Dmytro Maltsev | Gene Regulation Epigenetics | Best Review Paper Award

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Mr. Dmytro Maltsev | Gene Regulation Epigenetics | Best Review Paper Award

Mr. Dmytro Maltsev , O’Bogomolets National Medical University , Ukraine

Dr. Dmytro Maltsev is a Ukrainian neuroimmunologist, physician-scientist, and clinical researcher with a PhD in medicine. He serves as the head of the Laboratory of Immunology and Molecular Biology at the Research Institute of Experimental and Clinical Medicine, O’Bogomolets National Medical University, Kyiv. His extensive body of work spans neuroimmunology, autoimmune encephalitis, herpesvirus infections, and immune deficiencies. He is the author of 29 books and over 340 scientific papers, with 50 indexed in Scopus. His work has earned several prestigious awards, including recognition from the National Academy of Sciences of Ukraine and international congresses. He actively collaborates with institutions like the Mayo Clinic (USA) and the Institute of Neurosurgery (Ukraine). Dr. Maltsev is a member of multiple professional societies, including the European Academy of Neurology. His groundbreaking GBINS protocol for autistic spectrum disorder highlights his contributions to precision medicine and multidisciplinary approaches in neuropsychiatric care.

Publication Profile: 

Orcid

✅ Strengths for the Award:

  1. Pioneering Work:
    Dr. Maltsev’s systematic review on herpesviral encephalitis presents a groundbreaking clinic-radiological classification, offering a unifying framework that enhances clinical diagnostics and therapeutic planning.

  2. Depth and Breadth of Expertise:
    The review showcases deep neuroimmunological insight, drawing from over 340 publications, including 50 in SCOPUS, and extensive experience in both clinical and laboratory settings.

  3. Interdisciplinary Integration:
    He combines advanced techniques—PCR, ELISA, western blot, flow cytometry—with clinical observations, resulting in practical classifications and diagnostic pathways.

  4. Relevance and Timeliness:
    The review addresses a critical gap in understanding viral encephalitides, which are often misdiagnosed or under-reported, contributing to early interventions and improved patient outcomes.

  5. International Collaboration:
    Collaborative ties with the Mayo Clinic (USA) and leading Ukrainian research institutions add credibility and global relevance to his work.

  6. Proven Impact:
    Recognized for prior scientific excellence through national and international awards, including recognition from the National Academy of Sciences of Ukraine and the World Congress of Immunopathology.

🧭 Areas for Improvement:

  1. Editorial Involvement:
    Currently, Dr. Maltsev does not hold editorial roles, which could enhance his influence in shaping the field’s publication standards and peer-review frameworks.

  2. Digital Science Communication:
    Expanding public engagement via open-access formats, social media science explainers, or video summaries would amplify the reach of his reviews beyond academia.

  3. Visual Data Representation:
    While the review is methodically comprehensive, adding infographics, visual summaries, or interactive diagnostic flowcharts could enhance reader accessibility, particularly for multidisciplinary teams.

🎓 Education:

Dr. Dmytro Maltsev pursued his medical education and PhD at O’Bogomolets National Medical University in Kyiv, Ukraine. Early in his academic career, he displayed an interest in immunopathology and clinical biology. His PhD focused on the clinical and immunological aspects of herpesvirus infections and their role in neuroinflammatory diseases. His educational path included specialization in molecular biology techniques such as PCR, ELISA, immunofluorescence, and flow cytometry. His training also incorporated translational research and clinical diagnostics, equipping him with a multidisciplinary approach essential for modern neuroimmunology. With further professional development in clinical immunology and collaboration with international research groups, including the Mayo Clinic, Dr. Maltsev has refined his knowledge in personalized medicine. He actively mentors postgraduate students, and his research findings are frequently integrated into educational materials, including textbooks and monographs used in university-level instruction throughout Ukraine and abroad.

💼 Professional Experience:

Dr. Dmytro Maltsev has over 20 years of professional experience in neuroimmunology and molecular medicine. As the head of the Laboratory of Immunology and Molecular Biology at O’Bogomolets National Medical University, he leads research on immune system dysfunction, neurodevelopmental disorders, and viral neuropathology. His professional journey includes clinical consultancy, authorship of 29 medical books, and over 340 published studies. He has completed 8 major research projects and collaborated on 4 industry-funded studies. Dr. Maltsev also holds 16 patents and actively participates in international scientific communities. His work spans diagnostics, therapy innovation, and personalized medicine, including the creation of GBINS, a treatment framework for children with autism spectrum disorders. Recognized for pioneering work on minor immunodeficiencies and viral encephalitis classifications, he has received multiple national and international awards. Dr. Maltsev collaborates globally with neurologists and immunologists, contributing to consensus guidelines, systematic reviews, and cross-continental case studies.

