Gary Chan | Host-Pathogen Interactions | Best Researcher Award

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Dr. Gary Chan | Host-Pathogen Interactions | Best Researcher Award

Dr. Gary Chan , SUNY Upstate Medical University , United States

Dr. Gary Ching-Tao Chan is a distinguished professor in the Department of Microbiology and Immunology at SUNY Upstate Medical University, Syracuse, NY. He completed his Ph.D. in Immunology at the University of Alberta, Canada, under the supervision of Dr. Larry J. Guilbert. Dr. Chan’s research expertise lies in viral immunology, particularly in human cytomegalovirus (HCMV) and dengue virus (DENV). He has a robust research portfolio with numerous contributions to the field, focusing on viral-host interactions and immune modulation. His work has led to groundbreaking discoveries in HCMV pathogenesis, including viral modulation of autophagy and cell signaling pathways. Dr. Chan has held academic appointments at prestigious institutions, including Louisiana State University Health Science Center, where he contributed significantly to advancing viral immunology. His commitment to research excellence is reflected in his impactful publications and active grant support.

Publication Profile: 

Orcid

Strengths for the Award:

  1. Prolific Research Contributions: Dr. Gary Chan has made significant contributions to the field of microbiology, particularly in the understanding of human cytomegalovirus (HCMV) and its complex interactions with the immune system. His work has been consistently published in top-tier peer-reviewed journals such as Journal of Virology, Antiviral Research, and mBio, highlighting his influence in virology.

  2. Innovative and High-Impact Research: Dr. Chan’s research addresses fundamental aspects of viral pathogenesis, focusing on viral-host interactions, immune modulation, and viral replication. His innovative exploration into the molecular mechanisms of HCMV, such as the modulation of mTORC1 and the role of host transcription factors like HSF1, is groundbreaking and provides valuable insights for potential therapeutic strategies. His studies have also demonstrated significant contributions in understanding how viruses, including HCMV and Dengue virus, alter host cell signaling pathways, making his work crucial in antiviral research.

  3. Successful Grant Support: Dr. Chan has received substantial funding for his research, including multiple NIH R01 grants. His current projects, such as targeting the nuclear HSF1 for anti-HCMV strategies, are promising avenues for the development of novel antiviral therapies, further solidifying his standing as a leading researcher in his field.

  4. Recognition by Peers and Journals: His work has been widely recognized by peers in the field, as evidenced by the Journal of Virology Editor’s Pick in 2024 and the Journal of Virology Spotlight Article of Significant Interest in 2020. These accolades underline the impact and relevance of his research.

  5. Mentorship and Academic Leadership: As a Professor at SUNY Upstate Medical University, Dr. Chan contributes significantly to the academic and professional development of students and colleagues alike. His role in shaping the next generation of researchers, combined with his leadership in the field, highlights his commitment to advancing science.

Areas for Improvement:

  1. Broader Impact Across Other Virus Families: While Dr. Chan’s research on HCMV is groundbreaking, exploring the broader spectrum of viral infections, including RNA viruses like SARS-CoV-2, could expand his impact across viral disease research. By diversifying his focus, he could address other significant public health threats, further enhancing the breadth of his research.

  2. Increased Interdisciplinary Collaboration: Although Dr. Chan has successfully collaborated with various experts in the field of virology, fostering interdisciplinary collaborations with researchers from fields such as bioinformatics, computational biology, and structural biology could accelerate the development of novel antiviral therapies and improve the understanding of viral mechanisms.

  3. Public Engagement and Communication: Dr. Chan’s impactful research is highly technical, and while it has contributed to the scientific community, increased efforts in communicating his findings to the broader public could help in promoting awareness of viral infections and their treatment. Public engagement through media, outreach programs, or collaborative projects with health organizations could amplify his work’s societal impact.

