Charles Wang | Epigenomics | Distinguished Scientist Award

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Prof. Charles Wang | Epigenomics | Distinguished Scientist Award

Prof. Charles Wang | Loma Linda University Center for Genomics | United States

Dr. Changhong Wang (now known as Dr. C. Wang), a U.S. citizen, is a distinguished molecular toxicologist and genomic scientist currently serving as Director and Tenured Professor at the Center for Genomics, Loma Linda University. Originally from China, Dr. Wang holds dual graduate degrees in Public Health and Toxicology from Tongji Medical University and the University of Washington, respectively. His early career laid the foundation for pivotal research into environmental toxicants and gene-environment interactions. Dr. Wang has significantly contributed to the understanding of xenobiotic metabolism, DNA methylation, and the transgenerational effects of toxins and epigenetics. His leadership in molecular genetics research is reflected in numerous peer-reviewed publications and competitive grants. A passionate educator and mentor, Dr. Wang’s work bridges foundational science and clinical application, marking him as a strong contender for the Research for Distinguished Scientist Award.

Publication Profile: 

Socpus

Education:

Dr. Wang received his Ph.D. in Toxicology from the University of Washington, Seattle. His doctoral work focused on aflatoxin metabolism and liver glutathione S-transferases in nonhuman primates, mentored by Dr. David L. Eaton. Prior to that, he earned an MPH in Environmental Epidemiology from Tongji Medical University, China, where he developed a foundation in public health and environmental sciences. His dual training in toxicology and epidemiology provided a unique cross-disciplinary approach to health sciences. This strong academic background enables Dr. Wang to address critical questions regarding how environmental exposures affect human health, especially through epigenetic and genomic pathways. His educational path reflects a continuous pursuit of scientific excellence and translational impact, positioning him to bridge molecular discoveries with public health relevance—a crucial quality for a candidate of the Distinguished Scientist Award.

Experience:

Dr. Wang currently serves as Director and Tenured Professor at the Center for Genomics, School of Medicine, Loma Linda University (LLU), where he has led translational and mechanistic genomic research. His responsibilities span academic leadership, mentorship, and collaborative research within the Division of Molecular Genetics. Prior to this, he held the role of Associate Professor-Adjunct in Microbiology & Molecular Genetics at LLU. His earlier roles include postdoctoral and research scientist positions at institutions where he investigated environmental carcinogens, drug metabolism, and gene expression. Over three decades, Dr. Wang has built a multidisciplinary portfolio in toxicology, environmental health, and genomics. He is a leading voice in DNA methylation, epigenetic inheritance, and cancer biology. His integrative research style and administrative skills have allowed him to create impactful programs that foster innovation and interdisciplinary collaboration—an essential trait for any distinguished scientist.

Awards and Honors:

Dr. Wang’s academic journey has been decorated with prestigious accolades from the outset. He received the Excellent Medical Student Award  and Distinguished Graduate Student Award from Tongji Medical University. His pioneering research at the University of Washington earned him the First-Place Graduate Award for Research Excellence from the Society of Toxicology in New Orleans. He was awarded multiple Student Travel Awards from the University of Washington’s School of Public Health. These early recognitions underscore his long-standing commitment to scientific excellence and innovation. Dr. Wang’s later career has been marked by continuous success in publication, grant acquisition, and institutional leadership. These honors reflect both peer recognition and academic merit, reinforcing his status as a credible and outstanding candidate for the Research for Distinguished Scientist Award.

