Yidong Wei | Immunology Cellular Interactions | Best Researcher Award

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Prof. Yidong Wei | Immunology Cellular Interactions | Best Researcher Award

Prof. Yidong Wei , Shanghai Tenth People’s Hospital, Tongji University , China

Dr. Yidong Wei, M.D., Ph.D., FACC, is a distinguished professor and the Chief of Cardiology at Shanghai Tenth People’s Hospital, Tongji University. He also holds a clinician management role at the Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford. With a strong foundation in both clinical and translational research, Dr. Wei has built an internationally recognized career focused on interventional cardiology, cardiac electrophysiology, and cardiovascular epidemiology. He is a Fellow of the American College of Cardiology, reflecting his global academic influence. Known for bridging clinical care with bench-side discovery, his work has advanced understanding in myocardial infarction, heart failure, and calcium signaling in cardiomyocytes. With numerous high-impact publications and leadership in multicenter registries like NOAFCAMI-SH, Dr. Wei’s contributions are widely cited and clinically relevant. His dual academic and clinical roles across China and the UK highlight his dedication to innovation, international collaboration, and excellence in cardiovascular medicine.

Publication Profile:

Scopus

✅ Strengths for the Award:

  1. High-Impact Research Output:
    Dr. Wei has authored or co-authored more than 18 recent peer-reviewed publications in prestigious journals such as Diabetes Metabolism Research and Reviews, Redox Biology, Cardiovascular Diabetology, and ESC Heart Failure. Many of these works are already cited, indicating early academic impact and relevance.

  2. Dual Focus – Basic and Clinical Science:
    His research bridges the gap between molecular mechanisms (e.g., calcium signaling, TRIM21, PTEN) and clinical cardiology (e.g., atrial fibrillation, myocardial infarction, cardiac remodeling), highlighting a robust translational focus.

  3. Leadership and Collaboration:
    He serves as Chief of Cardiology at Shanghai Tenth People’s Hospital and a Clinician Manager at the University of Oxford, demonstrating international leadership and cross-border collaboration.

  4. Registry Leadership (NOAFCAMI-SH):
    His work through the NOAFCAMI-SH registry provides real-world evidence on cardiovascular disease progression, risk prediction, and treatment response—critical for patient-centered care.

  5. Prestigious Recognition:
    Dr. Wei is a Fellow of the American College of Cardiology (FACC), a title reserved for top-tier cardiovascular professionals with sustained excellence.

⚠️ Areas for Improvement:

  1. Broader International Research Leadership:
    While Dr. Wei has strong China–UK collaborations, leading global multicenter clinical trials or international consortia would further solidify his standing.

  2. Public Engagement and Knowledge Translation:
    Though academically prolific, increased involvement in public health education or policy advocacy could amplify the real-world impact of his research.

  3. Mentorship Track Record Visibility:
    Highlighting mentorship of junior researchers and postdocs more explicitly in profiles and bios would enhance his case for a holistic academic leadership award.

🎓 Education:

Dr. Wei began his medical education at Henan Medical University, where he completed clinical training with a focus on cardiovascular medicine. Driven by a passion for research, he pursued and completed his Ph.D. in 2004, with a specialization in cardiac electrophysiology and calcium signaling pathways. His graduate studies were complemented by advanced basic science training at the University of Kentucky, USA, a leading institution in biomedical research. Between 2004 and 2006, Dr. Wei completed postdoctoral research, focusing on the molecular mechanisms of cardiac dysfunction and electrophysiology. His educational background reflects a balanced integration of rigorous clinical education and innovative research development, equipping him with the tools necessary to bridge bedside care with laboratory insights. This foundation has allowed Dr. Wei to contribute to both academic medicine and cutting-edge cardiovascular research, distinguishing him as a leader with comprehensive and global training in the field.

🏥 Experience:

With over two decades of experience, Dr. Yidong Wei serves as Professor and Chief of the Department of Cardiology at Shanghai Tenth People’s Hospital, Tongji University. His role extends internationally, acting as Clinician Manager at the University of Oxford’s Centre for Diabetes, Endocrinology and Metabolism. His clinical expertise spans interventional cardiology, acute coronary syndromes, and electrophysiological interventions, while his research roles emphasize trial design, biomarker discovery, and cellular cardiology. He has led and contributed to large-scale registries like NOAFCAMI-SH, generating evidence that informs guidelines for myocardial infarction and atrial fibrillation. His professional experience combines healthcare leadership, cross-border academic collaboration, and impactful research. As a Fellow of the American College of Cardiology, he is actively engaged in academic societies and peer-reviewed journals. Dr. Wei’s experience reflects an enduring commitment to patient care, innovation in research, and mentorship of future cardiology leaders, marking him as a high-impact contributor in his field.