🔬 Research Focus:

Dr. Maltsev’s research focuses on neuroimmunology, specifically immune-related neurological and psychiatric disorders. He investigates immunodeficiency syndromes, herpesvirus-induced encephalitis, autoimmune epilepsies, and autism spectrum disorders (ASD) associated with folate cycle genetic deficiencies. His work emphasizes personalized, multidisciplinary treatments through laboratory diagnostics like PCR, ELISA, immunoblotting, immunofluorescence, and flow cytometry. A core achievement is the GBINS protocol, offering a targeted therapy model for children with ASD. He also researches immunoglobulin E deficiency and alpha/beta-defensin involvement in oral cancer complications. His aim is to bridge immune dysfunction with neurological pathologies, improving diagnostic accuracy and patient outcomes. By classifying new immune-related diseases and pioneering treatment options, Dr. Maltsev contributes significantly to immunotherapy and neurorehabilitation. He also explores how AI can enhance diagnosis and therapy across various disciplines. His dedication to translational research supports the development of individualized care protocols, with ongoing global collaborations in Europe, the USA, and beyond.

📚 Publication Top Notes:

  1. 🧠 Clinic-radiological classification of herpesviral encephalitis in humans (Systematic review)

  2. 🧬 Integrative concept of pathogenesis and GBINS personalized multidisciplinary approach to ASD in children

  3. 💉 Risk factors for grade III radiation-induced mucositis in oral/oropharyngeal cancer therapy

  4. 🧫 Microbial infections in children with ASD and genetic folate cycle deficiency

  5. 🧪 Primary minor immunodeficiencies as a cause of immune-dependent pathology (Systematic review)

  6. 🌍 Global presence and penetrance of CSF1-related disorder

  7. 💊 Treatment of reactivated EBV, HHV-6, HHV-7 in children with ASD and folate cycle disruption

  8. 🤖 Trends in the use of AI in diagnosis and treatment

  9. 🛡️ Alpha/beta-defensins’ influence on immunity in oral/oropharyngeal cancer

  10. 🌐 Global presence of CSF1R-Related disorder: A multinational case series

🏁 Conclusion:

Dr. Dmytro Maltsev is highly deserving of the Best Review Paper Award for his exemplary scholarly contribution titled:
“Clinic-radiological classification of herpesviral encephalitis in humans (Systematic Review)”, published in the Journal of NeuroVirology (2025).

His work offers clinical utility, theoretical innovation, and a robust, evidence-based approach to a complex neuroinfectious condition. With continued emphasis on global engagement and editorial leadership, Dr. Maltsev is poised to remain a key thought leader in neuroimmunology.

Alexej Abyzov | Gene Regulation Epigenetics | Best Researcher Award

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Dr. Alexej Abyzov | Gene Regulation Epigenetics | Best Researcher Award

Dr. Alexej Abyzov , Mayo Clinic , United States

Dr. Alexej Abyzov is an Associate Professor of Biomedical Informatics at the Mayo College of Medicine and a consultant at the Mayo Clinic’s Department of Quantitative Health Sciences. He is also an adjunct professor at Yale University and a graduate faculty member at the University of Minnesota. Dr. Abyzov’s research focuses on computational biology and bioinformatics, particularly in understanding genomic variability, somatic mosaicism, and the genetic basis of neurodevelopmental disorders. He has made substantial contributions to the study of human genome structure and its impact on health. Dr. Abyzov has led numerous research projects funded by NIH and has published extensively in high-impact journals. He is a respected speaker, having presented at international conferences and workshops. Beyond his research, Dr. Abyzov is involved in mentorship and community service, contributing to education and outreach efforts in science and technology.

Publication Profile:

Google Scholar

Strengths for the Award:

Dr. Alexej Abyzov’s work exemplifies excellence in the field of Biomedical Informatics and Computational Biology. His remarkable research contributions span areas such as genetic variation, neurodevelopment, and the understanding of neuropsychiatric diseases. He has been an integral part of cutting-edge projects like investigating somatic mosaicism in schizophrenia and modeling autism in organoids. His ability to bridge the gap between computational techniques and biological applications is demonstrated in his extensive list of high-impact publications, many of which have been published in top-tier journals like Science and Nature. Furthermore, his leadership role in symposia and collaborations with renowned institutions such as Yale University and the University of Minnesota showcases his influence in the scientific community.