Education:

Dr. Gary Chan earned his Ph.D. in Immunology from the University of Alberta, Edmonton, Canada, from 1999 to 2005. His doctoral research focused on “Human cytomegalovirus-induced trophoblast apoptosis,” under the mentorship of Dr. Larry J. Guilbert in the Department of Medical Microbiology and Immunology. Following his Ph.D., Dr. Chan pursued postdoctoral training at Louisiana State University Health Science Center (2006–2011) in the Department of Microbiology and Immunology. Under the guidance of Dr. Andrew Yurochko, his postdoctoral research expanded his expertise in virology and immune modulation. Dr. Chan’s extensive academic background, coupled with his training in cutting-edge viral immunology, has laid the foundation for his pioneering work on viral-host interactions, particularly with human cytomegalovirus (HCMV), contributing to novel therapeutic strategies.

Experience:

Dr. Gary Chan is a Professor at the Department of Microbiology and Immunology at SUNY Upstate Medical University, a role he has held since 2023. Prior to this, he was an Associate Professor at the same department from 2018 to 2023. Dr. Chan has a wealth of experience in virology and immunology, with a focus on human cytomegalovirus (HCMV) and dengue virus (DENV). He has been instrumental in advancing research on the molecular mechanisms of viral infections and their impact on the host immune system. Dr. Chan’s academic journey includes several years of postdoctoral training at Louisiana State University, where he contributed to significant findings in viral replication and immune responses. With a comprehensive background in molecular virology, cell biology, and immunology, Dr. Chan is recognized for his expertise in viral pathogenesis and therapeutic research.

Awards and Honors:

Dr. Gary Chan has received numerous prestigious awards and recognitions for his research excellence. In 2024, his publication, Human cytomegalovirus modulates mTORC1 to redirect protein translation within quiescently infected monocytes, was selected as an Editor’s Pick by the Journal of Virology. Additionally, his article on HCMV-induced autophagy preventing necroptosis of infected monocytes was featured as a Spotlight Article of Significant Interest in 2020. His innovative research has earned him continuous recognition within the virology community, including numerous peer-reviewed publications. Dr. Chan’s research contributions have also attracted substantial NIH grant support, including an R01 from the NIAID, to explore novel anti-HCMV strategies targeting nuclear HSF1. His scholarly achievements, including the successful funding of multi-year research projects, underscore his dedication to advancing our understanding of viral diseases and their immune modulation.

Research Focus:

Dr. Gary Chan’s research primarily focuses on viral immunology, specifically human cytomegalovirus (HCMV) and dengue virus (DENV). His work explores how these viruses manipulate host cellular processes, such as signaling pathways and immune responses, to promote viral replication and persistence. One of his major research areas is investigating the interactions between HCMV and monocytes, particularly how the virus modulates autophagy and apoptosis to avoid immune detection and promote its survival. Additionally, Dr. Chan’s research delves into the role of host transcription factors, such as HSF1, in regulating viral replication. His innovative work also involves creating bioswitches through protein and DNA engineering to combat HCMV. Through these projects, Dr. Chan aims to identify novel therapeutic targets to limit viral infections and improve antiviral strategies. His work is pivotal in advancing the understanding of how viral infections impact the host immune system and contribute to disease pathogenesis.

Publications Top Notes:

  1. Targeting HSF1 prevents HCMV replication 🦠

  2. DENV infection induces differential immunotranscriptomic profiles 🦟

  3. B cell receptor enhancement of dengue virus infection 🧬

  4. Virion-associated US28 modulates Akt activity in monocytes 💉

  5. The harms of promoting the leak lab hypothesis for SARS-CoV-2 🧫

  6. HCMV modulates mTORC1 in infected monocytes 💪

  7. Virology – The path forward 🔬

  8. Inhibition of SIRT2 promotes HCMV-infected monocyte death ⚔️

  9. Virology under the Microscope – A call for rational discourse 📚

  10. Modulation of host cell signaling in HCMV latency 🧪

Conclusion:

Dr. Gary Ching-Tao Chan is highly deserving of the Best Researcher Award due to his outstanding contributions to the field of virology, particularly in the area of human cytomegalovirus and its interaction with the immune system. His innovative research has shaped the understanding of viral pathogenesis, leading to potential therapeutic breakthroughs. With significant funding, prestigious recognition, and a strong academic presence, Dr. Chan continues to push the boundaries of scientific knowledge. While there are opportunities for expansion into other viral research areas and greater public outreach, his accomplishments make him a leading figure in microbiology and an excellent candidate for this award.

