Gisela D’ANGELO | Cell Biology and Cancer | Best Researcher Award

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Dr. Gisela D’ANGELO | Cell Biology and Cancer | Best Researcher Award

Dr. Gisela D’ANGELO, CNRS, France

Dr. Gisela D’Angelo is a distinguished cell biologist and Research Director at CNRS, currently based at Institut Curie, Paris. Born in Montevideo, Uruguay (1961), she has built a notable career in molecular biology, specializing in the roles of extracellular vesicles (EVs) in cell communication, development, and disease. With over three decades of international experience and a profound academic foundation from top French institutions, she has contributed significantly to understanding vesicle-mediated signaling pathways. Her work has reshaped knowledge of cellular dynamics in development, virology, and cancer. She is affiliated with the UMR144 Cell Biology and Cancer Department, and her scientific leadership has guided impactful projects and collaborations across Europe. A mentor to several postdoctoral researchers, her prolific publication record and active role in translational research solidify her position as a leader in EV biology.

Publication Profile: 

Scopus

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✅ Strengths for the Award:

  1. World-Class Researcher in Extracellular Vesicles (EVs):
    Dr. D’Angelo has made pivotal contributions to understanding the biogenesis and function of extracellular vesicles in both developmental and pathological contexts, such as placental biology, viral infection, and cancer.

  2. Prolific Publication Record:
    She has authored and co-authored multiple high-impact journal articles in top-tier journals like PNAS, Nature Methods, Current Biology, and Development. Her publications are often collaborative and interdisciplinary, indicating a strong network in the global scientific community.

  3. Leadership Role and Institutional Prestige:
    Holding the title of Research Director (DR2 CNRS) at the Institut Curie—a premier research center in Europe—underscores her leadership and scientific excellence. She also mentors young scientists and leads innovative projects.

  4. Innovative Use of Imaging & Model Systems:
    Her work combines advanced microscopy, Drosophila genetics, and molecular biology to explore intercellular communication—offering novel insights with translational potential.

  5. International Profile and Experience:
    Originally from Uruguay, educated in Paris, and professionally established in France, Dr. D’Angelo reflects a truly international scientific career.

⚠️ Areas for Improvement:

  1. Teaching and Public Engagement:
    While she is involved in a Master-level course, increasing her visibility in teaching, mentoring, and public science outreach could enhance her broader scientific influence.

  2. Expanded Global Collaborations:
    Most of her research collaborations are within France or Europe. Developing larger-scale international consortia or initiatives could amplify her global impact.

  3. Science Communication and Media Presence:
    Her profile and findings could benefit from more exposure via science communication platforms, conferences, and open-access forums to reach broader audiences.

🎓 Education:

Dr. Gisela D’Angelo’s academic journey began at Université Pierre et Marie Curie (Paris VI), where she earned a BS in Cell Biology and Physiology (1984), followed by a Master’s degree in Reproductive Physiology (1986). She went on to complete her PhD in Molecular Biology and Reproductive Physiology in 1990 at the same university. Her research skills and academic rigor led her to pursue the Habilitation à Diriger des Recherches (HDR) in 2003 at Université de Nice Sophia-Antipolis, qualifying her to supervise doctoral research and lead independent scientific programs. Her education laid a strong interdisciplinary foundation, integrating molecular biology, cell physiology, and developmental biology—skills that she continues to apply in her research on intercellular communication and extracellular vesicles.

💼 Experience:

Dr. D’Angelo began her research career in France, first as a Research Associate at INSERM U615, University of Nice (2000–2005), followed by a role at CNRS UMR 7277/INSERM 1091 (2005–2017). She then joined Institut Curie, Paris, as a Senior Research Scientist (CRCN, CNRS), and was promoted to Research Director in 2024. Her extensive experience spans cellular communication, reproductive biology, and cancer research, with a focus on extracellular vesicles (EVs). She undertook a sabbatical at Institut Curie in 2016, which helped deepen collaborative efforts in vesicle biology. She is recognized for leading multidisciplinary teams, mentoring early-career scientists, and contributing to major breakthroughs in developmental biology, particularly through high-resolution imaging and molecular tools. With over 20 publications in top-tier journals, Dr. D’Angelo’s career reflects innovation, academic rigor, and impactful science.

