Erna Van Niekerk | Spinal Cord Injury | Best Researcher Award

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Dr. Erna Van Niekerk | Spinal Cord Injury | Best Researcher Award

University of California San Diego | United States

Dr. Erna A. Van Niekerk’s research focuses on advancing central nervous system (CNS) repair through the integration of molecular neuroscience, artificial intelligence, and translational neurobiology. Her work emphasizes uncovering molecular and cellular mechanisms that drive neural regeneration and developing innovative therapeutic strategies to promote recovery after CNS injury. With a strong background in physiology and neuroscience, she has contributed to understanding neuroplasticity, neural signaling pathways, and the molecular determinants of axonal growth and synaptic repair. Dr. Van Niekerk’s recent research explores computational and AI-based models to analyze large-scale neurobiological datasets, aiming to predict regenerative outcomes and optimize therapeutic targets. Her interdisciplinary approach bridges fundamental neuroscience with clinical applications, particularly in the development of bioengineered and data-driven interventions for neurodegenerative diseases and traumatic brain or spinal cord injuries. Through her academic and industry experience, she has contributed to translational research efforts aimed at improving functional outcomes following neural damage and enhancing the precision of therapeutic design in neuroregeneration.

Profiles: Google Scholar | Scopus

Featured Publications:

Zahavi, E. E., Koppel, I., Kawaguchi, R., Oses-Prieto, J. A., Briner, A., Monavarfeshani, A., Dalla Costa, I., van Niekerk, E., Lee, J., Matoo, S., Hegarty, S., Donahue, R. J., Sahoo, P. K., Ben-Dor, S., Feldmesser, E., Ryvkin, J., Leshkowitz, D., Ben-Tov Perry, R., Cheng, Y., … Fainzilber, M. (2025). Repeat-element RNAs integrate a neuronal growth circuit. Cell. Advance online publication.

van Niekerk, E., Kawaguchi, R., Marques de Freria, C., Groeniger, K., Marchetto, M. C., Dupraz, S., Bradke, F., Geschwind, D. H., Gage, F. H., & Tuszynski, M. H. (2022). Methods for culturing adult CNS neurons reveal a CNS conditioning effect. Cell Reports Methods, 2, 100255. 5

de Freria, C. M., van Niekerk, E., Blesch, A., & Lu, P. (2022). Neural stem cells: Promoting axonal regeneration and spinal cord connectivity. Cells, 10(12), 3296.

Poplawski, G. H. D., Kawaguchi, R., van Niekerk, E., Lu, P., Mehta, N., Canete, P., Lie, R., Dragatsis, I., Meves, J. M., Zheng, B., Coppola, G., & Tuszynski, M. H. (2020). Injured adult neurons regress to an embryonic transcriptional growth state. Nature, 581(7806), 77–82.

Wang, W., van Niekerk, E. A., Zhang, Y., Du, L., Ji, X., Wang, S., & Baker, D. E. (2007). Extracellular stimuli specifically regulate localized levels of individual neuronal mRNAs. The Journal of Cell Biology, 178(6), 965–980.

van Niekerk, E. A., Willis, D. E., Chang, J. H., Reumann, K., Heise, T., & Twiss, J. L. (2007). Sumoylation in axons triggers retrograde transport of the RNA-binding protein La. Proceedings of the National Academy of Sciences, 104(31), 12913–12918. https://doi.org/10.1073/pnas.0705488104

Wang, W., van Niekerk, E., Willis, D. E., & Twiss, J. L. (2007). RNA transport and localized protein synthesis in neurological disorders and neural repair. Developmental Neurobiology, 67(9), 1166–1182.

van Niekerk, E. A., Tuszynski, M. H., Lu, P., & Dulin, J. N. (2016). Molecular and cellular mechanisms of axonal regeneration after spinal cord injury. Molecular & Cellular Proteomics, 15(2), 394–408.

