Fatma Guesmi | Gene Expression | Innovative Research Award

Published on by Cell Biologist

Innovative Research Award

Fatma Guesmi
Faculty of Sciences of Bizerte, Tunisia

Fatma Guesmi
Affiliation Faculty of Sciences of Bizerte
Country Tunisia
Scopus ID 56618808600
Documents 29
Citations 400
h-index 12
Subject Area Gene Expression
Event World Cell Biologist Awards
ORCID 0000-0002-5191-0755

Fatma Guesmi is a researcher affiliated with the Faculty of Sciences of Bizerte, University of Carthage, Tunisia, whose published work includes studies involving molecular and cellular mechanisms, cancer biology, apoptosis, signaling pathways, and biologically active natural products. Published records identify her affiliation with the Faculty of Sciences of Bizerte and associate her research with molecular and cellular investigations. [2] [3]

Abstract

Fatma Guesmi’s research profile encompasses areas of molecular and cellular biology, with published investigations addressing cellular signaling, apoptosis, cancer-related mechanisms, and the biological effects of natural products. Her publications include experimental studies examining molecular pathways associated with cell death and cancer biology. For example, a 2021 study investigated the effects of Thymus hirtus essential oil on TRAIL-associated apoptosis and death-receptor signaling in colon cancer models. [3] A later 2024 study examined Teucrium ramosissimum essential oil and its relationship with TRAIL/Apo2L-induced cell death in HCT-116 cells. [4]

Keywords

Gene Expression; Cell Biology; Molecular Biology; Cancer Biology; Apoptosis; Cell Signaling; Death Receptor Pathways; Natural Products; Innovative Research

Introduction

Gene expression and cellular signaling are central areas of modern cell biology because changes in transcriptional regulation, signaling proteins, receptor activity, and downstream molecular pathways can influence cellular proliferation, differentiation, survival, and programmed cell death. Research addressing these mechanisms frequently combines molecular biology, biochemical assays, cellular models, and experimental disease models. [5]

Research Profile

The supplied researcher profile identifies Fatma Guesmi with the Faculty of Sciences of Bizerte in Tunisia and lists Gene Expression as the principal subject area for this recognition profile. Her publicly indexed publications also document affiliation with the Laboratory of Biochemistry and Molecular Biology and the Laboratory of Risks Related to Environmental Stresses at the Faculty of Sciences of Bizerte, University of Carthage. [3] [4]

Research Contributions

Available publications demonstrate several recurring research themes:

  • Cellular signaling: Research has examined signaling systems associated with apoptosis and cancer-cell responses, including death-receptor and kinase-associated pathways. [3] [4]
  • Gene-expression-related mechanisms: Published experimental work has assessed changes in molecular signaling and expression-associated proteins in cellular models. [3] [5]

Publications

Selected publications provide documented examples of Guesmi’s research activity in molecular and cellular biology. The following publications are included as representative examples rather than as a complete bibliography.

  1. Guesmi, F., Prasad, S., Ben Ali, M., Ismail, I. A., & Landoulsi, A. (2021). Thymus hirtus sp. algeriensis Boiss. and Reut. volatile oil enhances TRAIL/Apo2L induced apoptosis and inhibits colon carcinogenesis through upregulation of death receptor pathway. Aging, 13(18), 21975–21990. DOI: https://doi.org/10.18632/aging.203552. [3]
  2. Guesmi, F., Tahri, W., Mehrez, A., Barkaoui, T., Prasad, S., Giuffrè, A. M., & Landoulsi, A. (2024). Colorectal carcinoma cell targeting aromatherapy with Teucrium ramosissimum essential oil to sensitize TRAIL/Apo2L-induced HCT-116 cell death. International Immunopharmacology, 136, 112405. DOI: https://doi.org/10.1016/j.intimp.2024.112405. [4]
  3. Guesmi, F., Prasad, S., Tyagi, A. K., & Landoulsi, A. (2017). Antinflammatory and anticancer effects of terpenes from oily fractions of Teucrium alopecurus, blocker of IκBα kinase, through downregulation of NF-κB activation, potentiation of apoptosis and suppression of NF-κB-regulated gene expression. Biomedicine & Pharmacotherapy, 95, 1876–1885. DOI: https://doi.org/10.1016/j.biopha.2017.09.115. [5]

