Marija Gjorgoska | Cancer Cell Biology | Best Researcher Award

Mrs. Marija Gjorgoska | Cancer Cell Biology | Best Researcher Award

Mrs. Marija Gjorgoska | Institute of Biochemistry and Molecular Genetics, Faculty of Medicine, University of Ljubljana | Slovenia

Marija Gjorgoska is a dedicated biomedical researcher and teaching assistant at the Faculty of Medicine, University of Ljubljana, Slovenia. With a strong background in biochemistry, molecular biology, and bioinformatics, she has contributed significantly to cancer research, focusing on steroid hormone signaling in gynecological cancers. Her scientific work combines analytical expertise in LC-MS/MS with a solid foundation in molecular biology and statistical analysis using R programming. Marija is passionate about advancing clinical diagnostics and cancer treatment through high-precision biomolecular profiling. Her academic journey reflects international exposure through internships in the UK and Macedonia. She is known for her collaborative spirit and commitment to scientific rigor, which has led to multiple high-impact publications. Marija continues to mentor students and contribute to the academic community through her teaching role, making her a rising figure in molecular oncology research.

publication profile:

scopus

Strengths:

  1. High Research Productivity 📈
    Marija Gjorgoska has authored or co-authored 10 peer-reviewed publications in high-impact journals such as Progress in Lipid Research (IF 14.0), Trends in Endocrinology and Metabolism (IF 11.4), and Cancers. Her work shows consistent scientific output, often with first or shared first authorship.

  2. Cutting-Edge Technical Expertise 🔬
    She demonstrates advanced proficiency in LC-MS/MS method development, multi-steroid profiling, and bioinformatics (R programming). This makes her an expert in translational hormone research and biomarker discovery.

  3. Clinical Relevance and Innovation ⚕️
    Her research addresses urgent clinical challenges like endometrial cancer diagnosis and ovarian cancer drug resistance, applying modern analytical techniques combined with machine learning, which positions her at the forefront of personalized medicine.

  4. Recognition and Collaboration 🤝
    She has been awarded prestigious grants (e.g., Society of Endocrinology, UK), collaborated internationally (UK, Macedonia), and contributes to academia as a teaching assistant—all signs of an emerging research leader.

  5. Interdisciplinary Impact 🌐
    Marija effectively integrates molecular biology, biochemistry, analytical chemistry, and computational biology—indicative of her versatility and broad scientific impact.

Areas for Improvement:

  1. Independent Research Leadership
    While she has made substantial contributions as a junior and co-investigator, future work could benefit from establishing herself as a principal investigator or project leader, including securing her own research funding.

  2. Diversification of Research Themes
    Her focus has been predominantly on hormone-related cancers. Expanding into other disease models or mechanisms could broaden her impact and create new collaborative opportunities.

  3. Public Engagement and Outreach
    Enhancing her visibility through conference presentations, science communication, or community health initiatives would further solidify her standing as a leader and advocate for biomedical research.

Education :

Marija Gjorgoska is currently enrolled in a doctoral program in Biomedicine, specializing in Biochemistry and Molecular Biology at the University of Ljubljana. Her academic foundation includes a Master’s degree in Molecular Biology (2018–2021) from the same university, completed with an outstanding GPA of 9.52/10. She also gained international experience through a short-term internship at the University of Birmingham, UK, in 2023, focusing on advanced LC-MS/MS techniques for clinical sample analysis. Earlier in her academic career, she completed a long-term internship at the Research Center for Genetic Engineering and Biotechnology in Skopje, Macedonia (2017), where she worked on genetic diagnostics involving haemoglobinopathies, HPV, HBV, and HCV detection. Her education has consistently emphasized both theoretical knowledge and hands-on laboratory skills, particularly in analytical chemistry, molecular biology, and bioinformatics, all of which shape her current research endeavors in cancer diagnostics and hormonal regulation.

