Dalia Saleh | Cancer Cell Biology | Innovative Research Award

Published on by Cell Biologist

Prof . Dalia Saleh | Cancer Cell Biology | Innovative Research Award

Prof . Dalia Saleh | National Research Centre | Egypt

Dr. Dalia Osama Abd El Fattah Saleh is a distinguished pharmacologist with over two decades of experience in experimental pharmacology and drug development. She holds a Ph.D. in Pharmacology from Cairo University and currently serves as a Professor at the National Research Centre in Cairo, Egypt. Dr. Saleh has contributed to numerous high-impact scientific journals and has led pioneering work in the areas of metabolic disorders, drug safety, and vascular pharmacology. Her multidisciplinary collaborations and continuous professional development from institutions like King’s College London demonstrate her dedication to excellence in research and education. She is also recognized for her commitment to academic instruction and quality assurance, having served as a Quality Assurance Director. Her work bridges scientific discovery and real-world therapeutic applications, making her a strong candidate for innovation-focused research awards.

publication profile:

scopus

Strengths for the Award:

  1. Robust Academic Background:
    Dr. Saleh holds a Ph.D. in Pharmacology from Cairo University and has a long-standing academic and research career in pharmacology and drug development. Her doctoral and master’s theses reflect a strong foundation in vascular pharmacology, metabolic disorders, and endocrine influence—fields of enduring relevance.

  2. Consistent Research Productivity:
    Her recent publication record (2022–2024) is prolific and impactful, with studies published in high-visibility journals such as Scientific Reports, Biochemistry and Cell Biology, Naunyn-Schmiedeberg’s Archives of Pharmacology, and Environmental Science and Pollution Research. Her work covers cutting-edge pharmacological topics, including:

    • AMPK/mTOR signaling pathways,

    • Neuroprotection and anti-inflammatory mechanisms,

    • Herbal and synthetic compounds in disease modulation,

    • Hepatic encephalopathy, diabetic nephropathy, and cystitis models.

  3. Interdisciplinary and Translational Approach:
    Dr. Saleh bridges basic pharmacological research with clinical relevance. Her investigations into molecular pathways (e.g., NF-κB, PI3K/Akt, SIRT-1) are grounded in disease models, thus demonstrating translational potential. Her inclusion of both natural and synthetic agents further adds diversity and innovation to her research.

  4. Capacity Building and International Exposure:
    She has participated in Continuing Professional Development modules at King’s College London, emphasizing drug safety, statistics, and ethics—key areas in modern drug development. This international engagement underscores her commitment to staying updated and aligned with global standards.

  5. Institutional Contribution and Leadership:
    As a Professor and former Quality Assurance Director at the National Research Centre (NRC), she has contributed to institutional excellence, including achieving ISO 9001/2008 certification. These roles reflect her leadership, organizational, and strategic planning skills.

Areas for Improvement:

  1. Principal Investigator Leadership:
    While her name appears consistently in multi-author studies, further highlighting her role as the principal investigator (PI) or corresponding author could strengthen her case for innovation leadership.

  2. Patents or Product Development:
    There is no mention of patents or direct product development based on her findings. Translating research into tangible therapeutics or clinical trials would significantly elevate her eligibility for innovation-specific awards.

  3. Global Collaborations and Grants:
    Although she has participated in international seminars, active global collaborations or leading major international grants/projects would further establish her as a global innovator.

  4. Public/Industry Impact:
    While the academic impact is strong, showcasing industry partnerships or policy-level influence (e.g., contributions to clinical guidelines or regulatory science) would align more directly with innovation awards that emphasize practical application.

🎓 Education Summary :

Dr. Dalia Saleh completed her higher education at Cairo University’s Faculty of Pharmacy, where she earned her Master of Science in Pharmacology in 2009 and Doctor of Philosophy in Pharmacology in 2012. Her M.Sc. thesis focused on the vascular and biochemical effects of rosiglitazone in diabetic rats, reflecting early interests in metabolic pharmacology. Her Ph.D. expanded on this foundation by exploring estrogen’s potential role in managing vascular changes related to insulin resistance. Both theses demonstrated robust experimental designs and contributed new insights into the interplay between hormonal and metabolic pathways in disease models. Dr. Saleh has since built on this academic background with advanced training in clinical drug development, safety, and biostatistics at King’s College London in 2023, indicating a continued commitment to integrating modern pharmaceutical science and translational research into her academic portfolio. This rich educational foundation underpins her success as a researcher and educator.

