Dr. Yatendra Singh | Plant Metabolomics | Best Researcher Award

Dr. Yatendra Singh | University of Mississippi Postdoctoral Research Associate | United States

Dr. Yatendra Singh is an accomplished analytical chemist and postdoctoral researcher at the University of Mississippi, USA. He earned his Ph.D. from CSIR – Central Drug Research Institute, India, where he developed expertise in mass spectrometry and natural product chemistry. With a strong foundation in organic and analytical chemistry, Dr. Singh has actively contributed to the understanding of phytochemicals, bioflavonoids, and cardiac glycosides using cutting-edge chromatographic techniques. His work bridges the fields of pharmacognosy, metabolomics, and cancer pharmacology. He has published widely in reputed journals, highlighting his interdisciplinary approach. At the University of Mississippi, he works under Dr. Sixue Chen, further advancing plant metabolomics. Dr. Singh is known for his diligence, collaboration, and innovation in natural product research. His growing publication record and contributions to therapeutic discovery reflect his promise as a leading figure in the field of analytical and medicinal chemistry.

Publication Profiles:

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Education:

Dr. Yatendra Singh’s educational journey reflects a solid progression in chemical and life sciences. He earned his Ph.D. in Analytical Chemistry from CSIR – Central Drug Research Institute, India, where he specialized in ultra-performance liquid chromatography coupled with tandem mass spectrometry (UPLC-MS/MS) for natural product analysis. Before his doctoral studies, Dr. Singh completed his M.S. in Organic Chemistry from M.J.P. Rohilkhand University, India, equipping him with a robust knowledge of chemical synthesis and structure elucidation. His academic foundation began with a B.S. in Zoology and Chemistry, also from M.J.P. Rohilkhand University, which provided an interdisciplinary perspective combining biological and chemical sciences. This diverse academic background allowed him to seamlessly integrate analytical chemistry techniques with pharmacognostic and pharmacological studies, ultimately contributing to novel therapeutic insights. His education has been instrumental in shaping his research trajectory toward impactful discoveries in natural product chemistry.

Experience:

Dr. Yatendra Singh is currently serving as a Postdoctoral Research Associate in the Department of Biology at the University of Mississippi, under the mentorship of Dr. Sixue Chen. His postdoctoral work focuses on plant metabolomics, mass spectrometry-based compound profiling, and bioactive molecule discovery. During his Ph.D. at CSIR-CDRI, Dr. Singh developed core competencies in analytical chemistry techniques, especially UHPLC-MS/MS and UPLC-QTOF-MS, applying them to study flavonoids, depsides, glycosides, and plant metabolites with pharmacological significance. His research also extended into the pharmacological effects of natural compounds on cancer and inflammation. With an interdisciplinary skill set, Dr. Singh has worked across both chemistry and biology domains, collaborating with pharmacologists, botanists, and analytical scientists. His cumulative academic and postdoctoral experience underscores his strengths in research design, data analysis, compound isolation, and scientific writing, with numerous peer-reviewed publications as evidence of his impactful work in the field.

Awards and Honors:

Dr. Yatendra Singh has been recognized multiple times for his academic excellence and research potential. He was awarded the CSIR – Senior Research Fellowship (SRF) in Chemical Science—one of India’s most competitive fellowships for doctoral research. He received the UGC – Junior Research Fellowship (JRF), and He was awarded the CSIR – JRF, both prestigious fellowships granted based on national-level competitive examinations. These awards reflect his strong academic foundation and his ability to meet the highest standards in research. His contributions to science have not only resulted in high-impact publications but also signify a steady progression in recognition from Indian scientific agencies. His accolades highlight his capability to lead independent research and his commitment to furthering the scientific understanding of natural compounds with therapeutic potential. These fellowships have also provided him with the necessary resources to develop and refine his technical and analytical expertise.

