Jiangang Zhang | Cell Metabolism | Research Excellence Award

Published on by Cell Biologist

Dr. Jiangang Zhang | Cell Metabolism | Research Excellence Award

School of Basic Medical Sciences, Lanzhou University | China

Dr. Jiangang Zhang. A senior academic and medical professional with extensive leadership in pathology, forensic medicine, and laboratory sciences at Lanzhou University and its affiliated hospitals. Holds multiple directorial roles across pathology departments, forensic appraisal institutes, dental hospitals, and GLP laboratory centers, contributing significantly to clinical diagnostics, forensic evaluation, and translational research. Recognized nationally and provincially as an expert in forensic appraisal, including insurance-related forensic assessments, and plays a key role in expert review and governance bodies. Academic training spans clinical medicine, tissue engineering, and advanced biomedical research, with doctoral-level experience at Peking University. Research expertise includes obesity, nutrition, chronic diseases, skin tissue engineering, and pathology-related biomedical sciences. Has led and completed several major nationally funded research projects, including multiple grants from the National Natural Science Foundation of China and military medical research programs, reflecting sustained contributions to medical science, education, and forensic pathology.

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Featured Publication

Willa Hsueh | Immunometabolism | Best Researcher Award

Published on by Cell Biologist

Prof. Willa Hsueh | Immunometabolism | Best Researcher Award

The Ohio State University | United States

Dr. Willa Hsueh is a leading researcher in endocrinology, diabetes, and metabolism, with a career spanning several decades of pioneering contributions to hormone regulation and metabolic disease. Her early research provided key insights into renin biochemistry and aldosterone metabolism, particularly focusing on inactive “big renin” forms and their activation mechanisms in normal and pathological conditions such as diabetic nephropathy. Dr. Hsueh’s investigations have significantly advanced the understanding of the renin-angiotensin-aldosterone system (RAAS) and its role in blood pressure regulation, sodium balance, and endocrine disorders. Her studies explored adrenal physiology, steroid metabolism, and hormonal responses to physiological and pharmacological stimuli, laying the groundwork for later research on cardiovascular and metabolic dysfunctions in diabetes. Through her interdisciplinary approach combining endocrinology, nephrology, and metabolism, she has elucidated biochemical pathways linking hormonal imbalances to metabolic diseases. Dr. Hsueh continues to lead impactful research in diabetes and metabolic regulation, contributing to translational advancements that bridge molecular mechanisms with clinical applications for improved patient outcomes in endocrine and metabolic disorders.

Profiles: Scopus | Orcid

Featured Publications:

Hsueh, W. A., Boonjaren, S., Stein, J., Baehler, H. R., Osgood, R. W., Cohen, S., Yashon, D., & Ferris, T. (1974). Effect of plasma sodium concentration on diluting segment sodium reabsorption. Kidney International, 5(1), 1–11.

Johnson, K. R., Hsueh, W. A., Glusman, S. M., & Arnett, F. C. (1976). Fibrous myopathy: A rheumatic complication of drug abuse. Arthritis & Rheumatism, 19(5), 923–926.

Hsueh, W. A., & Hsu, T. H. (1978). Thyrotoxicosis in a patient with secondary hypothyroidism. Southern Medical Journal, 71(9), 1174–1177.

Hsueh, W. A., Luetscher, J. A., Carlson, E., & Grislis, G. (1978). Big renin in plasma of healthy subjects on high-sodium intake. The Lancet, 1(8077), 1281–1284.

Hsueh, W. A., Hsu, T. H., & Federman, D. D. (1978). Endocrine features of Klinefelter’s syndrome. Medicine, 57(5), 447–461.

Hsueh, W. A., Luetscher, J. A., Carlson, E., Grislis, G., Elbaum, D., & Chavarri, M. (1978). A comparison of cold and acid activation of big renin and of inactive renin in normal plasma. Journal of Clinical Endocrinology and Metabolism, 47(4), 792–799.