Prbhu Narayan Meena | Host-Pathogen Interactions | Best Paper Award

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Dr. Prbhu Narayan Meena | Host-Pathogen Interactions | Best Paper Award

Dr. Prbhu Narayan Meena , ICAR-NRIIPM, New delhi , India

Dr. P. N. Meena, M.Sc. (Ag), Ph.D., is a renowned Scientist in the field of Plant Pathology. With a career that began in 2013 at ICAR-CRIJAF, Kolkata, Dr. Meena played a crucial role in developing two varieties of kenaf resistant to foot and stem rot disease. Over the years, Dr. Meena has made significant contributions to plant pathology research, publishing 7 international and 27 national research papers, 12 abstracts, 2 books/compendiums, and numerous other scientific works. She has delivered over 13 invited lectures, organized several farmer field schools, and participated in 22 trainings and conferences. Her research has earned her awards, including the Best Plant Pathologist Award in 2019 and 2024. Dr. Meena’s work continues to benefit horticulture, fibre, and pulse crops through innovative disease management solutions.

Publication Profile:

Google Scholar

Strengths for the Award:

  1. Outstanding Contributions to Plant Pathology: Dr. P. N. Meena has made significant contributions to plant pathology research, particularly in the development of disease-resistant crops and bio-control strategies. Her work on kenaf varieties resistant to foot and stem rot disease, and her extensive publications on molecular detection and disease management strategies, are impressive achievements that underscore her excellence in the field.

  2. Comprehensive Research Focus: Dr. Meena has worked across multiple aspects of plant disease management, including molecular diagnostics, eco-friendly management practices, and bio-control agents like Trichoderma harzianum, Bacillus subtilis, and Pseudomonas fluorescens. This broad research focus ensures her work impacts horticulture, fibre crops, and pulses.

  3. Recognition & Awards: She has received prestigious awards such as the Best Plant Pathologist Award in 2019 and 2024, highlighting her esteemed position in the research community.

  4. Extensive Publication Record: With over 7 international papers, 27 national papers, 2 books, 13 book chapters, and numerous abstracts and technical bulletins, Dr. Meena has demonstrated a prolific research output. Her works are valuable for both academia and practical applications in agriculture.

  5. Leadership & Community Engagement: Dr. Meena has played a leadership role in organizing numerous farmer training programs, field schools, and workshops. This active engagement with the farming community, along with her work in disseminating scientific knowledge, strengthens her candidacy for the award.

Areas for Improvement:

  1. Collaborative Research in Emerging Fields: While Dr. Meena has a strong background in traditional crop disease management, there is potential to expand her research into emerging fields like genomic data integration and precision agriculture. Collaborations with experts in genomics or climate change could open new avenues for disease resistance and crop resilience.

  2. Expansion in Global Research Networks: While her contributions are highly recognized nationally and regionally, further involvement in international research collaborations, especially with top global agricultural institutions, could elevate the global impact of her research.

  3. Publication of Research in High-Impact Journals: Though Dr. Meena’s publication record is commendable, focusing more on high-impact international journals could further boost the visibility of her work on a global scale, ensuring that her research reaches a wider, more diverse audience.

Education:

Dr. P. N. Meena pursued her Master’s in Science (Agriculture) with a specialization in Plant Pathology and later completed her Ph.D. in the same field. Her academic journey has been marked by an unwavering commitment to understanding plant diseases and finding sustainable solutions. Her advanced education laid the foundation for her impactful research at ICAR-CRIJAF, where she actively contributed to various projects focused on disease resistance in crops. Throughout her educational career, Dr. Meena has exhibited excellence, being well-versed in molecular detection and plant disease management. Her knowledge has allowed her to develop various technologies in disease management strategies, particularly for horticultural and fibre crops. She has remained engaged with both national and international research communities, collaborating extensively to share insights and expertise.

