Chalton Manengu | Cerebral Ischemia-Reperfusion | Innovative Research Award

Published on by Cell Biologist

Innovative Research Award

Chalton Manengu
Southwest University, China

Chalton Manengu
Affiliation Southwest University
Country China
Scopus ID 59130694500
Documents 2
Citations 18
h-index 2
Subject Area Cerebral Ischemia-Reperfusion
Event World Cell Biologist Awards
ORCID 0000-0003-3535-9892

Chalton Manengu is a researcher affiliated with Southwest University, China, whose documented scholarly profile includes research activity in the area of cerebral ischemia-reperfusion. The research profile records 2 documents, 18 citations, and an h-index of 2 in the supplied Scopus-indexed record. These indicators provide a bibliometric context for evaluating the researcher’s scholarly contribution and emerging research impact. [1]

Abstract

The Innovative Research Award profile for Chalton Manengu recognizes an emerging research record associated with Southwest University and the scientific field of cerebral ischemia-reperfusion. Cerebral ischemia-reperfusion research examines the biological consequences of restoring blood flow following an ischemic event and encompasses molecular, cellular, physiological, and therapeutic dimensions. Reperfusion is essential for tissue recovery but may also initiate secondary cellular and inflammatory processes that influence neurological outcomes. [2]

Keywords

Cerebral ischemia-reperfusion, ischemic brain injury, reperfusion injury, neuroprotection, cellular mechanisms, oxidative stress, neuroinflammation, cell biology, translational neuroscience, Innovative Research Award, Southwest University, Chalton Manengu.

Introduction

Cerebral ischemia-reperfusion is a complex biological process in which restoration of cerebral blood flow after ischemia can produce both beneficial and adverse effects. Although reperfusion is necessary to restore oxygen and nutrient delivery, the transition from ischemia to reperfusion can involve oxidative stress, inflammatory signaling, mitochondrial dysfunction, blood-brain barrier disruption, and neuronal injury. These processes have made ischemia-reperfusion an important area of investigation in neuroscience and cellular biology. [2] [3]

Research Profile

The supplied researcher information places Chalton Manengu at Southwest University in China and identifies cerebral ischemia-reperfusion as the principal subject area. The associated Scopus author identifier is 59130694500. The recorded publication metrics are 2 documents, 18 citations, and an h-index of 2. Bibliometric data should be interpreted as indicators of scholarly visibility rather than standalone measures of scientific quality. [1][4]

Research Contributions

The available information supports characterization of the researcher’s contribution primarily through the subject-area focus and documented scholarly record. Cerebral ischemia-reperfusion research has broad relevance to cellular neuroscience because ischemia and subsequent reperfusion can alter redox balance, inflammatory pathways, mitochondrial activity, cellular signaling, and tissue homeostasis. [3] [2]

Publications

The supplied Scopus profile records 2 documents associated with the researcher and 18 citations. Because complete publication titles, journal information, publication years, and DOI identifiers were not supplied in the source data, individual publications are not attributed here without independent bibliographic verification. The Scopus author profile provides the appropriate source for reviewing the indexed publication record. [2] [4]

Research Impact

The supplied bibliometric profile reports 18 citations from 2 documents and an h-index of 2. These figures indicate that the indexed work has received measurable scholarly attention. Citation counts, however, vary according to database coverage, publication age, field-specific citation practices, and indexing differences. They should therefore be considered alongside qualitative evidence of originality, methodological quality, scientific influence, and reproducibility. [1]

Award Suitability

The Innovative Research Award profile is relevant to Chalton Manengu based on the supplied alignment between the researcher’s subject area and contemporary cell-biological investigation of cerebral ischemia-reperfusion. The subject involves cellular mechanisms that are central to understanding ischemic injury and subsequent tissue responses. [2]

Conclusion

Chalton Manengu of Southwest University, China, is presented in this academic recognition profile as a researcher working in the area of cerebral ischemia-reperfusion. The supplied Scopus information records 2 documents, 18 citations, and an h-index of 2. The research area has established importance within cellular neuroscience because ischemia-reperfusion involves interconnected mechanisms affecting neuronal, vascular, metabolic, inflammatory, and molecular processes. [1] [4]