Experience:

Marija Gjorgoska has been actively engaged in research since 2020 as a Research Assistant at the Institute of Biochemistry and Molecular Genetics, Faculty of Medicine, University of Ljubljana. Her core responsibilities include developing and validating LC-MS/MS analytical methods, conducting proteomic and genetic analyses of cancer tissues, and performing bioinformatic evaluations using R programming. In October 2024, she also began serving as a Teaching Assistant for the course “Principles of Biochemistry,” demonstrating her commitment to education and mentorship. Marija’s prior internships have equipped her with valuable skills in prenatal and infectious disease diagnostics. Her research contributions span experimental planning, scientific writing, and instrument maintenance, establishing her as a versatile scientist. Her collaborative projects with international researchers and clinicians further underline her strength in translational biomedical research. This combination of teaching, laboratory, and analytical expertise supports her growing influence in molecular oncology.

Awards and Honors:

Marija Gjorgoska has been recognized for both academic and research excellence. In 2023, she was awarded the Practical Skills Grant by the Society of Endocrinology, UK, enabling her to undergo advanced training in LC-MS/MS at the University of Birmingham. Earlier, in 2021, she received the Krka Recognition with Special Praise for her Master’s thesis, highlighting her early promise as a researcher in molecular biology. Her scientific publications have appeared in top-tier journals such as Progress in Lipid Research and Trends in Endocrinology and Metabolism, some with impact factors exceeding 14.0. Notably, she earned shared first co-authorship in Methods in Enzymology for her work on enzymatic assay development. These accolades reflect her technical excellence, originality, and scientific contributions in the field of steroid metabolism and gynecological cancers. Marija’s achievements distinguish her as a young researcher with significant impact and high potential for further contributions to science and medicine.

Research Focus :

Marija Gjorgoska’s research focuses on the role of steroid hormones in the development and progression of gynecological cancers, particularly endometrial and ovarian cancers. Her work integrates analytical chemistry (LC-MS/MS), bioinformatics, and molecular biology to uncover diagnostic and prognostic biomarkers. She has developed multi-steroid profiling techniques to differentiate between normal and cancerous tissues, aiding early diagnosis. Marija’s studies also address the pre-receptor regulation of androgenic and estrogenic hormones, exploring their signaling dynamics at the tissue level. Using tools such as Mendelian randomization, she investigates genetic influences on hormone-related disease risk. Her interdisciplinary approach combines advanced mass spectrometry, statistical modeling, and clinical collaboration to translate bench science into meaningful medical applications. Through high-impact publications, she contributes to understanding hormone metabolism in cancer microenvironments, with the goal of informing targeted therapies and overcoming drug resistance. Her work is critical for advancing personalized medicine in hormone-driven malignancies.

Publications Top Notes:

  1. 📘 From fallopian tube epithelium to high-grade serous ovarian cancer: A single-cell resolution review of sex steroid hormone signalingProgress in Lipid Research, 2024

  2. 📘 Integration of androgen hormones in endometrial cancer biologyTrends in Endocrinology and Metabolism, 2022

  3. 📘 Steroid sulfatase and sulfotransferases in gynecological cancers: current status and perspectivesEssays in Biochemistry, 2024

  4. 📘 Estrogens and the Schrödinger’s cat in the ovarian tumor microenvironmentCancers, 2021

  5. 📘 Multi-Steroid Profiling and Machine Learning Reveal Androgens as Biomarkers for Endometrial CancerCancers, 2025

  6. 📘 Simultaneous measurement of 17 endogenous steroid hormones by LC-MS/MSJ. of Steroid Biochemistry and Molecular Biology, 2024

  7. 📘 11-oxyandrogens in normal vs. cancerous endometriumFrontiers in Endocrinology, 2024

  8. 📘 Targeting estrogen metabolism to overcome platinum resistance in ovarian cancerBiomedicine & Pharmacotherapy, 2024

  9. 📘 Effect of androgens on risk of endometriosis sub-phenotypes and ovarian neoplasmsJ. of Steroid Biochemistry and Molecular Biology, 2024

  10. 📘 Enzymatic assays for 17β-HSD types 1 and 2 using mass spectrometryMethods in Enzymology, 2023

Conclusion:

Marija Gjorgoska is a highly promising early-career researcher with a strong and growing international publication record, deep technical expertise in analytical biochemistry, and a clear focus on clinically relevant research. Her integration of hormonal pathway analysis with state-of-the-art analytical methods has already contributed valuable insights to the field of gynecological oncology. She has the academic rigor, curiosity, and collaborative drive essential for impactful science.

