Miroslaw Markiewicz | Cancer Cell Biology | Best Researcher Award

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Prof. Dr. Miroslaw Markiewicz | Cancer Cell Biology | Best Researcher Award

Prof. Dr. Miroslaw Markiewicz , Faculty of Medicine, Collegium Medicum, University of Rzeszow , Poland

Mirosław Markiewicz is a distinguished medical professional specializing in hematology, internal medicine, and bone marrow transplantation. With over three decades of experience in the medical field, he holds the title of Professor and has made significant contributions to the advancement of hematopoietic stem cell transplantation (HSCT) and hematological research. He earned his MD from the Medical University of Silesia in 1989, followed by a fellowship in 1990. Throughout his career, he has worked in prestigious institutions such as the Medical University of Silesia, Katowice, Poland, and the Albany Medical College in New York. Professor Markiewicz’s research has led to numerous high-impact publications, and he is known for his expertise in myelodysplastic syndrome (MDS), graft-versus-host disease (GVHD), and treatment outcomes in bone marrow transplantation. His commitment to research and clinical excellence has earned him recognition as a leader in his field.

Publication Profile: 

Orcid

Strengths for the Award:

Prof. Mirosław Markiewicz is a leading expert in the field of hematology, particularly in hematopoietic stem cell transplantation (HSCT), graft-versus-host disease (GVHD), and myelodysplastic syndrome (MDS). His vast clinical experience and academic achievements, including over 114 publications with an impressive impact factor (IF 217.467) and a Hirsch Index of 12, demonstrate his dedication to advancing medical science. Prof. Markiewicz’s research contributions have been instrumental in improving patient outcomes in hematology, particularly in understanding conditioning regimens for HSCT, and exploring genetic and environmental factors in diseases like multiple myeloma. His leadership roles in various institutions and collaborative work with other prominent scientists further underscore his position as a top researcher in his field.

Areas for Improvements:

While Prof. Markiewicz has an extensive publication record, further engagement in multi-disciplinary research approaches could strengthen his contributions to immunotherapy and the intersection of hematology and precision medicine. Additionally, more involvement in international collaborative research projects could expand the global impact of his findings.

Education:

Mirosław Markiewicz completed his academic journey at renowned institutions, beginning with his MD degree from the Medical University of Silesia in 1989. He further enhanced his expertise through a fellowship in hematology in 1990. His early career was focused on internal medicine and hematology, which laid the foundation for his future work in hematopoietic stem cell transplantation. In 2008, he achieved habilitation, the Polish equivalent of a postdoctoral qualification, and in 2015, he attained professorship status. Over the years, Professor Markiewicz has continued to enrich his academic portfolio with numerous research accomplishments. He has worked at several leading medical institutions, including the Medical University of Silesia, Katowice, and the Department of Hematology at the University of Masku. His educational journey reflects an unwavering commitment to advancing knowledge in hematology and improving patient care through clinical and laboratory research.

Experience:

Professor Mirosław Markiewicz boasts an extensive career in hematology and bone marrow transplantation. From 1992 to 2001, he served as an Assistant Professor at the Medical University of Silesia, where he began his work in the Department of Hematology and Bone Marrow Transplantation. He subsequently became the Head of the Department of Hematology at the same institution, a role he held from 2001 to 2017. During this period, he contributed to expanding the scope of hematological care and research in Poland. Between 2017 and 2019, Professor Markiewicz held a prominent position as Head of the Department at the Department of Hematology at Rzeszów University. In 2019, he joined the University of Ransomw, continuing his research and clinical leadership in hematology. His vast clinical experience spans diagnosis, treatment, and transplantation, particularly focusing on myelodysplastic syndrome and acute leukemia, among other complex hematological disorders.

Research Focus:

Professor Mirosław Markiewicz’s research primarily revolves around hematopoietic stem cell transplantation (HSCT), bone marrow transplantation (BMT), and the management of hematological malignancies. His work focuses on the clinical outcomes of hematopoietic stem cell transplantation in patients with myelodysplastic syndrome (MDS), acute leukemia, and other hematologic disorders. Additionally, his research explores graft-versus-host disease (GVHD), a common complication following allogeneic stem cell transplantation, and strategies for its prevention and management. One of his primary areas of interest is the use of novel conditioning regimens, such as treosulfan-based conditioning, and their comparison with traditional therapies in improving patient outcomes. Furthermore, Professor Markiewicz has contributed to studies on the genetic predisposition to hematological cancers and the molecular mechanisms of disease progression. His publications, covering clinical trials, transplant outcomes, and immunological factors, have had a significant impact on the field of hematology and transplantation.