References

  1. Elsevier. (n.d.). Scopus author details: Chalton Manengu, Author ID 59130694500. Scopus.
    https://www.scopus.com/authid/detail.uri?authorId=59130694500
  2. C Manengu, CH Zhu, GD Zhang, et al. (2024). HDAC inhibitors as a potential therapy for chemotherapy-induced neuropathic pain.
    https://link.springer.com/article/10.1007/s10787-024-01488-x
  3. C Manengu. (2026). Bisdemethoxycurcumin attenuates sciatic nerve damage in Vincristine-induced Neuropathic Pain Mice.
    https://europepmc.org/article/ppr/ppr1207864
  4. C Manengu, CH Zhu, GD Zhang, et al. (2025). Metabotropic glutamate receptor 5: a potential target for neuropathic pain treatment.
    https://www.benthamdirect.com/content/journals/cn/10.2174/1570159X23666241011163035

Erna Van Niekerk | Spinal Cord Injury | Best Researcher Award

Published on by Cell Biologist

Dr. Erna Van Niekerk | Spinal Cord Injury | Best Researcher Award

University of California San Diego | United States

Dr. Erna A. Van Niekerk’s research focuses on advancing central nervous system (CNS) repair through the integration of molecular neuroscience, artificial intelligence, and translational neurobiology. Her work emphasizes uncovering molecular and cellular mechanisms that drive neural regeneration and developing innovative therapeutic strategies to promote recovery after CNS injury. With a strong background in physiology and neuroscience, she has contributed to understanding neuroplasticity, neural signaling pathways, and the molecular determinants of axonal growth and synaptic repair. Dr. Van Niekerk’s recent research explores computational and AI-based models to analyze large-scale neurobiological datasets, aiming to predict regenerative outcomes and optimize therapeutic targets. Her interdisciplinary approach bridges fundamental neuroscience with clinical applications, particularly in the development of bioengineered and data-driven interventions for neurodegenerative diseases and traumatic brain or spinal cord injuries. Through her academic and industry experience, she has contributed to translational research efforts aimed at improving functional outcomes following neural damage and enhancing the precision of therapeutic design in neuroregeneration.

Profiles: Google Scholar | Scopus

Featured Publications:

Zahavi, E. E., Koppel, I., Kawaguchi, R., Oses-Prieto, J. A., Briner, A., Monavarfeshani, A., Dalla Costa, I., van Niekerk, E., Lee, J., Matoo, S., Hegarty, S., Donahue, R. J., Sahoo, P. K., Ben-Dor, S., Feldmesser, E., Ryvkin, J., Leshkowitz, D., Ben-Tov Perry, R., Cheng, Y., … Fainzilber, M. (2025). Repeat-element RNAs integrate a neuronal growth circuit. Cell. Advance online publication.

van Niekerk, E., Kawaguchi, R., Marques de Freria, C., Groeniger, K., Marchetto, M. C., Dupraz, S., Bradke, F., Geschwind, D. H., Gage, F. H., & Tuszynski, M. H. (2022). Methods for culturing adult CNS neurons reveal a CNS conditioning effect. Cell Reports Methods, 2, 100255. 5

de Freria, C. M., van Niekerk, E., Blesch, A., & Lu, P. (2022). Neural stem cells: Promoting axonal regeneration and spinal cord connectivity. Cells, 10(12), 3296.

Poplawski, G. H. D., Kawaguchi, R., van Niekerk, E., Lu, P., Mehta, N., Canete, P., Lie, R., Dragatsis, I., Meves, J. M., Zheng, B., Coppola, G., & Tuszynski, M. H. (2020). Injured adult neurons regress to an embryonic transcriptional growth state. Nature, 581(7806), 77–82.

