Kyushu University | Japan
Jeonghyun Kim’s research centers on mechanobiology and bioengineering, focusing on the interplay between mechanical forces and cellular function in tissue regeneration. His work explores mechanotransduction in osteocytes using advanced three-dimensional culture models, providing insights into how physical stimuli influence bone formation and remodeling. He has developed innovative hydrostatic pressure bioreactors to promote osteogenesis, contributing to bone regenerative strategies. In tissue engineering, he investigates the application of endometrial stromal cells in engineered constructs to enhance uterine regeneration and support early embryo implantation, bridging fundamental mechanobiology with translational regenerative medicine. His earlier studies examined the effects of hydrostatic pressure on chondrogenesis, elucidating mechanotransduction pathways critical for cartilage formation. Kim integrates computational modeling with experimental approaches, including finite element analysis, to optimize scaffold designs and predict cellular responses to mechanical stimuli. His research has been recognized with multiple awards, highlighting contributions to bioengineering and mechanobiology. Ongoing projects aim to dissect cellular responses under mechanical loading and improve tissue-engineered constructs for clinical applications. Through interdisciplinary approaches combining mechanical engineering, cell biology, and regenerative medicine, his work advances understanding of how mechanical environments guide tissue development and repair, with implications for musculoskeletal, reproductive, and cartilage regenerative therapies.
Featured Publications:
Inagaki, T., Kim, J.*, Maeda, E., Adachi, T., & Matsumoto, T. (2025). Macroscopic and microscopic biomechanical analysis of mineralized spheroids derived from human mesenchymal stem cells. Journal of Biomechanics.
Kim, J., Nagashima, S., Wang, J., Matsubara, S., Maeda, E., Okumura, D., & Matsumoto, T. (2025). Hierarchical wrinkle pattern drives tenogenic differentiation from human mesenchymal stem cells. Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine, 239(10), 1000–1009.
Shinokawa, K., Sugawara-Narutaki, A., Kim, J., Matsumoto, T., & Maeda, E. (2025). A novel method to fabricate elastin/collagen fiber composites: Proof of concept. Materials Letters: X, 26, 100255.
Kamiya, T., Ito, Y., Iwasaki, T., Suzuki, D., Hayashi, T., Kim, J., Matsumoto, T., & Maeda, E.* (2025). Structural characterisation of newt tendon regeneration after complete transection: In vivo two-photon imaging and transmission electron microscopy. Journal of Anatomy.
Wang, J., Kim, J., Maeda, E., & Matsumoto, T.* (2025). An osteoblast-like cell line derived from mice expressing FRET-based tension sensor reveals cellular tension increase during osteogenic differentiation. Biochemistry and Biophysics Reports, 43, 102131.
Suzuki, S., Imajo, K., Wang, J., Kim, J., Maeda, E., Nagayama, K., & Matsumoto, T.* (2025). Orthogonal alignment of multilayered MC3T3-E1 cells induced by cyclic stretch. Biomechanics and Modeling in Mechanobiology.
Ohashi, Y., Suzuki, T., Iwasaki, T., Goto, K., Kim, J., Matsumoto, T., Saeki, M., & Maeda, E.* (2025). Quasi-static and dynamic mechanical properties of artificial tissue fabricated from concentrated collagen using mechano-chemical treatment. Materials Today Communications, 46, 112498.
Masuda-Otsuka, Y., Kamiya, T., Suzuki, D., Hayashi, T., Iwasaki, T., Kim, J., Matsumoto, T., & Maeda, E.* (2025). Biomechanical properties of regenerated digital flexor tendon in immature newt following complete transection. Bio-medical Engineering and Materials, 36(6), 335–342.
Kim, J.*, Niioka, K., Maeda, E., & Matsumoto, T. (2025). Application of hydrostatic pressure up-regulates Sost gene expression in osteocytic spheroid. Bioscience, Biotechnology, and Biochemistry, 89(2), 263–267. cellular biomechanics
Inagaki, T., Kim, J.*, Maeda, E., & Matsumoto, T. (2025). Macroscopic creep behavior of spheroids derived from mesenchymal stem cells under compression. Journal of the Mechanical Behavior of Biomedical Materials, 161, 106816.