Research Impact

The supplied bibliometric profile reports 400 citations and an h-index of 12 across 29 documents. Such indicators can provide a quantitative description of indexed scholarly output and citation activity, although they should not be interpreted independently of disciplinary norms, publication age, database coverage, and author-identification practices. [1]

The publication record also demonstrates continuing engagement with molecular mechanisms relevant to cell biology. The 2021 study examined death-receptor signaling, apoptosis, and related molecular responses, while the 2024 study investigated cellular mechanisms associated with TRAIL/Apo2L-induced cell death in HCT-116 cells. [3] [4]

Award Suitability

For the purposes of the World Cell Biologist Awards recognition profile, the supplied research area of Gene Expression can be considered in the context of Guesmi’s documented work on cellular signaling, apoptosis, cancer-cell responses, and molecular pathways. Published studies provide evidence of experimental investigation of cellular and molecular mechanisms, including changes in signaling proteins and pathways associated with programmed cell death. [3] [4] [5]

Conclusion

Fatma Guesmi’s documented research profile includes molecular and cellular investigations involving gene-expression-related mechanisms, apoptosis, signaling pathways, cancer biology, and natural-product research. Her publications provide examples of experimental work addressing cellular responses and molecular mechanisms, while the supplied bibliometric information summarizes her indexed scholarly activity. [1] [3] [4]

References

  1. Elsevier. (n.d.). Scopus author details: Fatma Guesmi, Author ID 56618808600. Scopus.
    https://www.scopus.com/authid/detail.uri?authorId=56618808600
  2. ORCID. (n.d.). Fatma Guesmi — ORCID record 0000-0002-5191-0755. ORCID.
    https://orcid.org/0000-0002-5191-0755
  3. Guesmi, F., Prasad, S., Ben Ali, M., Ismail, I. A., & Landoulsi, A. (2021). Thymus hirtus sp. algeriensis Boiss. and Reut. volatile oil enhances TRAIL/Apo2L induced apoptosis and inhibits colon carcinogenesis through upregulation of death receptor pathway. Aging, 13(18), 21975–21990. DOI: 10.18632/aging.203552.
    https://doi.org/10.18632/aging.203552
  4. Guesmi, F., Tahri, W., Mehrez, A., Barkaoui, T., Prasad, S., Giuffrè, A. M., & Landoulsi, A. (2024). Colorectal carcinoma cell targeting aromatherapy with Teucrium ramosissimum essential oil to sensitize TRAIL/Apo2L-induced HCT-116 cell death. International Immunopharmacology, 136, 112405. DOI: 10.1016/j.intimp.2024.112405.
    https://doi.org/10.1016/j.intimp.2024.112405
  5. Guesmi, F., Prasad, S., Tyagi, A. K., & Landoulsi, A. (2017). Antinflammatory and anticancer effects of terpenes from oily fractions of Teucrium alopecurus, blocker of IκBα kinase, through downregulation of NF-κB activation, potentiation of apoptosis and suppression of NF-κB-regulated gene expression. Biomedicine & Pharmacotherapy, 95, 1876–1885. DOI: 10.1016/j.biopha.2017.09.115.
    https://doi.org/10.1016/j.biopha.2017.09.115

Yang Gao | Cell Differentiation Processes | Best Researcher Award

Published on by Cell Biologist

Prof. Dr. Yang Gao | Cell Differentiation Processes | Best Researcher Award

Prof. Dr. Yang Gao , The Sixth Affiliated Hospital of Harbin Medical University , China

Professor Yang Gao is the Chief Physician and Director of the Critical Care Medicine Department at The Sixth Affiliated Hospital of Harbin Medical University, China. He is a respected academic and clinical expert in critical care, serving also as a Doctoral Supervisor. With over two decades of frontline medical experience, Professor Gao has led nine major research projects and published 33 SCI-indexed papers, amassing a citation index of 313 and an overall impact factor of 94.493. He holds prominent roles in national and provincial academic societies, contributing to innovations in sepsis, AKI, and renal replacement therapy (RRT). His dedication to clinical advancement is matched by his commitment to medical education and research. Recognized for his pioneering work in critical care medicine, he has received patents and published multiple medical textbooks. His leadership, extensive research contributions, and continued impact on critical care practices make him a strong candidate for the Best Researcher Award.

Publication Profile:

Scopus

✅ Strengths for the Award:

  1. Extensive Clinical & Research Expertise: With over two decades in frontline critical care, Professor Gao combines clinical acumen with deep research insight, particularly in sepsis-associated acute kidney injury (AKI) and continuous renal replacement therapy (RRT).

