Hatice Yesim Karasulu | Cellular Microenvironment Interactions | Excellence in Research

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Prof. Dr. Hatice Yesim Karasulu | Cellular Microenvironment Interactions | Excellence in Research

Prof. Dr. Hatice Yesim Karasulu , Ege University , Turkey

Prof. Dr. H. Yesim Karasulu is a distinguished academician in the field of pharmaceutical technology, currently serving as a Professor in the Department of Pharmaceutical Technology at Ege University, Faculty of Pharmacy, Turkey. She completed her Ph.D. at Ege University and advanced to Associate Professor in 2006 and Professor in 2011. Her work as a consultant at Ege University’s ARGEFAR since 2011 and her contributions to the Turkish Ministry of Health’s Pharmaceutical and Medical Devices Agency (2006–2024) underscore her significant impact on both academia and industry. She has collaborated on international research and development projects, and her achievements include patents and international grant-funded projects. Prof. Karasulu has published over 50 scientific papers and delivered numerous oral and poster presentations. Her expertise spans pharmaceutical formulations, drug delivery systems, and biopharmaceutics, positioning her as a leader in her field.

Publication Profile:

Google Scholar

Strengths for the Award:

Prof. Dr. H. Yeşim Karasulu is a highly accomplished and influential researcher in the field of pharmaceutical technology. With more than 50 publications, including articles in top journals and book chapters, she has demonstrated a deep commitment to advancing pharmaceutical research, particularly in the area of drug delivery systems. Her pioneering work on colloidal drug delivery systems such as liposomes, nano/microparticles, and SEDDS has had significant implications for drug development. Her collaboration with both academic institutions and the pharmaceutical industry, leading to patents and commercial products under pharmaceutical license, highlights the practical impact of her work. Additionally, her extensive involvement in research projects funded at national and international levels, as well as her leadership roles, showcases her ability to drive innovation and contribute to the scientific community.

Areas for Improvement:

While Prof. Dr. Karasulu has made remarkable contributions, continuing to build collaborative networks with global research institutions and fostering interdisciplinary research could help broaden the impact of her findings. Enhancing visibility in high-impact international conferences or fostering collaborations in underexplored regions might allow her work to reach new audiences, ensuring that her innovations in drug delivery systems are applied more widely across different health sectors.

Education:

Prof. Dr. H. Yesim Karasulu earned her Ph.D. in Pharmaceutical Technology from Ege University, Faculty of Pharmacy, where she also completed her undergraduate studies. Her academic journey includes post-doctoral research at the University of Vienna, Department of Pharmaceutical Technology and Biopharmaceutics, working under Prof. Dr. Franz Gabor. Prof. Karasulu’s comprehensive education laid a strong foundation for her pioneering research in the field of drug delivery systems. Her work has been recognized both nationally and internationally, as evidenced by her academic promotions and various prestigious grants. She has also contributed to the development of new pharmaceutical technologies, and her research has influenced both educational and professional practices in the pharmaceutical industry. Prof. Karasulu’s educational journey is marked by continuous development and contributions to advancing pharmaceutical sciences, which is reflected in her ongoing academic and consulting roles.

Experience:

Prof. Dr. H. Yesim Karasulu has a rich professional background in pharmaceutical sciences. After earning her Ph.D., she quickly advanced in academia, being promoted to Associate Professor in 2006 and Professor in 2011. Alongside her academic career, Prof. Karasulu has served as a consultant at Ege University’s ARGEFAR, contributing to the development of innovative drug delivery systems and pharmaceutical technologies. Her extensive experience in the pharmaceutical sector includes her role as a member of the Pharmaceutical Technology Commission at the Turkish Ministry of Health’s Pharmaceuticals and Medical Devices Agency from 2006 to 2024. Prof. Karasulu has also conducted post-doctoral research in Vienna, enhancing her expertise in drug delivery and biopharmaceutics. Her broad range of experiences has led to successful collaborations with both the academic and industrial sectors, resulting in patent applications and new pharmaceutical products, further highlighting her significant contributions to the field of pharmaceutical technology and drug delivery.

Research Focus:

Prof. Dr. H. Yesim Karasulu’s research focuses on the development, characterization, and evaluation of advanced drug delivery systems, particularly colloidal systems such as liposomes, nanoparticles, microemulsions, and self-emulsifying drug delivery systems (SEDDS). Her work aims to enhance the efficacy, stability, and bioavailability of pharmaceuticals, particularly through non-invasive routes like transdermal, nasal, and vaginal delivery. Prof. Karasulu is particularly interested in the physicochemical properties that govern drug absorption and permeation, conducting numerous studies on skin permeation, mucosal delivery, and targeted drug delivery to various organs. Her research is driven by a strong desire to bridge the gap between basic pharmaceutical technology and real-world clinical applications. She has contributed significantly to the scientific understanding of drug release mechanisms and the potential of microemulsions as novel carriers for active pharmaceutical ingredients. Prof. Karasulu’s work has been supported by numerous grants and has led to the development of several patents and ongoing product innovations in the pharmaceutical industry.