In my opinion, she is a highly suitable candidate for the Best Researcher Award. Continued mentorship and support toward independent research leadership will elevate her even further in the years to come.

Guojie Ji | Cancer Cell Biology | Cancer Cell Biology Award

Mr. Guojie Ji | Cancer Cell Biology | Cancer Cell Biology Award

Mr. Guojie Ji, NORTH HENAN MEDICAL UNIVERSITY, China

Guojie Ji, Master of Medicine Science, is a laboratory technician and the Provincial Director of the Demonstration Center for Biological and Basic Medical Experimental Teaching. With a core research focus on fertility preservation and tumor therapy, he brings an interdisciplinary approach to biomedical science. Ji has played a pivotal role in guiding over 30 research papers and acquiring 13 national patents. In addition to managing over 15 national and provincial projects, his mentorship has led students to win numerous innovation and entrepreneurship awards at both national and provincial levels. Ji is an editorial board member for Contemporary Chemical Research and a peer reviewer for Cell Death Discovery. His leadership and scholarly work have earned him several honors, including being named Outstanding Teacher and Provincial Outstanding Mentor. His recent research delves into ferroptosis in cancer and reproductive toxicity, making impactful contributions to both cancer biology and regenerative medicine.

Publication Profile:

Orcid

✅ Strengths for the Award:

  1. Relevant Research Contributions:

    • Ji has made direct contributions to cancer biology, particularly through:

      • Ferroptosis mechanisms in breast cancer cells (2025, BBRC)

      • 5-Fluorouracil-induced oxidative damage and DNA disruption (2024, Ecotoxicology & Environmental Safety)

      • Exosome impact on melanoma cell growth (2021, Journal of Yangzhou University)

    • These studies reflect deep involvement in molecular mechanisms of cancer cell death, a central theme in cancer cell biology.

  2. Multidisciplinary Integration:

    • Ji’s research spans stem cells, oxidative stress, and reproductive toxicity, all of which tie into cancer research—especially in terms of chemotherapy side effects and regenerative implications.

  3. High Research Output and Recognition:

    • Over 30 peer-reviewed articles, including in high-impact journals such as Cell Death Discovery and BBRC.

    • 13 national patents, indicating applied innovation in biomedical research.

    • Leads national and provincial projects with substantial funding (~¥1 million), showcasing leadership and research management.

  4. Mentorship and Scientific Community Service:

    • Recognized as an Outstanding Innovation Mentor, Editorial Board Member, and Peer Reviewer, reflecting active participation in advancing the field.

    • Mentored award-winning student teams in national competitions, indicating talent cultivation in biomedical research.

⚠️ Areas for Improvement:

  1. Primary Focus Is Fertility & Reproductive Biology:

    • While Ji has notable cancer-related studies, his primary research base lies in fertility preservation. For this award, a broader and more central focus on oncogenic signaling, tumor microenvironments, or immunotherapy might strengthen his profile.

  2. Limited Clinical Cancer Studies:

    • Most cancer work is preclinical or in vitro; integrating clinical collaborations or translational oncology trials could enhance relevance to applied cancer therapy.

Education:

Guojie Ji holds a Master of Medicine Science, with specialized training in biological sciences, biomedical research, and clinical applications in fertility and tumor biology. His academic background includes comprehensive training in cell biology, molecular biology, reproductive medicine, and translational oncology. Through this foundation, he developed a research orientation focused on bridging cell-level discoveries with clinical potential, particularly in the areas of cryopreservation, stem cell differentiation, and tumor cell regulation. Ji’s academic excellence and commitment to research have driven his involvement in interdisciplinary fields, where he combines elements of life sciences and therapeutic innovation. His deep-rooted academic experiences have been critical in enabling his success as a project leader, educator, and recognized biomedical scientist. His education is not just academic but applied, demonstrated by his integration of research into experimental teaching models and training future life scientists.

