Gary Chan | Host-Pathogen Interactions | Best Researcher Award

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Dr. Gary Chan | Host-Pathogen Interactions | Best Researcher Award

Dr. Gary Chan , SUNY Upstate Medical University , United States

Dr. Gary Ching-Tao Chan is a distinguished professor in the Department of Microbiology and Immunology at SUNY Upstate Medical University, Syracuse, NY. He completed his Ph.D. in Immunology at the University of Alberta, Canada, under the supervision of Dr. Larry J. Guilbert. Dr. Chan’s research expertise lies in viral immunology, particularly in human cytomegalovirus (HCMV) and dengue virus (DENV). He has a robust research portfolio with numerous contributions to the field, focusing on viral-host interactions and immune modulation. His work has led to groundbreaking discoveries in HCMV pathogenesis, including viral modulation of autophagy and cell signaling pathways. Dr. Chan has held academic appointments at prestigious institutions, including Louisiana State University Health Science Center, where he contributed significantly to advancing viral immunology. His commitment to research excellence is reflected in his impactful publications and active grant support.

Publication Profile: 

Orcid

Strengths for the Award:

  1. Prolific Research Contributions: Dr. Gary Chan has made significant contributions to the field of microbiology, particularly in the understanding of human cytomegalovirus (HCMV) and its complex interactions with the immune system. His work has been consistently published in top-tier peer-reviewed journals such as Journal of Virology, Antiviral Research, and mBio, highlighting his influence in virology.

  2. Innovative and High-Impact Research: Dr. Chan’s research addresses fundamental aspects of viral pathogenesis, focusing on viral-host interactions, immune modulation, and viral replication. His innovative exploration into the molecular mechanisms of HCMV, such as the modulation of mTORC1 and the role of host transcription factors like HSF1, is groundbreaking and provides valuable insights for potential therapeutic strategies. His studies have also demonstrated significant contributions in understanding how viruses, including HCMV and Dengue virus, alter host cell signaling pathways, making his work crucial in antiviral research.

  3. Successful Grant Support: Dr. Chan has received substantial funding for his research, including multiple NIH R01 grants. His current projects, such as targeting the nuclear HSF1 for anti-HCMV strategies, are promising avenues for the development of novel antiviral therapies, further solidifying his standing as a leading researcher in his field.

  4. Recognition by Peers and Journals: His work has been widely recognized by peers in the field, as evidenced by the Journal of Virology Editor’s Pick in 2024 and the Journal of Virology Spotlight Article of Significant Interest in 2020. These accolades underline the impact and relevance of his research.

  5. Mentorship and Academic Leadership: As a Professor at SUNY Upstate Medical University, Dr. Chan contributes significantly to the academic and professional development of students and colleagues alike. His role in shaping the next generation of researchers, combined with his leadership in the field, highlights his commitment to advancing science.

Areas for Improvement:

  1. Broader Impact Across Other Virus Families: While Dr. Chan’s research on HCMV is groundbreaking, exploring the broader spectrum of viral infections, including RNA viruses like SARS-CoV-2, could expand his impact across viral disease research. By diversifying his focus, he could address other significant public health threats, further enhancing the breadth of his research.

  2. Increased Interdisciplinary Collaboration: Although Dr. Chan has successfully collaborated with various experts in the field of virology, fostering interdisciplinary collaborations with researchers from fields such as bioinformatics, computational biology, and structural biology could accelerate the development of novel antiviral therapies and improve the understanding of viral mechanisms.

  3. Public Engagement and Communication: Dr. Chan’s impactful research is highly technical, and while it has contributed to the scientific community, increased efforts in communicating his findings to the broader public could help in promoting awareness of viral infections and their treatment. Public engagement through media, outreach programs, or collaborative projects with health organizations could amplify his work’s societal impact.

Education:

Dr. Gary Chan earned his Ph.D. in Immunology from the University of Alberta, Edmonton, Canada, from 1999 to 2005. His doctoral research focused on “Human cytomegalovirus-induced trophoblast apoptosis,” under the mentorship of Dr. Larry J. Guilbert in the Department of Medical Microbiology and Immunology. Following his Ph.D., Dr. Chan pursued postdoctoral training at Louisiana State University Health Science Center (2006–2011) in the Department of Microbiology and Immunology. Under the guidance of Dr. Andrew Yurochko, his postdoctoral research expanded his expertise in virology and immune modulation. Dr. Chan’s extensive academic background, coupled with his training in cutting-edge viral immunology, has laid the foundation for his pioneering work on viral-host interactions, particularly with human cytomegalovirus (HCMV), contributing to novel therapeutic strategies.

Experience:

Dr. Gary Chan is a Professor at the Department of Microbiology and Immunology at SUNY Upstate Medical University, a role he has held since 2023. Prior to this, he was an Associate Professor at the same department from 2018 to 2023. Dr. Chan has a wealth of experience in virology and immunology, with a focus on human cytomegalovirus (HCMV) and dengue virus (DENV). He has been instrumental in advancing research on the molecular mechanisms of viral infections and their impact on the host immune system. Dr. Chan’s academic journey includes several years of postdoctoral training at Louisiana State University, where he contributed to significant findings in viral replication and immune responses. With a comprehensive background in molecular virology, cell biology, and immunology, Dr. Chan is recognized for his expertise in viral pathogenesis and therapeutic research.

