Chenlong YANG | Cancer Cell Biology | Best Researcher Award

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Prof. Chenlong YANG | Cancer Cell Biology | Best Researcher Award

Prof. Chenlong YANG, Peking University Third Hospital, China

Dr. Chenlong Yang, M.D., Ph.D., is an accomplished neurosurgeon and research associate professor at the Department of Neurosurgery, Peking University Third Hospital. With over 15 years of clinical and research experience, he specializes in neuro-oncology, spinal neurosurgery, and translational neuroscience. Dr. Yang earned his M.D. from Shandong University and his Ph.D. in Neurological Surgery from Capital Medical University. He has trained and worked in prestigious institutions including Beijing Tiantan Hospital and the State Key Laboratory of Vascular Homeostasis and Remodeling. He has contributed significantly to advancements in brain tumor diagnostics, neuroimmunology, and surgical innovations, with numerous high-impact publications. Recognized internationally, he frequently presents at top neurosurgical conferences such as EANS and the Japan-China Neurosurgery Alliance. His research bridges basic science and clinical neurosurgery, aiming to improve surgical precision and therapeutic outcomes. Dr. Yang is also known for his leadership in collaborative, multidisciplinary research teams.

Publication Profile: 

Google Scholar

✅ Strengths for the Award:

  1. 📚 Robust Academic and Clinical Training

    • Earned an M.D. from Shandong University and a Ph.D. in Neurological Surgery from Capital Medical University.

    • Completed clinical training at Beijing Tiantan Hospital, a top-tier neurosurgical institution in China.

  2. 🔬 Multidisciplinary and Translational Research Excellence

    • His research spans neuro-oncology, neuroimmunology, spinal neurosurgery, and advanced neuroimaging.

    • Conducted preclinical work on Alzheimer’s disease models and neuroprotection, along with current research in immune checkpoint therapy and intraoperative imaging.

  3. 📈 High-Impact Publications

    • Over 20 peer-reviewed publications in journals such as Scientific Reports, J Exp Clin Cancer Res, Neurosurgical Review, and Biophysical Journal.

    • His research on chordomas, gliomas, and spinal tumors has significantly contributed to the field.

  4. 🌍 International Recognition

    • Speaker at major international conferences like EANS 2025 and KSNS 2024.

    • Previously awarded a scholarship by the Turkish Neurosurgical Society.

  5. 🤝 Leadership in Collaboration

    • Plays a key role at the Center for Precision Neurosurgery and Oncology and the State Key Laboratory of Vascular Homeostasis and Remodeling, fostering interdisciplinary collaborations across neurosurgery, imaging, and immunotherapy.

  6. 🎯 Focus on Precision and Innovation

    • Pioneering high-resolution MRI techniques, fluorescent intraoperative navigation, and predictive modeling for neurosurgical outcomes.

🔄 Areas for Improvement:

  1. 📊 Independent Research Lead

    • While he has several corresponding author papers, increasing his share of first-author or sole-PI grants would further elevate his research identity.

  2. 🌐 Global Collaborations

    • Though he has spoken at international conferences, expanding collaborative projects with leading global neuroscience centers could amplify impact.

  3. 💡 Technology Commercialization

    • Given his innovation in imaging and diagnostics, pursuing intellectual property rights or translational funding (e.g., for clinical tools or surgical systems) could be a valuable next step.

  4. 📄 Diversification of Research Outputs

    • A few review articles and meta-analyses would strengthen his role as a thought leader and field synthesizer.

📘 Education:

Dr. Yang pursued his foundational medical education at Shandong University, earning an M.D. in Clinical Medicine (2006–2011). This training provided a solid clinical base and early exposure to neurology and internal medicine. He then advanced to a doctoral program at Capital Medical University, Beijing (2011–2017), earning his Ph.D. in Neurological Surgery. During his Ph.D., he received specialized training in neurosurgical techniques and engaged in cutting-edge research, particularly focusing on neuro-oncology and degenerative neural diseases. As part of his early research career, he also worked at the Institute of Neurobiology, Shandong University, investigating neuroprotective agents and Alzheimer’s disease models. Dr. Yang’s academic journey is characterized by rigorous clinical training and scientific inquiry, equipping him with the knowledge and skills essential for bridging the gap between the lab bench and the operating room. His education laid a strong foundation for his future contributions to precision neurosurgery and translational neuroscience.

