Huifeng Hao | Tumor pharmacology | Best Researcher Award

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Dr. Huifeng Hao | Tumor pharmacology | Best Researcher Award

Dr. Huifeng Hao , Peking University Cancer Hospital , China

Dr. Huifeng Hao is an Assistant Investigator at Peking University Cancer Hospital, specializing in the integration of Chinese and Western medicine. He holds a Ph.D. from Peking University Health Science Center, where he explored Chinese-Western medical integration. His research journey began with a Bachelor’s in Clinical Medicine from Hebei Medical University. Dr. Hao has accumulated valuable postdoctoral experience at Peking Union Medical College (PUMC) in Vascular Pharmacology. His work has greatly contributed to the understanding of cancer progression, focusing on the interactions between cancer cells and vascular endothelial cells and the therapeutic effects of Traditional Chinese Medicine. With over a decade of expertise, Dr. Hao has published extensively in renowned journals, addressing critical topics in cancer research, endothelial cell function, and vascular health.

Publication Profile:

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Strengths for the Award:

  1. Extensive Educational and Research Background: Dr. Huifeng Hao has a comprehensive and solid academic foundation. With a Bachelor’s degree in Clinical Medicine from Hebei Medical University and a Ph.D. in the Integration of Chinese and Western Medicine from Peking University Health Science Center, his educational background is robust. Moreover, his postdoctoral research in Vascular Pharmacology at Peking Union Medical College significantly bolsters his expertise, particularly in vascular biology and its implications in cancer progression.

  2. Groundbreaking Research Areas: Dr. Hao’s research primarily focuses on the complex interactions between cancer cells and vascular endothelial cells, along with exploring how Traditional Chinese Medicine (TCM) can influence cancer progression. This intersection of modern pharmacology and traditional medicine offers a unique and innovative approach to cancer therapy. His studies on cancer metastasis, endothelial cell signaling, and the use of TCM as a potential therapeutic strategy for cancer represent cutting-edge work.

  3. Impressive Publication Record: Dr. Hao has co-authored numerous high-impact publications in leading journals, such as Phytomedicine, Frontiers in Pharmacology, Journal of Ethnopharmacology, and Journal of Cellular and Molecular Medicine. His work spans across critical cancer pathways, pharmacological interventions, and the exploration of novel therapeutic agents like Marsdenia Tenacissima and Berberine in combating metastasis and endothelial dysfunction.

    • His 2022 papers on the modified Bu-Fei decoction’s effects on lung metastasis and the role of CUEDC2 in promoting breast cancer progression are particularly notable for their novel findings and potential clinical applications.

  4. Collaborative and Multi-Disciplinary Research: Dr. Hao’s ability to collaborate with a wide array of experts and researchers in diverse fields demonstrates his interdisciplinary approach to solving complex scientific questions. This collaboration enhances the relevance and applicability of his work in various research areas, particularly in cancer biology, pharmacology, and integrative medicine.

  5. Pioneering Work on TCM in Cancer Therapy: Dr. Hao’s research on the role of Traditional Chinese Medicine (TCM) in cancer therapy is especially noteworthy. His studies examining how TCM influences tumor microenvironments and endothelial cell interactions provide critical insights into how integrative medicine might be leveraged to treat cancer in combination with conventional therapies. This pioneering research has the potential to redefine cancer treatments and offer patients holistic therapeutic options.

  6. Strong Impact on Cancer Research: His work on vascular pharmacology, tumor angiogenesis, and metastasis in lung cancer, particularly through the modulation of transforming growth factor beta receptors and nitric oxide signaling, has significant implications for the development of new cancer therapies. His publications are contributing valuable knowledge toward better understanding cancer progression and discovering more effective treatments.

Areas for Improvement:

  1. Broader Research Scope in Clinical Settings: While Dr. Hao’s research has focused heavily on preclinical studies, including animal models and cellular assays, expanding his research into clinical trials or human-based studies would provide essential validation for his findings. Involving clinical datasets and patient-centered research could strengthen the real-world applicability of his work.