Areas for Improvement:

Although Dr. Abyzov has an impressive track record, expanding the outreach of his work into more interdisciplinary collaborations and ensuring greater engagement with clinical applications could enhance the direct societal impact of his findings. Additionally, increasing public-facing communication of his research could foster more public awareness and policy implications, given the importance of his work in understanding neurodevelopmental and psychiatric disorders

Education:

Dr. Alexej Abyzov holds a Ph.D. in Biomedical Informatics, which laid the foundation for his career in computational biology. He began his academic journey with a focus on bioinformatics, later earning a tenure-track faculty position in 2014 at Mayo College of Medicine. In 2020, he was promoted to Associate Professor in Biomedical Informatics. Dr. Abyzov is also an adjunct professor at Yale University’s Child Study Center, where he continues to collaborate on research projects involving neurodevelopmental disorders. Throughout his academic career, Dr. Abyzov has been involved in shaping educational curricula and mentoring students and researchers, providing opportunities for both hands-on research and professional development. He has served as a graduate faculty member at the University of Minnesota, emphasizing his broad academic influence. His educational background is complemented by ongoing work in the development of new bioinformatics tools and approaches for genomics research.

Experience:

Dr. Alexej Abyzov’s career has been marked by continuous growth and contributions in the field of biomedical informatics. He is currently an Associate Professor at Mayo College of Medicine and a Consultant in the Department of Quantitative Health Sciences at Mayo Clinic. Since 2016, he has also served as an adjunct professor at Yale University and has been a part of the Graduate Faculty at the University of Minnesota. His experience includes supervising summer interns, Ph.D. students, and post-doctoral fellows. Dr. Abyzov’s work in bioinformatics has helped lead groundbreaking studies on somatic mosaicism, genetic mutations, and neurodevelopmental disorders. He has actively participated in a number of international collaborations, including co-chairing a symposium at the Molecular Psychiatry Association and providing consulting services for personalized medicine projects. Through his diverse teaching and research roles, Dr. Abyzov has significantly advanced the field of computational biology and genomics.

Awards and Honors:

Dr. Alexej Abyzov has received numerous accolades throughout his career, reflecting his significant contributions to the field of biomedical informatics. He was elected as a member of the New York Academy of Sciences in 2008, a prestigious recognition for his early career achievements. In 2007, he became a member of The Honor Society of Phi Kappa Phi, acknowledging his academic excellence. Dr. Abyzov was also inducted into the International Society for Computational Biology (ISCB) in 2005, further solidifying his position as a leader in the field of bioinformatics. These recognitions underscore his dedication to advancing scientific knowledge, especially in genomics and computational biology. Dr. Abyzov’s honors serve as a testament to his ability to drive meaningful research, collaborate with other leading scientists, and contribute to educational initiatives, all while maintaining a strong commitment to community outreach and mentorship.

Research Focus:

Dr. Alexej Abyzov’s research focuses on bioinformatics, computational biology, and human genomics, with an emphasis on understanding the role of genetic and somatic mutations in health and disease. His work has greatly advanced the understanding of somatic mosaicism, particularly in neurodevelopmental disorders like autism spectrum disorder and Tourette syndrome. He is also deeply involved in exploring the molecular mechanisms behind genetic mutations in the brain, investigating how these mutations may contribute to mental health disorders such as schizophrenia. Dr. Abyzov is known for developing innovative tools and methodologies for analyzing large-scale genomic data, including CNVpytor and CRISPR-Cas editing. His research also explores transgenerational transmission of mutations, revealing insights into how genetic variations are passed down through generations. By combining computational biology with experimental data, Dr. Abyzov’s work provides critical insights into the genetic basis of complex diseases, offering potential pathways for personalized medicine and targeted treatments.

Publications Top Notes:

  1. Interneuron loss and microglia activation in Tourette disorder 🔬🧠 (2025)

  2. Transgenerational transmission of post-zygotic mutations in human germline 🔬👶🧬 (2024)

  3. Somatic mosaicism in schizophrenia reveals prenatal mutational processes 🧠🧬 (2024)

  4. Genome-wide analysis of copy number with CNVpytor in igv.js 💻📊 (2024)

  5. Resolving the 22q11.2 deletion with CTLR-Seq 🧬🔍 (2024)

  6. Characterization of enhancer activity using MPRA and forebrain organoids 🧬🔬 (2024)

  7. Genomic resources of the Brain Somatic Mosaicism Network for neuropsychiatric diseases 🧠🧬 (2023)

  8. Modeling idiopathic autism in forebrain organoids reveals imbalances in excitatory neurons 👶🧠 (2023)

  9. Clonally Selected Lines After CRISPR-Cas Editing Are Not Isogenic 🧬⚙️ (2023)

  10. Efficient reconstruction of cell lineage trees for cancer and cell ancestry 🧬🧪 (2023)

Conclusion:

Dr. Alexej Abyzov is an ideal candidate for the Research for Best Researcher Award due to his profound contributions to the understanding of genetic and somatic variation, his leadership in major collaborative research efforts, and his ongoing influence in shaping the field of Biomedical Informatics. His ongoing work and future potential make him a standout figure for this prestigious recognition.