Herbeuval Jean-Philippe | Immunology Cellular Interactions | Best Innovator Award

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Dr. Herbeuval Jean-Philippe | Immunology Cellular Interactions | Best Innovator Award

Dr. Herbeuval Jean-Philippe | CNRS | France

Jean-Philippe Herbeuval is a French immunologist and CNRS Director of Research, renowned for pioneering contributions to translational immunology and biomedical innovation. A PhD holder in immuno-oncology, he completed a prestigious Fogarty Fellowship at the NIH, USA, where he earned the Norman P. Salzman Award. He founded and leads the CBMIT team at Université Paris Cité, integrating immunology, virology, and chemistry for therapeutic discovery. Herbeuval has launched two biotech companies: Ermium Therapeutics, based on anti-interferon therapies, and Elyris Pharma, centered on PDK1 as a novel anti-inflammatory target. With 9 patents (3 licensed), €8.8M in research funding, and >70 publications (h-index 28), his innovations span diagnostics to therapeutics. He also contributes to policy and innovation strategy through national and international committees. Recognized for his vision, leadership, and mentorship, Herbeuval exemplifies the intersection of academic research and impactful biotechnology entrepreneurship.

Publication Profile:

Google Scholar

✅ Strengths for the Award:

  1. Exceptional Innovation in Immunology & Therapeutics

    • Discovered key therapeutic targets such as CXCR4 and PDK1.

    • Founded Ermium Therapeutics (2019) and Elyris Pharma (2024), securing over €12M in funding.

    • Holds 9 patents, with 3 already licensed — a key indicator of translational success.

  2. Proven Scientific Leadership

    • Director of Research (CNRS), Head of CBMIT at Université Paris Cité.

    • Established and led multiple interdisciplinary research teams and platforms (Cyto2BM, CBMIT).

    • Supervised 10 PhD students, 7 postdocs, and over 18 master’s students, many of whom reached elite positions.

  3. High-Impact Research Output

    • 70+ publications, including high-citation studies on interferon signaling in HIV.

    • Over 3,500 citations, h-index: 28 — showing strong impact and visibility.

  4. Strong National and International Recognition

    • Winner of the prestigious i-Lab National Innovation Prize (France, 2019).

    • Invited speaker at over 24 international conferences; reviewer for Nature Medicine and PNAS.

    • Advisor for funding agencies across the US (NIH), UK (MRC), China, and Brazil.

  5. Valuable Public and Government Engagement

    • CNRS Innovation Ambassador (2024) and expert for multiple national programs (ANRS, Campus France).

    • Actively engages in public science communication (TV, radio, press).

🔧 Areas for Improvement:

  1. Scaling Global Industry Impact

    • While Ermium and Elyris are high-potential, further proof of market adoption and therapeutic success will solidify his innovation leadership globally.

  2. Broader Patent Commercialization

    • More patents could potentially be moved from licensing to full-scale clinical trials or product development phases.

  3. Diversity of Therapeutic Areas

    • While the focus on interferon biology and immunomodulation is powerful, broader expansion into other disease domains (e.g., neuroinflammation, metabolic syndromes) could enhance reach.

🎓 Education:

Jean-Philippe Herbeuval earned his PhD in immuno-oncology in 2001 from Université Jean Monnet, Saint-Étienne, working under the INSERM network. He then pursued a highly competitive five-year Fogarty Postdoctoral Fellowship at the National Institutes of Health (NIH), USA, under Dr. Gene Shearer, focusing on the antiviral response to HIV. During this time, he earned multiple prestigious awards including the Norman P. Salzman Award and an NIH Young Scientist Cash Award. Upon returning to France, he secured a CNRS Junior PI position in 2006 and received his Habilitation to Direct Research (HDR) in 2008 from Université Paris Descartes. His rapid career progression continued with his appointment as Director of Research (2nd class) in 2013 and promotion to 1st class in 2019 at CNRS UMR8601. His educational path reflects an exceptional blend of scientific rigor, international exposure, and leadership in innovation.

💼 Experience:

Jean-Philippe Herbeuval brings over two decades of distinguished experience at the interface of academic research and biotech innovation. Starting with his postdoctoral fellowship at NIH (2001–2006), he led groundbreaking studies on interferon responses in HIV. Since 2006, he has served within CNRS, creating and leading the CBMIT interdisciplinary team. He established the Cyto2BM core facility and spearheaded multiple translational projects. As scientific founder of Ermium Therapeutics (2019) and Elyris Pharma (2024, in progress), he has successfully attracted venture capital and secured technology transfer agreements. His strategic involvement extends to national innovation committees (ANRS, CNRS, Campus France) and advisory roles. He has trained over 35 researchers and supervised major national/international grants. Notably, he combines deep scientific insight with an entrepreneurial mindset, as shown by his participation in Deeptech Founders and RISE programs. His experience spans leadership, translational science, investment negotiations, and scientific mentoring.