💼 Experience:

Dr. Yang has over a decade of diversified experience across top medical and research institutions. He currently serves as a Research Associate Professor and Attending Physician at the Department of Neurosurgery, Peking University Third Hospital (2020–present), where he leads several clinical and translational research projects. Prior to this, he completed a postdoctoral fellowship (2017–2020) in the Department of Orthopedics at the same hospital, emphasizing spinal and neuro-oncologic conditions. From 2011 to 2017, he worked as a resident in Neurosurgery at Beijing Tiantan Hospital, one of China’s premier neurosurgical centers, gaining extensive experience in surgical treatments and neurovascular procedures. His roles span clinical surgery, research coordination, and academic instruction. Additionally, he actively contributes to the Center for Precision Neurosurgery and Oncology and the State Key Laboratory of Vascular Homeostasis and Remodeling, leading initiatives to improve patient outcomes through interdisciplinary innovations in neurosurgical care.

🧠 Research Focus:

Dr. Chenlong Yang’s research integrates neurosurgery, oncology, immunology, and biomedical engineering. His primary focus lies in neuro-oncology, with a strong emphasis on chordoma biology, glioma immunotherapy, and molecular diagnostics. He explores immune checkpoint therapies, tumor microenvironment modulation, and the development of predictive models for neurosurgical complications such as postoperative delirium. Dr. Yang is also deeply involved in technological innovation in neurosurgery, investigating intraoperative fluorescence imaging, high-resolution MRI, and minimally invasive spinal techniques. His work on spatial learning, Alzheimer’s models, and neuroprotection during his early career continues to inform his translational research. He collaborates across disciplines, from molecular biologists to radiologists, aiming to build precision-guided therapeutic frameworks. His research is extensively published in journals like Scientific Reports, J Exp Clin Cancer Res, and Frontiers in Neurology. Through this work, Dr. Yang seeks to advance the standard of care in neurosurgical oncology and promote patient-specific interventions.

📚 Publication Top Notes:

  1. 🧬 SMARCB1 orchestrates cellular plasticity and oncogenic pathways in typical and chondroid chordomas

  2. 🛡️ Cracking Chordoma’s Conundrum: Immune Checkpoints Provide a Potential Modality

  3. 🌱 From glioma gloom to immune bloom: unveiling novel immunotherapeutic paradigms – a review

  4. 💡 Intraoperative fluorescence redefining neurosurgical precision

  5. 🧠 The evolution and integration of technology in spinal neurosurgery: A scoping review

  6. 👁️ Single-cell transcriptomic atlas of aging macaque ocular outflow tissues

  7. 🧮 Risk stratification and predictive modeling of postoperative delirium in chronic subdural hematoma

  8. 📶 Characteristic fingerprint spectrum of α-synuclein mutants on terahertz time-domain spectroscopy

  9. 🐒 Normative profile of retinal nerve fiber layer thickness in cynomolgus monkeys

  10. 🌀 Accurate diagnosis and treatment of sacral meningeal cysts using high-resolution MRI

  11. 🧪 Intraspinal hemangioblastomas: analysis of 92 cases in a single institution

🏁 Conclusion:

Dr. Chenlong Yang exemplifies the ideal profile of a cutting-edge clinician-scientist, merging neurosurgical precision with immunological insight and technological innovation. His commitment to patient-centered research, consistent academic output, and recognition on international platforms underscores his eligibility for the Best Researcher Award. With continued growth in independent leadership and global research impact, Dr. Yang is not only a deserving candidate now but is poised to become a prominent global figure in neurosurgical research in the years to come.

