Dr. Sabyasachy Mistry , US FDA , United States
Sabyasachy (Babu) Mistry is a highly skilled bioanalyst with over sixteen years of experience in analytical chemistry, organic synthesis, and bioanalytical method development. He is currently working at the US Food and Drug Administration (FDA) in Silver Spring, MD. Mistry has a broad expertise that spans liquid chromatography-mass spectrometry (LC-MS/MS), enzyme-linked immunosorbent assay (ELISA), nuclear magnetic resonance (NMR), and various organic chemistry techniques. With strong communication and problem-solving skills, Mistry excels both as a team member and independent researcher. He has contributed to multiple scientific publications, focusing on pharmacokinetics, drug discovery, and regulatory practices, in addition to mentoring students and offering leadership roles in academic settings.
Publication Profile:
Scopus
Strengths for the Award:
Sabyasachy (Babu) Mistry’s distinguished experience in analytical and bioanalytical chemistry makes him a strong contender for the Research for Best Researcher Award. With over sixteen years of experience, his expertise spans liquid chromatography-mass spectrometry (LC-MS/MS), enzyme-linked immunosorbent assays (ELISA), and computational chemistry, among others. His work in drug solubility and pharmacokinetics, particularly his contributions to hERG assays, is highly relevant to regulatory sciences. Mistry’s capacity to bridge scientific inquiry with FDA regulations ensures his research not only advances scientific understanding but also directly supports regulatory science. His well-documented research, combined with leadership roles and multiple awards, reinforces his research excellence.
Areas for Improvements:
While Mistry’s expertise is extensive, further expansion into collaborative, cross-disciplinary projects could further enrich his body of work. Engaging more in international research initiatives could lead to innovative research outcomes and foster broader scientific networks.
Education:
Sabyasachy Mistry holds a Ph.D. in Analytical Chemistry from Purdue University, where he conducted research under the guidance of Professor Paul G. Wenthold. His dissertation focused on mass spectrometric detection of indophenols for phenol analysis. Prior to this, Mistry completed his M.S. in Organic Chemistry from the University of Dhaka in Bangladesh, where he worked with Professor Nilufar Nahar. His solid educational foundation, combined with his hands-on research experience, has provided him with expertise in a wide range of scientific disciplines, including analytical chemistry, organic synthesis, and bioanalytical methods. Furthermore, Mistry completed the CERSI Immersion Course in Drug Discovery, Drug Development, and Regulation at the UCSF-Stanford Center of Excellence in Regulatory Science and Innovation, strengthening his knowledge in FDA regulations and drug development processes.
Experience:
Mistry’s extensive professional experience spans over a decade in both academic and regulatory environments. Since 2020, he has been serving as a Bio-analyst at the US Food and Drug Administration (FDA), where he applies his expertise in analytical chemistry to support drug discovery and regulatory science. At Purdue University, Mistry worked as a Teaching Assistant (TA) and Head TA in the Department of Chemistry from 2014 to 2020, fostering the growth of new scientists while also contributing to research. His responsibilities included conducting experiments, guiding graduate students, and presenting research findings. Mistry’s work involves advanced techniques such as LC-MS/MS, HPLC, NMR, and computational chemistry tools like Gaussian and Q-Chem. His cross-disciplinary research has contributed to the scientific understanding of pharmacokinetics, drug solubility, and enzyme activity, aligning with regulatory practices in drug approval processes.
Awards and Honors:
Sabyasachy Mistry has been recognized for his outstanding contributions to analytical and bioanalytical chemistry. He was awarded the Graduate Student Travel Award at the 67th ASMS Conference on Mass Spectrometry and Allied Topics in June 2019 in Atlanta, GA. Additionally, Mistry received multiple Travel Scholarships for his student work at the ASMS conferences from 2016 to 2018, showcasing his dedication to advancing scientific knowledge. His role as a volunteer and mentor further exemplifies his leadership within the academic community. These awards highlight his exceptional skills in mass spectrometry and analytical techniques, further solidifying his expertise in the field of chemical research. Mistry’s ability to present complex scientific data and his contributions to regulatory science have garnered recognition from peers and industry professionals alike.
Research Focus:
Sabyasachy Mistry’s research focuses on bioanalytical chemistry, pharmacokinetics, and regulatory science, particularly in drug discovery and development. His work involves the application of advanced techniques such as LC-MS/MS, ELISA, HPLC, and mass spectrometry to investigate drug interactions, solubility, and bioavailability. Mistry’s research also extends to the computational aspects of chemistry, using density functional theory (DFT) calculations to predict reaction profiles and optimize molecular interactions. A key area of interest for Mistry is studying the effects of drug formulations on biological systems, particularly through hERG assays to assess drug safety and efficacy. His work aligns with FDA regulations and contributes to improving drug regulatory processes. Additionally, Mistry has a strong background in organic chemistry, working on the synthesis and modification of small organic molecules. This combination of experimental and computational chemistry makes his research multifaceted, bridging the gap between scientific discovery and regulatory implementation.
Publications Top Notes:
- Determination of Lopinavir and Ritonavir in hERG solution to Support In Vitro hERG Block Potency Assessment Using LC-MS/MS: The Challenge of Poor Drug Solubility 📑
- Evaluation of a Sequential Antibiotic Treatment Regimen of Ampicillin, Ciprofloxacin, and Fosfomycin against Escherichia coli CFT073 in the Hollow Fiber Infection Model Compared with Simultaneous Combination Treatment 💊
- Determination of Five Positive Control Drugs in hERG External Solution (Buffer) by LC-MS/MS to Support In Vitro hERG Assay as Recommended by ICH S7B ⚖️
- Probing the Pyrolysis of Guaiacol and Dimethoxybenzenes Using Collision-Induced Dissociation Charge-Remote Fragmentation Mass Spectrometry 🔬
- Investigation of the Substituent Effects of the Azide Functional Group Using the Gas-Phase Acidities of 3- and 4-Azidophenols 📚
- Mass Spectrometric Detection of the Gibbs Reaction for Phenol Analysis 🔍
- Participation of C-H Protons in the Dissociation of a Proton Deficient Dipeptide 💡
- The HIVToolbox 2 Web System Integrates Sequence, Structure, Function and Mutation Analysis 🧬
- The Geogenomic Mutational Atlas of Pathogens (GoMAP) Web System 🌍
- Effect of Sodium Bicarbonate on the Mechanical and Degradation Properties of Short Jute Fiber Reinforced Polypropylene Composite by Extrusion Technique 🔧
Conclusion:
Sabyasachy Mistry has demonstrated exceptional scientific acumen and practical contributions in the field of bioanalytical chemistry. His expertise and leadership in various research domains position him as an excellent candidate for the Research for Best Researcher Award. His continued work on drug discovery and regulatory science will likely result in even greater contributions to both the scientific and regulatory communities.