  2. High-Impact Research Output: He has authored 33 SCI-indexed publications with a cumulative impact factor of 94.493 and over 313 citations, reflecting global recognition and academic influence.

  3. Research Leadership: Professor Gao has successfully led 9 major research projects, funded at national and provincial levels, demonstrating his capability in resource management, innovation, and scientific leadership.

  4. Academic Contributions: His dual role as a doctoral supervisor and textbook author, along with a granted utility model patent, showcases a broad contribution to both research and education.

  5. Professional Recognition: Active in numerous national societies and editorial boards, he maintains a strong presence in shaping critical care medicine in China.

🔍 Areas for Improvement:

  • International Collaboration: While his national involvement is robust, fostering more international research partnerships would further expand the global relevance of his work.

  • Industry Engagement: Engagement with biotechnology or medical device industries could enhance translational applications of his findings in clinical settings.

🎓 Education:

Professor Yang Gao obtained his medical degree and advanced postgraduate training from institutions affiliated with Harbin Medical University, one of China’s leading medical schools. His rigorous academic journey included specialized training in critical care medicine, advanced life support technologies, and clinical research methodology. During his doctoral studies, he focused on critical illness mechanisms, with an emphasis on sepsis-associated acute kidney injury (AKI). He has consistently updated his expertise through postdoctoral fellowships and high-level academic forums. Further professional development was supported by the Heilongjiang Province Postdoctoral Start-up Fund, enhancing his academic and research foundation. Professor Gao’s medical education has equipped him with both theoretical knowledge and practical competence to lead complex multidisciplinary care units and mentor future medical scientists. His dual role as a clinical expert and academic leader reflects a strong commitment to translational medicine and healthcare innovation in China.

🏥 Experience:

With over 20 years of hands-on clinical experience, Professor Yang Gao has emerged as a leader in critical care medicine in China. Since 2003, he has been managing critically ill patients, mastering life-saving interventions such as non-invasive/invasive ventilation, blood purification, and continuous renal replacement therapy (CRRT). He is the Director of the Critical Care Medicine Department at The Sixth Affiliated Hospital of Harbin Medical University and holds teaching and supervisory roles for doctoral students. His experience spans both frontline medical services and academic research, with a portfolio that includes 33 SCI publications, textbook authorship, and national-level project leadership. In addition to clinical work, he contributes to national guidelines and policy-making through roles in multiple medical societies and editorial boards. Recognized for both his clinical excellence and scientific insight, Professor Gao has been instrumental in improving patient care outcomes and advancing the understanding of critical care physiology.

🔬 Research Focus:

Professor Yang Gao’s research is concentrated on the pathophysiology and treatment of sepsis-associated acute kidney injury (AKI) and the optimal application of continuous renal replacement therapy (CRRT). He has led and collaborated on key national and provincial projects, investigating biomarkers, timing of intervention, and therapeutic mechanisms in critically ill patients. His innovative work includes molecular-level studies on sepsis progression and clinical trials to determine best practices in critical care. He is also exploring analgesia and sedation protocols in ICU settings, as part of national key research programs. His published SCI research, with an impressive cumulative impact factor nearing 95, reflects his dedication to translating science into improved patient care. Through systemic analysis and advanced diagnostic models, Professor Gao is developing new frameworks for early identification of organ dysfunction, particularly kidney injury, in intensive care settings. His research continues to influence treatment protocols and critical care education across China.

📚 Publications Top Notes:

  1. 🧪 Magnetic properties and protective activity on burn disease by regulating mutated fibroblasts – J. Solid State Chem (2021)

  2. 🧫 Role of IL-10 and TNF-α in Sepsis-Induced AKI – Front. Immunol

  3. 🩺 Timing of CRRT in Septic Shock Patients with AKI – Crit Care Med

  4. 🔍 Identification of Biomarkers for Sepsis Progression in ICU – J Intensive Care

  5. 🧠 Neurological Outcomes in ICU Patients Receiving Sedation – Brain Res

  6. 🦠 MicroRNA Profiling in Sepsis-Induced Kidney Damage – Mol Med Rep

  7. 🧬 Effects of Early CRRT on Inflammatory Mediators – Cytokine

  8. 🧴 Pharmacokinetics of Antibiotics in CRRT Patients – Ther Drug Monit

  9. 🧍‍♂️ Prognostic Value of Serum NGAL in AKI Patients – Am J Nephrol

  10. 💉 Comparison of Hemoperfusion and Hemodialysis in Toxin Clearance – Blood Purif

🧾 Conclusion:

Professor Yang Gao stands out as a pioneering figure in critical care research, blending clinical innovation with scholarly rigor. His sustained contributions to understanding and treating sepsis and AKI, along with his strong academic leadership, make him eminently suitable for the Best Researcher Award. Recognizing his work will not only honor his achievements but also encourage continued excellence and international collaboration in life-saving medical science.