Romain Villéger | Host-bacteria interactions | Cell Metabolism Award

Published on by Cell Biologist

Assist. Prof. Dr. Romain Villéger | Host-bacteria interactions | Cell Metabolism Award

Assist. Prof. Dr. Romain Villéger , Université de Poitiers , France

Dr. Romain Villéger is an Assistant Professor at the University of Poitiers, France, in the Ecology & Biology of Interactions (EBI) lab, within the Microorganisms-Hosts-Environments (MHE) team. With a Ph.D. from the University of Limoges, his work explores the intricate interactions between probiotics and host cells. He has held postdoctoral positions at the University of Bordeaux and the University of Texas Medical Branch, USA, focusing on microbiota-host relationships and metabolomics. Dr. Villéger’s research aims to unravel the role of bacterial interactions, particularly in the context of gastrointestinal health, microbiota, and cancer. His research has led to significant advancements in understanding microbial pathogenesis, including the effects of probiotics and endocrine disruptors on host cell metabolism. A dedicated researcher, he has contributed to numerous scientific publications and currently leads several high-impact projects on bacteria-host interactions.

Publication Profile:

Scopus

Strengths for the Award:

  1. Expertise in Metabolomics: Dr. Romain Villéger’s extensive work in metabolomics, especially in the context of host-bacteria interactions, positions him as a strong candidate for the Cell Metabolism Award. His research on bacterial influence on host cellular metabolism and gut microbiota interactions contributes significantly to the field of cellular metabolism.
  2. Innovative Research Contributions: His research, particularly on the metabolic changes during amoeba-Legionella interactions, showcases a novel approach to understanding microbial pathogenesis. By identifying metabolic vulnerabilities in pathogens, his work has the potential for therapeutic applications, thus addressing fundamental questions in cell metabolism.
  3. Multidisciplinary Approach: Dr. Villéger combines microbiology, immunology, and metabolomics, which enriches his contributions to cellular metabolism. His research is collaborative, evidenced by numerous projects across different institutions and fields, indicating a broad and innovative approach to the subject.
  4. Publications and Impact: He has a strong publication record, with numerous articles in peer-reviewed journals (19 publications), with high visibility in top-tier journals such as British Journal of Cancer, Frontiers in Cellular and Infection Microbiology, and Environmental Microbiology Reports. This demonstrates his influence and impact in the scientific community.
  5. Research Leadership: As the principal investigator of multiple projects, including those on the effects of phthalates on gut microbiota and cancer development, Dr. Villéger has demonstrated leadership in advancing scientific knowledge in areas that intersect with cell metabolism, host-microbe interactions, and metabolic changes in disease.

Areas for Improvement:

  1. Broader Clinical Translation: While his research shows deep insights into fundamental mechanisms, further work on translating these findings into practical clinical applications or therapeutic interventions would strengthen his impact in applied cellular metabolism.
  2. Interdisciplinary Team Development: While Dr. Villéger collaborates with many renowned researchers, fostering additional interdisciplinary partnerships could enrich his research by incorporating diverse techniques and perspectives from fields like drug development or personalized medicine.
  3. Expanding Metabolomic Toolkits: His research could benefit from exploring emerging and cutting-edge techniques in metabolomics, like single-cell analysis or multi-omics approaches, to gain deeper insights into cellular metabolism at the individual cell level.

Education:

Dr. Villéger completed his Ph.D. at the University of Limoges, where his thesis focused on the interactions between probiotics and host cells. His postdoctoral work spans institutions in France, the USA, and beyond, each contributing valuable insights into microbial-host dynamics and cellular microbiology. At the University of Bordeaux, he developed metabolomic approaches using GC/MS to study microbiota interactions. Later, at the University of Texas Medical Branch, he delved deeper into the effects of probiotics on intestinal homeostasis. Further postdoctoral experiences at the University of Clermont Auvergne involved examining the relationship between E. coli and colorectal cancer. Through these experiences, Dr. Villéger has gained expertise in microbiota research, cell biology, and metabolic analysis, providing a foundation for his ongoing work in the field. His education has provided a strong interdisciplinary framework, integrating microbiology, molecular biology, and toxicology into his research.