Publications Top Notes:

  1. “Alogeneic hematopoietic stem cell transplantation with CD14-selected CITT cells add-back in high-risk patients” 🧬💉
  2. “Hematopoietic stem cell transplantation with minor biocompatibility antigen disparities” ⚖️🧬
  3. “Treating rapid development of unclassified myeloid lineage acute leukaemia with trisomy 6 and U2AF1 mutation” 🔬⚡
  4. “Real world outcome analysis of treosulfan-based conditioning prior to allo-HCT in patients with MDS” 📊🔬
  5. “The role of lifestyle and environmental factors in the pathogenesis of multiple myeloma” 🌱🧬
  6. “Fludarabine-treosulfan versus fludarabine-melphalan conditioning in older AML patients” 🧪💉
  7. “Polymorphisms within autophagy-related genes as susceptibility biomarkers for multiple myeloma” 🧬📚
  8. “Graft-versus-host disease and survival in patients with MDS after treosulfan- versus busulfan-based conditioning” 🔬🧬
  9. “Profiles of interferon-gamma and interleukin-2 in patients after allogeneic hematopoietic stem cell transplantation” 🧪🧬
  10. “Treosulfan compared with reduced-intensity busulfan improves allogeneic hematopoietic cell transplantation outcomes” 💉⚖️

Conclusion:

Prof. Mirosław Markiewicz’s work represents the cutting edge of hematology research, particularly in stem cell transplantation and the treatment of hematologic malignancies. His academic rigor, innovative research, and clinical expertise make him a deserving candidate for the Research for Best Researcher Award.

 

 

Yimin Zhu | Immunology Cellular Interactions | Women Researcher Award

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Prof. Yimin Zhu | Immunology Cellular Interactions | Women Researcher Award

Prof. Yimin Zhu , Suzhou Institute of Nanotechnology, Chinese Academy of Sciences , China

Prof. Yimin Zhu is a distinguished researcher in bioengineering, specializing in cancer therapies, biomaterials, and peptide screening platforms. With a background in both clinical medicine and biotechnology, she bridges the gap between medical applications and cutting-edge biotechnological innovations. Prof. Zhu completed her master’s in Clinical Medicine from Tianjin Medical University in 1996 and a Ph.D. in Biochemistry from the National University of Singapore in 2005. She has made significant contributions to cancer immunotherapy, drug delivery systems, and biomarker identification. Prof. Zhu’s work has led to over 30 first-author/co-corresponding publications in leading scientific journals, and she holds more than 20 patents. She currently holds a professorship at Suzhou Institute of Nano-Tech and Nano-Bionics, CAS, where her research continues to advance cancer treatments through novel molecular mechanisms and drug delivery platforms.

Publication Profile:

Scopus

Strengths for the Award:

  1. Interdisciplinary Expertise: Prof. Yimin Zhu has a unique blend of clinical medicine and advanced biotechnology expertise, making her well-suited to bridge the gap between medical practice and cutting-edge cancer research. Her background in both the clinical and research fields allows her to tackle cancer therapies from multiple angles.
  2. Impactful Research: Prof. Zhu’s research focuses on critical areas in cancer therapy, such as peptide-based immunotherapy, tumor mechanisms, drug delivery systems, and biomarker discovery. She has published over 30 high-impact papers in leading journals, showcasing her leadership in the field.
  3. Innovative Contributions: She has made substantial contributions to developing peptide-based bispecific CAR T cells and innovative drug delivery systems, with several patents granted. These innovations hold great promise for advancing cancer therapy and improving patient outcomes.
  4. Support and Funding: Prof. Zhu has successfully secured substantial research funding, including multiple grants from the National Natural Science Foundation of China, supporting her groundbreaking research in cancer immunotherapy and biomaterial development.

Areas for Improvement:

  1. Broader Outreach: Although Prof. Zhu has made impressive advancements in cancer research, expanding her work’s visibility to a broader audience in the medical and biotechnology communities, as well as among the general public, could increase the impact of her innovations.
  2. Collaboration and Mentorship: Further expanding interdisciplinary collaborations, particularly with social scientists or clinicians in oncology, could strengthen the practical application of her research and increase its translation into clinical practice. Additionally, mentoring young women in STEM could increase her contribution to fostering diversity in the field.
  3. Public Engagement: Enhancing communication efforts to present her research in a more accessible format for non-experts could be a significant avenue for impact, particularly in terms of attracting additional funding and public interest in her cancer-focused work.