Research Focus:

Dr. Wang’s research focuses on environmental toxicology, genomics, and epigenetics, particularly in the context of transgenerational health effects. He investigates how toxicants such as cadmium, aflatoxin B1, and p,p’-DDE affect gene regulation through epigenetic reprogramming. His lab has pioneered work on DNA methylation, histone modifications, and miRNA signatures in diseases like cancer, neurodevelopmental disorders, and diabetes. Recent work has addressed the effects of e-cigarette exposure on neonatal brain methylomes and the epigenetic inheritance of addiction vulnerability. Dr. Wang also explores copy number variation and drug resistance mechanisms in oncology, using cutting-edge tools like single-cell RNA sequencing and patient-derived models. His integrative, multi-omics approach allows for deep mechanistic insights and clinical translation. His ability to lead multidisciplinary teams in high-impact research areas demonstrates both visionary thinking and the technical prowess necessary for distinguished scientific leadership.

Publications Top Notes:

  1. Cadmium-induced negative calcium balance in multiparous birth women

  2. Effect of cadmium on bone calcium in nonpregnant mice: Direct evidence on bone

  3. Cadmium’s impact on bone calcium in mouse dams: Itai-Itai-like syndrome model

  4. Induction of drug-metabolizing enzymes by BHA, ethoxyquin, and oltipraz

  5. Diquat and ciprofibrate effects on hepatic enzyme expression

  6. Mu-class GSTs mediate aflatoxin B1 epoxide conjugation in Macaca liver

  7. CYP1B1 expression analyzed in human tissues via hybridization techniques

  8. Cloning and characterization of alpha-class GSTs from Macaca liver

  9. Proteomic comparison of hepatocyte preparation methods

  10.  CYP3A41B polymorphism linked to puberty onset and breast cancer risk*

Conclusion:

In conclusion, Dr. Wang’s long-standing academic excellence, innovative research in toxicogenomics, and his leadership in advancing our understanding of environmental and epigenetic factors in disease clearly distinguish him as an outstanding scientist. His achievements fulfill and surpass the expectations for the Research for Distinguished Scientist Award. His profile reflects not only a deep commitment to rigorous science but also a visionary approach to public health and molecular research. With minor expansion in global engagement and translational outreach, Dr. Wang’s impact could be even more far-reaching. He is highly recommended for this honor.

John Carethers | DNA Repair | Best Researcher Award

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Prof. John Carethers | DNA Repair | Best Researcher Award

Prof. John Carethers, UC San Diego, United States

Dr. John M. Carethers is a distinguished academic leader and physician-scientist in the field of gastroenterology and cancer genetics. Serving as Vice Chancellor for Health Sciences at the University of California San Diego, he also holds professorial appointments in both the School of Medicine and the Herbert Wertheim School of Public Health. His extensive contributions to colorectal cancer research, health disparities, and tumor biology have earned him national recognition. Dr. Carethers is renowned for his work on DNA mismatch repair mechanisms and their implications in cancer progression and treatment responsiveness. With a prolific publication record and influential roles in medicine and science policy, he stands as a model for translational research excellence. His commitment to mentorship and health equity further underscores his holistic impact on the field of medicine. Dr. Carethers continues to push scientific boundaries while advocating for inclusive healthcare solutions.

Publication Profile: 

Google Scholar

Scopus

Education:

Dr. Carethers completed his undergraduate education at Wayne State University, earning a B.S. in Biological Sciences with a minor in Chemistry (1981–1985). He graduated with distinction and was a recipient of the Michigan State Competitive Scholarship. He continued at Wayne State University School of Medicine, where he earned his M.D. with High Distinction in 1989. His academic performance was recognized with multiple honors including the Dean’s Academic Achievement Award and awards from the Black Medical Association. Dr. Carethers then completed an internship in Internal Medicine at Massachusetts General Hospital (1989–1990), a prestigious Harvard-affiliated institution, under the guidance of Chief of Medicine Dr. John T. Potts. His medical and research training provided the foundation for a career focused on gastrointestinal disorders, tumor genetics, and health disparities, particularly in colorectal cancer. His formative years reflect academic excellence and an early commitment to advancing medicine through both practice and research.

