributes to both research and education. Fluent in Turkish, English, and Spanish, Dr. Ceylan bridges global scientific collaborations. Her work spans oxidative stress, inflammation, and cellular mechanisms in cardiovascular, metabolic, and neurodegenerative diseases. She is a prolific author and recipient of several international fellowships and project grants. Dr. Ceylan stands out as a dedicated scientist whose work contributes meaningfully to the field of signal transduction and molecular pharmacology.

Publication profile:

Orcid

✅ Strengths for the Award:

  1. Extensive Research in Signal Transduction Pathways
    Dr. Ceylan’s body of work demonstrates a consistent and high-impact focus on key signal transduction pathways—including NLRP3 inflammasome activation, mitophagy, ferroptosis, oxidative stress, and autophagy—across cardiovascular, metabolic, and neurological disease models.

  2. International Research Recognition
    She has held prestigious fellowships from NIH, the American Heart Association, and INBRE, contributing to globally relevant research while collaborating with international teams, especially in the U.S. and Europe.

  3. Strong Translational Relevance
    Her research links molecular mechanisms to potential therapies, such as her exploration of aldose reductase inhibitors, natural antioxidants, and neuroprotective compounds (e.g., rosemary extracts), bridging the gap between basic science and clinical relevance.

  4. Consistent Publication Record
    Dr. Ceylan has co-authored over a dozen peer-reviewed publications in the past three years alone, with topics directly tied to signal transduction, and published in reputable journals (e.g., Biochimica et Biophysica Acta, JACC: Basic to Translational Science).

  5. Leadership and Mentorship
    As a Principal Investigator for NIH-funded thematic research projects and an academic at a medical university, she demonstrates strong leadership, mentoring capabilities, and a sustained contribution to the scientific community.

🛠️ Areas for Improvement:

  1. Greater Focus on Human Clinical Studies
    While her animal model work is comprehensive, integrating more human cell or clinical data would increase the translational applicability of her research.

  2. Expanded Thematic Clarity in Signal Transduction
    Some of her recent works, while impactful, focus broadly on pharmacological effects of natural compounds. More thematic emphasis on specific intracellular signaling cascades (e.g., MAPK, PI3K/Akt, or JAK/STAT) could strengthen her profile specifically for a signal transduction-focused award.

  3. Visibility in Global Scientific Forums
    Increased participation as a speaker, panelist, or chair in international conferences focused on signal transduction would enhance her global academic footprint.

📘 Education:

Dr. Aslı F. Ceylan completed her entire academic training in Pharmacology at the prestigious Ankara University Faculty of Pharmacy. She earned her Bachelor of Science (B.Sc.) in Pharmacy in 1998, followed by a Master of Science (M.Sc.) in Pharmacology in 2001. Her strong interest in cellular mechanisms and drug interactions led her to pursue a Ph.D. in Pharmacology, which she successfully completed in 2007. Her doctoral research was further enhanced by a research fellowship at the National Institutes of Health (NIH) during 2004-2005, providing her hands-on experience in internationally recognized labs. This rigorous academic journey solidified her expertise in pharmacological mechanisms and preclinical modeling. Her academic training was consistently supported by competitive scholarships from the Turkish Scientific and Research Council (TÜBİTAK). Dr. Ceylan’s academic path reflects a deep commitment to understanding complex cellular systems and contributes significantly to her current role as a leader in molecular pharmacology and signal transduction.

💼 Experience:

Dr. Aslı F. Ceylan is currently a faculty member at Ankara Yıldırım Beyazıt University School of Medicine, where she serves in the Department of Medical Pharmacology. She has extensive academic and research experience spanning over 20 years. Her postdoctoral research at the University of Wyoming School of Pharmacy (2008–2009) focused on cardiovascular research, where she worked on signal transduction pathways involved in heart failure and metabolic disease. She also held a Principal Investigator (PI) role in NIH-funded INBRE research projects in the U.S. from 2011 to 2020. Dr. Ceylan has consistently contributed to multi-disciplinary research projects and collaborative studies, mentoring young researchers and postgraduate students. She has a solid background in oxidative stress, inflammation, and cellular apoptosis. Her translational approach, blending basic science with therapeutic innovation, aligns perfectly with the goals of signal transduction research. Her international exposure and consistent academic productivity make her a valuable asset to any scientific initiative.