Research Focus:

Dr. Yatendra Singh’s research is centered around the analytical characterization of bioactive natural products using advanced chromatographic and mass spectrometric techniques. He specializes in ultra-performance liquid chromatography (UPLC) coupled with tandem mass spectrometry (MS/MS), employing these tools to explore secondary metabolites in medicinal plants. His work often focuses on flavonoids, cardiac glycosides, depsides, and alkaloids, examining their quantification, seasonal variation, and pharmacological potential. Dr. Singh’s research lies at the interface of analytical chemistry, pharmacognosy, and pharmacology, contributing to the discovery and validation of therapeutic compounds against diseases such as cancer and inflammation. His recent postdoctoral efforts involve plant metabolomics and data-driven compound identification, integrating network pharmacology to predict molecular targets. This integrative approach positions him as a valuable contributor to both basic science and translational research. Through his work, he aims to facilitate the identification of new leads for drug development from natural sources.

Publications Top Notes:

Exploring the pharmacological effect of cardiac glycosides against hepatocellular carcinoma using network pharmacology – Pharmacological Research – Natural Products, 2025
The Purified Fraction of Persicaria capitata Flowers Attenuates Proliferation in A-431 Cell Lines – Pharmacognosy Magazine, 2025
Pharmacognostic Evaluation of Parmelia sulcata Taylor and its Cytotoxic Effects on A Glioblastoma Cell Line – J. of Pharmacology and Pharmacotherapeutics, 2024
Structure analysis of depsides, dibenzofuran and sugar derivatives from Cladia aggregata using UPLC-MS/MS – European Journal of Mass Spectrometry, 2024
Exploration of new and alternative sources of targeted bioflavonoids using UPLC-MS/MS – Separation Science Plus, 2023
Bone fracture-healing properties and UPLC-MS analysis of flavonoid fraction from Oxystelma esculentum – Planta Medica, 2023
Characterization of Dactylorhin and loroglossin in Dactylorhiza hatagirea using UPLC-MS – International Journal of Mass Spectrometry, 2023
Characterization and quantification of Cajanus scarabaeoides phytochemicals using UPLC-MS/MS – Rapid Communications in Mass Spectrometry, 2022
Quantitative evaluation of cardiac glycosides in Nerium oleander using UHPLC-ESI-MS/MS – Phytochemical Analysis, 2022
Aurintricarboxylic acid mitigates cigarette smoke-induced oxidative stress via NF-κB/p65 inhibition – Toxicology Mechanisms and Methods, 2022

Conclusion:

In conclusion, Dr. Yatendra Singh stands out as a talented, driven, and impactful researcher with a remarkable ability to bridge analytical chemistry and pharmacology. His growing record of publications, advanced analytical skills, and strong academic background make him a compelling candidate for the Best Researcher Award. While there is always scope for growth, particularly in research leadership and global outreach, his current achievements reflect excellence, innovation, and dedication. Dr. Singh’s contributions to the discovery and characterization of bioactive natural compounds are timely and relevant, particularly in an era emphasizing sustainable and plant-based therapeutic solutions. Recognizing his efforts through this award would not only honor his individual excellence but also encourage continued high-impact research in areas of significant scientific and societal importance. Dr. Singh embodies the spirit of innovation and academic rigor, making him highly deserving of this recognition.

Prof. Irena Roterman , Jagiellonian University – Medical College , Poland

Irena Roterman-Konieczna is a distinguished biochemist specializing in bioinformatics and protein structure. With a PhD in biochemistry from the Nicolaus Copernicus Medical Academy Krakow, she has held significant academic positions, including Professor of Medical Sciences at Jagiellonian University. Irena is recognized for her innovative contributions, particularly the fuzzy oil drop model, which emphasizes environmental influence on protein folding. She has published extensively, contributing to the understanding of protein dynamics and interactions. As a committed educator, she has guided numerous PhD students and served as the Chief Editor for the journal Bio-Algorithms and Med-Systems. Her work continues to impact the fields of protein folding, membrane proteins, and systems biology.

Strengths for the Award

Irena Roterman-Konieczna’s extensive academic background and innovative contributions to the field of bioinformatics and protein structure make her an exceptional candidate for the Best Researcher Award. Her pioneering work on the fuzzy oil drop model has provided critical insights into the environmental influences on protein folding. With a prolific publication record of 149 articles, she has consistently advanced the understanding of protein dynamics, particularly in membrane proteins and chaperonins. Additionally, her role as Chief Editor of the journal Bio-Algorithms and Med-Systems demonstrates her leadership in the scientific community. Her commitment to mentoring future researchers is evident through her advisory work with 15 PhD students, ensuring the continued growth of the field.

