University of Lübeck | Germany
Dr. Mariana Grieben is a biochemist and structural biologist whose research spans the molecular mechanisms of membrane proteins and virus-host interactions. She earned her Ph.D. in structural biology with a focus on ATP synthases and subsequently advanced her expertise as a postdoctoral researcher at the Structural Genomics Consortium (SGC), University of Oxford, where she investigated the structural characterization of human integral membrane proteins, including TRP channels, TMEM proteins, and SLCs, in collaboration with pharmaceutical companies to identify therapeutic small molecules. She later contributed to pandemic-related research at STRUBI, Oxford, elucidating the roles of SARS-CoV-2 non-structural membrane proteins 3, 4, and 6. Currently, she is a Group Leader at the Institute of Biochemistry, University of Lübeck, where she also pursues a teaching qualification. Her research contributions include the cryo-EM and X-ray structures of TRPP1, TRPC6, TRPA1, and TMEM45A, alongside work on viral proteins such as CHPV M protein and hHAX-1, advancing understanding of diseases including polycystic kidney disease, focal segmental glomerulosclerosis, cancer, pain, and virus-induced heart failure. Dr. Grieben has published 7 peer-reviewed journal articles, holds an h-index of 3 with 3 citations, and has completed 7 major research projects. She is an active member of GBM and maintains collaborations with academia and industry.
Featured Publications:
Wang, Q., Corey, R. A., Hedger, G., Aryal, P., Grieben, M., Nasrallah, C., Baronina, A., Pike, A. C. W., Shi, J., Carpenter, E. P., & Sansom, M. S. P. (2020). Lipid interactions of a ciliary membrane TRP channel: Simulation and structural studies of polycystin-2. Structure, 28(2), 169-184.e5.