Publications Top Notes:

  1. Transdermal delivery of diclofenac sodium through rat skin from various formulations 📄💊
  2. Evaluation of skin permeation and anti-inflammatory and analgesic effects of new naproxen microemulsion formulations 🌿💉
  3. Microemulsions as novel drug carriers: the formation, stability, applications and toxicity 🔬⚗️
  4. Comparison of different water/oil microemulsions containing diclofenac sodium: preparation, characterization, release rate, and skin irritation studies 💧💊
  5. Extended release lipophilic indomethacin microspheres: formulation factors and mathematical equations fitted drug release rates 📊💉
  6. Modeling of theophylline release from different geometrical erodible tablets 🧬📖
  7. Efficacy of a new ketoconazole bioadhesive vaginal tablet on Candida albicans 🦠💊
  8. Permeation studies and histological examination of sheep nasal mucosa following administration of different nasal formulations with or without absorption enhancers 🐑👃
  9. Synthesis, molecular modeling, in vivo study, and anticancer activity of 1,2,4‐triazole containing hydrazide–hydrazones derived from (S)‐naproxen 💡🔬
  10. Preparation and evaluation of novel microemulsion-based hydrogels for dermal delivery of benzocaine 💧🧴

Conclusion:

Prof. Dr. H. Yeşim Karasulu is an exemplary candidate for the Excellence in Research award due to her consistent and impactful contributions to pharmaceutical research. Her work has led to significant advancements in drug delivery systems, evidenced by her substantial publication record, patents, and collaborations. Her achievements place her at the forefront of pharmaceutical technology and innovation, making her well-deserving of this recognition.

 

 

 

 

Ting LI | Cellular Microenvironment Interactions | Women Researcher Award

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Assoc. Prof. Dr. Ting LI | Cellular Microenvironment Interactions | Women Researcher Award

Assoc. prof. Dr. Ting Li , College of Food Engineering and Nutritional Science, Shaanxi Normal University , China

Dr. Ting Li is a Vice Dean, Associate Professor, and Doctoral Supervisor at the College of Food Engineering and Nutritional Science, Shaanxi Normal University, China. She earned her Ph.D. from Hong Kong Baptist University in 2017, fully supported by a scholarship. Over the past 5 years, she has focused on dietary nutrition and gut health, contributing significantly to these fields. Dr. Li has authored over 40 SCI papers, including a high-impact publication in Cell Metabolism. Her academic achievements also include publishing an academic monograph and leading 14 research projects, with eight at provincial or national levels. She has been awarded the Shaanxi Youth Science Star and participated in projects receiving the Shaanxi Provincial Science and Technology Award. As a researcher, she has made notable strides in uncovering novel mechanisms in nutrition and gut microbiome interactions.

Publication Profile:

Scopus

Strengths for the Award:

  1. Exceptional Research Contributions:
    Dr. Ting Li has made groundbreaking contributions to the field of food nutrition and gut microbiota. Notably, her research on stachyose’s novel function in regulating exosomal miRNAs in the gut has been published in top-tier journals such as Cell Metabolism. This is a highly innovative finding, challenging previous assumptions about oligosaccharides and opening new avenues in gut health research.
  2. Impressive Publication Record:
    With over 40 peer-reviewed publications in SCI journals, Dr. Li demonstrates not only a consistent output of high-quality research but also a strong ability to address pressing scientific questions related to diet, gut microbiota, and metabolic disorders. Her work is widely recognized in the academic community, as evidenced by the significant citations of her papers.
  3. Leadership in Research:
    Dr. Li is leading 14 research projects, many of which are provincial or national in scope. She has also been recognized with prestigious honors like the Shaanxi Youth Science Star award, showcasing her leadership role in advancing scientific knowledge in her field.
  4. Recognition and Impact:
    Her research has direct implications for improving human health, such as her work on dietary interventions for metabolic disorders and inflammatory bowel diseases. Her contributions are not only academically significant but also have the potential to influence public health policy and industry practices.
  5. International Collaboration and Editorial Role:
    As a young editorial board member of the Journal of Food Science and Technology and efood, Dr. Li is actively involved in shaping the future of food science research. Her collaborations further extend the global impact of her work.