  2. Increase in Independent Research Funding: While Dr. Hao has contributed significantly to various collaborative projects, securing independent research grants would allow him more freedom to explore his unique research hypotheses in greater depth and broaden the scope of his investigations.

  3. Expansion of International Collaborations: While Dr. Hao’s collaborations are impressive, further expanding his international network could provide additional insights and allow him to take his research to the global forefront. Partnerships with leading international cancer research institutions could also amplify the impact of his work.

Education:

  • 2004.09-2009.06: Hebei Medical University (Bachelor Degree in Clinical Medicine)
  • 2009.09-2014.06: Peking University Health Science Center (Ph.D. in Integration of Chinese and Western Medicine)
  • 2014.09-2018.08: Peking Union Medical College (Postdoctoral Training in Vascular Pharmacology)

Dr. Hao’s academic journey spans over a decade of rigorous training, blending Western scientific research with Traditional Chinese Medicine. He received his bachelor’s degree in clinical medicine and later pursued his Ph.D. in an interdisciplinary program that focused on integrating these two approaches to medicine. His postdoctoral research in vascular pharmacology furthered his expertise in understanding the physiological and molecular mechanisms of cancer-related vascular changes.

Experience:

  • 2014.09-2018.08: Postdoctoral Researcher, Peking Union Medical College, Vascular Pharmacology
  • 2018.08-Present: Assistant Investigator, Peking University Cancer Hospital, Integration of Chinese and Western Medicine

Dr. Hao’s research career spans significant academic institutions in China. During his postdoctoral research at PUMC, he specialized in vascular pharmacology, focusing on the molecular pathways involved in tumor vasculature. At Peking University Cancer Hospital, Dr. Hao continues to investigate how traditional medicine can alter the interactions between cancer cells and endothelial cells, with a goal of developing novel therapeutic strategies for cancer treatment. His interdisciplinary approach has led to multiple breakthrough discoveries in cancer biology and integrative medicine.

Research Focus:

Dr. Hao’s primary research areas include:

  • Investigating the interactions between cancer cells and vascular endothelial cells, and how these affect cancer progression
  • Exploring the role of Traditional Chinese Medicine (TCM) in regulating cancer cell interactions within the tumor microenvironment, especially with endothelial cells

By bridging the gap between modern biomedical science and traditional medicine, Dr. Hao aims to develop therapies that utilize both modalities to inhibit tumor growth and metastasis. His work focuses on understanding how TCM can modulate endothelial cells and vascular pathways, potentially leading to new treatments for cancer that are more holistic and effective.

Publications Top Notes:

  1. Modified Bu-Fei decoction inhibits lung metastasis via suppressing angiopoietin-like 4 🫁🦠
  2. CUEDC2 Drives β-Catenin Nuclear Translocation and Promotes Triple-Negative Breast Cancer Tumorigenesis 🧬💥
  3. Berberine Suppresses Lung Metastasis of Cancer via Inhibiting Endothelial Transforming Growth Factor Beta Receptor 1 🌱🏥
  4. Marsdenia tenacissima extract disturbs the interaction between tumor-associated macrophages and non-small cell lung cancer cells by targeting HDGF 🌿🧫
  5. The cyclic adenosine monophosphate elevating medicine, forskolin, reduces neointimal formation and atherogenesis in mice 🐭💉
  6. Nitric oxide, a communicator between tumor cells and endothelial cells, mediates the anti-tumor effects of Marsdenia Tenacissima Extract (MTE) 💡🔬
  7. Marsdenia tenacissima extract promotes gefitinib accumulation in tumor tissues of lung cancer xenograft mice via inhibiting ABCG2 activity 💊🔬
  8. Marsdenia tenacissima extract dilated small mesenteric arteries via stimulating endothelial nitric oxide synthase and inhibiting calcium influx 🧪🩸
  9. Protective Role of mPGES-1 (Microsomal Prostaglandin E Synthase-1)-Derived PGE(2) (Prostaglandin E-2) and the Endothelial EP4 (Prostaglandin E Receptor) in Vascular Responses to Injury 💥🩺
  10. Loss of Endothelial CXCR7 Impairs Vascular Homeostasis, and Cardiac Remodeling After Myocardial Infarction ❤️🫀