Guojie Ji | Cancer Cell Biology | Cancer Cell Biology Award

Published on by Cell Biologist

Mr. Guojie Ji | Cancer Cell Biology | Cancer Cell Biology Award

Mr. Guojie Ji, NORTH HENAN MEDICAL UNIVERSITY, China

Guojie Ji, Master of Medicine Science, is a laboratory technician and the Provincial Director of the Demonstration Center for Biological and Basic Medical Experimental Teaching. With a core research focus on fertility preservation and tumor therapy, he brings an interdisciplinary approach to biomedical science. Ji has played a pivotal role in guiding over 30 research papers and acquiring 13 national patents. In addition to managing over 15 national and provincial projects, his mentorship has led students to win numerous innovation and entrepreneurship awards at both national and provincial levels. Ji is an editorial board member for Contemporary Chemical Research and a peer reviewer for Cell Death Discovery. His leadership and scholarly work have earned him several honors, including being named Outstanding Teacher and Provincial Outstanding Mentor. His recent research delves into ferroptosis in cancer and reproductive toxicity, making impactful contributions to both cancer biology and regenerative medicine.

Publication Profile:

Orcid

✅ Strengths for the Award:

  1. Relevant Research Contributions:

    • Ji has made direct contributions to cancer biology, particularly through:

      • Ferroptosis mechanisms in breast cancer cells (2025, BBRC)

      • 5-Fluorouracil-induced oxidative damage and DNA disruption (2024, Ecotoxicology & Environmental Safety)

      • Exosome impact on melanoma cell growth (2021, Journal of Yangzhou University)

    • These studies reflect deep involvement in molecular mechanisms of cancer cell death, a central theme in cancer cell biology.

  2. Multidisciplinary Integration:

    • Ji’s research spans stem cells, oxidative stress, and reproductive toxicity, all of which tie into cancer research—especially in terms of chemotherapy side effects and regenerative implications.

  3. High Research Output and Recognition:

    • Over 30 peer-reviewed articles, including in high-impact journals such as Cell Death Discovery and BBRC.

    • 13 national patents, indicating applied innovation in biomedical research.

    • Leads national and provincial projects with substantial funding (~¥1 million), showcasing leadership and research management.

  4. Mentorship and Scientific Community Service:

    • Recognized as an Outstanding Innovation Mentor, Editorial Board Member, and Peer Reviewer, reflecting active participation in advancing the field.

    • Mentored award-winning student teams in national competitions, indicating talent cultivation in biomedical research.

⚠️ Areas for Improvement:

  1. Primary Focus Is Fertility & Reproductive Biology:

    • While Ji has notable cancer-related studies, his primary research base lies in fertility preservation. For this award, a broader and more central focus on oncogenic signaling, tumor microenvironments, or immunotherapy might strengthen his profile.

  2. Limited Clinical Cancer Studies:

    • Most cancer work is preclinical or in vitro; integrating clinical collaborations or translational oncology trials could enhance relevance to applied cancer therapy.

Education:

Guojie Ji holds a Master of Medicine Science, with specialized training in biological sciences, biomedical research, and clinical applications in fertility and tumor biology. His academic background includes comprehensive training in cell biology, molecular biology, reproductive medicine, and translational oncology. Through this foundation, he developed a research orientation focused on bridging cell-level discoveries with clinical potential, particularly in the areas of cryopreservation, stem cell differentiation, and tumor cell regulation. Ji’s academic excellence and commitment to research have driven his involvement in interdisciplinary fields, where he combines elements of life sciences and therapeutic innovation. His deep-rooted academic experiences have been critical in enabling his success as a project leader, educator, and recognized biomedical scientist. His education is not just academic but applied, demonstrated by his integration of research into experimental teaching models and training future life scientists.