🔬 Research Focus :

Dr. Saleh’s research focuses on experimental pharmacology, with a special interest in metabolic diseases, drug-induced toxicities, inflammation, and vascular pharmacology. Her studies frequently involve animal models to investigate the mechanisms of drug action and to evaluate the protective or therapeutic roles of natural products and synthetic compounds. A recurring theme in her work is exploring the modulation of signaling pathways like AMPK, NF-κB, PI3K/mTOR, and Nrf2 in the context of oxidative stress, inflammation, and cellular apoptosis. She has also studied the role of hormonal influences in disease models, such as estrogen’s effect on insulin resistance. Her research employs modern analytical techniques and integrates molecular biology with pharmacodynamics to derive mechanistic insights. This strong focus on mechanistic pharmacology enhances her work’s relevance in drug development, particularly for conditions such as diabetic complications, hepatic encephalopathy, nephropathy, and chemotherapy-induced toxicities.

📚 Publications Top Note:

  1. 🧪 Eugenol alleviates acrylamide-induced testicular toxicity via AMPK/pAKT/mTOR modulation – Scientific Reports, 2024

  2. 🧠 Trimetazidine prevents cisplatin neuropathy through AMPK, Nrf2, and NF-κB pathways – Biochemistry and Cell Biology, 2023

  3. 🔬 Novel chromone-thiazolopyrimidines as TNF-α, IL-6, and PGE2 inhibitors – Polycyclic Aromatic Compounds, 2023

  4. 🚽 Chrysin protects against cyclophosphamide-induced hemorrhagic cystitis via anti-inflammatory signaling – Chemico-Biological Interactions, 2023

  5. 🧃 Linagliptin & L-arginine synergy in gastric hyperacidity via EP4 receptor upregulation – Naunyn-Schmiedeberg’s Archives of Pharmacology, 2023

  6. 🧠 L-arginine reduces thioacetamide-induced hepatic encephalopathy via NF-κB downregulation – Environmental Science and Pollution Research, 2023

  7. 🌿 Calotropis procera seed oil shows anti-inflammatory and antiparasitic activity – Arabian Journal of Chemistry, 2022

  8. 🛡️ Olmesartan mitigates diabetic nephropathy via AGE/PKC and TLR4/SIRT-1 pathways – European Journal of Pharmacology, 2022

  9. 🍃 Plumbago species show anti-fibrotic effects in liver fibrosis rat models – Scientific Reports, 2022

  10. 🫀 Omega-3 combats doxorubicin-induced liver toxicity via Nrf2/PI3K/Akt signaling – Pending Publication

Conclusion:

Dr. Dalia O. Saleh presents a strong candidacy for the Research for Innovative Research Award, particularly due to her sustained publication record, mechanistic depth in pharmacology, and commitment to professional development and institutional excellence. Her work spans innovative mechanistic explorations and novel therapeutic evaluations, showing real promise in addressing current pharmacological challenges.

Arunima Biswas | Cancer Cell Biology | Best Researcher Award

Published on by Cell Biologist

Assist. Prof. Dr. Arunima Biswas | Cancer Cell Biology | Best Researcher Award

Assist. Prof. Dr. Arunima Biswas , university of kalyani , India

Dr. Arunima Biswas is an Assistant Professor in the Department of Zoology at the University of Kalyani, India. With a Ph.D. in Biochemistry from the Indian Institute of Chemical Biology, Kolkata, she has focused her career on understanding the molecular mechanisms underlying diseases, particularly cancer and parasitic infections. She leads multiple funded research projects, aiming to develop targeted therapies for various cancers. Dr. Biswas has worked extensively on the cyclic nucleotide signaling pathways in unicellular eukaryotes like Leishmania and cancer. A passionate educator and researcher, she mentors Ph.D. students and collaborates with international scientists to advance medical research.

Publication Profile:

Scopus

Strengths for the Award:

Dr. Arunima Biswas demonstrates significant contributions to cancer research and parasitology. She is highly skilled in understanding and manipulating cyclic nucleotide signaling pathways, which play a crucial role in cancer biology and parasitic diseases like Leishmania infections. With several ongoing research projects, including the repurposing of phosphodiesterase inhibitors for cancer therapy and the development of targeted drug delivery systems, Dr. Biswas has shown an innovative approach to solving complex medical challenges. Her leadership as Principal Investigator for high-impact projects, such as cancer screening and drug targeting, highlights her as a leading researcher in her field. Furthermore, her dedication to mentoring and producing highly qualified Ph.D. students is commendable.

