Cletus Ukwubile | Nanomedicine | Research Excellence Award

Published on by Cell Biologist

Dr. Cletus Ukwubile | Nanomedicine | Research Excellence Award

University of Maiduguri | Nigeria

Dr. Cletus Ukwubile is a pharmacognosy researcher whose work integrates natural product chemistry, analytical instrumentation, and biomedical investigation. His expertise spans advanced chromatographic and spectroscopic techniques, including GC-MS, HPLC, TLC, PTLC, and VLC, which he applies to the characterization of bioactive compounds from medicinal plants. He has extensive experience in statistical and data-driven research using SPSS, GraphPad, R, SQL, and Tableau to support evidence-based scientific inquiry. His research contributions include leadership in university-level pharmacognostic studies and cancer-related investigations, particularly through funded projects such as the TETFund Nigeria Institutional Based Research Grant for brain tumour research. He has also benefited from international training, including a Royal Society of Chemistry fellowship in GC-MS analytics. With additional involvement in scientific societies and editorial bodies, he contributes to advancing natural product research, pharmacological discovery, and translational applications in biomedical science.

Profiles: Google Scholar | Scopus | Orcid

Featured Publications: 

Ukwubile, C. A., Robert, A. E., Nuhu, A., Ahuchaogu, A. A., Ikpefan, E. O., & others. (2026). Nano-enhanced phytotherapy of prostate cancer: Evaluating the combined efficacy of Telfairia occidentalis seed and Annona muricata leaf extracts. Fitoterapia, 188, 106998.

Ukwubile, C. A., Robert, A. E., Ezema, B. O., Yesufu, H. B., Famurewa, A. C., Ikpefan, E. O., & others. (2025). Methanol extract of young Lantana camara leaves exhibits anti-ovarian cancer and anti-inflammatory effects via inhibition of PI3K/AKT/mTOR and MAPK pathways. Chemistry & Biodiversity, e01758.

Ukwubile, C. A., Clement, C. K., Ijoh, B. B., & others. (2025). Evaluation of anticancer and anti-inflammatory properties of Crescentia cujete and Citrullus vulgaris methanol seed extracts against MCF-7 breast cancer cells and molecular docking. Dutse Journal of Pure and Applied Sciences, 11(3e), 260–273.

Ukwubile, C. A., & Malgwi, T. S. (2025). Lantana camara leaf extract-loaded chitosan nanoparticles induce apoptosis and suppress PI3K/AKT and NF-κB signalling in triple-negative breast and colorectal cancer cells. Journal of Pharmacy & Bioresources, 22(3), 185–194.

Ukwubile, C. A., Lawan, M. Z., Malgwi, T. S., Yesufu, H. B., & others. (2025). Evaluation of anti-inflammatory and anticancer activities of Maerua angolensis leaf extract-loaded chitosan nanoparticles. Biomaterials Connect, 2, Article 0018.

Ukwubile, C. A., Yesufu, B. H., Okoro, N. R., & others. (2025). Chitosan-encapsulated linoleic acid from Leucaena leucocephala inhibits FOXL2 mutation in MNU-induced ovarian granulosa cell tumors in Wistar rats. Next Nanotechnology, 8, 100191.

Ukwubile, C. A., Nuhu, A., Famurewa, A. C., Nettey, H., Odugu, J. A., & others. (2025). Chitosan nanoparticles encapsulating Ipomoea digitata tuber and Jatropha gossypiifolia leaf extracts suppress NF-κB, Wnt/β-catenin, and MAPK signalling pathways in colorectal cancer cells. International Journal of Advanced Multidisciplinary Research and Studies, 5(5), 45–58.

Dibal, M. Y., Ukwubile, C. A., Ibrahim, H., Malgwi, T. S., Mohammed, Z., & others. (2025). Pharmacognostic and phytochemical studies of the leaves and stembark of Anogeissus leiocarpus. Journal of Medical Research and Reviews, 4(3), 89–105.

Ikpefan, E. O., & Ukwubile, C. A. (2025). GC-MS analysis and evaluation of analgesic and anticancer activities of Cadaba farinosa methanol leaf extract. Academic Journal of Pharmacy & Biomedical Sciences, 2(1), 10–18.

Amir Zarebkohan | Nanomedicine | Best Researcher Award

Published on by Cell Biologist

Dr. Amir Zarebkohan | Nanomedicine | Best Researcher Award

Tabriz University of Medical Sciences | Iran

Dr. Amir Zarebkohan’s research focuses on the development of advanced nanomedicine strategies for targeted drug delivery and cancer therapy. His work integrates medical nanotechnology and physiology to design innovative nanosystems capable of precise drug transport within biological environments. He specializes in smart targeted delivery platforms, nano–bio interface studies, and nano chemo-immunotherapy approaches aimed at improving therapeutic efficacy while minimizing systemic toxicity. His current projects involve the co-delivery of cyclophosphamide and HLH peptide using D8 and RIVAP-modified chitosan nanoparticles, engineered to respond to the redox conditions of the tumor microenvironment for glioma targeting in rat models. Additionally, he is developing chitosan-based nanoparticles containing dendrimers loaded with cyclophosphamide and sitagliptin, further functionalized with targeting ligands for enhanced delivery efficiency. His research emphasizes translational applications of nanotechnology in oncology and the exploration of biocompatible polymeric carriers for controlled and localized drug release. Through his studies, Dr. Zarebkohan contributes to advancing nano-chemoimmunotherapeutic platforms that bridge the gap between nanoscience and clinical medicine, offering potential breakthroughs in the treatment of complex and resistant cancers.

Profiles:  Google Scholar | Scopus | Orcid

Featured Publications:

Zarebkohan, A., & colleagues. (2024). Enhanced docetaxel therapeutic effect using dual targeted SRL-2 and TA1 aptamer conjugated micelles in inhibition Balb/c mice breast cancer model. Scientific Reports, 14, Article 75042.

Zarebkohan, A., & colleagues. (2024). Discovery of a novel dual targeting peptide for human glioma: From in-silico simulation to acting as targeting ligand. Advanced Pharmaceutical Bulletin, 14, Article 033.

Zarebkohan, A., & colleagues. (2023). Dual targeting salinomycin-loaded smart nano-micelles for enhanced accumulation and therapeutic outcome in breast cancer. International Journal of Pharmaceutics, 123095.

Zarebkohan, A., & colleagues. (2023). CDX-modified chitosan nanoparticles remarkably reduce therapeutic dose of fingolimod in the EAE model of mice. International Journal of Pharmaceutics, 122815.

Zarebkohan, A., & colleagues. (2023). Exosomal transmission of viruses, a two-edged biological sword. Cell Communication and Signalling, 21, Article 37.