🔬 Research Focus:

Jean-Philippe Herbeuval’s research is centered on translational immunology, particularly type I interferons, autoinflammatory pathways, and host-pathogen interactions. His work explores immune dysregulation in infectious diseases such as HIV, SARS-CoV-2, dengue, and influenza, with a special focus on the immune-modulatory roles of dendritic cells and apoptotic pathways. He has identified novel therapeutic targets including CXCR4 and PDK1, leading to two biotech start-ups and multiple patents. His interdisciplinary CBMIT team integrates immunology, virology, medicinal chemistry, and computational modeling to develop innovative therapeutic strategies and biomarkers. He has a keen interest in immunomodulation, therapeutic interference with IFN pathways, and discovery of druggable checkpoints in innate immunity. With over 70 peer-reviewed publications, his scientific output has shaped current understanding of immune pathogenesis and opened new avenues for therapy in inflammatory and infectious diseases. His approach bridges fundamental research with practical applications in drug discovery and biotech development.

📚 Publications Top Notes:

  1. 🧬 HIV inhibits CD4+ T-cell proliferation by inducing indoleamine 2,3-dioxygenase in plasmacytoid dendritic cells

  2. ⚰️ CD4+ T-cell death induced by infectious and noninfectious HIV-1: role of type 1 interferon–dependent, TRAIL/DR5-mediated apoptosis

  3. 🚻 Sex differences in plasmacytoid dendritic cell levels of IRF5 drive higher IFN-α production in women

  4. 🧪 HIV-1 immunopathogenesis: how good interferon turns bad

  5. 🔄 Regulation of indoleamine 2,3-dioxygenase and tryptophanyl-tRNA-synthetase by CTLA-4-Fc in human CD4+ T cells

  6. 🧠 Differential expression of IFN-α and TRAIL/DR5 in lymphoid tissue of progressor vs. nonprogressor HIV-1-infected patients

  7. 🧟 HIV turns plasmacytoid dendritic cells into TRAIL-expressing killer pDC via TLR7-induced IFN-α

  8. 🧬 Regulation of TRAIL on primary CD4+ T cells by HIV-1: role of plasmacytoid dendritic cells

  9. 💉 TRAIL in HIV-1–infected patients and its production by antigen-presenting cells

  10. 🧫 Recruitment of STAT3 for production of IL-10 by colon carcinoma cells induced by macrophage-derived IL-6

🧾 Conclusion:

Dr. Jean-Philippe Herbeuval stands out as a highly qualified and deserving candidate for the Best Innovator Award. His rare combination of scientific excellence, translational innovation, entrepreneurial leadership, and mentorship places him in the top tier of biomedical innovators. His work not only bridges science and industry but also directly contributes to addressing global health challenges. Continued support and recognition of his efforts will likely catalyze further innovation in therapeutic immunology.

Xiaoyan Wang | Immunology Cellular Interactions | Best Researcher Award.

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Ms. Xiaoyan Wang | Immunology Cellular Interactions | Best Researcher Award

Ms. Xiaoyan Wang, Fudan University, China

Dr. Xiaoyan Wang is a postdoctoral fellow at Fudan University with a strong foundation in both clinical and basic cardiovascular research. She holds a PhD in Cardiology from Fudan University and is currently advancing her expertise through the Global Clinical Scholars Research Training Program at Harvard Medical School. Her academic journey spans over a decade of progressive education and clinical experience, complemented by multiple high-impact publications. She actively contributes to scholarly communities as an editor for AME Clinical Trials Review and the organizer of an academic communication club. Dr. Wang’s work bridges immunology and cardiology, particularly in understanding immune mechanisms in cardiovascular diseases. She has received several prestigious fellowships and awards, reflecting her strong scientific rigor and leadership. With her multidisciplinary research background and international exposure, Dr. Wang is an emerging leader in cardiovascular translational research and a strong contender for the Best Researcher Award.

Publication Profile: 

Scopus

✅ Strengths for the Award:

  1. Strong Academic Foundation

    • Trained at top-tier institutions including Fudan University and currently enrolled at Harvard Medical School for global clinical research training.

    • Holds a PhD in Cardiology with a solid foundation in both clinical and basic research.

  2. Extensive Research Experience

    • Over a decade of research with a focus on ventricular remodeling, immune mechanisms in cardiovascular diseases, and non-coding RNAs.

    • Published in high-impact journals such as Signal Transduction and Targeted Therapy, Annals of Translational Medicine, and Heliyon.

  3. Recognized Expertise and Leadership

    • Awarded Postdoctoral Fellowship by CPSF and Super Postdoctoral Fellowship by Fudan University in 2023.

    • Section Editor at AME Clinical Trials Review and organizer of the “Excellent Academic Research Communication Club”.

  4. Interdisciplinary and Translational Focus

    • Combines clinical cardiology with molecular immunology, enhancing the translational potential of her research.

  5. Global Perspective

    • Active participation in international research forums like the Japanese Circulation Society, which reflects global relevance.

⚙️ Areas for Improvement:

  • Broader Collaboration: While her core work is well-recognized, expanding interdisciplinary and international collaborations could amplify her visibility.

