Arvind Singh Negi | Medicinal chemistry | Outstanding Scientist Award

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Dr. Arvind Singh Negi | Medicinal chemistry | Outstanding Scientist Award

Dr. Arvind Singh Negi  , csir-cimap , India

Dr. Arvind Singh Negi, born on January 1, 1970, is a prominent scientist in the field of medicinal chemistry, currently serving as Chief Scientist and Head of the Phytochemistry Division at CSIR-Central Institute of Medicinal and Aromatic Plants, Lucknow, India. With a distinguished academic background and over three decades of experience, he specializes in natural product chemistry and the development of cancer chemotherapeutics. Dr. Negi has published extensively, contributing significantly to the understanding of plant-based medicinal compounds. His work has garnered numerous accolades, reflecting his commitment to advancing science in medicinal chemistry and natural products.

Publication Profile

Google Scholar

Strengths for the Award

Dr. Arvind Singh Negi possesses a robust academic background and extensive experience in medicinal chemistry, particularly in the development of cancer therapeutics from natural products. His impressive publication record, with over 106 research papers and significant citations, showcases his impact on the field. His leadership as Chief Scientist at CSIR-CIMAP reflects his ability to drive innovative research initiatives. Additionally, his multiple prestigious awards and fellowships, including recognition from the Royal Society of Chemistry and the National Academy of Sciences, underscore his scientific contributions and collaborations on a global scale.

Areas for Improvement

While Dr. Negi’s research achievements are commendable, expanding his outreach to interdisciplinary collaborations could enhance the applicability of his findings. Increasing engagement in public awareness and education on the significance of his research in medicinal chemistry could also strengthen his influence beyond academic circles. Further diversification of research themes might attract funding and foster novel explorations in related areas.

Education 

Dr. Negi completed his B.Sc. in Physics, Chemistry, and Mathematics from Lucknow Christian Degree College, University of Lucknow, in 1989. He excelled academically, earning his M.Sc. in Chemistry with First Rank from the same university in 1991. He further pursued a Ph.D. in Medicinal Chemistry at CSIR-Central Drug Research Institute, obtaining his degree in 1999. His educational journey includes significant research experiences, starting as a Scientist at ICAR-Indian Grassland and Fodder Research Institute in 1995. Dr. Negi has continuously advanced his knowledge and expertise through various fellowships, including prestigious opportunities at renowned international institutions, shaping his specialization in organic and natural product chemistry.

Experience 

Dr. Arvind Singh Negi boasts over 25 years of research experience in the field of medicinal chemistry. He began his career as a Scientist at ICAR-Indian Grassland and Fodder Research Institute in 1995, moving on to join CSIR-CIMAP in 2000. Over the years, he has progressed through various ranks, becoming a Chief Scientist in 2018. His extensive experience encompasses research and development of natural product-based pharmaceuticals, focusing on cancer therapeutics and organic synthesis. Dr. Negi has also supervised multiple Ph.D. theses and collaborated with national and international researchers, contributing to over 100 research publications. His leadership in the Phytochemistry Division has fostered innovative research projects, enhancing the institute’s reputation in medicinal plant research.

Awards and Honors 

Dr. Negi’s exemplary contributions to science have been recognized through numerous awards and honors. He was awarded the CSIR-JRF and Lectureship in 1991, followed by the ICAR Assistant Professorship in 1994. His research has earned him the Bioorganic & Medicinal Chemistry Most Cited Paper Award three times (2007, 2008, 2010) from Elsevier Press. He has received prestigious fellowships, including the ICS-UNIDO Fellowship in Italy (2008) and the Raman Research Fellowship in the USA (2010). Dr. Negi became a member of the National Academy of Sciences (NASI) in 2013 and was later invited to the Royal Society of Chemistry, achieving Fellow status in 2022. His recognition underscores his significant impact on medicinal chemistry and natural product research.

Research Focus 

Dr. Arvind Singh Negi specializes in medicinal chemistry, with a primary focus on the development of cancer chemotherapeutics. His current research involves designing target-specific molecules to modulate microtubule dynamics, a crucial aspect of cancer treatment. By harnessing the therapeutic potential of natural products, he investigates plant-based compounds that exhibit anticancer properties. His work encompasses extensive studies on the chemical and biological profiles of medicinal plants, contributing to the discovery of novel anticancer agents. Dr. Negi’s innovative approaches aim to bridge the gap between traditional knowledge and modern scientific methodologies, making significant strides in the field of phytochemistry. His research not only enhances our understanding of cancer therapeutics but also promotes the exploration of sustainable and effective treatments derived from nature.