Areas for Improvement:

  1. Broader Industry Engagement:
    While Dr. Li has an extensive academic portfolio, expanding her work into direct industry applications (such as consulting, product development, or partnerships with food or health industries) could further enhance the practical impact of her research.
  2. Wider Outreach and Advocacy:
    While Dr. Li’s academic contributions are commendable, increasing her involvement in public engagement, such as in public health education, could raise awareness about the importance of dietary nutrition and gut health. This could involve outreach programs, public talks, or educational campaigns targeting broader audiences.
  3. Building Mentorship Programs:
    As a doctoral supervisor, Dr. Li has the opportunity to expand her mentoring role, guiding more students and early-career researchers, particularly women in science, and creating a more inclusive research environment.\

Education:

Dr. Ting Li’s educational journey began with a scholarship from Hong Kong to pursue a Ph.D. at Hong Kong Baptist University, where she obtained her degree in 2017. This opportunity marked a pivotal point in her academic development, fostering her deep interest in food science and nutrition. Her Ph.D. research focused on the complex relationships between food, gut microbiota, and metabolic health, laying the foundation for her future work. Since completing her doctorate, Dr. Li has joined Shaanxi Normal University, where she has continued her studies in food engineering, specifically within the fields of dietary nutrition and gut health. Her academic success, including publishing more than 40 peer-reviewed articles, reflects her dedication to advancing the understanding of nutrition’s role in promoting health, and her ongoing research focuses on innovative ways to improve gut microbiome health.

Experience:

Dr. Ting Li has extensive experience as an academic and researcher. After earning her Ph.D. in 2017, she joined Shaanxi Normal University, where she quickly established herself as a leader in the fields of food science, nutrition, and gut microbiome research. She is currently a Vice Dean and Associate Professor at the College of Food Engineering and Nutritional Science, also supervising doctoral students. Dr. Li has led 14 research projects, eight of which are at the provincial or national levels. She has authored over 40 research articles, with notable publications in Cell Metabolism and other high-impact journals. In addition, Dr. Li has published an academic monograph and contributed significantly to understanding dietary influences on gut health. Her work has been recognized with several accolades, including the Shaanxi Youth Science Star award. As a professional member of the Shaanxi Food Science and Technology Society and other nutrition-related organizations, she plays an active role in promoting scientific research.

Research Focus:

Dr. Ting Li’s primary research focuses on the relationship between dietary nutrition, gut health, and microbiome dynamics. Specifically, her work explores how various dietary components, including functional oligosaccharides and polyphenols, interact with gut microbiota and influence metabolic health. Dr. Li has uncovered new functions of indigestible stachyose, which alters exosomal miRNA profiles in small intestinal epithelial cells to reshape the gut microbiota. This finding challenges the conventional view of oligosaccharides as simple pass-through agents in the digestive system. Her research also delves into how food-derived nanoparticles, such as exosome-like particles from broccoli and garlic, can alleviate gut-related disorders. Additionally, her work extends into the therapeutic potential of food compounds to treat conditions like obesity, type 2 diabetes, and colitis. Dr. Li’s research offers valuable insights into the nutritional properties of functional foods and their potential for enhancing gut health.

Publications Top Notes:

  1. Nondigestible stachyose binds membranous HSP90β on small intestinal epithelium to regulate the exosomal miRNAs: A new function and mechanism. 🧬📖 (Cell Metabolism, 2024)
  2. Peu-MIR2916-p3-enriched garlic exosomes ameliorate murine colitis by reshaping gut microbiota, especially by boosting the anti-colitic Bacteroides thetaiotaomicron. 🧄🔬 (Pharmacological Research, 2024)
  3. Broccoli-derived exosome-like nanoparticles alleviate loperamide induced constipation, in correlation with regulation on gut microbiota and tryptophan metabolism. 🥦💩 (Journal of Agricultural and Food Chemistry, 2023) (Cover)
  4. Roundup-induced gut dysbiosis, irrelevant to aromatic amino acid deficiency, impairs the gut function in rats. 🚜💥 (Journal of Agricultural and Food Chemistry, 2024) (Cover)
  5. Extracellular vesicle miRNAs as key mediators in diet-gut microbiome-host interplay. 🧬🌱 (Trends in Food Science & Technology, 2023)
  6. Effects of Fu brick tea polysaccharides on gut microbiota and fecal metabolites of HFD/STZ-induced type 2 diabetes rats. 🍵💊 (Food & Function, 2023)
  7. Polyphenols and pectin enriched golden kiwifruit alleviates high fructose-induced glucolipid disorders and hepatic oxidative damage in rats. 🥝🍇 (Food Science and Human Wellness, 2023)
  8. Heimao tea polysaccharides ameliorate obesity by enhancing gut microbiota-dependent adipocytes thermogenesis in mice fed with high fat diet. 🍃🔥 (Food & Function, 2022)
  9. Protective effect of coriander on high-fructose and high-salt diet-induced hypertension: relevant to improvement of renal and intestinal function. 🌿💪 (Journal of Agricultural and Food Chemistry, 2022)
  10. Luteolin binds Src, promotes STAT3 protein ubiquitination and exerts anti-melanoma effects in cell and mouse models. 🍊🦠 (Biochemical Pharmacology, 2022)

Conclusion:

Dr. Ting Li is a highly deserving candidate for the Women Researcher Award. Her outstanding contributions to food science and nutrition, combined with her leadership in research and publication, make her an exemplary figure in her field. The novelty and potential impact of her work, particularly in understanding the role of dietary components on gut health and microbiota, distinguish her as an innovator. Her academic success and recognition underscore her role as a rising star in the global scientific community, and the award would further empower her to continue her impactful research.