Awards and Honors:

Dr. Gary Chan has received numerous prestigious awards and recognitions for his research excellence. In 2024, his publication, Human cytomegalovirus modulates mTORC1 to redirect protein translation within quiescently infected monocytes, was selected as an Editor’s Pick by the Journal of Virology. Additionally, his article on HCMV-induced autophagy preventing necroptosis of infected monocytes was featured as a Spotlight Article of Significant Interest in 2020. His innovative research has earned him continuous recognition within the virology community, including numerous peer-reviewed publications. Dr. Chan’s research contributions have also attracted substantial NIH grant support, including an R01 from the NIAID, to explore novel anti-HCMV strategies targeting nuclear HSF1. His scholarly achievements, including the successful funding of multi-year research projects, underscore his dedication to advancing our understanding of viral diseases and their immune modulation.

Research Focus:

Dr. Gary Chan’s research primarily focuses on viral immunology, specifically human cytomegalovirus (HCMV) and dengue virus (DENV). His work explores how these viruses manipulate host cellular processes, such as signaling pathways and immune responses, to promote viral replication and persistence. One of his major research areas is investigating the interactions between HCMV and monocytes, particularly how the virus modulates autophagy and apoptosis to avoid immune detection and promote its survival. Additionally, Dr. Chan’s research delves into the role of host transcription factors, such as HSF1, in regulating viral replication. His innovative work also involves creating bioswitches through protein and DNA engineering to combat HCMV. Through these projects, Dr. Chan aims to identify novel therapeutic targets to limit viral infections and improve antiviral strategies. His work is pivotal in advancing the understanding of how viral infections impact the host immune system and contribute to disease pathogenesis.

Publications Top Notes:

  1. Targeting HSF1 prevents HCMV replication 🦠

  2. DENV infection induces differential immunotranscriptomic profiles 🦟

  3. B cell receptor enhancement of dengue virus infection 🧬

  4. Virion-associated US28 modulates Akt activity in monocytes 💉

  5. The harms of promoting the leak lab hypothesis for SARS-CoV-2 🧫

  6. HCMV modulates mTORC1 in infected monocytes 💪

  7. Virology – The path forward 🔬

  8. Inhibition of SIRT2 promotes HCMV-infected monocyte death ⚔️

  9. Virology under the Microscope – A call for rational discourse 📚

  10. Modulation of host cell signaling in HCMV latency 🧪

Conclusion:

Dr. Gary Ching-Tao Chan is highly deserving of the Best Researcher Award due to his outstanding contributions to the field of virology, particularly in the area of human cytomegalovirus and its interaction with the immune system. His innovative research has shaped the understanding of viral pathogenesis, leading to potential therapeutic breakthroughs. With significant funding, prestigious recognition, and a strong academic presence, Dr. Chan continues to push the boundaries of scientific knowledge. While there are opportunities for expansion into other viral research areas and greater public outreach, his accomplishments make him a leading figure in microbiology and an excellent candidate for this award.

Huiying Fan | Host-Pathogen Interactions | Best Researcher Award

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Dr. Huiying Fan | Host-Pathogen Interactions | Best Researcher Award

Dr. Huiying Fan , College of Veterinary Medicine, South China Agricultural University , China

Dr. Huiying Fan is a distinguished professor and doctoral supervisor at the College of Veterinary Medicine, South China Agricultural University, specializing in veterinary virology and immunology. As a core member of the Key Laboratory for Veterinary Vaccine Development, his expertise includes creating genetically engineered vaccines for animal viruses. Dr. Fan has published over 40 research papers in leading journals, including Journal of Virology and Emerging Microbes & Infections, and holds 11 invention patents. His career has been marked by significant contributions to animal virus research and vaccine development, with extensive involvement in national research programs. He has been recognized with several provincial and ministerial-level awards and is actively involved in scientific development and industry collaboration in China.

Publication Profile:

Scopus

Strengths for the Award:

Dr. Huiying Fan has demonstrated exceptional contributions to the field of veterinary virology and immunology, particularly in the development of vaccines for animal viruses. He is a recognized leader in the creation of genetically engineered vaccines, with over 40 SCI papers published in high-impact journals such as Journal of Virology, Emerging Microbes & Infection, and Vaccines. His involvement in groundbreaking research on the pathogenic mechanisms of viruses like avian influenza, porcine epidemic diarrhea, and African swine fever underscores his expertise. Furthermore, Dr. Fan has been granted 11 invention patents and is an influential figure in national research programs, such as the National Key Research and Development Program. His leadership as a professor and mentor, coupled with his ongoing innovations in virus detection and vaccine development, showcases his remarkable impact in the field.

