Dr. Felicia ANTOHE , Inst. Cellular Biology and Pathology NS , Romania
Dr. Felicia Antohe is the Head of the Proteomics Department at the Institute of Cellular Biology and Pathology, Romanian Academy. With a background in cellular biology and biophysics, she has contributed significantly to biomedical research, particularly in vascular endothelium, atherosclerosis, diabetes, and immune disorders. She has received multiple prestigious awards and conducted pioneering research, especially on the transcytosis of macromolecules in endothelial cells. As a PhD advisor, she mentors young researchers, having guided 12 PhD students to date. Dr. Antohe is an internationally recognized expert with extensive experience in immunology, cell biology, and proteomics.
Publication Profile:
Google Scholar
Strengths for the Award:
Dr. Felicia Antohe stands out as an exceptional candidate for the Research for Molecular Cell Biology Award due to her extensive academic and research achievements. As Head of the Proteomics Department at the Institute of Cellular Biology and Pathology, Romanian Academy, her leadership in pioneering research in endothelial cell biology and vascular pathologies has been transformative. Dr. Antohe’s strong academic background, with a Master’s in Biophysics and a PhD in Cellular Biology, complements her robust research portfolio. With over 170 scientific papers, 90 of which are indexed in Web of Science, she is recognized for her contributions to molecular mechanisms in diseases such as atherosclerosis, diabetes, and immune disorders. Furthermore, her work on monoclonal antibodies and proteomics has had a significant impact on both scientific and clinical advancements.
Areas for Improvement:
While Dr. Antohe’s research is highly regarded, there is potential for greater integration of her research with cutting-edge technologies in bioinformatics and computational biology. This could further expand her work on proteomics and molecular mechanisms. Additionally, there is an opportunity for broader outreach to apply her findings in practical therapeutic contexts through collaborations with pharmaceutical companies or clinical trials. Expanding her influence in translational research could have a larger impact on public health, especially in diseases such as diabetes and cardiovascular disorders.
Education:
Dr. Felicia Antohe holds a Master’s degree in Biophysics from the University of Bucharest (1977). She completed her PhD in Cellular Biology at the Romanian Academy’s Institute of Cellular Biology and Pathology (1994). In addition to her formal education, she has been a PhD coordinator since 2000 and has contributed significantly to research training at national and international levels. Her work blends theoretical knowledge with cutting-edge lab techniques in molecular biology, proteomics, and immunology.
Experience:
Dr. Antohe’s research experience spans numerous roles. She is currently the Principal Investigator and Member of the Scientific Council at the Romanian Academy’s Institute of Cellular Biology and Pathology. She has also worked as a visiting scientist at prestigious institutions like McGill University, University of Alberta, and Max Planck Institute. She has coordinated over 44 research projects, including national and international grants, and is actively involved in multiple collaborative research efforts across Europe and beyond. Her leadership in cell biology and proteomics is widely recognized.
Awards and Honors:
Dr. Antohe has received numerous awards, including the EURESCO Prize (2001), the BIO-RAD Laboratories Prize for valuable research (2002), and the Romanian Academy Emil Racovita Prize (1991). She has also won multiple international recognitions for her scientific contributions, such as the Best Poster award at the “8th International Conference on Vascular Endothelium” (2005), and various fellowships and grants from organizations like COST and the European Science Foundation.
Research Focus:
Dr. Antohe’s research focuses on endothelial cell biology, particularly transcytosis, endocytosis, and cell receptor mechanisms in both health and disease. She investigates the bio-pathology of atherosclerosis, diabetes, and immune disorders, with particular attention to the transport of macromolecules across vascular cells. Her work also explores the role of monoclonal antibodies as diagnostic and therapeutic tools. She applies proteomic techniques to study endothelial cell function, aiming to understand vascular biology at molecular and cellular levels.
Publications Top Notes:
- The MHC class I-related receptor, FcRn, plays an essential role in the maternofetal transfer of γ-globulin in humans 📄
- Functional expression of the MHC class I-related receptor, FcRn, in endothelial cells of mice 📄
- Transcytosis of plasma macromolecules in endothelial cells: a cell biological survey 📄
- Expression of functionally active FcRn and the differentiated bidirectional transport of IgG in human placental endothelial cells 📄
- Analytical techniques for multiplex analysis of protein biomarkers 📄
- Functional ultrastructure of the vascular endothelium: changes in various pathologies 📄
- Effect of enoxaparin on high glucose-induced activation of endothelial cells 📄
- Albumin-binding proteins function in the receptor-mediated binding and transcytosis of albumin across cultured endothelial cells 📄
- Carbapenemase-Producing Klebsiella pneumoniae in Romania: A Six-Month Survey 📄
- Establishment of a pure vascular endothelial cell line from human placenta 📄
Conclusion:
Dr. Felicia Antohe is an outstanding researcher whose work has greatly advanced our understanding of endothelial cell biology, molecular transport, and disease mechanisms. Her combination of technical expertise, leadership in multiple high-impact research projects, and numerous prestigious awards positions her as an ideal candidate for the Research for Molecular Cell Biology Award. While there is always room to expand her research applications, her contributions to science are already substantial and impactful.