Experience:

Dr. Villéger has accumulated extensive experience in both academic and research settings. After earning his Ph.D. in 2014, he completed several postdoctoral positions, with notable work at the University of Bordeaux, where he pioneered metabolomics techniques for microbiota research. His tenure at the University of Texas Medical Branch expanded his focus to the effects of probiotics on intestinal homeostasis. Additionally, his work at the University of Clermont Auvergne involved exploring the connection between microbial interactions and cancer. Since joining the University of Poitiers in 2020 as an Assistant Professor, Dr. Villéger has led several research projects, including investigating the impact of endocrine disruptors on colorectal cancer development. He is also a leader in metabolomics and microbial pathogenesis, with a particular focus on bacteria-host interactions and microbiota modulation. His research has contributed to numerous publications and collaborations with institutions worldwide, showcasing his ability to manage complex research projects.

Research Focus:

Dr. Villéger’s research primarily focuses on bacteria-host interactions, gut microbiota, and cellular microbiology, with a special interest in how microbial populations affect host metabolism. His work integrates metabolomics, a powerful tool for studying metabolic processes, to better understand microbial influence on host cells. Dr. Villéger’s recent studies explore the role of oxidative stress in microbial infections, including Legionella pneumophila’s subversion of host immune defenses during infection. He has also investigated the impact of endocrine disruptors on microbial virulence, providing insights into the potential links between environmental factors and microbial pathogenesis. His contributions to understanding the microbiota-gut-brain axis, particularly in the context of colorectal cancer, emphasize the metabolic changes induced by bacterial interactions. Dr. Villéger’s research aims to identify biomarkers for disease and therapeutic interventions, with a broader goal of advancing precision medicine through a better understanding of the cellular and metabolic processes that underlie microbial-host dynamics.

Publications Top Notes:

  1. Legionella pneumophila subverts the antioxidant defenses of its amoeba host Acanthamoeba castellanii 💥🦠
  2. Increased Activity of MAPKAPK2 within Mesenchymal Cells as a Target for Inflammation-Associated Fibrosis in Crohn’s Disease 🔬🧬
  3. Exposure to endocrine disruptors promotes biofilm formation and contributes to increased virulence of Pseudomonas aeruginosa 💧🦠
  4. Loss of alcohol dehydrogenase 1B in cancer-associated fibroblasts: contribution to the increase of tumor-promoting IL-6 in colon cancer 🧬🦠
  5. Effect of endocrine disruptors on bacterial virulence 🌿🧪
  6. Proteomic analysis of Acanthamoeba castellanii response to Legionella pneumophila infection 🔬🦠
  7. Disruption of retinol-mediated IL-6 expression in colon cancer-associated fibroblasts: new perspectives on the role of vitamin A metabolism 🧬🍊
  8. Microbiota medicine: towards clinical revolution 🌍💊
  9. Deletion of cystathionine-γ-lyase in bone marrow-derived cells promotes colitis-associated carcinogenesis 🔬🦠
  10. Prebiotic Isomaltooligosaccharide Provides an Advantageous Fitness to the Probiotic Bacillus subtilis CU1 🍞🦠

Conclusion:

Dr. Romain Villéger is a highly qualified candidate for the Cell Metabolism Award. His research contributions in understanding microbial influence on cellular metabolism and gut health, combined with his innovative approach to metabolomics, make him stand out in the field. His work bridges basic science and potential clinical applications, positioning him as a key figure in the ongoing exploration of microbial and metabolic influences on host physiology. With some expansion into clinical applications and further exploration of new metabolomics techniques, his contributions could significantly impact both scientific knowledge and medical practice.