💼 Experience:

Guojie Ji currently serves as a Laboratory Technician and Provincial Director for a Demonstration Center dedicated to experimental biological and medical teaching. He has led or completed 10+ major national and provincial research projects, along with 5 horizontal interdisciplinary research collaborations, collectively funded with nearly 1 million yuan. Ji’s lab has been instrumental in developing fertility-preservation protocols, studying sperm cryopreservation, and examining cancer cell response to drugs like 5-FU. He has authored over 30 peer-reviewed papers, including key publications in Cell Death Discovery, Ecotoxicology and Environmental Safety, and Biochemical and Biophysical Research Communications. Ji is a mentor to undergraduate innovators, guiding teams to national victories in prestigious competitions. Additionally, he holds editorial and peer-review roles in prominent scientific journals. His work demonstrates strong leadership, scholarly innovation, and an enduring commitment to experimental medical education and biomedical research.

🏆 Awards and Honors:

Guojie Ji’s contributions to research and education have earned him widespread recognition. He has been honored as a Key Teacher, Civilized Teacher, and Outstanding Teacher, along with awards for Outstanding Innovation and Entrepreneurship Mentorship at the provincial level. He has received accolades as Outstanding Supervisor for Bachelor’s Degree Dissertations and Life Sciences Competition Mentor. Ji has successfully supervised student teams winning over 25 awards, including 5 national-level prizes in events such as the Challenge Cup, Internet+, and the National College Life Sciences Competition. These honors reflect his commitment to combining cutting-edge research with student training and public impact. His ability to mentor and lead both in the lab and the classroom has set a benchmark for excellence in academic innovation and practical scientific development. Ji’s holistic excellence makes him a role model in both research mentorship and scientific discovery.

🔬 Research Focus:

Guojie Ji’s research lies at the intersection of fertility preservation, cryobiology, and tumor cell biology. He explores the mechanisms of cell damage, oxidative stress, and DNA integrity during sperm and stem cell preservation, with a growing emphasis on ferroptosis—a regulated form of cell death—in cancer biology. His recent studies demonstrate how agents like 5-Fluorouracil affect cancer cells and male fertility via oxidative and mitochondrial pathways. Ji also investigates mesenchymal stem cell-derived exosomes in tumor growth, highlighting a promising field of cell-free therapies. In plant and animal models, he’s contributed to understanding protein and lipid roles in cell signaling and disease resistance, reinforcing the depth and range of his biomedical expertise. With a diverse research portfolio, Ji aims to translate basic discoveries into therapeutic strategies, particularly targeting tumor suppression and reproductive health. His work continues to expand the molecular understanding of cell survival and death pathways in medicine.

📚 Publications Top Notes:

  1. 🧊 Protective Effect of Sucrose and Antioxidants on Cryopreservation of Sperm Motility and DNA Integrity in C57BL/6 Mice

  2. 💧 Effects of MTG and GSH on Human Sperm Motility and DNA Integrity during Vitrification in the Presence of Trehalose

  3. ❄️ Comparison of Rapid Freezing vs. Vitrification for Human Sperm Cryopreservation Using Sucrose in Closed Straw Systems

  4. 🔍 Studies on Basic Issues Relevant to Sperm Cryopreservation in Humans

  5. 📦 Effects of Exosomes Derived from Mesenchymal Stem Cells on the Growth of Melanoma Cells

  6. 🌱 BMP4 is Insufficient to Differentiate Umbilical Cord MSCs into Germ Cell-like Cells In Vitro

  7. 🧬 Current Status of Male Fertility Preservation in Humans

  8. 🧪 Protein Glycosylation Changes During Systemic Acquired Resistance in Arabidopsis thaliana

  9. 🛡️ Lipid Transfer Proteins in Plant-Pathogen Interactions and Their Molecular Mechanisms

  10. 🔥 Emerging Roles of Ferroptosis in Male Reproductive Diseases

🧾 Conclusion:

Guojie Ji is a strong interdisciplinary researcher with a credible and impactful body of work in cancer cell biology, particularly in the context of ferroptosis, chemotherapy-induced toxicity, and tumor suppression mechanisms. His contributions bridge the fields of cell death, oxidative biology, and reproductive toxicology, offering unique insights into the systemic effects of anti-cancer agents. While cancer is not his sole research domain, his innovative work and translational potential clearly qualify him as a compelling nominee for the Research for Cancer Cell Biology Award—particularly in molecular cancer mechanisms and therapeutic research.