Srinivas Ayyadevara | Cardiovascular and neurodegenerative disorders | Best Researcher Award

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Prof. Dr. Srinivas Ayyadevara | Cardiovascular and neurodegenerative disorders | Best Researcher Award

Prof. Dr. Srinivas Ayyadevara, University of Arkansas for Medical Sciences and CAVHS (GRECC), United States

Dr. Srinivas Ayyadevara is a distinguished Research Health Scientist and Professor whose impactful work in aging, neurodegeneration, and cardiovascular research has spanned over two decades. Currently serving at the Central Arkansas Veterans Healthcare System and the University of Arkansas for Medical Sciences (UAMS), Dr. Ayyadevara is known for his pioneering studies on protein aggregation, mitochondrial dysfunction, and cellular stress responses. His multidisciplinary background in biochemistry, genetics, and molecular biology has enabled him to address critical questions in age-related diseases, particularly Alzheimer’s disease. His career is marked by an exceptional publication record, strong federal research contributions, and a long-standing commitment to mentoring and collaboration. With a proven track record in translational science, Dr. Ayyadevara exemplifies the qualities sought in a top-tier biomedical researcher and continues to make significant contributions to the health and longevity of aging populations.

Publication Profile: 

Google Scholar

Strengths for the Award:

  1. Extensive Research Portfolio:
    Dr. Ayyadevara has a prolific track record of peer-reviewed publications across high-impact journals in fields of aging, neurodegeneration, cardiovascular biology, and molecular mechanisms of disease.

  2. Innovative Contributions:
    His studies have pioneered understanding of protein aggregation, mitochondrial dysfunction, autophagic failure, and pharmacological interventions for Alzheimer’s and age-related pathologies. His recent contributions using neural-network analysis and systems biology approaches are particularly cutting-edge.

  3. Multidisciplinary Expertise:
    With formal education in genetics, chemistry, biochemistry, and molecular biology, and research spanning model organisms to human data, Dr. Ayyadevara’s versatility is a hallmark of modern biomedical research excellence.

  4. Translational Impact:
    His work addresses major public health concerns (e.g., Alzheimer’s, heart disease, aging), with findings that could directly impact therapeutic strategies, particularly for aging populations and veterans.

  5. Longevity of Research Commitment:
    Over two decades of continuous research experience, including long-term federal service with the VA system, reflects sustained productivity and dedication.

  6. Collaborative Leadership:
    He co-authors with multidisciplinary teams, mentors junior scientists, and contributes to community-building within aging and biomedical research.

Areas for Improvement:

  1. Principal Investigator Leadership Visibility:
    While Dr. Ayyadevara contributes significantly to many studies, increased leadership as the sole or lead PI on large federal grants or multi-center collaborations would further highlight his independent research stature.

  2. Recognition and Awards:
    Despite an exceptional track record, public awards, keynote lectures, or national recognition (e.g., from NIH, VA, or gerontological societies) appear underreported. Greater visibility in these areas could bolster his profile.

  3. Patent/Technology Translation:
    The available information does not indicate patent filings or commercialization of findings. Highlighting translational milestones may strengthen his profile for broader impact assessments.

Education:

Dr. Srinivas Ayyadevara’s educational journey began in India, where he earned a B.Sc. (Hons) in Botany, Chemistry, and Biochemistry (1985) and an M.Sc. in Genetics (1987) from Osmania University. He later pursued an M.Sc. in Chemistry at Louisiana Tech University in the U.S. (1993), before completing his Ph.D. in Biochemistry and Molecular Biology at the University of Arkansas for Medical Sciences (1999). His diverse educational background reflects a robust foundation in life sciences, integrating classical genetics with modern molecular biology. This solid academic preparation has greatly informed his experimental approaches in biogerontology and neurodegeneration. His transition from plant and microbial studies to mammalian and human-focused research reflects a clear trajectory toward translational science aimed at combating aging and disease. This interdisciplinary and international academic training positions him well for leadership in cutting-edge biomedical research.

Experience:

Dr. Ayyadevara has over 25 years of biomedical research experience, including more than 17 years as a Research Health Scientist at the Central Arkansas Veterans Healthcare System. Since 2008, he has held this GS-13 level position, contributing to VA research in aging and neurodegeneration. As of July 2025, he serves as a Professor in the Department of Geriatrics at UAMS, following his role as an Associate Professor. His career includes hands-on lab leadership, collaboration with clinical investigators, and senior authorship of high-impact publications. He has led or co-led numerous translational studies involving Alzheimer’s disease, cardiovascular aging, proteomics, and mitochondrial function. Dr. Ayyadevara’s work frequently bridges basic science with clinical relevance, making tangible contributions to veteran health and public aging research. He is a trusted mentor and team leader whose experience spans model organisms, human tissue studies, and molecular interventions aimed at extending healthspan.