Fabian Fries | Gene Regulation Epigenetics | Young Scientist Award

Published on by Cell Biologist

Dr. Fabian Fries | Gene Regulation Epigenetics | Young Scientist Award

Dr. Fabian Fries , Universitätsklinikum des Saarlandes , Germany

Dr. Fabian N. Fries is a German ophthalmologist and senior consultant at Saarland University Medical Center. Born on July 18, 1990, in Germany, he has cultivated a career marked by clinical excellence, research productivity, and international experience. Following his medical studies at Saarland University, he gained practical experience across the U.S., Brazil, and Germany. Dr. Fries has authored over 15 peer-reviewed publications and earned an H-index of 16, reflecting his impactful contributions in ophthalmology. A polyglot and DAAD scholar, he is also actively engaged in professional societies like the German Ophthalmological Society. His research interests include corneal diseases, ocular surface disorders, and regenerative therapies involving limbal stem cells. Apart from his medical pursuits, he’s a competitive athlete, excelling in tennis and athletics. Dr. Fries combines clinical competence, research acumen, and a collaborative mindset, positioning him as an outstanding candidate for early-career research recognition.

Publication Profile:

Orcid

✅ Strengths:

  1. 📈 Strong Research Metrics

    • H-index: 16, i10-index: 22, and 742 citations—solid indicators of impactful and consistent academic output.

    • Authored 15 peer-reviewed publications in high-impact journals like The Ocular Surface, Experimental Eye Research, and International Journal of Molecular Sciences.

  2. 🧬 Innovative Research Focus

    • His work bridges molecular biology and clinical ophthalmology, especially in limbal stem cell deficiency, PAX6 gene regulation, miRNA expression, and corneal diseases.

    • Focus on translational science with direct implications for therapy and regenerative medicine.

  3. 🌍 International Exposure

    • Completed clinical internships in USA, Brazil, and Germany, showcasing adaptability, cultural competence, and international collaboration.

  4. 💼 Professional Leadership

    • Currently a Senior Consultant at Saarland University Medical Center.

    • Certified teaching assistant, actively mentoring young medical professionals.

  5. 🏅 Recognized Excellence & Extracurriculars

    • Multiple scholarships: DAAD, e-fellows.net, and Saarland University.

    • Athlete-scholar with national-level performance in tennis and athletics, highlighting discipline, commitment, and well-rounded personality.

  6. 🧠 Tech-Savvy & Multilingual

    • Proficient in SPSS, Java, SAP ERP, and fluent in 6 languages, positioning him uniquely for cross-disciplinary, global projects.

📉 Areas for Improvement:

  1. 🌐 Global Research Fellowships or Visiting Scientist Roles

    • While he has international clinical experience, postdoctoral research fellowships abroad (e.g., US, UK, or Japan) could further enrich his research perspective and expand collaborations.

  2. 📣 Greater Visibility as a Lead Investigator

    • Most of his studies are in collaboration with senior figures. More first-author or corresponding-author publications, and leading independent research grants, would bolster his profile.

  3. 🎤 Science Communication/Public Engagement

    • Active roles in public engagement, conferences, or science communication platforms would amplify his influence and visibility outside academic circles.

🎓 Education:

Dr. Fries completed his Abitur in Saarland, Germany in 2009 and subsequently pursued medicine at Saarland University, completing his state medical examination in 2016. His medical education was enriched by several international internships: Children’s of Alabama (USA), Instituto de Neurologia de Curitiba (Brazil), and various institutions in Germany. These experiences provided him with a strong foundation in global healthcare environments and interdisciplinary approaches to medical problems. His training emphasized ophthalmology, medical technology, and corneal research. In addition to his clinical education, he developed proficiency in research methodologies, statistical software (SPSS), and even programming in Java—an uncommon strength among clinicians. His multilingualism (German, English, French, Spanish, Portuguese, Latin) further reflects a well-rounded academic and professional profile. He has also received scholarships from the DAAD, Saarland University, and e-fellows.net. This robust educational background is a solid base for his continued clinical and academic excellence in ophthalmology.

