Shuxin Han | Molecular Mechanisms Signaling | Best Researcher Award

Published on by Cell Biologist

Dr. Shuxin Han | Molecular Mechanisms Signaling | Best Researcher Award

Dr. Shuxin Han | Xinjiang University | China

Dr. Shuxin Han is a distinguished molecular biologist and professor at Xinjiang University, widely recognized for his pioneering work in hepatobiliary and metabolic biology. With a research career spanning over two decades, Dr. Han has made major contributions to understanding how Kruppel-like factors, especially KLF15, regulate endobiotic and xenobiotic metabolism, impacting drug detoxification and metabolic disease mechanisms. He earned his Ph.D. from Kent State University and has held prestigious positions at Harvard Medical School and Case Western Reserve University. His groundbreaking studies have been published in high-impact journals like Nature Metabolism and Nature Communications, with several articles naming him as first or corresponding author. In addition to research, Dr. Han serves as a reviewer for top-tier journals in pharmacology, hepatology, and clinical science. He is also an academic leader, currently shaping the next generation of scientific talent and metabolic disease research in China.

Publication Profile: 

Scopus

Education:

Dr. Shuxin Han began his academic journey in Animal Sciences, earning a bachelor’s degree from Anhui Agricultural University (1994–1998). He advanced to a research assistant role at Peking University (1999–2000), where he deepened his scientific foundation. He then moved to the U.S. to pursue a Master’s in Biology at Temple University (2000–2003), followed by a Ph.D. in Molecular Biology from Kent State University (2004–2009), focusing on metabolic biology and gene regulation. This progression from general animal sciences to highly specialized molecular biology reflects a systematic and deep commitment to biomedical research. His strong academic preparation laid the foundation for a research career investigating how transcriptional regulators impact health and disease. Dr. Han’s training spans world-class institutions across both China and the United States, equipping him with diverse scientific perspectives and techniques.

Experience:

Dr. Shuxin Han has accumulated rich research and academic experience over nearly 30 years. His early career included a pivotal research assistant role at Peking University, followed by advanced training in biology and molecular biology at Temple and Kent State Universities. He completed prestigious postdoctoral training at Harvard Medical School (2009–2012) and Case Western Reserve University (2012–2015), where he later became a Senior Research Associate (2015–2019). He returned to China in 2019 as a Researcher at the University of Science and Technology of China First Affiliated Hospital, simultaneously engaging in academic duties at the university until 2023. Currently, he serves as a Professor and Academic Leader at Xinjiang University. Throughout his career, Dr. Han has built strong international collaborations, led research groups, and guided innovative projects in metabolic biology, demonstrating his leadership, research excellence, and academic mentorship capabilities.

Research Focus:

Dr. Shuxin Han’s research centers on the molecular regulation of metabolism, particularly focusing on the hepatobiliary and gastrointestinal systems. His work has elucidated the critical role of the Kruppel-like factor (KLF) family, especially KLF15, in controlling endobiotic and xenobiotic metabolism (EXM). These pathways govern how the body metabolizes both internal compounds and external substances like drugs. Dr. Han’s studies have shown that KLF15 acts as a master regulator, influencing drug resistance, liver injury, and metabolic homeostasis. His discoveries offer new insight into personalized medicine and treatment for metabolic disorders and drug-related toxicities. With numerous first-author and corresponding-author publications in journals such as Nature Metabolism, Nature Communications, and Drug Metabolism and Disposition, his work has significantly impacted both fundamental science and clinical applications. He is also active in peer-reviewing for top-tier journals and is recognized for his leadership in translational research.

Publications Top Notes:

  1. Unveiling KLF15 as the Key Regulator of Cyclosporine A Metabolism and Adverse Effects – Drug Metabolism and Disposition, 2025

  2. Distribution and Functional Significance of KLF15 in Mouse Cerebellum – Molecular Brain, 2025

  3. Personalized Statin Therapy: Targeting Metabolic Processes – Heliyon, 2025

  4. Current Status and New Directions for Hepatocellular Carcinoma Diagnosis – Liver Research, 2024

  5. KLF15-Cyp3a11 Axis Regulates Rifampicin-Induced Liver Injury – Drug Metabolism and Disposition, 2024

  6. Advancing Drug Delivery and Bioengineering in Liver Research – Bioengineering and Translational Medicine, 2024

  7. Advances in IL-7 Research on Tumor Therapy – Pharmaceuticals, 2024 (Co-author)

  8. Pathogenic Mechanisms in Alcoholic Liver Disease – Journal of Translational Medicine, 2023

  9. Beta-Hydroxybutyrate Effects on iPSC-Derived Cardiac Myocytes – Biomolecules, 2022

  10. Interactions Between Intestinal Flora and Bile Acids – International Journal of Molecular Sciences, 2022 (Corresponding author)