💼 Experience:

Guojie Ji currently serves as a Laboratory Technician and Provincial Director for a Demonstration Center dedicated to experimental biological and medical teaching. He has led or completed 10+ major national and provincial research projects, along with 5 horizontal interdisciplinary research collaborations, collectively funded with nearly 1 million yuan. Ji’s lab has been instrumental in developing fertility-preservation protocols, studying sperm cryopreservation, and examining cancer cell response to drugs like 5-FU. He has authored over 30 peer-reviewed papers, including key publications in Cell Death Discovery, Ecotoxicology and Environmental Safety, and Biochemical and Biophysical Research Communications. Ji is a mentor to undergraduate innovators, guiding teams to national victories in prestigious competitions. Additionally, he holds editorial and peer-review roles in prominent scientific journals. His work demonstrates strong leadership, scholarly innovation, and an enduring commitment to experimental medical education and biomedical research.

🏆 Awards and Honors:

Guojie Ji’s contributions to research and education have earned him widespread recognition. He has been honored as a Key Teacher, Civilized Teacher, and Outstanding Teacher, along with awards for Outstanding Innovation and Entrepreneurship Mentorship at the provincial level. He has received accolades as Outstanding Supervisor for Bachelor’s Degree Dissertations and Life Sciences Competition Mentor. Ji has successfully supervised student teams winning over 25 awards, including 5 national-level prizes in events such as the Challenge Cup, Internet+, and the National College Life Sciences Competition. These honors reflect his commitment to combining cutting-edge research with student training and public impact. His ability to mentor and lead both in the lab and the classroom has set a benchmark for excellence in academic innovation and practical scientific development. Ji’s holistic excellence makes him a role model in both research mentorship and scientific discovery.

🔬 Research Focus:

Guojie Ji’s research lies at the intersection of fertility preservation, cryobiology, and tumor cell biology. He explores the mechanisms of cell damage, oxidative stress, and DNA integrity during sperm and stem cell preservation, with a growing emphasis on ferroptosis—a regulated form of cell death—in cancer biology. His recent studies demonstrate how agents like 5-Fluorouracil affect cancer cells and male fertility via oxidative and mitochondrial pathways. Ji also investigates mesenchymal stem cell-derived exosomes in tumor growth, highlighting a promising field of cell-free therapies. In plant and animal models, he’s contributed to understanding protein and lipid roles in cell signaling and disease resistance, reinforcing the depth and range of his biomedical expertise. With a diverse research portfolio, Ji aims to translate basic discoveries into therapeutic strategies, particularly targeting tumor suppression and reproductive health. His work continues to expand the molecular understanding of cell survival and death pathways in medicine.

📚 Publications Top Notes:

  1. 🧊 Protective Effect of Sucrose and Antioxidants on Cryopreservation of Sperm Motility and DNA Integrity in C57BL/6 Mice

  2. 💧 Effects of MTG and GSH on Human Sperm Motility and DNA Integrity during Vitrification in the Presence of Trehalose

  3. ❄️ Comparison of Rapid Freezing vs. Vitrification for Human Sperm Cryopreservation Using Sucrose in Closed Straw Systems

  4. 🔍 Studies on Basic Issues Relevant to Sperm Cryopreservation in Humans

  5. 📦 Effects of Exosomes Derived from Mesenchymal Stem Cells on the Growth of Melanoma Cells

  6. 🌱 BMP4 is Insufficient to Differentiate Umbilical Cord MSCs into Germ Cell-like Cells In Vitro

  7. 🧬 Current Status of Male Fertility Preservation in Humans

  8. 🧪 Protein Glycosylation Changes During Systemic Acquired Resistance in Arabidopsis thaliana

  9. 🛡️ Lipid Transfer Proteins in Plant-Pathogen Interactions and Their Molecular Mechanisms

  10. 🔥 Emerging Roles of Ferroptosis in Male Reproductive Diseases

🧾 Conclusion:

Guojie Ji is a strong interdisciplinary researcher with a credible and impactful body of work in cancer cell biology, particularly in the context of ferroptosis, chemotherapy-induced toxicity, and tumor suppression mechanisms. His contributions bridge the fields of cell death, oxidative biology, and reproductive toxicology, offering unique insights into the systemic effects of anti-cancer agents. While cancer is not his sole research domain, his innovative work and translational potential clearly qualify him as a compelling nominee for the Research for Cancer Cell Biology Award—particularly in molecular cancer mechanisms and therapeutic research.