Publication Top Notes

  1. Plant-based anticancer molecules: A chemical and biological profile of some important leads 🌱
  2. Antimicrobial potential of Glycyrrhiza glabra roots 🌿
  3. Recent advances in plant hepatoprotectives: a chemical and biological profile of some important leads 🌿
  4. Current status on development of steroids as anticancer agents 💊
  5. Antifungal activity of Glycyrrhiza glabra extracts and its active constituent glabridin 🌿
  6. Gallic acid-based indanone derivatives as anticancer agents 🌿
  7. Synergistic anticandidal activity of pure polyphenol curcumin I in combination with azoles and polyenes generates reactive oxygen species leading to apoptosis 🌿
  8. Natural antitubulin agents: Importance of 3, 4, 5-trimethoxyphenyl fragment 🌱
  9. Synthesis of chalcone derivatives on steroidal framework and their anticancer activities 💊
  10. Synthesis of 1-(3′,4′,5′-trimethoxy) phenyl naphtho[2,1b]furan as a novel anticancer agent 🌱
  11. Plant isoquinoline alkaloids: Advances in the chemistry and biology of berberine 🌱
  12. An insight into medicinal chemistry of anticancer quinoxalines 💊
  13. Antitubercular potential of some semisynthetic analogues of phytol 🌱
  14. Defective in cuticular ridges (DCR) of Arabidopsis thaliana, a gene associated with surface cutin formation, encodes a soluble diacylglycerol acyltransferase 🌱
  15. Nutritive evaluation of some nitrogen and non-nitrogen fixing multipurpose tree species 🌳
  16. Antiproliferative and antioxidant activities of Juglans regia fruit extracts 🌰
  17. Synthesis of pharmacologically important naphthoquinones and anticancer activity of 2-benzyllawsone through DNA topoisomerase-II inhibition 💊
  18. A bioactive labdane diterpenoid from Curcuma amada and its semisynthetic analogues as antitubercular agents 🌿
  19. Anticancer activity and toxicity profiles of 2-benzylidene indanone lead molecule 💊
  20. A promising anticancer and antimalarial component from the leaves of Bidens pilosa 🌿

Conclusion

Dr. Arvind Singh Negi is an exemplary candidate for the Outstanding Scientist Award. His pioneering work in medicinal chemistry, along with his dedication to advancing cancer therapeutics through innovative research, positions him as a leader in the field. With strategic enhancements in collaboration and outreach, his impact could extend even further, benefiting both scientific communities and public health.

 

 

Yuan Ma | Cell Death Pathway | Best Researcher Award

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Prof Yuan Ma | Cell Death Pathway | Best Researcher Award

Prof Yuan Ma , Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Nanjing Medical University , China

Yuan Ma is a prominent Professor in the Department of Respiratory and Critical Care Medicine at The First Affiliated Hospital of Nanjing Medical University, China. With a medical background and a focus on bronchial asthma, Dr. Ma has made significant contributions to understanding the mechanisms of airway inflammation and remodeling. Through extensive research, he aims to identify novel molecular targets for asthma therapies. His work has been recognized internationally, underscoring his dedication to advancing clinical applications in respiratory medicine.

Publication Profile

Scopus

Strengths for the Award

  1. Extensive Research Experience: Yuan Ma has a robust academic background as a Professor in Respiratory and Critical Care Medicine. His focus on airway inflammation and remodeling in asthma is critical, given the increasing prevalence of respiratory diseases.
  2. Publication Record: With 25 articles in domestic journals and 13 in international journals, his publication record demonstrates both local and global recognition of his work. Notable articles in high-impact journals underscore the significance and relevance of his research.
  3. Innovative Contributions: Ma’s identification of necroptosis-related targets in asthma and the discovery of potential therapeutic compounds indicate significant advancements in the understanding and treatment of asthma, contributing to both academic knowledge and clinical practice.
  4. Grant Funding: Successfully presiding over projects funded by the National Natural Science Foundation of China highlights his ability to secure funding for impactful research, a crucial aspect of a successful research career.
  5. Patents: The issuance of 13 patents illustrates his innovative capacity and the potential for practical applications of his research findings.