Conclusion:

In conclusion, Dr. Shuxin Han is a highly deserving candidate for the Best Researcher Award. His pioneering work on KLF15 and metabolic regulation has reshaped fundamental understanding in the field of hepatobiliary biology and pharmacology. His academic background, research productivity, international experience, and editorial service all reflect a well-rounded and impactful scientist. While there is room to increase clinical translation and international engagement, the depth, originality, and consistency of his research make him a strong contender for this recognition. Honoring Dr. Han with this award would acknowledge a career dedicated to scientific advancement with substantial implications for human health and drug therapy.

Minjian Chen | Metabolism | Best Researcher Award

Published on by Cell Biologist

Prof. Dr. Minjian Chen | Metabolism | Best Researcher Award

Prof. Dr. Minjian Chen, Nanjing Medical University, China

Professor Minjian Chen is a leading academic in toxicology and reproductive health at Nanjing Medical University (NMU). After earning both his Bachelor’s in Preventive Medicine (2008) and Ph.D. in Toxicology (2013) at NMU, he undertook postdoctoral research there and served as a guest researcher at the U.S. National Institute of Environmental Health Sciences (NIEHS), NIH. Since 2023, he has held a professorial position and was recognized as an Outstanding Young Backbone Teacher in Jiangsu’s prestigious “Qinglan Project.” His work spans reproductive toxicity, metabolomics, and exposomics, focusing on environmental and nutritional factors affecting fertility. With over 10 funded national and provincial research projects and numerous peer-reviewed publications, Professor Chen has significantly contributed to understanding spermatogenic dysfunction and metabolic profiling in reproductive biology. He continues to push boundaries in public health and environmental toxicology.

Publication Profile: 

Orcid

✅ Strengths for the Award:

  1. Strong Academic Foundation

    • Bachelor’s and Ph.D. in Preventive Medicine and Toxicology from a top Chinese institution (Nanjing Medical University).

    • Postdoctoral research and international exchange experience, including at the U.S. National Institute of Environmental Health Sciences (NIH/NIEHS).

  2. Outstanding Research Leadership

    • Principal Investigator (PI) for multiple competitive national and provincial grants, with over ¥2 million in individual research funding and participation in projects exceeding ¥70 million total budget.

    • Active contributor in 11 funded research projects, with core themes on reproductive toxicology, metabolomics, and AI-based diagnostics.

  3. High-Impact Publications

    • Recent publications in top-tier international journals including EMBO Journal, Molecular & Cellular Proteomics, IJMS, Theriogenology, and Toxics.

    • Regular authorship and collaborations on cutting-edge studies in exposomics, spermatogenesis, and reproductive metabolomics.

  4. Recognition and Honors

    • Named Outstanding Young Backbone Teacher under Jiangsu’s “Qinglan Project”.

    • Appointed Distinguished Young Academic Leader at Nanjing Medical University.

  5. Interdisciplinary & Translational Approach

    • Work spans basic toxicology, systems biology, and big-data-driven clinical research, positioning him well for translational impact in reproductive health and environmental medicine.

⚠️ Areas for Improvement:

  1. Expanded Global Visibility

    • While Prof. Chen has published widely, further collaboration with global institutions could help amplify international recognition.

  2. Clinical Translation

    • While he has contributed to diagnostic R&D and cohort-based studies, greater emphasis on real-world clinical application or intervention trials could boost impact and societal benefit.

  3. Leadership in Multi-National Consortia

    • Assuming leadership roles in global consortia or organizations could further solidify his position as a top-tier researcher.