Areas for Improvement:

While Dr. Fan’s scientific research has been groundbreaking, expanding his focus on broader global collaborations could enhance the scope of his work. In particular, his work could benefit from incorporating more interdisciplinary approaches, combining cutting-edge technologies such as artificial intelligence or big data analytics, which are becoming increasingly crucial in disease surveillance and vaccine development. Moreover, his research could further address the application of his vaccine technologies in low-resource settings, to maximize global health impact. Engaging more actively in science communication could also help translate his findings into policies or programs that benefit larger populations, both within China and internationally.

Education:

Dr. Fan completed his Ph.D. in Preventive Veterinary Medicine at the College of Veterinary Medicine, Huazhong Agricultural University, in June 2007. During his doctoral research, he focused on the study of veterinary diseases and virus-host interactions, laying a strong foundation for his future work in vaccine development. His commitment to advancing veterinary science continued through postdoctoral training, followed by his establishment as a professor at South China Agricultural University. His education reflects his dedication to merging academic research with practical applications for the improvement of animal health and disease prevention.

Experience:

Dr. Fan’s career began in 2007 as a professor at South China Agricultural University, where he became a leading figure in veterinary medicine. He has also contributed significantly to international research, evidenced by his six-month research visit to City University of Hong Kong in 2016. As a core member of several high-impact research initiatives, including the National Key Research and Development Program, he has played a vital role in advancing veterinary virology and vaccine development. Dr. Fan’s extensive expertise has led to collaborations across national projects and scientific endeavors, particularly in the realm of infectious diseases and immune responses in animals.

Awards and Honors:

Dr. Fan has received multiple prestigious awards throughout his career, including 8 provincial and ministerial-level honors. Notably, he was named a “Pearl River Science and Technology Star” in Guangzhou and recognized as a “Science and Technology Commissioner” by the People’s Government of Guangdong Province. His contributions to veterinary science have garnered recognition both within China and internationally, highlighting his commitment to scientific excellence and industry collaboration. These accolades underscore his leadership in veterinary vaccine research and his influence on public health initiatives concerning animal diseases.

Research Focus:

Dr. Fan’s primary research interests lie in the molecular design of genetically engineered vaccines for animal viruses, including those affecting poultry and swine. His studies explore the immune mechanisms and pathogenesis of viruses such as avian influenza and porcine viral diarrhea. In addition to his work on vaccine development, he investigates the use of innovative techniques, including CRISPR/Cas12a and proteomics, to better understand virus-host interactions and to improve diagnostic and therapeutic strategies for animal diseases. His focus on veterinary virology aims to enhance both animal and public health outcomes.

Publication Top Notes:

  1. “A single immunization with H5N1 virus-like particle vaccine protects chickens against divergent H5N1 influenza viruses” 🐔🦠
  2. “Influenza H7N9 Virus Hemagglutinin with T169A Mutation Possesses Enhanced Thermostability” 🦠❄️
  3. “Immune Escape Mechanism and Vaccine Research Progress of African Swine Fever Virus” 🐖🦠
  4. “Supplementation of H7N9 Virus-Like Particle Vaccine With Recombinant Epitope Antigen Confers Full Protection” 🦠💉
  5. “PEDV infection affects the expression of polyamine-related genes inhibiting viral proliferation” 🐖🧬
  6. “Proteome Analysis in PAM Cells Reveals That African Swine Fever Virus Can Regulate Intracellular Polyamines” 🧬🔬
  7. “CRISPR/Cas12a Technology Combined with Immunochromatographic Strips for Portable Detection of ASF Virus” 🧬🦠
  8. “Quantitative Proteomics Reveals Changes in Vero Cells in Response to Porcine Epidemic Diarrhea Virus” 🐖🔬
  9. “Coimmunization with recombinant epitope-expressing baculovirus enhances protective effects of H5N1 vaccine” 💉🦠
  10. “Either fadD1 or fadD2, Which Encode acyl-CoA Synthetase, Is Essential for the Survival of Haemophilus parasuis SC096” 🦠🔬
  11. “Two Glycosyltransferase Genes of Haemophilus parasuis SC096 Implicated in Lipooligosaccharide Biosynthesis” 🧬🦠
  12. “Recombinant baculovirus vaccine containing multiple M2e and adjuvant LT induces T cell-dependent protection against H5N1” 💉🦠
  13. “BacMam virus-based surface display of IBV S1 glycoprotein confers strong protection against virulent IBV challenge” 🐔🦠
  14. “Quantitative Proteomics by Amino Acid Labeling in Foot-and-Mouth Disease Virus-Infected Cells” 🐄🧬
  15. “Quantitative proteomics using SILAC reveals protein and pathway regulation in porcine circovirus type 2 infected PK-15 cells” 🐖🧬

Conclusion:

Dr. Huiying Fan is undoubtedly a strong contender for the Research for Best Researcher Award, given his outstanding contributions to animal virus research, innovative vaccine design, and leadership in national research initiatives. His extensive publication record, patent portfolio, and recognition through prestigious awards highlight his scientific excellence. Although expanding his collaborative network and exploring interdisciplinary methodologies could elevate his impact further, Dr. Fan’s work has already had a profound effect on veterinary medicine and public health, making him a well-deserved nominee for this award.