Conclusion:

Dr. Huifeng Hao’s contributions to cancer research, particularly the intersection of TCM and Western medicine, make him an excellent candidate for the Best Researcher Award. His innovative studies, combined with his dedication to advancing cancer treatment, position him as a leading researcher in his field. His continued research promises to significantly impact both scientific understanding and clinical practices in cancer therapy.

Jacob Wekalao | Cancer Cell Biology | Best Researcher Award

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Mr. Jacob Wekalao | Cancer Cell Biology | Best Researcher Award

Mr. Jacob Wekalao , USTC CHINA , China

Jacob Wekalao is a Physics professional and researcher with extensive experience in both academia and industry. He holds a Doctor of Philosophy from the University of Science and Technology and a Master of Science in Physics from Marwadi University, India. Jacob has worked as a physics teacher, leading the physics department at Kwale High School, Kenya, and is currently a software expert at Eujim Solutions, where he specializes in creating innovative business solutions. He is also a Research Assistant at Marwadi University, contributing to advanced research in physics and nanotechnology. His expertise spans across terahertz sensors, graphene-based biosensors, and surface plasmon resonance techniques. In addition to his academic endeavors, Jacob has authored several peer-reviewed publications, showcasing his contributions to forensic science, health, and biomedical applications. Jacob is passionate about research, mentoring, and leveraging technology to solve real-world problems.

Publication Profile:

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Strengths for the Award:

Jacob Wekalao is an exceptional researcher in the field of experimental physics, particularly in the areas of nanotechnology, terahertz sensors, and biosensing. His work integrates cutting-edge research with practical applications, demonstrating a high level of innovation and expertise. Jacob’s contributions to the development of graphene-based sensors for various applications, including healthcare, forensic science, and security, have positioned him as a thought leader in his field. His published works in prestigious journals and his active role in research projects, such as designing biosensors for early disease detection, highlight his proficiency in both theoretical and applied physics. Additionally, Jacob’s ability to collaborate internationally and present at major conferences reflects his commitment to advancing scientific knowledge and networking within the global research community.

Areas for Improvement:

While Jacob excels in his research and technological expertise, expanding his focus on interdisciplinary collaborations could further elevate his work. Engaging more with industry experts in areas like artificial intelligence or machine learning could also open doors for more transformative innovations, especially in optimizing sensor technologies. Further involvement in policy or public science initiatives could help bridge the gap between research and broader societal applications.

Education:

Jacob Wekalao has an impressive educational background that supports his expertise in physics and technology. He is currently pursuing a Doctor of Philosophy at the University of Science and Technology, China. His academic journey began with a Bachelor of Education in Science with a focus on Physics and Mathematics from the University of Embu, Kenya (2016-2020). This solid foundation propelled him to obtain a Master of Science in Physics from Marwadi University, Rajkot, Gujarat, India (2021-2023). During his time at Marwadi University, Jacob excelled academically, earning an Academic Gold Medal in November 2023 for his outstanding performance. His commitment to learning is also reflected in certifications from institutions like KAIST and the Israel Institute of Technology. Jacob’s education is characterized by a blend of theoretical knowledge and practical skills, which has enabled him to contribute significantly to the fields of experimental physics and applied technology.