Experience:

Dr. P. N. Meena began her career as a Scientist (Plant Pathology) at ICAR-CRIJAF, Kolkata, in 2013, where she made notable contributions to the development of kenaf varieties resistant to major diseases. Her extensive experience includes publishing 7 international and 27 national research papers, authoring 2 books, and developing 21 technologies for disease management. Dr. Meena has served as a Co-PI in 2 externally funded projects, PI in 2 institute projects, and Co-PI in 14 institute projects. She has delivered 14 oral/poster presentations and 13 invited lectures in farmer training programs. Her leadership is reflected in organizing 18 farmer field schools (FFS) and coordinating 5 FLDs. Dr. Meena has received multiple awards for her contribution to plant pathology, including the Best Plant Pathologist Award in 2019 and 2024. Her active involvement in conferences, workshops, and research continues to influence the agricultural community.

Research Focus:

Dr. P. N. Meena’s research focus primarily revolves around plant diseases, particularly in horticultural, fibre, and pulse crops. Her groundbreaking work includes developing molecular detection technologies for various plant pathogens and strategies for managing diseases like foot and stem rot in crops. A significant part of her research is centered on eco-friendly disease management, using bioagents such as Trichoderma harzianum, Bacillus subtilis, and Pseudomonas fluorescens. Additionally, she is passionate about exploring host plant resistance, disease diagnostics, and sustainable agricultural practices. Dr. Meena’s work extends to protecting crops like jute and groundnut from harmful pathogens, improving yield, and promoting environmental sustainability. With 21 technologies developed in disease management and ongoing research in biocontrol, her work contributes substantially to integrated pest management (IPM). Her research also involves extensive work in genetic diversity and the development of resistant crop varieties.

Publications Top Notes:

  1. Biocontrol activity of Trichoderma harzianum, Bacillus subtilis and Pseudomonas fluorescens against Meloidogyne incognita, Fusarium oxysporum, and Rhizoctonia solani 🌱
  2. Bio-efficacy of phytoextracts and oil cakes on Macrophomina phaseolina causing stem rot disease of jute, Corchorus spp. 🌿
  3. Host plant resistance in cultivated jute and its wild relatives towards jute hairy caterpillar Spilosoma obliqua (Lepidoptera: Arctiidae) 🦋
  4. Eco-friendly management of major diseases in jute (Corchorus olitorius L.) 🌾
  5. Evaluation of stem rot disease in jute (Corchorus olitorius) germplasm caused by Macrophomina phaseolina (Tassi) Goid 🍂
  6. Problems and prospects of pest management in jute and allied fibre crops 🌱
  7. Simultaneous detection of potato viruses A and M using CP gene-specific primers in an optimized duplex RT-PCR 🥔
  8. Detection of Mesta yellow vein mosaic virus (MeYVMV) in field samples by a loop-mediated isothermal amplification reaction 🌾
  9. In vitro screening of white Jute (Corchorus capsularis L) against salinity stress 💧
  10. Evaluation of efficacy of different bioagents and fungicides against Rhizoctonia solani (Kuhn) ⚗️

Conclusion:

Dr. P. N. Meena is an exceptional researcher with a proven track record of developing innovative solutions for plant disease management, particularly in the horticultural and fibre crop sectors. Her work is characterized by both depth and breadth, making a significant impact on the agricultural community. The strengths of her research, leadership, and recognition make her a strong contender for the Research for Best Paper Award. However, future directions could involve expanding collaborations into cutting-edge technologies and increasing visibility through international journals. Overall, Dr. Meena’s work stands out for its scientific rigor, practical applications, and contribution to sustainable agriculture.