Published on 23/09/202523/09/2025 by Cell Biologist Prof. Xinghua Pan | Single Cell and Spatial Omics | Excellence in Research Award Macau University of Science and Technology | China Professor Xinghua (Victor) Pan, PhD, MD, is a distinguished researcher in the fields of single-cell technology, spatial omics, genome medicine, regenerative biology, and cancer heterogeneity. Currently serving as a professor at the Precision Regenerative Medicine Research Centre (PRMRC), Macau University of Science and Technology (MUST), he is also affiliated with the State Key Laboratory of Quality Research in Chinese Medicine. Dr. Pan earned his MD and MS degrees from Southern Medical University and completed his PhD in genetics at Fudan University under the mentorship of renowned geneticist Dr. CC Tan. His interdisciplinary research integrates cutting-edge single-cell and multi-omics platforms to investigate tumor microenvironments, stemness, and disease mechanisms at cellular resolution. Dr. Pan has authored over 280 peer-reviewed publications, with a current h-index of 48, more than 9,200 citations, and his work spans high-impact journals such as Nature, Nature Communications, Advanced Science, Nucleic Acids Research, and Cancer Research. He is frequently recognized as a corresponding or co-corresponding author in key studies advancing genomic technologies and translational applications in precision medicine. His contributions continue to shape the landscape of cellular and molecular research globally. Profiles: Google Scholar | Orcid Featured Publications: Zhang, Y., Lu, Y., Mai, L., Wen, Z., Dai, M., Xu, S., Lin, X., Luo, Y., Qiu, Y., Chen, Y., Dong, Z., Chen, C., Meng, W., Luo, X., Lin, G., Tam, P. K. H., & Pan, X. (2025). Dynamic heterogeneity towards drug resistance in AML cells is primarily driven by epigenomic mechanism unveiled by multi-omics analysis. Journal of Advanced Research. Advance online publication. Su, H., Zhou, X., Lin, G., Luo, C., Meng, W., Lv, C., Chen, Y., Wen, Z., Li, X., Wu, Y., Xiao, C., Yang, J., Lu, J., Luo, X., Hong, X., Chen, Y., Tam, P. K. H., Li, C., Sun, H., & Pan, X. (2025). Deciphering the oncogenic landscape of hepatocytes through integrated single-nucleus and bulk RNA-seq of hepatocellular carcinoma. Advanced Science, 12, e2412944. Huang, Y., Wang, Q., Zhou, W., Jiang, Y., He, K., Huang, W., Feng, Y., Wu, H., Liu, L., Pan, Y., Huang, Y., Chen, Z., Li, W., Huang, Y., Lin, G., Zhang, Y., Ren, Y., Xu, K., Yu, Y., … Hu, Y. (2024). Prenatal p25-activated Cdk5 induces pituitary tumorigenesis through MCM2 phosphorylation-mediated cell proliferation. Neoplasia, 57, 101054. Gao, J., Wu, Y., Yu, J., Qiu, Y., Yi, T., Luo, C., Zhang, J., Lu, G., Li, X., Xiong, F., Wu, X., & Pan, X. (2024). Impact of genomic and epigenomic alterations of multigene on a multicancer pedigree. Cancer Medicine, 13(13), e7394. Chen, F., Zhang, K., Wang, M., He, Z., Yu, B., Wang, X., Pan, X., Luo, Y., Xu, S., Lau, J. T. Y., Han, C., Shi, Y., Sun, Y. E., Li, S., & Hu, Y. P. (2024). VEGF-FGF signaling activates quiescent CD63(+) liver stem cells to proliferate and differentiate. Advanced Science, 11, e2308711. Mai, L., Wen, Z., Zhang, Y., Gao, Y., Lin, G., Lian, Z., Yang, X., Zhou, J., Lin, X., Luo, C., Peng, W., Chen, C., Peng, J., Liu, D., Marjani, S. L., Tao, Q., Cui, Y., Zhang, J., Wu, X., Weissman, S. M., & Pan, X. (2023). Shortcut barcoding and early pooling for scalable multiplex single-cell reduced-representation CpG methylation sequencing at single nucleotide resolution. Nucleic Acids Research, 51, e108. Xinghua Pan | Single Cell and Spatial Omics | Excellence in Research Award