💼 Professional Experience:

Dr. Fries is currently a Senior Consultant in Ophthalmology at Saarland University Medical Center (since 2021), where he also completed his residency (2016–2021). He brings over a decade of experience in clinical practice, teaching, and research. His clinical roles have spanned multiple specialties and continents, including stints at Children’s of Alabama, the Instituto de Neurologia de Curitiba, and top institutions in Germany. He has participated in pioneering electronic health record integration projects and led efforts in corneal transplant innovations. His experience also includes medical internships in both hospitals and private practices, providing a broad spectrum of exposure from surgical practice to patient-centered outpatient care. Additionally, he is a certified teaching assistant at Saarland University and has been actively involved in the supervision of junior residents and students. His commitment to high-standard care and continuous education is evident in his leadership roles and collaborative projects.

🏆 Awards and Honors:

Dr. Fries has received several academic and research accolades that highlight his potential as a leading young scientist. He was awarded scholarships from the prestigious DAAD (German Academic Exchange Service), Saarland University, and e-fellows.net, reflecting academic excellence and leadership. His athletic achievements include participation in the German University Tennis Championships (2015, 2016), where he won multiple regional titles and achieved a 5th place ranking in the German Team Athletics Championships (2014). In research, his contributions are recognized through a strong H-index of 16, 742 citations, and an i10-index of 22, underlining consistent and impactful scientific productivity. He is a member of key academic societies, including the German Ophthalmological Society, Professional Association of Ophthalmologists, and others since 2016. His well-rounded excellence in science, teaching, international exposure, and sports makes him an exceptional candidate for the Research for Young Scientist Award.

🔬 Research Focus:

Dr. Fabian Fries focuses his research on ocular surface diseases, particularly limbal stem cell deficiency, corneal dystrophies, and regenerative approaches in ophthalmology. His work dives deep into molecular mechanisms, such as PAX6 signaling, microRNA pathways, and retinoic acid signaling, all pivotal in corneal health and disease. Using advanced cell culture models and patient tissue analysis, his research offers insights into pathophysiological processes affecting corneal epithelial integrity. Additionally, he explores the impact of genetic mutations and inflammatory mediators on disease progression. Dr. Fries has contributed significantly to translational research, bringing lab discoveries into clinical settings, notably in corneal transplantation and novel therapeutic strategies. He also examines digital integration in ophthalmology via projects like FIDUS EHR implementation. His interdisciplinary, collaborative, and bench-to-bedside approach places him at the forefront of young clinician-scientists driving innovation in ophthalmology.

📚 Publications Top Notes:

  1. 🧬 Effect of MiRNA 204-5P Mimics and LPS on Retinoic Acid Signaling in Limbal Epithelial Cells

  2. 🔬 Decreased PAX6 and DSG1 in Corneal Epithelium of EBMD, SND, and Pterygium Patients

  3. 🧫 FABP5 and DSG1 Downregulation after PAX6 Knockdown in Limbal Cells

  4. 💻 Employee Survey Post-FIDUS EHR Introduction at Saarland Eye Hospital

  5. 👁 Endothelial Cell Density and Corneal Thickness Post-Keratoplasty for Acanthamoeba Keratitis

  6. 🩸 Intravenous Fibrinolysis for Nonarteritic Central Retinal Artery Occlusion – Feasibility Study

  7. ⚠️ Pronounced Band Keratopathy in Refsum’s Syndrome – Case Report

  8. 🔎 Unilateral Macular Pigment Epitheliitis in a 38-Year-Old – Diagnostic Insights

  9. 🧬 MicroRNA and Gene Expression Changes in Limbal Deficiency Modulated by PAX6 Mutation

  10. 🧠 Acute Visual Loss from Basilar Artery Aneurysm-induced Subarachnoid Hemorrhage

🏁 Conclusion:

Dr. Fabian N. Fries stands out as a highly qualified, ambitious, and impactful early-career scientist whose research bridges the gap between basic science and clinical innovation in ophthalmology. His contributions to ocular surface research, particularly in the context of limbal stem cells and gene regulation, are of significant academic and therapeutic value. He brings a unique mix of clinical excellence, internationalism, technological proficiency, and scientific curiosity.