Shenzhen Hospital of Integrated Chinese and Western Medicine | China
Ziwei Luo is an emerging researcher specializing in molecular mechanisms underlying osteoarthritis, stem cell biology, and regenerative medicine. His work focuses on the regulatory roles of microRNAs in cellular differentiation and disease progression, with a particular emphasis on cartilage degeneration and hair follicle stem cell regulation. He has contributed significant findings demonstrating how novel-miR-81 acts as a key modulator in osteoarthritis by targeting IL16, offering new insights into potential therapeutic pathways for degenerative joint diseases. Additionally, his research has elucidated the function of miR-203a-3p in promoting loureirin A–induced differentiation of hair follicle stem cells through Smad1 signaling, expanding understanding of microRNA-mediated control in tissue repair processes. Luo has also identified a regulatory mechanism in which novel-miR-81 enhances chondrocyte differentiation from bone marrow mesenchymal stem cells by suppressing Rac2 expression, highlighting its importance in cartilage regeneration. Collectively, his research advances the field of molecular medicine by uncovering critical microRNA-gene interactions that influence stem cell fate and musculoskeletal tissue remodeling, contributing to the development of innovative therapeutic strategies.
Featured Publications:
1. Luo, Z., Xie, J., Ye, H., Zhang, J., Liu, Y., Ma, C., Cao, J., Pan, H., Liu, X., Zhou, X., et al. (2025). Novel-miR-81 promotes the chondrocytes differentiation of bone marrow mesenchymal stem cells through inhibiting Rac2 expression. CARTILAGE, 16(3), 333–344.
2. Luo, Z., Han, Q., Lu, J., Ouyang, X., Fan, Y., Liu, Y., Zhou, X., Kong, J., Liu, H., Liu, A., et al. (2024). IL16 regulates osteoarthritis progression as a target gene of Novel-miR-81. CARTILAGE.
3. Ye, S., Si, W., Qin, W., Yang, L., Luo, Z., Li, Z., Xie, Y., Pan, H., Li, X., Huang, Z., et al. (2023). Atractylodes lancea volatile oils target ADAR2-miR-181a-5p signaling to mesenchymal stem cell chondrogenic differentiation. The Anatomical Record.
4. Luo, Z., Dou, J., Xie, F., Lu, J., Han, Q., Zhou, X., Kong, J., Chen, D., & Liu, A. (2021). miR-203a-3p promotes loureirin A-induced hair follicle stem cells differentiation by targeting Smad1. The Anatomical Record, 304(3), 531–540.