Geraldine Zimmer-Bensch | Neuroepigenetics | Best Researcher Award

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Prof. Geraldine Zimmer-Bensch | Neuroepigenetics | Best Researcher Award

Prof. Geraldine Zimmer-Bensch | RWTH Aachen University | Germany

Prof. Dr. Geraldine Zimmer-Bensch is a distinguished neuroepigeneticist at RWTH Aachen University, Germany. With over two decades of academic and research excellence, she has significantly contributed to understanding how epigenetic mechanisms influence brain development and disorders. Her research spans neuronal migration, cortical circuit formation, and neurodevelopmental diseases. She earned her PhD under Prof. Jürgen Bolz in Jena, followed by impactful postdoctoral stints, including one with Prof. Roberto Lent in Rio de Janeiro. As an editor for high-impact journals and collaborator on international projects, she remains a key voice in neuroepigenetics. Prof. Zimmer-Bensch’s research not only advances fundamental neuroscience but also provides translational insights into conditions such as schizophrenia and neurodegeneration. Through interdisciplinary approaches and global collaborations, she exemplifies academic leadership and innovation in modern neuroscience.

Publication Profiles: 

Google Scholar 
Orcid

Education:

Prof. Geraldine Zimmer-Bensch began her academic journey with a diploma in Biology from the University of Jena. She pursued her PhD in Neurobiology at the same institution under the mentorship of Prof. Jürgen Bolz. Her doctoral research focused on molecular and cellular mechanisms guiding interneuron development. She then expanded her training with postdoctoral research in neurodevelopment at the University of Jena and the Federal University of Rio de Janeiro under Prof. Roberto Lent, exploring neural migration and guidance cues in developing brain structures. This robust educational background laid the foundation for her expertise in epigenetics and neurodevelopment. Her interdisciplinary education across molecular biology, neuroanatomy, and epigenetics equips her to address complex neuroscientific questions at the intersection of genomics and brain function, contributing to groundbreaking insights into brain evolution, neural plasticity, and neuropsychiatric disorders.

Experience:

Prof. Dr. Zimmer-Bensch has held a professorship in Neuroepigenetics at RWTH Aachen University. Prior to this, she led a research group at the Institute of Human Genetics, University Hospital Jena, where she conducted seminal research on epigenetic mechanisms in neuronal development. Her postdoctoral experience includes prestigious positions in Jena and Brazil, where she worked with leading scientists on neural migration and brain structure formation. She is currently involved in several interdisciplinary collaborations across Europe and Asia, including research on brain-gut interactions, electrophysiology, microscopy, and computational modeling. As Editor-in-Chief of Neurogenetics and topic editor for multiple high-impact journals, she actively shapes scientific discourse in her field. Her mentoring, leadership, and ability to integrate cross-disciplinary methodologies make her a standout scientist in neuroepigenetics. Her work bridges basic and translational neuroscience, with applications in understanding developmental disorders, psychiatric conditions, and age-related cognitive decline.

Research Focus:

Prof. Zimmer-Bensch’s research centers on the epigenetic regulation of brain development and function, particularly focusing on cortical interneuron migration, neuronal integration, and circuit maturation. She investigates how DNA methylation and histone modifications orchestrate the formation and plasticity of cortical networks, with a special focus on DNMT1’s non-canonical roles. Her studies reveal how disruptions in epigenetic control mechanisms may lead to neurodevelopmental disorders, psychiatric conditions, and neurodegeneration. Recent projects explore the brain-gut axis in anxiety, sex-specific epigenetic vulnerabilities, and computational models of synaptic regulation. Utilizing cutting-edge tools like microfluidics, microscopy, molecular simulations, and electrophysiology, her work is highly interdisciplinary. Through collaborations with institutions across Germany, France, Switzerland, Japan, and India, her lab contributes to both mechanistic insights and potential therapeutic pathways for brain diseases. Her future research aims to integrate multi-omics approaches to uncover novel targets for neuropsychiatric and neurodegenerative therapies.

Publications Top Notes: 

  1. A hereditary spastic paraplegia mouse model supports a role of ZFYVE26/SPASTIZIN for the endolysosomal system – PLoS Genetics

  2. Emerging roles of long non-coding RNAs as drivers of brain evolution – Cells

  3. Ephrin‐A5 acts as a repulsive cue for migrating cortical interneurons – European Journal of Neuroscience

  4. A spastic paraplegia mouse model reveals REEP1-dependent ER shaping – The Journal of Clinical Investigation

  5. The epigenome in neurodevelopmental disorders – Frontiers in Neuroscience

  6. Bidirectional ephrinB3/EphA4 signaling mediates interneuron segregation in the migratory stream – Journal of Neuroscience

  7. Chondroitin sulfate and semaphorin 3A guide tangential interneuron migration – Cerebral Cortex

  8. Ephrins guide migrating cortical interneurons in the basal telencephalon – Cell Adhesion & Migration

  9. EphA/ephrin A reverse signaling promotes migration of cortical interneurons – Development

  10. Multiple effects of ephrin-A5 on cortical neurons mediated by SRC kinases – Journal of Neuroscience

Conclusion:

