Zhejiang University | China
Dr. Junning Ma has developed a multidisciplinary portfolio spanning neurosurgery, neural engineering, biomaterials, and nanomedicine. Their work integrates neural stem cell biology, targeted drug delivery, and tumor microenvironment modulation to create innovative therapeutic strategies for brain diseases. They have conducted advanced postdoctoral and doctoral research at major institutions, contributing to National Natural Science Foundation of China (NSFC) Youth Fund projects and multiple US-funded NIH and AHA grants. Their research focuses on biomimetic nanocarriers, including cell membrane-coated nanoparticles, PLGA-based delivery systems, and fusion-membrane technologies designed for precision therapy of glioma, pituitary adenoma, and ischemic stroke.
Key projects include engineered neural stem cell membrane-coated nanoparticles for stroke targeting, biomimetic nanoplatforms for cancer immunotherapy, and tumor microenvironment–responsive delivery systems. They have also contributed to studies on neuromodulation, neurotrophic factor-based therapy, neural stem cell transplantation, and photothrombotic stroke models. Their publication record includes high-impact journals such as Materials Today Bio, Biomaterials, Nano Letters, Small, and Cell Reports Physical Science, covering topics like vascular-targeting nanoclusters, polyphenol nanoparticles, and membrane-engineered carriers.
Overall, their research advances translational nanomedicine and regenerative neuroscience, with an emphasis on targeted therapies capable of overcoming the challenges of brain tumor heterogeneity, the blood–brain barrier, and ischemic neural injury.
Featured Publications:
Ma, J., Win, Y., Xiaojian, Z., et al. (2023). Enhanced EPR effects by folliculostellate cell membrane–coated nanoparticles on invasive pituitary adenoma. Materials Today Bio.
Ma, J., Dai, L., Jianbo, Y., et al. (2023). Tumor microenvironment targeting system for glioma treatment via fusion cell membrane coating nanotechnology. Biomaterials.
Ma, J., Liu, F., Wendy, C., et al. (2020). Co-presentation of tumor antigens with costimulation via biomimetic nanoparticles for effective cancer immunotherapy. Nano Letters.
Ma, J., Zhang, S., Jun, L., et al. (2019). Targeted drug delivery to stroke via chemotactic recruitment of nanoparticles coated with membranes of engineered neural stem cells. Small.