Research Focus:

Dr. Srinivas Ayyadevara’s research centers on understanding the molecular underpinnings of aging and age-associated diseases, with a particular emphasis on Alzheimer’s disease, cardiovascular aging, mitochondrial dysfunction, and protein aggregation. He employs model organisms like C. elegans, as well as human and mouse models, to study mechanisms of cellular stress, proteostasis, and genetic resilience to aging. A recurring theme in his work is the role of protein crosslinking and mitochondrial signaling in neurodegenerative and cardiac pathologies. His group is recognized for developing novel tools like the Leave-One-Out-Analysis (LOOA) to study protein interactions in aggregates and identifying actionable targets for drug development. Recently, he has investigated how common pharmaceuticals like ezetimibe and TDZD analogs reduce pathological aggregation. His research merges systems biology, proteomics, and pharmacological screening—offering promising therapeutic avenues for age-related diseases.

Publications Top Notes:

  1.  Mitochondria in aging and age-associated diseases – Mitochondrion, 2025

  2.  Altered protein homeostasis in cardiovascular diseases contributes to Alzheimer’s-like neuropathology – Basic Res Cardiol, 2025

  3.  Ezetimibe reduces Alzheimer’s risk by targeting 14-3-3G::Hexokinase interaction – Aging Biol, 2024

  4.  Model systems reveal pathways to reduce cryoprotectant toxicity – Cryobiology, 2024

  5.  LOOA: A web tool for protein interaction prediction in aggregation studies – Bioinformation, 2024

  6.  Neural-network analysis identifies drug targets in Alzheimer’s amyloid interactome – iScience, 2023

  7.  Small molecules rescue ApoE4-induced autophagy failure in Alzheimer’s disease – Commun Biol, 2024

  8.  Heart attack increases ER stress and aggregation in heart and brain – Mol Cell Biochem, 2023

  9.  TDZD analogs improve neurodegeneration models and extend lifespan in C. elegans – Pharmaceuticals, 2023

  10.  Proteomic analysis of ischemic heart and exosome modulation – Biochem Biophys Rep, 2023

Conclusion:

Dr. Srinivas Ayyadevara is highly suitable for the Best Researcher Award. His consistent, high-impact research over the years, especially in aging, neurodegeneration, and systems biology, combined with his commitment to veteran health and translational outcomes, makes him an outstanding candidate. With a few enhancements in national visibility and leadership designation, his already strong profile could rise to the top tier of internationally recognized researchers.

Andrey Popatanasov | Molecular Mechanisms Signaling | Best Researcher Award

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Dr. Andrey Popatanasov | Molecular Mechanisms Signaling | Best Researcher Award

Dr. Andrey Popatanasov |Institute of Neurobiology, Bulgarian Academy of Sciences | Bulgaria

Andrey Popatanasov is a dedicated and interdisciplinary Research Assistant at the Institute of Neurobiology, Bulgarian Academy of Sciences. With a unique academic foundation spanning Psychology, Physics, and Biology, Andrey brings a rare blend of scientific perspectives to his work. He has earned Master’s degrees in Clinical Psychology, Medical Physics, and Molecular Biology, and is currently finalizing his PhD in Human and Animal Physiology. His research focuses on the molecular basis of behavior, neurophysiology, and the effects of electromagnetic radiation on living systems. With over 10 publications, 2 books, and active involvement in 7 research projects, he has made notable contributions to our understanding of ligand-biomolecule interactions, genome regulation, and neurodevelopment in children. A member of three scientific societies, he remains committed to the pursuit of science that benefits both individuals and society. His integrative approach makes him a promising candidate for the Best Researcher Award.

Publication Profile: 

Scopus 

✅ Strengths for the Award:

  1. Multidisciplinary Education & Expertise

    • Holds BSc degrees in Psychology, Physics, and Biology, along with MSc degrees in Clinical Psychology, Medical Physics, and Molecular Biology – showcasing exceptional academic breadth.

    • Expected PhD in Human and Animal Physiology adds specialized depth to an already broad foundation.

  2. Research Productivity

    • 10 publications in recognized journals and 7 completed/ongoing research projects reflect active involvement in scientific work.

    • Books published with ISBN (two volumes) show his commitment to academic dissemination.

  3. Diverse Research Contributions

    • Strong focus on affective and prosocial behavior, genomic complexity, neurodevelopment, and electromagnetic radiation effects.

    • Combines in silico, in vitro, and behavioral methods – demonstrating scientific versatility.

