Innovative Research Award
Fatma Guesmi
Faculty of Sciences of Bizerte, Tunisia
Fatma Guesmi is a researcher affiliated with the Faculty of Sciences of Bizerte, University of Carthage, Tunisia, whose published work includes studies involving molecular and cellular mechanisms, cancer biology, apoptosis, signaling pathways, and biologically active natural products. Published records identify her affiliation with the Faculty of Sciences of Bizerte and associate her research with molecular and cellular investigations. [2] [3]
Abstract
Fatma Guesmi’s research profile encompasses areas of molecular and cellular biology, with published investigations addressing cellular signaling, apoptosis, cancer-related mechanisms, and the biological effects of natural products. Her publications include experimental studies examining molecular pathways associated with cell death and cancer biology. For example, a 2021 study investigated the effects of Thymus hirtus essential oil on TRAIL-associated apoptosis and death-receptor signaling in colon cancer models. [3] A later 2024 study examined Teucrium ramosissimum essential oil and its relationship with TRAIL/Apo2L-induced cell death in HCT-116 cells. [4]
Keywords
Gene Expression; Cell Biology; Molecular Biology; Cancer Biology; Apoptosis; Cell Signaling; Death Receptor Pathways; Natural Products; Innovative Research
Introduction
Gene expression and cellular signaling are central areas of modern cell biology because changes in transcriptional regulation, signaling proteins, receptor activity, and downstream molecular pathways can influence cellular proliferation, differentiation, survival, and programmed cell death. Research addressing these mechanisms frequently combines molecular biology, biochemical assays, cellular models, and experimental disease models. [5]
Research Profile
The supplied researcher profile identifies Fatma Guesmi with the Faculty of Sciences of Bizerte in Tunisia and lists Gene Expression as the principal subject area for this recognition profile. Her publicly indexed publications also document affiliation with the Laboratory of Biochemistry and Molecular Biology and the Laboratory of Risks Related to Environmental Stresses at the Faculty of Sciences of Bizerte, University of Carthage. [3] [4]
Research Contributions
Available publications demonstrate several recurring research themes:
- Cellular signaling: Research has examined signaling systems associated with apoptosis and cancer-cell responses, including death-receptor and kinase-associated pathways. [3] [4]
- Gene-expression-related mechanisms: Published experimental work has assessed changes in molecular signaling and expression-associated proteins in cellular models. [3] [5]
Publications
Selected publications provide documented examples of Guesmi’s research activity in molecular and cellular biology. The following publications are included as representative examples rather than as a complete bibliography.
- Guesmi, F., Prasad, S., Ben Ali, M., Ismail, I. A., & Landoulsi, A. (2021). Thymus hirtus sp. algeriensis Boiss. and Reut. volatile oil enhances TRAIL/Apo2L induced apoptosis and inhibits colon carcinogenesis through upregulation of death receptor pathway. Aging, 13(18), 21975–21990. DOI: https://doi.org/10.18632/aging.203552. [3]
- Guesmi, F., Tahri, W., Mehrez, A., Barkaoui, T., Prasad, S., Giuffrè, A. M., & Landoulsi, A. (2024). Colorectal carcinoma cell targeting aromatherapy with Teucrium ramosissimum essential oil to sensitize TRAIL/Apo2L-induced HCT-116 cell death. International Immunopharmacology, 136, 112405. DOI: https://doi.org/10.1016/j.intimp.2024.112405. [4]
- Guesmi, F., Prasad, S., Tyagi, A. K., & Landoulsi, A. (2017). Antinflammatory and anticancer effects of terpenes from oily fractions of Teucrium alopecurus, blocker of IκBα kinase, through downregulation of NF-κB activation, potentiation of apoptosis and suppression of NF-κB-regulated gene expression. Biomedicine & Pharmacotherapy, 95, 1876–1885. DOI: https://doi.org/10.1016/j.biopha.2017.09.115. [5]
Research Impact
The supplied bibliometric profile reports 400 citations and an h-index of 12 across 29 documents. Such indicators can provide a quantitative description of indexed scholarly output and citation activity, although they should not be interpreted independently of disciplinary norms, publication age, database coverage, and author-identification practices. [1]
The publication record also demonstrates continuing engagement with molecular mechanisms relevant to cell biology. The 2021 study examined death-receptor signaling, apoptosis, and related molecular responses, while the 2024 study investigated cellular mechanisms associated with TRAIL/Apo2L-induced cell death in HCT-116 cells. [3] [4]
Award Suitability
For the purposes of the World Cell Biologist Awards recognition profile, the supplied research area of Gene Expression can be considered in the context of Guesmi’s documented work on cellular signaling, apoptosis, cancer-cell responses, and molecular pathways. Published studies provide evidence of experimental investigation of cellular and molecular mechanisms, including changes in signaling proteins and pathways associated with programmed cell death. [3] [4] [5]
Conclusion
Fatma Guesmi’s documented research profile includes molecular and cellular investigations involving gene-expression-related mechanisms, apoptosis, signaling pathways, cancer biology, and natural-product research. Her publications provide examples of experimental work addressing cellular responses and molecular mechanisms, while the supplied bibliometric information summarizes her indexed scholarly activity. [1] [3] [4]
External Links
References
- Elsevier. (n.d.). Scopus author details: Fatma Guesmi, Author ID 56618808600. Scopus.
https://www.scopus.com/authid/detail.uri?authorId=56618808600
- ORCID. (n.d.). Fatma Guesmi — ORCID record 0000-0002-5191-0755. ORCID.
https://orcid.org/0000-0002-5191-0755
- Guesmi, F., Prasad, S., Ben Ali, M., Ismail, I. A., & Landoulsi, A. (2021). Thymus hirtus sp. algeriensis Boiss. and Reut. volatile oil enhances TRAIL/Apo2L induced apoptosis and inhibits colon carcinogenesis through upregulation of death receptor pathway. Aging, 13(18), 21975–21990. DOI: 10.18632/aging.203552.
https://doi.org/10.18632/aging.203552
- Guesmi, F., Tahri, W., Mehrez, A., Barkaoui, T., Prasad, S., Giuffrè, A. M., & Landoulsi, A. (2024). Colorectal carcinoma cell targeting aromatherapy with Teucrium ramosissimum essential oil to sensitize TRAIL/Apo2L-induced HCT-116 cell death. International Immunopharmacology, 136, 112405. DOI: 10.1016/j.intimp.2024.112405.
https://doi.org/10.1016/j.intimp.2024.112405
- Guesmi, F., Prasad, S., Tyagi, A. K., & Landoulsi, A. (2017). Antinflammatory and anticancer effects of terpenes from oily fractions of Teucrium alopecurus, blocker of IκBα kinase, through downregulation of NF-κB activation, potentiation of apoptosis and suppression of NF-κB-regulated gene expression. Biomedicine & Pharmacotherapy, 95, 1876–1885. DOI: 10.1016/j.biopha.2017.09.115.
https://doi.org/10.1016/j.biopha.2017.09.115