🏆 Awards and Honors:

Dr. Aslı F. Ceylan has earned numerous national and international fellowships and honors throughout her career. She was awarded the Postdoctoral Fellowship by the American Heart Association and the University of Wyoming in 2008, which significantly propelled her research on cardiovascular signaling. She also received a Ph.D. research fellowship from the NIH (2004–2005), supporting her studies in cell signaling and oxidative stress. Domestically, she was funded by TÜBİTAK (Turkish Scientific and Research Council) for both her master’s and Ph.D. degrees. Most notably, she served as Principal Investigator for NIH INBRE Thematic Research Projects from 2011 to 2020, underlining her leadership and innovation in biomedical research. These accolades reflect her ongoing commitment to excellence in pharmacological science and her impact on the field of signal transduction, particularly in cardiovascular and neurodegenerative diseases. Her strong track record of competitive funding and recognition underscores her eligibility for the Signal Transduction Award.

🔬 Research Focus:

Dr. Ceylan’s research is centered on signal transduction pathways involved in oxidative stress, inflammation, mitophagy, and ferroptosis. Her work delves into the molecular mechanisms underlying cardiovascular diseases, diabetic complications, neurodegenerative disorders, and cancer, with a particular focus on mitochondrial function and cellular defense systems. She employs both in vivo and in vitro models to study how specific pharmacological agents modulate pathways like NLRP3 inflammasome activation, aldose reductase inhibition, and autophagy. Additionally, her recent research explores the therapeutic potential of natural compounds such as carnosol, carnosic acid, and rosemary extract in modulating redox balance and apoptotic pathways. Her interdisciplinary approach links natural product pharmacology with molecular signaling, making her contributions relevant across multiple domains. The translational value of her research, aiming to bridge the gap between bench and bedside, aligns directly with the core objectives of signal transduction studies and reinforces her eligibility for this distinguished award.

📚 Publications Top Notes:

  1. 🧬 Cardiomyocyte-specific deletion of endothelin receptor A obliterates cardiac aging via mitophagy and ferroptosis (2024)

  2. 🧫 Tackling chronic wound healing using nanomaterials: Advancements and future perspectives (2023)

  3. 🧪 Dual-acting aldose reductase inhibitor impedes oxidative stress in diabetic rat tissues (2023)

  4. 👁️ Cemtirestat induces ocular defense against glycotoxic stress in diabetic rats (2023)

  5. 🍷 NLRP3 inhibition protects against ethanol-induced cardiotoxicity in FBXL2-dependent manner (2023)

  6. 💉 Oxytocin and enalapril reduce epidural fibrosis post-laminectomy in rats (2023)

  7. 🧠 Calcium dobesilate therapy in cerebral hypoxia/reperfusion injury in rats (2023)

  8. 🧬 Beclin1 deficiency attenuates alcohol-induced cardiac dysfunction via ferroptosis inhibition (2022)

  9. 💓 Parkin insufficiency exacerbates cardiac remodeling through mitochondrial Ca2+ overload (2022)

  10. ❤️‍🩹 Beclin 1 haplosufficiency compromises stem-cell cardioprotection post-MI (2022)

🧾 Conclusion:

Dr. Aslı F. Ceylan is a highly qualified, internationally active, and academically productive researcher whose expertise lies in elucidating molecular mechanisms of disease through signal transduction pathways. Her deep involvement in studies on oxidative stress, mitochondrial dynamics, inflammation, and natural product pharmacology positions her as a valuable contributor to the advancement of molecular medicine.

Given her research output, grant leadership, and commitment to translational science, she is highly suitable for the Signal Transduction Award. Her work not only contributes to the understanding of intracellular signaling but also bridges basic research with therapeutic potential, making her a standout candidate for this recognition.