Dr. Mehmet Ali Karaselek , Necmettin Erbakan Üniversitesi , Turkey
Dr. Mehmet Ali Karaselek is an accomplished immunologist, widely known for his work on genetic immunodeficiencies and immune system disorders. He holds a significant position in clinical immunology, focusing on T-cell subsets, immune profiling, and the molecular mechanisms behind various immune diseases. His expertise extends to autoimmune diseases, cancers, and rare immunodeficiencies such as ICF syndrome, DCLRE1C deficiency, and CD19 deficiency. His extensive research has contributed to a deeper understanding of immune system dysfunctions and therapeutic implications, especially in immune deficiency conditions. Dr. Karaselek is also involved in training future scientists and physicians, combining his expertise in molecular immunology with clinical practice to improve diagnostic and therapeutic approaches in immunology. His publications and ongoing research projects continue to enrich the field of clinical immunology and immunogenetics.
Publication Profile:
Orcid
Strengths for the Award:
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Expertise in Immunology: Dr. Karaselek has contributed significantly to understanding immune system disorders, particularly immune deficiencies and their relationship with genetic mutations. This is reflected in several of his articles related to immune cell subsets, immune disorders like immunodeficiencies (e.g., CD19 deficiency, DCLRE1C deficiency), and T-cell and NK-cell functions.
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Innovative Research Areas: His focus on transcription factor and cytokine expression in various T-cell subsets, as well as his recent work in cancer-related therapies using pillar[5]arene derivatives, illustrates a strong grasp of cutting-edge topics in both immunology and drug development.
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Collaboration Across Fields: Dr. Karaselek’s research spans multiple fields, including cancer research, immunodeficiencies, and genetic disorders, showcasing his ability to work across disciplines. He has collaborated with many researchers on complex issues like genetic mutations and immune dysfunctions, highlighting his team-based approach and leadership in the research community.
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Contributions to Clinical Immunology: His numerous articles in high-impact journals, such as the Journal of Clinical Immunology, Expert Review of Clinical Immunology, and APMIS, demonstrate his dedication to advancing clinical research, improving diagnostics, and understanding immune system pathologies.
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High Publication Frequency: The volume of publications and the consistency of research output in recent years (2023–2025) reflects a high level of productivity and dedication to his field. This output signifies Dr. Karaselek’s capacity to consistently push the boundaries of immunology research.
Areas for Improvement:
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Broader Global Recognition: While Dr. Karaselek’s publications are substantial, increasing the international impact of his work through higher-profile collaborations or by engaging in high-impact, globally recognized studies could further elevate his standing in the scientific community.
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Interdisciplinary Impact: Although his work covers a broad spectrum, a more explicit focus on interdisciplinary applications of his research, especially between immunology, genomics, and personalized medicine, could help translate his research findings into clinical practice more effectively.
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Public Engagement: Engaging in public-facing work such as writing for science outreach or sharing research insights in a more accessible format could further enhance his visibility and allow his discoveries to have a broader societal impact.
Education:
Dr. Mehmet Ali Karaselek earned his medical degree from a prestigious institution, followed by specialized training in clinical immunology. He furthered his education with a focus on advanced immunology and immunogenetics, completing multiple certifications and postdoctoral research programs. His early academic interests were rooted in understanding the molecular basis of immune system disorders, which led him to pursue an in-depth study of genetic immunodeficiencies. He has continually sought to enhance his expertise by participating in various national and international conferences and workshops on immunology. Throughout his career, Dr. Karaselek has combined clinical education with practical experience, which has enabled him to contribute effectively to both scientific research and patient care. His comprehensive educational background has been instrumental in his ability to lead complex research projects, investigate the immunological aspects of rare diseases, and educate others in the field.
Experience:
Dr. Mehmet Ali Karaselek has extensive experience in clinical immunology, with a focus on the genetic and molecular mechanisms of immune disorders. He has worked in academic and clinical settings, leading research projects and contributing to major breakthroughs in immunodeficiencies and autoimmune diseases. Over the years, he has collaborated with a wide range of medical professionals, contributing to the diagnosis and treatment of rare genetic conditions such as ICF syndrome, DCLRE1C deficiency, and CD19 deficiency. His expertise also spans cellular immunology, where he has conducted research on T-cell subsets and cytokine expression. His clinical experience, combined with his research background, has positioned him as a leader in the immunology community, with a focus on improving immunogenetic diagnostic techniques. Dr. Karaselek has also mentored numerous students and professionals, further advancing the field through knowledge dissemination and collaboration.
Research Focus:
Dr. Mehmet Ali Karaselek’s research focuses on the molecular and genetic mechanisms underlying immune system disorders, particularly in the context of immunodeficiencies and autoimmune diseases. He is deeply involved in studying T-cell subsets, immune cell profiling, and cytokine expression in patients with rare genetic mutations. His work has shed light on the pathophysiology of conditions such as ICF syndrome, DCLRE1C deficiency, and CD19 deficiency, with the aim of improving diagnosis and treatment options. Dr. Karaselek is also interested in the immunological aspects of cancer, having explored immune cell interactions in various cancer types. His research contributions extend to immune modulation, studying how intensive physical activity like weightlifting affects immune cells. By integrating clinical observations with laboratory-based research, Dr. Karaselek seeks to bridge the gap between basic science and clinical practice, providing new insights into immune system functionality and dysfunctions.
Publications Top Notes:
- Investigation of Transcription Factor and Cytokine Gene Expression Levels in Helper T Cell Subsets Among Turkish Patients Diagnosed with ICF2 and ICF3 Syndrome 🧬🧪
- Association of NK cell subsets and cytotoxicity with FCGR3A gene polymorphism in functional NK cell deficiency 🧫🔬
- Changes in T-cell subsets occur in interstitial lung disease and may contribute to pathology via complicated immune cascade 🫁🩸
- Effect of intensive training on immune system cells in elite female weightlifters 🏋️♀️🦠
- Evaluation of transcription factors and cytokine expressions of T-cell subsets in CD19 deficiency and their possible relationship with autoimmune disease 🤧🔬
- Molecular investigations on T cell subsets in patients affected by hypomorphic DCLRE1C mutation 🧬🔬
- Variable clinical presentation of hypomorphic DCLRE1C deficiency from childhood to adulthood 👶👨⚕️
- Water-soluble Pillar[5]arene-based drug candidates for lung and breast cancer 🧪🌊
- Could immune cells be associated with nephropathy in Fabry disease patients? 💉🩺
- Effective anticancer agents based-on two Pillar[5]arene derivatives for pancreas cancer cell lines 🧬💊
Conclusion:
Dr. Mehmet Ali Karaselek is a highly qualified and productive researcher with significant contributions in immunology and genetics. His vast experience, innovative approaches, and contributions to key scientific areas make him an ideal candidate for the Researcher for Best Researcher Award. Enhancing his global influence and promoting public engagement in his research would be valuable next steps.