🔬 Research Focus:

Dr. Gisela D’Angelo’s research revolves around the biogenesis, trafficking, and function of extracellular vesicles (EVs)—small, membrane-bound particles that mediate intercellular communication. Her work elucidates how EVs participate in developmental signaling pathways, immune regulation, placental communication, and disease pathogenesis (e.g., cancer, viral infections). A core part of her focus is understanding how microvilli-derived vesicles contribute to morphogenesis and tissue homeostasis, using advanced imaging and model organisms like Drosophila. She has also explored EV modifications by pathogens such as cytomegalovirus and their effects on fetal development. Her cutting-edge research combines molecular genetics, imaging technologies, and cell biology to dissect the subcellular mechanics of EV trafficking. As a leading figure in this dynamic field, she has significantly advanced understanding of how EVs act as messengers during physiological and pathological processes, making her work highly relevant to regenerative medicine, oncology, and developmental biology.

📚 Publications Top Notes:

  1. 🧪 Extracellular vesicles released by keratinocytes regulate melanosome maturation, melanocyte dendricity, and pigment transfer – PNAS, 2024

  2. 🤰 Placental extracellular vesicles in maternal-fetal communication during pregnancy – Biochemical Society Transactions, 2022

  3. 🦠 Human Cytomegalovirus modifies placental small extracellular vesicle composition to enhance infection of fetal neural cells in vitro – Viruses, 2022

  4. 🧬 Microvilli-derived extracellular vesicles carry Hedgehog morphogenic signals for Drosophila wing imaginal disc development – Current Biology, 2022

  5. 🔬 The power of imaging to understand extracellular vesicle biology in vivo – Nature Methods, 2021

  6. 🧫 Human Cytomegalovirus infection changes the pattern of surface markers of small extracellular vesicles – Frontiers in Cell and Developmental Biology, 2021

  7. 🧠 Centrosome amplification mediates small extracellular vesicle secretion via lysosome disruption – Current Biology, 2021

  8. 🧭 The GTPase Rab8 differentially controls Hedgehog gradient by regulating its apico-basal distribution – Development, 2021

  9. 🐛 Microvilli-derived extracellular vesicles govern morphogenesis in Drosophila wing epithelium – bioRxiv preprint, 2020

  10. 🧪 Centrosome amplification mediates EV secretion via lysosome disruption – bioRxiv preprint, 2020

  11. 🧩 The cell biology of extracellular vesicles: A jigsaw puzzle with a myriad of pieces – Review/Essay (unlisted journal)

🧾 Conclusion:

Dr. Gisela D’Angelo is highly suitable for the Best Researcher Award. Her exceptional contributions to extracellular vesicle research—combined with leadership, publication quality, and scientific impact—place her among the top scientists in her field. While she could enhance her visibility in teaching and international collaboration, her track record demonstrates consistent excellence, innovation, and commitment to advancing biomedical research. She represents the ideal profile of a senior investigator who bridges fundamental science and translational relevance.

Noureddine Allouche | Molecular Mechanisms Signaling | Best Research Article Award

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Prof. Noureddine Allouche | Molecular Mechanisms Signaling | Best Research Article Award

Prof. Noureddine Allouche , Faculty of Sciences of Sfax, University of Sfax , Tunisia

Professor Noureddine Allouche, born in 1971, is a Full Professor of Chemistry at the Faculty of Sciences of Sfax (FSS), Tunisia. He is the Head of the Natural Substances Team in the Laboratory of Organic Chemistry. With over 150 peer-reviewed publications, an h-index of 35, and more than 4500 citations, he is recognized for his impactful research on natural products and environmental valorization. He has led and contributed to multiple national and European research projects, including FP7, H2020, Erasmus+, and ARIMNET. His work focuses on extraction, isolation, and bioactivity of plant-based compounds and sustainable management of industrial waste. Prof. Allouche has supervised 20 Ph.D. theses and 42 M.Sc. students, contributing significantly to scientific advancement in Tunisia and beyond. He is also involved in applied research in green chemistry and cosmetic sciences. His collaborative work and leadership have earned him recognition in the academic and research communities.

Publication Profile: 

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✅ Strengths for the Award:

  1. High Research Productivity and Impact

    • Over 150 peer-reviewed scientific articles with a h-index of 35 and 4,500+ citations, which reflect sustained academic influence and quality.

    • Contributor to top-tier journals such as Plants, Biomolecules, and Molecules.

  2. Strong Focus on Societal Relevance

    • Work addresses critical environmental issues such as olive mill waste valorisation, bioconversion, and sustainable resource use.

    • Research applied in green chemistry, natural product-based pharmaceuticals, and eco-cosmetics.

  3. International Collaboration and Leadership

    • Coordinator of six major European and international research projects (FP7, H2020, Erasmus+, ARIMNET).

    • Active partnerships with institutions in France, Germany, and the Mediterranean region, showcasing leadership in multidisciplinary and multinational research.

  4. Methodological Rigor and Innovation

    • Use of advanced analytical techniques (e.g., HPLC-HESI-MS/MS, LC-MS/MS, ESI-MS/MS).