Professor Xinghua (Victor) Pan, PhD, MD, is a distinguished researcher in the fields of single-cell technology, spatial omics, genome medicine, regenerative biology, and cancer heterogeneity. Currently serving as a professor at the Precision Regenerative Medicine Research Centre (PRMRC), Macau University of Science and Technology (MUST), he is also affiliated with the State Key Laboratory of Quality Research in Chinese Medicine. Dr. Pan earned his MD and MS degrees from Southern Medical University and completed his PhD in genetics at Fudan University under the mentorship of renowned geneticist Dr. CC Tan. His interdisciplinary research integrates cutting-edge single-cell and multi-omics platforms to investigate tumor microenvironments, stemness, and disease mechanisms at cellular resolution. Dr. Pan has authored over 280 peer-reviewed publications, with a current h-index of 48, more than 9,200 citations, and his work spans high-impact journals such as Nature, Nature Communications, Advanced Science, Nucleic Acids Research, and Cancer Research. He is frequently recognized as a corresponding or co-corresponding author in key studies advancing genomic technologies and translational applications in precision medicine. His contributions continue to shape the landscape of cellular and molecular research globally. Profiles: Google Scholar | Orcid Featured Publications: Zhang, Y., Lu, Y., Mai, L., Wen, Z., Dai, M., Xu, S., Lin, X., Luo, Y., Qiu, Y., Chen, Y., Dong, Z., Chen, C., Meng, W., Luo, X., Lin, G., Tam, P. K. H., & Pan, X. (2025). Dynamic heterogeneity towards drug resistance in AML cells is primarily driven by epigenomic mechanism unveiled by multi-omics analysis. Journal of Advanced Research. Advance online publication. Su, H., Zhou, X., Lin, G., Luo, C., Meng, W., Lv, C., Chen, Y., Wen, Z., Li, X., Wu, Y., Xiao, C., Yang, J., Lu, J., Luo, X., Hong, X., Chen, Y., Tam, P. K. H., Li, C., Sun, H., & Pan, X. (2025). Deciphering the oncogenic landscape of hepatocytes through integrated single-nucleus and bulk RNA-seq of hepatocellular carcinoma. Advanced Science, 12, e2412944. Huang, Y., Wang, Q., Zhou, W., Jiang, Y., He, K., Huang, W., Feng, Y., Wu, H., Liu, L., Pan, Y., Huang, Y., Chen, Z., Li, W., Huang, Y., Lin, G., Zhang, Y., Ren, Y., Xu, K., Yu, Y., … Hu, Y. (2024). Prenatal p25-activated Cdk5 induces pituitary tumorigenesis through MCM2 phosphorylation-mediated cell proliferation. Neoplasia, 57, 101054. Gao, J., Wu, Y., Yu, J., Qiu, Y., Yi, T., Luo, C., Zhang, J., Lu, G., Li, X., Xiong, F., Wu, X., & Pan, X. (2024). Impact of genomic and epigenomic alterations of multigene on a multicancer pedigree. Cancer Medicine, 13(13), e7394. Chen, F., Zhang, K., Wang, M., He, Z., Yu, B., Wang, X., Pan, X., Luo, Y., Xu, S., Lau, J. T. Y., Han, C., Shi, Y., Sun, Y. E., Li, S., & Hu, Y. P. (2024). VEGF-FGF signaling activates quiescent CD63(+) liver stem cells to proliferate and differentiate. Advanced Science, 11, e2308711. Mai, L., Wen, Z., Zhang, Y., Gao, Y., Lin, G., Lian, Z., Yang, X., Zhou, J., Lin, X., Luo, C., Peng, W., Chen, C., Peng, J., Liu, D., Marjani, S. L., Tao, Q., Cui, Y., Zhang, J., Wu, X., Weissman, S. M., & Pan, X. (2023). Shortcut barcoding and early pooling for scalable multiplex single-cell reduced-representation CpG methylation sequencing at single nucleotide resolution. Nucleic Acids Research, 51, e108.