Areas for Improvement

While Irena’s contributions to theoretical models are significant, there may be opportunities to further integrate experimental validation into her research. Collaborating with experimentalists could enhance the practical applications of her models, particularly in understanding real-world protein behavior. Additionally, increasing outreach to interdisciplinary fields could broaden the impact of her research on medicine and biotechnology.

Education

Irena Roterman-Konieczna completed her basic education in theoretical chemistry at Jagiellonian University in 1974. She earned her PhD in biochemistry in 1984, focusing on the structure of the recombinant IgG hinge region at the Nicolaus Copernicus Medical Academy in Krakow. Following her doctoral studies, Irena undertook postdoctoral research at Cornell University from 1987 to 1989 in Harold A. Scheraga’s group, where she analyzed force fields in molecular modeling programs like Amber and Charmm. In 1994, she achieved habilitation in biochemistry at Jagiellonian University’s Faculty of Biotechnology and later attained the title of Professor of Medical Sciences in 2004. This strong educational foundation laid the groundwork for her extensive research and contributions to the field of biochemistry and bioinformatics.

Experience

Irena Roterman-Konieczna has a robust academic and research background spanning several decades. She has held key academic positions at Jagiellonian University, where she is currently a Professor of Medical Sciences. Irena’s postdoctoral research at Cornell University deepened her expertise in molecular modeling and protein interactions. Throughout her career, she has authored numerous publications and books, significantly advancing the understanding of protein folding and structure. As Chief Editor of the journal Bio-Algorithms and Med-Systems from 2005 to 2020, she played a vital role in disseminating research in the field. Additionally, she has supervised 15 PhD students, fostering the next generation of researchers. Irena’s collaborative efforts and advisory roles in various projects highlight her commitment to scientific advancement and education in biochemistry and bioinformatics.

Research Focus

Irena Roterman-Konieczna’s research centers on bioinformatics, particularly in understanding protein structure and dynamics. Her innovative fuzzy oil drop model explores the role of environmental factors in protein folding, proposing that external force fields influence hydrophobic core formation and overall structure. Irena investigates the effects of membrane environments on protein behavior, examining how hydrophobic factors can alter folding dynamics. Her work also delves into chaperonins and their role in facilitating proper protein folding under varying conditions. Additionally, she explores domain-swapping structures and their implications for complex formation in proteins. Irena’s research emphasizes the necessity of simulating external force fields in computational protein folding, integrating both internal and external interactions. Her contributions to systems biology and the development of quantitative models for protein behavior continue to advance the field, making significant impacts in both theoretical and practical applications.

Publications Top Notes

Chameleon Sequences─Structural Effects in Proteins Characterized by Hydrophobicity Disorder 🌊

Transmembrane proteins—Different anchoring systems ⚓

External Force Field for Protein Folding in Chaperonins─Potential Application in In Silico Protein Folding 💻

Structural features of Prussian Blue-related iron complex FeT of activity to peroxidate unsaturated fatty acids 🔬

Domain swapping: a mathematical model for quantitative assessment of structural effects 📊

Editorial: Structure and function of trans-membrane proteins 🧬

Model of the external force field for the protein folding process—the role of prefoldin 🌐

Role of environmental specificity in CASP results 📈

Ab initio protein structure prediction: the necessary presence of external force field as it is delivered by Hsp40 chaperone 🔍

Secondary structure in polymorphic forms of alpha-synuclein amyloids 🧪

Conclusion

Irena Roterman-Konieczna’s innovative research, leadership in academia, and dedication to mentorship position her as a strong contender for the Best Researcher Award. Her groundbreaking work in bioinformatics not only advances scientific understanding but also lays the groundwork for future discoveries in protein dynamics and interactions. Recognizing her contributions would not only honor her achievements but also inspire ongoing research in the field.

Yatendra Singh | Plant Metabolomics | Best Researcher Award