University of Medicine and Pharmacy Iuliu Hatieganu Cluj-Napoca | Romania
Ioan Tomuță is a leading researcher in pharmaceutical technology with extensive expertise in the design, development, and optimization of modern dosage forms. His work focuses on understanding the physicochemical and mechanical properties of active substances and excipients, their processing behavior, and their influence on drug release kinetics and bioavailability. He has made significant contributions to advanced drug delivery systems, including liposomes, nanoparticles, polymeric films, and gastroretentive drug delivery platforms produced through 3D printing. His research also advances the use of NIR spectroscopy, chemometrics, and Quality-by-Design principles for pharmaceutical development and process analytical control. He has played key roles in national and European research projects involving process engineering, tissue regeneration technologies, and artificial intelligence–based prediction tools for 3D-printable medicines. His work spans formulation science, process optimization, GMP-oriented industrial applications, and innovation in personalized medicine manufacturing technologies.
Featured Publications:
Savencu, I., Iurian, S., Porfire, A., Bogdan, C., & Tomuță, I. (2021). Review of advances in polymeric wound dressing films. Reactive and Functional Polymers, 168, 105059.
Ilyés, K., Kovács, N. K., Balogh, A., Borbás, E., Farkas, B., Casian, T., Marosi, G., … & Tomuță, I. (2019). The applicability of pharmaceutical polymeric blends for the fused deposition modelling (FDM) 3D technique: Material considerations, printability, process modulation, with particular interest in additive manufacturing applications. European Journal of Pharmaceutical Sciences, 129, 110–123.
Tefas, L. R., Sylvester, B., Tomuță, I., Sesarman, A., Licarete, E., Banciu, M., … & Porfire, A. (2017). Development of antiproliferative long-circulating liposomes co-encapsulating doxorubicin and curcumin through the use of a quality-by-design approach. Drug Design, Development and Therapy, 1605–1621.
Tefas, L. R., Tomuță, I., Achim, M., & Vlase, L. (2015). Development and optimization of quercetin-loaded PLGA nanoparticles by experimental design. Clujul Medical, 88(2), 214.
Barbalata, C. I., Tefas, L. R., Achim, M., Tomuță, I., & Porfire, A. S. (2020). Statins in risk-reduction and treatment of cancer. World Journal of Clinical Oncology, 11(8), 573.
Bogdan, C., Iurian, S., Tomuță, I., & Moldovan, M. (2017). Improvement of skin condition in striae distensae: Development, characterization and clinical efficacy of a cosmetic product containing Punica granatum seed oil and Croton lechleri resin extract. Drug Design, Development and Therapy, 521–531.
Rusu, M. E., Gheldiu, A. M., Mocan, A., Moldovan, C., Popa, D. S., Tomuță, I., … & Vlase, L. (2018). Process optimization for improved phenolic compounds recovery from walnut (Juglans regia L.) septum: Phytochemical profile and biological activities. Molecules, 23(11), 2814.
Colobatiu, L., Gavan, A., Potarniche, A. V., Rus, V., Diaconeasa, Z., Mocan, A., … & Tomuță, I. (2019). Evaluation of bioactive compounds-loaded chitosan films as a novel and potential diabetic wound dressing material. Reactive and Functional Polymers, 145, 104369.
Rusu, M. E., Fizeșan, I., Pop, A., Gheldiu, A. M., Mocan, A., Crișan, G., Vlase, L., … & Tomuță, I. (2019). Enhanced recovery of antioxidant compounds from hazelnut (Corylus avellana L.) involucre based on extraction optimization: Phytochemical profile and antioxidant activity. Antioxidants, 8(10), 460