Dr. Sabir Khan’s research focuses on transcription factors, gene expression regulation, and the biosynthetic pathways of antibiotics. His work integrates microbiology and synthetic biology to explore the molecular mechanisms underlying fungal and bacterial diseases. He has contributed significantly to understanding antifungal susceptibility and the development of resistance mechanisms in pathogenic microorganisms. In addition, his studies on glioma (brain cancer) investigate microbial interactions and secondary metabolites that may offer therapeutic potential. His research extends to fermentation technology, optimizing microbial processes for enhanced antibiotic production. Dr. Khan’s postdoctoral research emphasizes ecological and synthetic biology approaches to manipulate microbial pathways for improved biosynthetic yields. By combining molecular genetics, microbiological assays, and bioinformatics tools, his work aims to identify regulatory networks and transcriptional controls involved in secondary metabolite production. Through this multidisciplinary approach, Dr. Khan contributes to the advancement of microbial biotechnology and the development of novel antimicrobial and anticancer strategies.
Featured Publications:
Khan, S., Bilal, H., Khan, M. N., Fang, W., Chang, W., Yin, B., Song, N. J., et al. (2024). Interleukin inhibitors and associated risk of candidiasis. Frontiers in Immunology, 28 March 2024.
Khan, S., Bilal, H., Shafiq, M., Zhang, D., Awais, M., Chen, C., Khan, M. N., et al. (2024). Distribution of Aspergillus species and risk factors for Aspergillosis from mainland China: A systematic analysis. Therapeutic Advances in Infectious Disease, 17 April 2024. https://doi.org/10.1177/2049936124xxxxx
(IF: 5.7)
Khan, S., Xu, X., Song, J., Wu, P., Liu, X., Liu, J., Chen, K., Xu, Z., Wu, H., & Zhang, B. (2022). Crosstalk of TetR-like regulator SACE_4839 and a nitrogen regulator for erythromycin biosynthesis. Applied Microbiology and Biotechnology, 106, 12345–12356.
Liu, Y.#, Khan, S.#, Wu, P.#, Liu, L., Li, B., Ni, J., Zhang, H., Chen, K., Wu, H., & Zhang, B. (2021). Uncovering and engineering mini-regulatory network of the TetR-family regulator SACE_0303 for yield improvement of erythromycin in Saccharopolyspora erythraea. Frontiers in Bioengineering and Biotechnology, 9, 715234.
Khan, S.†, Cai, L.†, Bilal, H., Khan, M. N., Fang, W., Zhang, D., & Yao, F. (2023). An 11-year retrospective analysis of candidiasis epidemiology, risk factors, and antifungal susceptibility in a tertiary care hospital in China. Scientific Reports, 13, 5678.
Khan, S.†, Hou, B., Khan, M. N., Shafiq, M., Cai, L.†, Fang, W., Wang, Q., Bilal, H., & Zeng, Y. (2025). A three-year retrospective analysis of microbial species and key biomarkers associated with wound infections in Shantou Hospital, China. Frontiers in Cellular and Infection Microbiology, 15, 15456.
Khan, S., Hameed, M. F., Zafar, I., Bibi, R., Mohany, M., Nazir, S., Kamal, M. A., & Shafiq, M. (2024). Synthesis, characterization, and pharmacological evaluation of Zn4O(BDC)3: Anticancer, antidiabetic, and drug delivery potential. Medicinal Chemistry, 20(3), 145–157.