Experience:

Jacob Wekalao has diverse experience spanning education, research, and industry. From September 2019 to August 2021, he worked as a Physics teacher at Kwale High School, Kenya, where he led the physics department, developed curriculum materials, and managed science projects. This role enabled him to foster critical thinking and scientific inquiry among students. In addition to his teaching experience, Jacob is currently employed as a Software Expert at Eujim Solutions, Kenya (July 2023 – Present), where he provides tailored software solutions, improves business efficiency, and implements cutting-edge technologies. Furthermore, he works as a Research Assistant at Marwadi University, collaborating on various physics research projects focused on terahertz sensors and biosensors. His involvement in multiple projects and publications has established him as a valuable contributor to advancements in technology and scientific research. Jacob’s work showcases a seamless integration of theoretical physics and practical application in technology.

Awards and Honors:

Jacob Wekalao’s dedication to academic excellence and research has earned him notable awards and honors. He received the prestigious Academic Gold Medal from Marwadi University, Rajkot, India, in November 2023, recognizing his exceptional performance in the Master of Science in Physics program. Jacob’s achievements are further validated by his numerous peer-reviewed publications, which have contributed to the global scientific community. His research in the fields of biosensing, terahertz technology, and nanomaterials has earned him recognition at various international platforms. In addition to academic awards, Jacob’s work has been presented at leading conferences, such as the International Conference on Chemical Safety and Security for Health and Environment (ICCSSHE), held in India in December 2023. His strong academic performance, leadership in research, and contributions to technological advancements continue to set him apart as an outstanding professional in his field.

Research Focus:

Jacob Wekalao’s research focuses on experimental physics, particularly in the areas of terahertz technology, biosensing, and nanomaterials. His work has significant implications for applications in healthcare, security, and forensic science. Jacob has developed and optimized graphene-based terahertz surface plasmon resonance sensors for the detection of various biomolecules, including hemoglobin and illicit drugs. His research has extended to the design of graphene metasurfaces for efficient detection of diseases like malaria and COVID-19. Jacob’s research in biosensors has led to highly sensitive, cost-effective solutions that hold promise for point-of-care diagnostics and environmental monitoring. Additionally, his work on the use of metasurfaces for explosive detection has practical implications for security. Through his research, Jacob combines advanced theoretical physics with real-world applications, contributing to the fields of biomedical technology, environmental monitoring, and security. His interest in machine learning also aids in optimizing these sensor technologies for better precision and performance.

Publications Top Notes:

  1. “Graphene-based THz surface plasmon resonance biosensor for hemoglobin detection applicable in forensic science.” 📖🔬
  2. “Design of ring and cross-shaped graphene metasurface sensor for efficient detection of malaria and 2-bit encoding applications.” 🦠🔍
  3. “Waterborne bacteria detecting highly sensitive graphene metasurface-based cost-efficient and efficient refractive index sensors.” 💧🔬
  4. “Design of graphene metasurface sensor for efficient detection of COVID-19.” 🦠💡
  5. “Graphene biosensor design based on glass substrate for forensic detection of illicit drugs.” 💊🔍
  6. “Graphene and Gold Metasurface-Based Terahertz Surface Plasmon Resonance Sensor for Explosive Detection.” 💥🛡️
  7. “Terahertz Optical Ultrasensitive Glucose Detection Using Graphene and Silver Surface Plasmon Resonance Metasurfaces for Biomedical Applications.” 🩺🔬
  8. “High-Sensitivity Graphene-Gold Metasurface Optical Biosensor for Early Melanoma Detection Optimized with Machine Learning Using a One-Dimensional Convolutional Neural Network and Binary Encoding.” 🧬🔬

Conclusion:

Jacob Wekalao’s contributions to the fields of physics and technology demonstrate an impressive combination of academic excellence, hands-on expertise, and innovative solutions. His drive to advance scientific knowledge and apply it for real-world impact, especially in healthcare and security, makes him a deserving candidate for the Best Researcher Award. Jacob’s ongoing work on high-sensitivity biosensors and his ability to stay ahead of technological trends make him a standout researcher in his field.