Areas for Improvement:

While Dr. Biswas’ research is already impactful, expanding her work on the practical clinical application of her findings could further bridge the gap between research and patient care. Collaboration with clinical trials or hospitals could expedite the translation of her findings into therapeutic solutions. Additionally, expanding interdisciplinary collaborations could bring novel insights into her research.

Education:

Dr. Arunima Biswas earned her Ph.D. in Biochemistry from the Indian Institute of Chemical Biology, Kolkata, with a thesis on Host-parasite interaction: Modulation of signaling pathways in Macrophage and Leishmania (2010). Prior to this, she completed her Master of Science in Zoology from the University of Calcutta with First Class honors (2005). She also holds a Bachelor of Science in Zoology from Maulana Azad College, University of Calcutta (2003). Her academic journey has been marked by a strong foundation in biochemistry, signaling pathways, and parasitology, forming the basis of her current research interests.

Experience:

Dr. Arunima Biswas has over a decade of teaching and research experience. As an Assistant Professor at the University of Kalyani, she has significantly contributed to the academic and research growth in the Department of Zoology. She is the Principal Investigator of several research projects funded by national bodies like CSIR, SERB, and UGC, with an emphasis on cancer research, especially targeting pathways involving cyclic nucleotides. Dr. Biswas has also collaborated with multiple national and international institutions and mentored several Ph.D. students, contributing to their academic and research advancements. Her experience in guiding research and mentoring future scientists is widely acknowledged.

Awards and Honors:

Dr. Arunima Biswas has received numerous accolades for her research and academic contributions. Notably, she won the Young Scientist Presentation Award at the Translational Cancer Research Conference (2020) and was honored with an International Congress of Cell Biology Travel Award (2016). She also received the American Society of Biochemistry and Cell Biology Travel Award (2015) and the prestigious DST-INSPIRE Faculty Scheme award (2012). These recognitions underscore her outstanding contributions to biomedical research, particularly in cancer biology and parasitology, further establishing her as a leader in her field.

Research Focus:

Dr. Arunima Biswas’s research focuses on cancer biology and parasitology, particularly the role of cyclic nucleotide signaling in cancer and Leishmania infections. She investigates therapeutic targets to modulate these pathways for better treatment options in cancer, including breast and gynecological cancers. Her ongoing projects include exploring phosphodiesterase inhibitors for breast cancer and cervical cancer, as well as developing vesicular drug carriers for targeted drug delivery. Dr. Biswas is dedicated to understanding the molecular intricacies of host-parasite interactions and their implications for disease management.

Publications Top Notes:

  1. Metal Oxide–Enhanced Para-Coumaric Acid Nanoparticles for Precision Targeting of Leishmania donovani
  2. Repurposing Approved Protein Kinase Inhibitors as Potent Anti-Leishmanials Targeting Leishmania MAP Kinases
  3. Anticancer, Antimicrobial, and Photocatalytic Activities of a New Pyrazole-Containing Thiosemicarbazone Ligand and Its Co(III) and Ni(II) Complexes
  4. Synthesis, Spectroscopy, and Structural Elucidation of Two New CoII and NiII Complexes of Pyrazole Derived Heterocyclic Schiff Base Ligand as Potential Anticancer and Photocatalytic Agents
  5. Vesicle-Encapsulated Rolipram (PDE4 Inhibitor) and Its Anticancer Activity
  6. Rhodamine Hydrazide-Linked Naphthalimide Derivative: Selective Naked Eye Detection of Cu2+, S2− and Understanding the Therapeutic Potential of the Copper Complex as an Anti-Cervical Cancer Agent
  7. Modulation and Determination of the Status of Inflammasomes in Leishmania-Infected Macrophages
  8. Catalytic and Anticancer Activity of Two New Ni(II) Complexes with a Pyrazole-Based Heterocyclic Schiff-Base Ligand
  9. Biophysical Study on DNA and BSA Binding Activity of Cu(II) Complex: Synthesis, Molecular Docking, Cytotoxic Activity, and Theoretical Approach
  10. Cytotoxic Behavior and DNA/BSA Binding Activity of Thiosemicarbazone-Based Ni(II) Complex: Bio-Physical, Molecular Docking, and DFT Study

Conclusion:

Dr. Arunima Biswas is an exceptional candidate for the “Best Researcher Award.” Her diverse research in cancer biology, parasitology, and drug development showcases her commitment to advancing healthcare. She has made significant strides in understanding complex molecular mechanisms, and her work holds great promise for improving cancer treatments. With a robust academic record, influential publications, and ongoing impactful projects, Dr. Biswas is undoubtedly a deserving contender for the award.