Education:

Prof. Yimin Zhu’s educational journey reflects her interdisciplinary approach to bioengineering and medical science. She earned her Master’s degree in Clinical Medicine from Tianjin Medical University in 1996, where she initially focused on medical practice, gaining hands-on experience as a resident and consultant in Neurology. Her passion for scientific research led her to pursue a Ph.D. in Biochemistry from the National University of Singapore, completed in 2005. This transition to biochemistry allowed her to explore molecular biology, cancer research, and biotechnology. Prof. Zhu’s postdoctoral work at the University of California, Santa Barbara, in Chemical Engineering, further honed her expertise in nanotechnology, bioengineering, and therapeutic innovations. This broad educational foundation, combining clinical experience with cutting-edge research, has uniquely positioned her as a leader in cancer bioengineering and drug delivery systems.

Experience:

Prof. Yimin Zhu’s diverse experience spans both clinical medicine and high-impact research. Between 1996 and 2000, she worked as a resident and consultant doctor in Neurology, which provided a strong foundation in patient care and medical science. Transitioning to research, she served as a research fellow at the National University of Singapore from 2003 to 2005, focusing on biochemistry and cancer-related molecular mechanisms. Prof. Zhu further developed her expertise during her postdoctoral training in the Chemical Engineering Department at the University of California, Santa Barbara, where she explored the intersection of chemical engineering, nanotechnology, and therapeutic interventions. Since joining the Suzhou Institute of Nano-Tech and Nano-Bionics in 2008, she has been a professor, where she leads innovative research in peptide-based cancer therapies, immunotherapy, and drug delivery systems. Her extensive academic background and practical experience have earned her numerous patents and substantial research funding.

Research Focus:

Prof. Yimin Zhu’s research primarily focuses on bioengineering for cancer treatment, peptide screening platforms, and targeted drug delivery systems. Her work involves identifying molecular mechanisms behind tumor cell behavior and developing innovative methods for cancer diagnosis and therapy. She is dedicated to advancing cancer immunotherapy, particularly through the development of peptide-based bispecific CAR T cells targeting key proteins like EGFR and tumor stroma. Prof. Zhu’s research aims to enhance the efficacy of cancer treatments while minimizing side effects. Her studies also explore the development of smart delivery systems, such as extracellular vesicle-based nanodrugs, to improve the precision and effectiveness of drug delivery to tumor sites. Additionally, her work delves into the identification of cancer biomarkers, offering new ways to predict tumor metastasis and optimize treatment regimens. By combining molecular biology, nanotechnology, and biotechnology, Prof. Zhu’s research holds great promise for advancing personalized cancer care.

Publications Top Notes:

  • The peptide-based bispecific CAR T cells target EGFR and tumor stroma for effective cancer therapy 🧬
  • Develop a PD-1-blockade peptide to reinvigorate T-cell activity and inhibit tumor progress 💉
  • Natural killer cells contribute to ‘hot’ tumor regression in the allergic inflammatory environment 🦠
  • Identification of cancer protein biomarker based on cell specific peptide and its potential role in predicting tumor metastasis 🔬
  • Extracellular Vesicle‐Based Nanodrug Delivery 💊
  • Inhibition of Autophagy Promotes the Elimination of Liver Cancer Stem Cells by CD133 Aptamer-Targeted Delivery of Doxorubicin 🧫
  • Dermatophagoides pteronyssinus allergen Der p 22: Cloning, expression, IgE-binding in asthmatic children, and immunogenicity 🌿
  • Reforming the Chimeric Antigen Receptor by Peptide Towards Optimized CAR T Cells With Enhanced Anti-Cancer Potency and Safety 🦠
  • Smart delivery of poly-peptide composite for effective cancer therapy 💡
  • The inhibition of ABCB1/MDR1 or ABCG2/BCRP enables doxorubicin to eliminate liver cancer stem cells ⚙️

Conclusion:

Prof. Yimin Zhu’s research excellence, particularly in cancer therapy, peptide-based immunotherapy, and novel drug delivery systems, positions her as a highly deserving candidate for the Research for Women Researcher Award. Her interdisciplinary approach, groundbreaking innovations, and leadership in publishing high-impact scientific papers make her a trailblazer in the field of bioengineering. By addressing the areas for improvement, particularly in outreach and mentorship, Prof. Zhu could amplify her contributions even further, inspiring the next generation of women scientists and advancing the fight against cancer.