  • Clinical Trial Leadership: Leading a multi-center clinical trial would significantly strengthen her clinical research credentials.

  • Grant Acquisition: More information on independently secured competitive research grants could further demonstrate leadership.

🎓 Education:

Dr. Xiaoyan Wang is currently enrolled in the Global Clinical Scholars Research Training Program (2024–2025) at Harvard Medical School, combining online and on-site learning. She earned her PhD in Cardiology at Fudan University’s Zhongshan Hospital (2016–2019), where she conducted basic research on ventricular remodeling under Prof. Yunzeng Zou, supported by national-level research funds. Earlier, she obtained her Master’s degree in clinical cardiology from Dalian Medical University (2013–2016), supervised by the esteemed Prof. Yaling Han. Her undergraduate training was completed at Fujian Medical University (2007–2012), where she laid the foundation for her clinical and academic career. Her education reflects a steady progression toward excellence in cardiovascular research, integrating both laboratory and patient-based studies. Dr. Wang’s cross-disciplinary and global educational background equips her with a unique perspective in translational medicine and scientific innovation.

🩺 Experience:

Dr. Xiaoyan Wang is a postdoctoral fellow at Fudan University (2023–present), where she continues her cardiovascular research under Prof. Yunzeng Zou and fosters academic exchange as the organizer of the “Excellent Academic Research Communication Club.” She also serves as a section editor for AME Clinical Trials Review (2024–present). Previously, she worked as a cardiologist at Shanghai Jiaotong University’s Ruijin Hospital (2022–2023) and as a cardiovascular specialist at Fudan University’s Zhongshan Hospital (2019–2022). Her clinical practice is complemented by a strong research portfolio and academic leadership. Dr. Wang’s diverse roles reflect her commitment to integrating clinical insight with research innovation. Her responsibilities span research coordination, patient care, publishing, and mentoring, positioning her as a clinician-scientist deeply embedded in academic medicine.

🏆 Awards and Honors:

Dr. Xiaoyan Wang has been recognized with several competitive awards that underscore her research excellence. In 2023, she received the Postdoctoral Fellowship Program of CPSF and was named a Super Postdoctoral Fellow at Fudan University—both high honors recognizing scientific innovation and impact. Her clinical insights and writing skills earned her third prize in the 8th “Buchang Cup” Young Physician Essay Contest (2019). She was also selected to present at the Late-Breaking Cohort Studies session at the Japanese Circulation Society (JCS) Annual Meeting in 2019, an indication of her work’s international relevance. These awards demonstrate her ability to balance rigorous clinical practice with pioneering research, making her a standout candidate for accolades like the Best Researcher Award.

🔬 Research Focus:

Dr. Wang’s research centers on the intersection of cardiology and immunology, with a special focus on ventricular remodeling, cGAS-STING signaling pathways, immune responses in myocardial infarction, and non-coding RNAs. Her work spans both basic and translational research, investigating the molecular mechanisms behind cardiovascular disease progression while aiming to identify therapeutic targets. She has explored the roles of Akt, β-arrestin-2, CaMKII, and immune gene signatures in heart failure and myocardial infarction. Dr. Wang’s research has practical clinical implications, informing diagnosis and prognosis in cardiovascular medicine. Through international collaborations and cutting-edge methodologies, she contributes to a deeper understanding of immune-cardiovascular crosstalk. Her publication track record and editorial roles affirm her impact in shaping current and future directions in cardiovascular research.

📚 Publications Top Notes: 

1️⃣ 🧬 The immune system in cardiovascular diseases: from basic mechanisms to therapeutic implications – Signal Transduction and Targeted Therapy (2025)
2️⃣ 🧠 The connection of immune response and cGAS-STING pathway in cardiovascular disease – International Journal of Biological Sciences (Revised)
3️⃣ 🧪 Left ventricular response in the transition from hypertrophy to failure… in mice with aortic regurgitation – Annals of Translational Medicine (2020)
4️⃣ 🩸 The diagnostic values of circulating miRNAs for hypertension and bioinformatics analysis – Bioscience Reports (2018)
5️⃣ 🚬 Galectin-3 inhibition alleviates cigarette smoke extract-induced EPC dysfunction by downregulating autophagy – Oxidative Medicine and Cellular Longevity (2019)
6️⃣ 🔁 Circular RNA in cardiovascular disease – Non-coding RNA Investigation (2017)
7️⃣ ❤️‍🔥 An Integrated Signature of Clinical Metrics and Immune-Related Genes as a Prognostic Indicator for STEMI Patient Survival – Heliyon (2024)

🧾 Conclusion:

Dr. Xiaoyan Wang is an exceptionally qualified candidate for the Best Researcher Award. Her research blends clinical relevance with molecular depth, showing a clear trajectory toward academic leadership in cardiovascular immunology. With a combination of high-impact publications, clinical acumen, and global training, she exemplifies the qualities this award seeks to honor. Minor expansions in clinical trial leadership and collaborative reach could further elevate her profile. Nevertheless, her current accomplishments already distinguish her as a top-tier emerging researcher.