Wang, W., van Niekerk, E. A., Zhang, Y., Du, L., Ji, X., Wang, S., & Baker, D. E. (2007). Extracellular stimuli specifically regulate localized levels of individual neuronal mRNAs. The Journal of Cell Biology, 178(6), 965–980.

van Niekerk, E. A., Willis, D. E., Chang, J. H., Reumann, K., Heise, T., & Twiss, J. L. (2007). Sumoylation in axons triggers retrograde transport of the RNA-binding protein La. Proceedings of the National Academy of Sciences, 104(31), 12913–12918. https://doi.org/10.1073/pnas.0705488104

Wang, W., van Niekerk, E., Willis, D. E., & Twiss, J. L. (2007). RNA transport and localized protein synthesis in neurological disorders and neural repair. Developmental Neurobiology, 67(9), 1166–1182.

van Niekerk, E. A., Tuszynski, M. H., Lu, P., & Dulin, J. N. (2016). Molecular and cellular mechanisms of axonal regeneration after spinal cord injury. Molecular & Cellular Proteomics, 15(2), 394–408.

Weiping Qin | Spinal Cord Injury | Best Researcher Award

Published on by Cell Biologist

Prof. Dr. Weiping Qin | Spinal Cord Injury | Best Researcher Award

The Icahn School of Medicine at Mount Sinai/James J. Peters VAMC | United States

Dr. Weiping Qin’s research focuses on developing innovative therapeutic strategies to prevent and reverse skeletal and neurological impairments associated with spinal cord injury (SCI). His laboratory investigates the molecular and cellular mechanisms underlying bone loss, muscle atrophy, and neurodegeneration following SCI, with the goal of identifying novel molecular targets for treatment. Dr. Qin’s work integrates approaches from molecular biology, neuroscience, and regenerative medicine to elucidate how injury-induced changes in signaling pathways, inflammation, and oxidative stress contribute to tissue degeneration. He also explores pharmacological and biological interventions that may enhance neural repair, bone regeneration, and functional recovery. Through translational studies, his team aims to bridge fundamental discoveries with clinical applications, advancing potential therapies to improve quality of life and outcomes for patients with SCI. His research has been recognized for its contributions to understanding neurodegenerative and skeletal pathology, and for identifying key therapeutic avenues to promote tissue protection and regeneration.

Profiles:  Google Scholar | Scopus

Featured Publications:

Qin, W., Ho, L., Pompl, P. N., Xiang, Z., Wang, J., Zhao, Z., Peng, Y., Cambareri, G., & others. (2004). Diet-induced insulin resistance promotes amyloidosis in a transgenic mouse model of Alzheimer’s disease. The FASEB Journal, 18(7), 902–904.

Qin, W., Yang, T., Ho, L., Zhao, Z., Wang, J., Chen, L., Zhao, W., Thiyagarajan, M., & others. (2006). Neuronal SIRT1 activation as a novel mechanism underlying the prevention of Alzheimer disease amyloid neuropathology by calorie restriction. Journal of Biological Chemistry, 281(31), 21745–21754.

Qin, W., Haroutunian, V., Katsel, P., Cardozo, C. P., Ho, L., Buxbaum, J. D., & others. (2009). PGC-1α expression decreases in the Alzheimer disease brain as a function of dementia. Archives of Neurology, 66(3), 352–361.

Wang, J., Ho, L., Qin, W., Rocher, A. B., Seror, I., Humala, N., Maniar, K., Dolios, G., & others. (2005). Caloric restriction attenuates β-amyloid neuropathology in a mouse model of Alzheimer’s disease. The FASEB Journal, 19(6), 1–18.

Yamashita, T., Kaneko, S., Shirota, Y., Qin, W., Nomura, T., Kobayashi, K., & others. (1998). RNA-dependent RNA polymerase activity of the soluble recombinant hepatitis C virus NS5B protein truncated at the C-terminal region. Journal of Biological Chemistry, 273(25), 15479–15486.

Shirota, Y., Luo, H., Qin, W., Kaneko, S., Yamashita, T., Kobayashi, K., & others. (2002). Hepatitis C virus (HCV) NS5A binds RNA-dependent RNA polymerase (RdRP) NS5B and modulates RNA-dependent RNA polymerase activity. Journal of Biological Chemistry, 277(13), 11149–11155.