🎓 Education:

Professor Minjian Chen pursued his entire academic training at Nanjing Medical University, beginning with a Bachelor’s degree in Preventive Medicine from 2003 to 2008. His passion for understanding environmental impacts on human health led him to complete a Ph.D. in Toxicology between 2008 and 2013. During his doctoral studies, he specialized in reproductive toxicology, investigating the metabolic mechanisms by which environmental toxins affect male fertility. Following his doctorate, he deepened his expertise with postdoctoral training (2013–2018) at the NMU School of Basic Medicine. In 2014, he was selected for the China–Australia Young Scientist Exchange Program, an early recognition of his academic promise and leadership. His international exposure was further enhanced through a research fellowship at the U.S. National Institute of Environmental Health Sciences (NIH) from 2019 to 2020. This robust educational background laid a strong foundation for his research in reproductive health, metabolomics, and environmental toxicology.

💼 Experience:

Professor Chen began his academic career as a Lecturer at NMU in 2013, shortly after completing his Ph.D. Over the following decade, he rose through the ranks, becoming a Professor in 2023, thanks to his prolific research and educational contributions. Between 2013 and 2018, he completed an intensive postdoctoral fellowship at NMU, focusing on toxicological studies related to male reproductive health. In 2019–2020, he broadened his global research experience by joining the NIEHS at the U.S. NIH as a guest researcher. His teaching and mentorship have earned him several accolades, including Distinguished Young Academic Leader at NMU and Outstanding Young Backbone Teacher in Jiangsu’s “Qinglan Project.” Professor Chen also plays a vital role in large-scale, national R&D programs and key provincial projects in China, acting as a Principal Investigator (PI) or Sub-project PI in more than ten funded initiatives in toxicology, reproductive biology, and data-driven diagnostics.

🔬 Research Focus:

Professor Minjian Chen’s research is centered on environmental toxicology, reproductive health, and metabolomics. His primary scientific contributions lie in uncovering how environmental toxins—including phytochemicals, metals, and industrial chemicals—disrupt male fertility through metabolic pathways. His studies on arachidonic acid metabolism, n-6 PUFA pathways, and sorbitol metabolism have advanced our understanding of oligospermia and other reproductive dysfunctions. More recently, Professor Chen has explored the application of integrative omics (metabolomics + transcriptomics) in reproductive cells like oocytes and cumulus cells, providing insights into fertility and early development. He is also involved in big-data-driven diagnosis for pregnancy complications such as intrahepatic cholestasis and macrosomia, and in nationwide projects investigating genetic risks in ART offspring and structural birth defects. His work is highly interdisciplinary, blending toxicology, biochemistry, epidemiology, and computational biology to push the frontiers of precision reproductive health and environmental health sciences.

📚 Publications Top Notes:

  1. 🧬 Association of Personal Care and Consumer Product Chemicals with Long-Term Amenorrhea: Insights into Serum Globulin and STAT3 (Toxics, 2025)

  2. 🧫 Characterization of Metabolic Patterns in Mouse Spermatogenesis and Its Clinical Implications in Humans (IJMS, 2025)

  3. 🧪 A Metabolome and Microbiome Analysis of Acute Myeloid Leukemia: Insights into the Carnosine–Histidine Metabolic Pathway (Toxics, 2024)

  4. 🐷 Characterization of Metabolic Patterns in Porcine Cumulus Cells During Meiotic Maturation (Theriogenology, 2024)

  5. 🐐 Combined Analysis of Temporal Metabolomics and Transcriptomics in Goat Oocytes During Maturation (Theriogenology, 2024)

  6. 🧍 Exposure to Molybdate Results in Metabolic Disorder: Urine Elementome and Serum Metabolome in Mice (Toxics, 2024)

  7. 🧬 Integrative Omics Reveals the Metabolic Patterns During Oocyte Growth (Molecular & Cellular Proteomics, 2024)

  8. 🌐 The Global Phosphorylation Landscape of Mouse Oocytes During Meiotic Maturation (EMBO Journal, 2024)

  9. ⚗️ Environmental Chemical Exposomics and Metabolomics in Toxicology: The Latest Updates (Toxics, 2024)

  10. 👶 Cohort Profile: The Jiangsu Birth Cohort (International Journal of Epidemiology, 2023)

📝 Conclusion:

Professor Minjian Chen is highly suitable for the Best Researcher Award. His consistent research excellence, broad project leadership, publication strength, and interdisciplinary work make him a standout candidate. His research is not only scientifically rigorous but also socially relevant—targeting reproductive health challenges through environmental and metabolic lenses. With additional emphasis on global outreach and clinical application, Prof. Chen’s impact could become even more transformative.