Dr. Chao He | Anhui University’s School of Life Sciences | China
Dr. Chao He is an accomplished Associate Professor at the School of Life Sciences, Anhui University, China. With a robust background in structural biology and enzymology, his research explores the intersection of microbiology, structural biology, and biotechnology. A Ph.D. graduate from the University of Science and Technology of China, he specializes in carbohydrate-active enzymes and their applications in health and industry. Dr. He has led significant projects funded by the National Natural Science Foundation of China (NSFC) and provincial science agencies. His work elucidates catalytic mechanisms and structural features of glycosyltransferases and glycoside hydrolases, with applications in gut microbiota research and industrial polysaccharide processing. He has authored 17 first/corresponding-author publications in top-tier journals including Nature Synthesis, PNAS, and Angewandte Chemie. His contributions position him as a leading figure in enzymology-driven biotechnological innovation.
Publication Profile:
Education:
Dr. Chao He began his academic journey with a Bachelor of Science in Biomedical Engineering from Southeast University, where he developed a solid foundation in molecular and cellular biology. Motivated to delve deeper into life sciences, he pursued his Ph.D. in Structural Biology at the University of Science and Technology of China (USTC). During his doctoral training, he honed his skills in protein structure analysis, enzyme mechanism elucidation, and X-ray crystallography. His education provided him with cross-disciplinary expertise, combining engineering principles with biological systems. This unique academic blend laid the groundwork for his current research in enzyme discovery and rational design. Dr. He’s academic record reflects his commitment to scientific excellence, critical thinking, and innovation, with early exposure to both theoretical and applied aspects of biomedical sciences—a synergy that continues to inform his research today.
Experience:
Dr. Chao He joined Anhui University as a Lecturer in the School of Life Sciences and was promoted to Associate Professor. Over the past decade, he has led innovative research in enzymology, focusing on glycosyltransferases and hydrolases involved in carbohydrate metabolism. As principal investigator, he manages an NSFC General Program grant, investigating Bacteroides-mediated degradation of polysaccharides, along with multiple provincial-level grants. His lab conducts both basic and applied research, ranging from structural characterization to biocatalytic engineering. Dr. He has extensive experience in high-resolution crystallography, enzyme kinetics, and polysaccharide bioprocessing. He has published 17 high-impact papers and serves as a mentor to graduate and undergraduate students. With a strong academic and technical background, Dr. He is a recognized contributor to the field of molecular enzymology and a reliable collaborator within the broader scientific community.
Research Focus:
Dr. Chao He’s research focuses on understanding the structure-function relationships of carbohydrate-active enzymes (CAZymes), including glycoside hydrolases and glycosyltransferases. He aims to reveal how microbial systems—particularly gut-associated Bacteroides—degrade complex polysaccharides using polysaccharide utilization loci (PULs). His team employs structural biology tools (e.g., X-ray crystallography) and biochemical assays to uncover catalytic mechanisms and binding specificities. This work has major implications in both basic biology and industrial biotechnology, such as the rational engineering of enzymes for improved substrate specificity and thermal stability. Applications include bioconversion of polysaccharides, synthesis of oligosaccharides for prebiotics, and enzyme-based biocatalysis. Dr. He’s integrative approach bridges enzymology, microbiome science, and bioengineering, aligning with global needs in food science, health, and sustainable materials. His research supports enzyme discovery pipelines and contributes to understanding host-microbe interactions via carbohydrate metabolism, thus representing a frontier area in molecular life sciences.
Publications Top Notes:
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Biocatalytic enantioselective γ-C–H lactonization of aliphatic carboxylic acids – Nature Synthesis, 2023
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Specific hydrolysis of curdlan with a novel glycoside hydrolase family 128 β-1,3-endoglucanase containing a carbohydrate-binding module – Carbohydrate Polymers, 2021
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Structural basis for histone H3K4me3 recognition by the N-terminal domain of the PHD finger protein Spp1 – Biochemical Journal, 2019
Conclusion:
In conclusion, Dr. Chao He exemplifies the qualities of a top-tier academic researcher whose work contributes significantly to the understanding and application of carbohydrate-active enzymes. His ability to combine structural biology with biotechnology showcases both scientific depth and interdisciplinary innovation. Although there is scope for increasing his outreach and collaborative engagements, his current achievements and research leadership make him a compelling nominee for the Best Researcher Award. His trajectory reflects a researcher who is not only productive and impactful but also poised for continued growth and international recognition.