🔬 Research Focus:

Dr. Yidong Wei’s research lies at the intersection of clinical cardiology and molecular medicine. He focuses on interventional cardiology, atrial fibrillation, myocardial infarction, and calcium signaling pathways in cardiac myocytes. A major theme in his work is the electrophysiological basis of heart failure and age-related changes in ventricular function. Using techniques like patch clamping, calcium imaging, laser confocal microscopy, and molecular biology, he investigates calcium channel regulation and excitation-contraction coupling in cardiac cells. Clinically, he leads research through the NOAFCAMI-SH registry, analyzing systemic inflammation, hyperglycemia, atrial fibrillation, and long-term cardiac outcomes. His work advances the understanding of post-infarction remodeling and atrial pathology. Combining basic science with real-world data, Dr. Wei’s research bridges gaps in translational cardiology and offers therapeutic targets for chronic cardiac conditions. His integrative approach makes him a pioneer in translating bench findings into bedside impact, with potential to redefine cardiac care strategies globally.

📚 Publications Top Notes:

  1. 📈 Association of stress hyperglycemia ratio with atrial fibrillation and outcomes in myocardial infarction

  2. 🧪 Prognostic implications of systemic immune-inflammation index in MI patients with and without diabetes

  3. 🧬 TRIM21 deficiency protects heart post-MI by reducing oxidative stress

  4. 🫀 4S-AF scheme for characterizing atrial fibrillation after myocardial infarction

  5. 🔬 TRIM21 worsens cardiac injury via M1 macrophage polarization post-MI

  6. 🧮 Stress hyperglycemia and outcomes in MI with and without diabetes mellitus

  7. 💉 ZPI protects endothelium via PI3K/Akt pathway activation against ox-LDL

  8. 📊 Atrial fibrillation’s prognosis across heart failure subtypes post-MI

  9. 🕒 Five-year outcomes post left atrial appendage occlusion

  10. 🧫 PTEN and serum deprivation-induced cytotoxicity via PI3K/AKT pathway

🧾 Conclusion:

Dr. Yidong Wei stands out as a highly suitable candidate for the Best Researcher Award. His contributions to cardiovascular research—spanning cutting-edge basic science to influential clinical trials—are both innovative and impactful. His leadership roles, international presence, and translational focus align perfectly with the goals of this prestigious recognition. Given his trajectory, Dr. Wei is not only a leader in current cardiovascular research but also a driver of future scientific breakthroughs.

Isabelle Brigaud | Immunology Cellular Interactions | Best Researcher Award

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Mrs. Isabelle Brigaud | Immunology Cellular Interactions | Best Researcher Award

Mrs. Isabelle Brigaud , CNRS IS2M , France

Isabelle Brigaud is an experienced research engineer at CNRS IS2M, Mulhouse, France. With a strong foundation in molecular biology, biochemistry, cell biology, and bioinformatics, she specializes in the study of biomaterials, tissue engineering, and immunology. Brigaud has made significant contributions to understanding the foreign body response to materials such as silicone breast implants and injectable hydrogels. Her expertise spans molecular cloning, protein analysis, and the development of study models using ex vivo, animal models (e.g., zebrafish, Drosophila, and Spodoptera littoralis), and advanced imaging techniques like confocal microscopy. Passionate about collaborative research, she is involved in managing cross-functional projects, fundraising, and mentoring students. Brigaud holds CNU qualifications in cell biology and physiology and is an advocate for continuous technical training. Her research has resulted in numerous high-impact publications in the field of biomaterials and molecular biology.