Prof. Dr. Geraldine Zimmer-Bensch is an exceptional researcher with a consistent record of high-impact contributions to neuroscience and epigenetics. Her ability to conduct pioneering research, lead international collaborations, and steer academic publishing speaks volumes about her expertise and influence. While there is scope for expanding into translational domains, her foundational work has laid critical groundwork for future therapeutic strategies in neurodevelopmental and neuropsychiatric disorders. Given her scientific rigor, leadership, and international collaborations, she is eminently suitable for the Best Researcher Award. Recognizing her achievements would not only honor her individual excellence but also spotlight the growing importance of neuroepigenetics in contemporary biomedical science.

Eunhee Lee | Neuronal Cell Biology | Best Research Article Award

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Dr. Eunhee Lee | Neuronal Cell Biology | Best Research Article Award

Dr. Eunhee Lee, Daegu Gyeongbuk Medical Innovation Foundation, K-MEDI hub, South Korea

Dr. Eun-Hee Lee, Ph.D., is a distinguished biomedical researcher with expertise in therapeutic ultrasound and neurobiology. Currently serving as Senior Researcher and Head of the Advanced Technology Department at the Medical Device Development Center, DGMIF, South Korea, she has consistently contributed to the advancement of focused ultrasound applications in neurological disorders. With over a decade of research experience spanning government institutions and clinical collaborations, Dr. Lee has published extensively in peer-reviewed journals on brain delivery mechanisms, neuroinflammation, and neurodegeneration. Her pioneering studies have deepened our understanding of the blood-brain barrier and the therapeutic potential of ultrasound. Her work stands at the forefront of translational neuroscience, aiming to enhance drug delivery and brain repair mechanisms. Dr. Lee’s dedication to impactful and clinically relevant research makes her a strong contender for the Best Research Article Award.

Publication Profile: 

Scopus

✅ Strengths for the Award

  1. Innovative Research Focus:
    Dr. Lee’s work on focused ultrasound (FUS)-mediated blood-brain barrier (BBB) disruption is at the cutting edge of neurotherapeutics and non-invasive brain drug delivery. Her investigations hold promise for treating neurodegenerative disorders like Alzheimer’s disease and traumatic brain injuries.

  2. Extensive Peer-Reviewed Publications:
    With over 15 high-quality, peer-reviewed articles published from 2019 to 2024 in reputable journals like Scientific Reports, Frontiers in Neuroscience, and Biomedicines, her research output reflects consistent and impactful contributions.

  3. Interdisciplinary Approach:
    Her integration of biomedical engineering, imaging, and neurobiology enhances the translational value of her findings. Numerical modeling and simulation studies further strengthen the clinical feasibility of her techniques.

  4. Clinical and Preclinical Impact:
    Dr. Lee’s work bridges preclinical models (rats, skull simulations) with potential human applications, offering real translational pathways for drug delivery across the BBB.

  5. Leadership and Collaboration:
    As the Head of the Advanced Technology Department at DGMIF, she demonstrates leadership in medical innovation and fosters collaboration between academia, hospitals, and research institutes.

⚠️ Areas for Improvement

  1. Greater International Collaboration:
    While her work is deeply embedded in Korean institutions, expanding partnerships internationally could amplify her research reach and global influence.

  2. Clinical Trial Transition:
    Much of her published work is preclinical. Advancing to clinical trials or human pilot studies would significantly increase the translational impact of her findings.

  3. Public Engagement and Visibility:
    Enhanced visibility through global neuroscience or biomedical engineering conferences could further validate and showcase her research excellence.

🎓 Education:

Dr. Eun-Hee Lee received all her academic training from Chonnam National University, Kwangju, South Korea. She earned her Ph.D. (2007–2010) and M.S. (2005–2007) in Biological Sciences and Technology, gaining extensive knowledge in cellular and molecular biology. Her B.S. in Genetic Engineering (2001–2005) laid the groundwork for her interest in biomedical innovations and neurogenetics. During her graduate and doctoral studies, she focused on cellular pathways and gene expression relevant to neurodegenerative diseases and molecular interventions. Her academic journey shaped her multidisciplinary perspective, merging genetics, bioengineering, and neurobiology. These foundations have enabled her to pursue cutting-edge research on the blood-brain barrier, drug delivery systems, and brain stimulation. Dr. Lee’s strong academic background provides her with the theoretical and technical expertise essential for high-impact research.