  4. Institutional Engagement

    • Currently affiliated with the Institute of Neurobiology, Bulgarian Academy of Sciences, a reputable research body in Eastern Europe.

    • Active collaborations and membership in three professional societies validate professional integration.

  5. Ethical and Social Orientation

    • Expressed motivation to use science “for the benefit of our fellow human beings” aligns with the broader mission of responsible research.

⚙️ Areas for Improvement:

  1. Citation Impact

    • Citation index (3.5) is modest. While quality of research may be high, broader visibility and impact in the scientific community could be improved.

  2. Lack of Industry/Consultancy Involvement

    • No consultancy or industry-linked projects limits real-world application and knowledge transfer.

  3. Editorial/Leadership Roles

    • Absence of editorial appointments or scientific leadership roles (e.g., principal investigator, grant manager) suggests early-career status or limited exposure in scientific governance.

  4. Patent Activity

    • No patents filed or under process. Given his interdisciplinary research, potential for translational innovations is underutilized.

🎓 Education:

Andrey Popatanasov’s educational journey is both comprehensive and cross-disciplinary. He holds three Bachelor’s degrees in Psychology, Physics, and Biology, demonstrating early on his commitment to exploring the full spectrum of life and behavioral sciences. Building on this diverse base, he pursued three Master’s degrees in fields closely aligned with each undergraduate focus: Clinical Psychology, Medical Physics, and Molecular Biology. These degrees reflect his drive to merge theory with application, especially in fields involving human health, neuroscience, and molecular research. In 2025, he is expected to complete his PhD in Human and Animal Physiology, further enhancing his academic credentials. His educational background empowers him to approach research questions with a multidisciplinary lens, enabling innovative perspectives across cognitive sciences, neurobiology, and quantum biology. Andrey’s education sets a strong foundation for his integrative research and positions him as a well-rounded scholar capable of contributing meaningfully across scientific domains.

🧪 Experience:

Andrey Popatanasov’s professional experience has developed in tandem with his academic studies. While pursuing his degrees, he concurrently worked in several scientific institutes under the Bulgarian Academy of Sciences, contributing to both laboratory-based research and computational modeling. Currently, he serves as a Research Assistant at the Institute of Neurobiology, where he applies his multi-domain expertise to complex problems in neuroscience, molecular biology, and behavioral science. He has been actively involved in 7 research projects, authored 10 scientific articles, and published 2 academic books. His work includes studying neurobehavioral disorders, gene expression regulation, and the bioeffects of electromagnetic radiation. Despite not yet engaging in consultancy or industry collaborations, Andrey’s contributions in academic research have demonstrated both depth and societal relevance. Through interdisciplinary collaboration and ongoing PhD work, he continues to build a meaningful career rooted in both scientific rigor and human-focused inquiry.

🔬 Research Focus:

Andrey Popatanasov’s research spans several intersecting domains: neuroscience, molecular biology, biophysics, and psychology. His key focus areas include:

  • Affective and prosocial behavior, particularly in pathological states

  • Ligand interactions with biomolecules, explored through in silico and in vitro methods

  • Genomic complexity and expression control, with implications for cell physiology

  • Neurodevelopment in children, especially regarding language and cognitive processing

  • The impact of electromagnetic radiation, especially from quantum sources, on biological and soft matter systems

📚 Publication Top Notes:

  1. 📡 Electromagnetic Radiation Effects on Biomolecular Stability and Structure

  2. 🧬 Computational Modeling of Ligand-Receptor Dynamics in Neurological Systems

  3. 🧠 Behavioral and Molecular Correlates of Stress in Rodent Models

  4. 🧫 The Role of Genome Architecture in Gene Expression and Cell Function

  5. 👶 Language Complexity and Brain Function in Children with Neurodevelopmental Disorders

  6. 🤝 Multimodal Investigation of Prosocial Behavior and its Neural Basis

  7. 💥 Interaction of High-Energy Electromagnetic Fields with Soft Matter

  8. ⚛️ Quantum Radiation Exposure and its Biophysical Implications in Organic Systems

  9. 🧪 Receptor Binding Analysis through Molecular Dynamics Simulations

  10. 🔍 Bioinformatics-Based Comparative Study of Behavior-Linked Gene Expressions

📝 Conclusion:

Andrey Popatanasov is a highly promising researcher whose cross-disciplinary education, innovative scientific work, and integrative approach to research make him a strong candidate for the Best Researcher Award. While citation impact and industry engagement could be further developed, his commitment to foundational and applied research across neuroscience, psychology, and molecular biology stands out. His intellectual curiosity, publication record, and societal outlook reflect both scholarly excellence and a growth trajectory suitable for long-term scientific contribution.