Publication Profile:

Orcid

Strengths for the Award:

  1. Diverse and High-Impact Research Focus: Isabelle Brigaud’s research spans multiple biological disciplines, including molecular biology, biochemistry, cell biology, and biophysics, showing a broad and in-depth understanding of biological processes. This is particularly demonstrated through her contributions to studies in immunogenic responses in breast implant tissue, the molecular mechanisms of endometriosis, and cellular interactions with biomaterials, indicating her versatility in tackling diverse biological challenges.
  2. Strong Publication Record: Brigaud has a consistent publication history in high-impact journals, such as Biomaterials, Nature Communications, Acta Biomater, and PRS. These publications focus on important topics like cellular migration, biomaterial interaction, and regenerative medicine, all of which are at the forefront of current biomedical research. Her work on the interaction of biomaterials with tissues, especially focusing on inflammatory responses, positions her as a leading researcher in the field.
  3. Expertise in Advanced Techniques: She is proficient in a wide range of cutting-edge techniques, from molecular biology techniques like RNAseq and PCR to cell biology methods, including cell differentiation and functional pharmacology. This technical expertise is key for producing reliable, reproducible results, which is crucial for advancing scientific knowledge.
  4. Cross-Disciplinary Collaboration: Brigaud’s experience in collaborating across various research teams, institutions, and international boundaries highlights her ability to contribute effectively to multidisciplinary research projects. She has also demonstrated leadership in supervising and training students and researchers, underscoring her role as a mentor and leader in the research community.
  5. Management and Funding Expertise: As a research engineer and project manager, she has led several important projects, such as those related to soft tissue reactions to implants and muscle regeneration. Her experience in fundraising and project management indicates strong organizational and leadership skills, both of which are crucial for steering complex research initiatives toward success.
  6. Commitment to Health-Related Research: Her work on health-related issues, such as the effects of silicone breast implants on immune responses and the management of endometriosis symptoms through exercise, shows a direct impact on improving human health. Her research addresses real-world health challenges, making it highly relevant and applicable to clinical settings.

Areas for Improvement:

  1. Broader Dissemination of Findings: While Brigaud has an impressive publication record, there is a potential for more dissemination of her findings to the broader scientific community, especially through high-visibility conferences and workshops. Increased visibility could attract more collaborative opportunities and funding for her projects.
  2. Expanding Research Focus on Novel Therapeutic Applications: Brigaud’s research has already significantly contributed to understanding biomaterials and cell interactions. Further expansion into therapeutic applications, such as designing and testing novel drug delivery systems or regenerative therapies, could strengthen her profile as a researcher with direct clinical and pharmaceutical applications.
  3. Increased Focus on Large-Scale Collaborative Projects: While Brigaud has demonstrated leadership in individual projects, engaging in larger, multi-institutional collaborative projects could provide even more resources and amplify the impact of her research on a global scale.
  4. Enhancing Outreach to Broader Audiences: Given her expertise in addressing important clinical and biomedical issues, there may be an opportunity for Brigaud to engage with broader non-specialist audiences, including through public science communication platforms, to make her work more accessible to the general public.

Education:

Isabelle Brigaud holds a PhD in Molecular Biology and Insect Physiology from Jussieu, Paris VI, awarded with first-class honors in 2008. She also completed a Master 2 in Integrative Biology and Physiology, specializing in adaptation to the environment, and a Master 1 in Population and Ecosystem Biology and Ecophysiology, both from Jussieu, Paris VI, with honors. Brigaud has expanded her academic credentials with postdoctoral research experiences at the University of Freiburg, Germany (2012-2014), focusing on the cytoskeleton organization in zebrafish development. Prior to that, she conducted research at CNRS/INSERM in Lyon, France (2009-2011), where she studied the plasticity of cell morphology during Drosophila oogenesis. Her academic journey reflects a deep commitment to understanding molecular biology, cell biology, and biochemistry, which has shaped her research trajectory and expertise in biomaterials and tissue engineering.

Experience:

Isabelle Brigaud has extensive experience in molecular biology, cell biology, and biochemistry. She has worked at CNRS IS2M, Mulhouse, France, since 2019 as a research engineer, managing biomolecule platforms and leading studies on the foreign body response to silicone implants and injectable hydrogels. Brigaud previously held postdoctoral research positions at the University of Freiburg, Germany, and CNRS/INSERM, Lyon, France, where she investigated cytoskeletal dynamics in zebrafish lateral line development and cell morphology plasticity during Drosophila oogenesis. During her PhD at INRAE, Versailles, she focused on pheromone detection mechanisms in pest moths, an experience that formed her expertise in molecular biology and insect physiology. In addition to her hands-on research, Brigaud is involved in cross-functional project management, collaborative teamwork, and student supervision, demonstrating strong leadership skills and a passion for advancing scientific knowledge.