Professional Experience:

Dr. John M. Carethers currently serves as the Vice Chancellor for Health Sciences at the University of California San Diego. He is also a Distinguished Professor in the Department of Medicine and an Adjunct Professor in the School of Public Health. His career has spanned prestigious academic roles, including clinical and research leadership in gastroenterology, particularly focused on colorectal cancer. A physician-scientist, Dr. Carethers has served in roles that bridge bench science and clinical application, contributing significantly to translational medicine. His academic journey includes mentorship of emerging scientists, leadership in national research initiatives, and board participation in scientific organizations. His experience also encompasses major roles in cancer health disparities research, aiming to close gaps in outcomes across racial and socioeconomic lines. Dr. Carethers is a prolific researcher and thought leader whose experience enhances institutional vision, diversity, and health equity. His impactful career exemplifies a dedication to excellence in science and medicine.

Awards and Honors:

Dr. Carethers has been recognized with numerous academic and professional honors throughout his career. As an undergraduate, he received the Michigan State Competitive Scholarship and was inducted into the Golden Key National Honor Society. During medical school, he earned the Dean’s Academic Achievement Award and awards from the Black Medical Association in 1986 and 1987. Over time, he has been widely honored for his contributions to colorectal cancer research, healthcare leadership, and advocacy for health equity. His published work has been highly cited and influential in advancing our understanding of tumor genetics and mismatch repair. He has received numerous invitations for keynote talks and appointments to national research boards and committees. Dr. Carethers’s career has been marked by his commitment to mentoring, scholarly productivity, and advocacy, positioning him as a leader and role model in academic medicine. These honors underscore his national and global influence in health sciences.

Research Focus:

Dr. John M. Carethers’s research primarily focuses on colorectal cancer, particularly mechanisms of tumor progression, genetic and epigenetic alterations, and mismatch repair (MMR) deficiency. He has deeply explored how MMR status influences treatment responses, especially to chemotherapy agents like 5-fluorouracil. A key aspect of his work includes identifying biomarkers for cancer prognosis and understanding familial cancer syndromes, including Lynch syndrome and polyposis syndromes. His studies also delve into the molecular mechanisms underlying microsatellite instability (MSI) and its role in genomic instability. Importantly, Dr. Carethers is a leading voice in cancer health disparities, examining how social, economic, and biological factors impact outcomes among underrepresented populations. His research bridges basic molecular science with clinical applications, enabling personalized approaches to treatment and surveillance. Through his work, he contributes to reducing cancer burden and mortality while promoting health equity in vulnerable communities—making him a pioneer in both biomedical research and public health.

Publications Top Notes:

  1.  Experimental and clinical observations on frostbite

  2.  The epidemiology of methicillin-resistant Staphylococcus aureus in a burn center

  3.  Extraintestinal Manifestations of Crohn’s Disease

  4.  Human chromosome 3 corrects mismatch repair deficiency in colon tumor cells

  5.  Delayed gastric emptying after laparoscopic vagotomy

  6.  Mismatch repair and the G2 cell cycle checkpoint

  7. In vitro assay for screening hMLH1 and hMSH2 mutations

  8.  Massive secretory diarrhea and pseudo-obstruction in Crohn’s disease

  9.  Mismatch repair blocks clonal expansion after DNA damage

  10.  Localization of Bannayan-Riley-Ruvalcaba syndrome gene to chromosome 10q23

Conclusion:

In conclusion, Dr. John M. Carethers embodies the highest standards of research excellence, leadership, and societal impact. His contributions to colorectal cancer genetics, DNA mismatch repair research, and cancer health disparities are not only scientifically rigorous but also clinically transformative. As a widely respected physician-scientist, educator, and health equity advocate, he represents the ideal blend of scholarly productivity and service to humanity. Despite minor opportunities for expanding the global and technological dimensions of his work, Dr. Carethers’s achievements place him in the top tier of biomedical researchers. His continued dedication to both advancing science and closing health outcome gaps aligns perfectly with the spirit of the Best Researcher Award. He is not only deserving of this honor but also serves as an inspiring model for current and future generations of researchers.