Areas for Improvement

  1. Broader Collaborations: While Ma has made significant contributions, fostering collaborations with researchers from diverse fields could enhance interdisciplinary insights and expand the impact of his work.
  2. Professional Memberships: Engaging in professional organizations could provide networking opportunities and enhance visibility in the research community, further strengthening his position.
  3. Public Outreach: Increasing public engagement and dissemination of research findings could elevate awareness about asthma and his innovations, potentially leading to broader societal impact.

Education 

Dr. Yuan Ma obtained his medical degree from a prestigious institution, followed by specialized training in respiratory medicine. He completed his PhD with a focus on airway diseases, where he gained insights into the cellular and molecular mechanisms underlying asthma. Throughout his academic journey, Dr. Ma has cultivated a robust foundation in both clinical practice and research methodology, allowing him to bridge the gap between laboratory findings and patient care. His continuous pursuit of knowledge in respiratory health has led him to engage in various professional development opportunities, enhancing his expertise and contributing to his role as a leader in his field.

Experience 

Dr. Yuan Ma has extensive experience in both clinical and research settings, spanning over a decade. He has presided over significant research projects funded by the National Natural Science Foundation of China, exploring the pathogenesis of asthma and potential therapeutic interventions. His impressive track record includes 25 publications in national journals and 13 in international peer-reviewed journals, showcasing his commitment to advancing respiratory medicine. As a professor, he mentors medical students and residents, fostering the next generation of researchers and clinicians. His collaborative work with national and international peers has enriched his research, contributing to innovative approaches in asthma treatment. Additionally, his contributions to patent development demonstrate his drive to translate research findings into practical applications for better patient outcomes.

Research Focus 

Dr. Yuan Ma’s research primarily focuses on the mechanisms of airway inflammation and remodeling in bronchial asthma. He investigates necroptosis-related biomarkers and their regulatory mechanisms, aiming to identify novel therapeutic targets. His work encompasses exploring molecular compounds that can effectively modulate these targets, enhancing asthma diagnosis and treatment options. Dr. Ma’s innovative studies delve into the role of oxidative stress and MAPK signaling pathways in airway smooth muscle cell behavior. By examining the intricate interactions within the airway microenvironment, he seeks to uncover underlying processes that contribute to asthma exacerbations. His research has significant implications for developing targeted therapies, addressing the unmet needs of asthma patients, and ultimately improving clinical outcomes in respiratory medicine.

Publications Top Notes

  1. Screening, identification and targeted intervention of necroptotic biomarkers of asthma. 📄
  2. Caffeic acid phenethyl ester alleviates asthma by regulating the airway microenvironment via the ROS-responsive MAPK/Akt pathway. 🌱
  3. Morin Attenuates Ovalbumin-induced Airway Inflammation by Modulating Oxidative Stress-responsive MAPK Signaling. 🩺
  4. A case of male primary pulmonary choriocarcinoma. 🦠
  5. Implication of dendritic cells in lung diseases: immunological role of Toll-like receptor 4. 🔬
  6. Glomus tumors of the trachea: 2 case reports and a review of the literature. 📚
  7. Diosmetin prevents TGF-β1-induced epithelial-mesenchymal transition via ROS/MAPK signaling pathways. 🧬
  8. SARS-CoV-2 in the pancreas and the impaired islet function in COVID-19 patients. 🦠
  9. Characteristics of H7N9 avian influenza pneumonia: a retrospective analysis of 17 cases. 📊
  10. Galangin attenuates airway remodeling by inhibiting TGF-β1-mediated ROS generation and MAPK/Akt phosphorylation in asthma. 🌿
  11. Melatonin modulates airway smooth muscle cell phenotype by targeting the STAT3/Akt/GSK-3β pathway in experimental asthma. 🌙
  12. Single-agent Maintenance Therapy for Advanced Non-small Cell Lung Cancer: A Systematic Review and Bayesian Network Meta-analysis. 🧑‍⚕️
  13. Effect of diosmetin on airway remodeling in a murine model of chronic asthma. 🐭

Conclusion

Yuan Ma’s exceptional research contributions in understanding and treating asthma position him as a strong candidate for the Best Researcher Award. His extensive publication record, innovative findings, and successful grant applications reflect a commitment to advancing respiratory medicine. Addressing areas for improvement could further enhance his profile and influence in the field. Overall, Ma’s achievements warrant recognition, and he is well-suited for this prestigious award.