    • Integration of green technologies for natural substance extraction.

  5. Mentorship and Academic Development

    • Supervised 20 Ph.D. theses (plus 4 ongoing), 42 Master’s theses, and numerous diploma projects, especially in applied fields like cosmetic science.

🛠️ Areas for Improvement:

  1. Broader International Recognition

    • While highly active in regional and EU collaborations, increased visibility in global North America/Asia-led consortia or global forums could enhance recognition.

  2. Science Communication and Outreach

    • Publishing in public engagement platforms or delivering talks/webinars to non-specialist audiences could expand the impact of his research beyond academia.

  3. Open Access and Data Sharing

    • Encouraging open data practices and reproducibility of extraction and formulation protocols could enhance scientific transparency and citations.

🎓 Education:

Professor Noureddine Allouche earned his Ph.D. in Chemistry from the University of Sfax between 2000 and 2005, focusing on the treatment and valorisation of olive mill waste, a subject that would lay the foundation for his future research career. Following this, he undertook a prestigious postdoctoral training (2006–2007) at the Institute of Natural Products Chemistry of CNRS in Gif-sur-Yvette, France, enhancing his expertise in natural substances and analytical chemistry. His academic foundation was built on rigorous training in organic chemistry, natural products, and environmental biotechnology. These experiences equipped him with robust research methodologies and an interdisciplinary approach, especially in the extraction and biological evaluation of phytochemicals. His educational path reflects a strong commitment to green and sustainable chemistry, positioning him well for leading high-impact research on natural product development and eco-friendly industrial applications.

💼 Experience:

Professor Allouche has over 20 years of academic and research experience. He currently leads the Natural Substances Team at the Faculty of Sciences of Sfax and supervises a group of over 20 researchers. He has played a vital role in international research collaborations, serving as the national coordinator of six European-funded projects under FP7, ARIMNET, H2020, Erasmus+, and PHC-Maghreb. His experience also includes participation in the INCO-MED project on detoxification and recovery from olive mill wastewater. Prof. Allouche has an extensive mentoring portfolio, having supervised 20 Ph.D. theses (with 4 ongoing) and 42 M.Sc. students. He has authored 150+ articles, two book chapters, and holds two patents. His career reflects a blend of scientific innovation and applied industrial research, particularly in green technologies, bioactive compounds, and waste valorisation. He is also a regular collaborator with European institutions, reflecting his global outlook and leadership in sustainable science.

🔍 Research Focus:

Prof. Noureddine Allouche’s research centers on natural substances chemistry, green extraction methods, and biotechnological valorisation of industrial wastes, particularly from agro-food sources. He has made significant contributions to the identification and biological evaluation of bioactive compounds such as phenolics, flavonoids, and essential oils. His team is particularly active in analyzing plant extracts for their antioxidant, antimicrobial, cytotoxic, and anti-aging activities, often employing advanced techniques like HPLC, LC-MS/MS, and ESI-MS/MS. Another pillar of his work includes developing biopesticides and bio-cosmetics through green and eco-sustainable approaches. He contributes to nanoformulation research and the design of nature-based products aligned with circular economy principles. His interdisciplinary projects bridge chemistry, pharmacology, environmental science, and cosmetic formulation, making his research highly relevant for addressing current scientific and industrial challenges. His recent involvement in projects like GreenCosmIn and 25MAG23 reflects his leading role in European research on sustainable innovation.

📚 Publications Top Notes:

  1. 🌿 HPLC-HESI-MS/MS Analysis of Phenolic Compounds from Cynoglossum tubiflorus Leaf Extracts (Plants, 2024)

  2. 🫒 Intensification of Biophenols Extraction Yield from Olive Pomace Using Innovative Green Technologies (Biomolecules, 2022)

  3. 🌸 Antioxidant and Antimicrobial Activities of Erodium arborescens Extracts Characterized by LC-HESI-MS² (Molecules, 2022)

  4. 🌿 ESI-MS/MS Analysis of Aeonium arboreum Leaf Extracts and Evaluation of Antioxidant and Antimicrobial Activities (Molecules, 2021)

  5. 🍇 Novel Natural Products for Healthy Ageing from Mediterranean Diet – The MediHealth Project (Molecules, 2018)

🧾 Conclusion:

Professor Noureddine Allouche stands out as a highly qualified and deserving candidate for the Best Research Article Award. His impressive record in sustainable chemistry, natural products research, international project coordination, and scholarly mentorship underlines his academic excellence and real-world impact. His research directly contributes to health, environmental sustainability, and circular economy principles, aligning well with the goals of high-impact, solution-driven science.