🧪 Experience:

Dr. Eun-Hee Lee has more than 14 years of progressive research experience. Since 2017, she has led the Advanced Technology Department at DGMIF, where she develops novel medical devices using therapeutic ultrasound. Prior to this, she worked as a Research Scientist at the Korea Atomic Energy Institute’s Advanced Radiation Technology Institute (2015–2017), where she explored radiation-mediated biological responses. Between 2013 and 2015, she contributed to TB and molecular microbiology research at the Korean Institute of Tuberculosis. Her postdoctoral fellowship (2011–2012) at the NIH’s Division of HIV/AIDS and Tumor Viruses expanded her expertise into virology and immunopathology. Dr. Lee’s multidisciplinary roles across leading institutions demonstrate her adaptability, leadership, and commitment to translational science. Her professional trajectory shows strong contributions to national research priorities in healthcare and medical technology.

🔬 Research Focus:

Dr. Eun-Hee Lee’s research centers on focused ultrasound (FUS) as a non-invasive modality for drug delivery and neural repair. Her work explores ultrasound-mediated blood-brain barrier (BBB) disruption to enhance targeted therapeutic access to the brain. She also investigates ultrasound stimulation’s effects on neurogenesis, neuroinflammation, and neuroprotection in various neurological models including Alzheimer’s disease and spinal cord injury. Another significant area of focus includes numerical modeling of skull structures to improve the precision of transcranial FUS applications. Through collaborations with clinicians and physicists, Dr. Lee has produced evidence-based methodologies for safer, more effective BBB modulation. Her integrative approach, combining bioengineering, neuroimmunology, and computational simulation, is impactful in the field of therapeutic neuromodulation and has implications for treating neurodegenerative and cerebrovascular disorders.

📚 Publications Top Notes: 

  • 🧠 Numerical Investigation of Layered Homogeneous Skull Model for Simulations of Transcranial Focused Ultrasound (2024)

  • 🔥 The New Insight into the Inflammatory Response Following Focused Ultrasound-Mediated Blood-Brain Barrier Disruption (2022)

  • 🧪 Methylene Blue Delivery via Focused Ultrasound Reduces Neural Damage and Amyloid-Beta by AQP-4 Upregulation (2022)

  • 🐀 Novel Animal Model of Spontaneous Cerebral Petechial Hemorrhage Using Focused Ultrasound in Rats (2022)

  • ♻️ Ultrasound Stimulation Improves Inflammation Resolution and Functional Recovery After Spinal Cord Injury (2022)

  • 🚑 Relationship Between Treatment Types and BBB Disruption in Acute Ischemic Stroke: Two Case Reports (2022)

  • 🧲 Effects of Transducer Displacement on Focused Ultrasound in the Rat Brain (2022)

  • 📉 BBB Disruption After Syncope: A DCE-MRI Case Report (2021)

  • 🧪 Verification of BBB Disruption Using Rat Model with Human Skull (2021)

  • 💧 Localized Water Molecule Transport Modulation Post-FUS BBB Disruption (2021)

  • 🚨 DCE-MRI for Evaluating BBB Disruption in Traumatic Brain Injury: Review (2021)

  • 🧬 TREM2 Promotes Natural Killer Cell Development in pNK Cells (2021)

  • 🌿 Gintonin Enhances Donepezil Brain Delivery via LPA and VEGF Receptors (2021)

  • 🔄 Cyclophilin A is a Ligand for TREM2 in Myeloid Cells (2021)

  • 🧠 Local Differences in BBB Permeability Induced by Focused Ultrasound (2020)

  • 💉 Advanced FUS Protocol Improves Doxorubicin Delivery in Rat Brain (2019)

  • 🔄 FUS-Induced Diminished P-glycoprotein via JNK Pathway in Cerebral Vessels (2019)

🧾 Conclusion:

Dr. Eun-Hee Lee is a highly suitable candidate for the Best Research Article Award. Her work is scientifically rigorous, clinically relevant, and methodologically innovative. The focus on ultrasound-mediated drug delivery through the BBB is a transformative area in neuroscience and drug delivery technology. Her comprehensive research output, leadership, and translational potential strongly position her among top contenders for recognition. Encouraging clinical application and broader dissemination will only enhance the already substantial value of her contributions.