Awards and Honors:

Isabelle Brigaud’s work has been recognized through several prestigious publications and her contributions to the fields of biomaterials and molecular biology. Her research on the foreign body response to silicone breast implants and injectable hydrogels has made significant strides in understanding tissue regeneration and inflammatory responses. As an active member of the research community, she has been involved in multiple high-impact journal articles published in prominent scientific journals such as Biomaterials, Acta Biomaterialia, and Nature Communications. Although specific awards are not detailed in her profile, her extensive publication record, including multiple first-author and co-author contributions, highlights her ongoing influence in the scientific community. Brigaud’s commitment to advancing knowledge in biomaterials, molecular biology, and tissue engineering is further demonstrated through her leadership roles in cross-disciplinary projects, mentoring students, and managing research collaborations.

Research Focus:

Isabelle Brigaud’s research focuses on the intersection of molecular biology, biomaterials, and tissue engineering, with a specific interest in understanding the foreign body response to implants and regenerative therapies. Her work explores the immune reactions induced by materials like silicone breast implants and injectable hydrogels, aiming to improve tissue regeneration and reduce inflammation. Brigaud’s expertise includes molecular cloning, protein analysis, cell culture, and advanced imaging techniques, all of which she applies to study cell behavior, tissue interactions, and the effects of materials on cellular processes. She uses animal models, including zebrafish and Drosophila, to investigate cell morphology plasticity and mechanotransduction. Her focus also extends to the development of drug delivery systems and the role of extracellular matrix in inflammation and tissue healing. Brigaud’s collaborative approach to research has led to significant advances in the study of immunology, regenerative medicine, and biomaterials.

Publications Top Notes:

  • Brigaud I et al., 2024. Breast implant silicone exposure induces immunogenic response and autoimmune markers in human periprosthetic tissues. Biomaterials 🔬💉
  • Ouedraogo C et al., 2024. Fabrication and characterization of thin self-rolling film for anti-inflammatory drug delivery. Colloids Surf B Biointerfaces 💊🧬
  • Escriva-Boulley G et al., 2023. Effects of physical activity and endometriosis-based education program delivered by videoconference on endometriosis symptoms: the CRESCENDO program. Trials 🏃‍♀️🩺
  • Brigaud I et al., 2020. Surface texturization of breast implants impacts extracellular matrix and inflammatory gene expression in asymptomatic capsules. PRS 🦠🔬
  • Wakhloo NT et al., 2019. Actomyosin, vimentin and LINC complex pull on osteosarcoma nuclei to deform on micropillar topography. Biomaterials 🦴🔬
  • Pieuchot L et al. 2018. Curvotaxis directs cell migration through cell-scale curvature landscapes. Nature Commun. 🌍🧬
  • Brigaud I et al. 2017. Synergistic effects of BMP-2, BMP-6 or BMP-7 with human plasma fibronectin onto hydroxyapatite coatings: A comparative study. Acta Biomater. 🧫
  • Brigaud I et al., 2015. TGFbeta/activin signaling induces epithelial cell flattening during Drosophila oogenesis. Biol Open 🦗💡
  • Montagné N et al., 2012. Functional characterization of a sex pheromone receptor in the pest moth Spodoptera littoralis by heterologous expression in Drosophila. European Journal of Neuroscience 🦋👃
  • Montagne N et al.,2011. Functional characterization of a sex pheromone receptor in the pest moth Spodoptera littoralis. Chemical Senses 🦋💨
  • Brigaud I et al., 2009. Identification of an atypical insect olfactory receptor subtype highly conserved within noctuids. FEBS Journal 🦗👃
  • Brigaud I et al. 2009. Cloning and expression pattern of a putative octopamine/tyramine receptor in antennae of the noctuid moth Mamestra brassicae. Cell and Tissue Research 🦋🧬

Conclusion:

Isabelle Brigaud is undoubtedly a strong contender for the Research for Best Researcher Award. Her multifaceted expertise, robust publication record, and impactful contributions to molecular biology, cell biology, and biochemistry, particularly in the context of health applications, position her as a leader in her field. With her proven ability to manage large-scale research projects and mentor the next generation of scientists, she continues to make significant strides in biomedical research. By focusing on increasing the visibility of her findings and expanding her research into therapeutic domains, Brigaud could further elevate her already outstanding career.