Hongrui Meng | RNA biology | Best Researcher Award

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Dr. Hongrui Meng | RNA biology | Best Researcher Award

Dr. Hongrui Meng, Institute of Neuroscience, Soochow University, China

Dr. Hongrui Meng is a distinguished neuroscientist specializing in the molecular mechanisms underlying neurodegenerative diseases. With a Ph.D. in Behavioral Neuroscience from Hamamatsu University School of Medicine, Japan, Dr. Meng furthered his expertise through postdoctoral training at Juntendo University, Tokyo. He served as an assistant professor before establishing the Laboratory of Molecular Neurology at the Institute of Neuroscience, Soochow University, where he became a full professor in 2020. His pioneering work has made notable advances in understanding Parkinson’s disease, ALS, and mitochondrial dysfunction. Dr. Meng’s research integrates cellular, genetic, and biochemical tools using models ranging from Drosophila to mice. He has authored over a dozen peer-reviewed publications and holds international patents for novel molecular diagnostic techniques. Additionally, he collaborates with pharmaceutical companies to develop plant-based neuroprotective agents. As a committed mentor and leader, he contributes to scientific societies and editorial boards and is known for his translational approach in bridging basic science and therapeutic innovation.

Publication Profile: 

Scopus

Orcid

✅ Strengths for the Award:

  1. Pioneering Research in Neurodegeneration:
    Dr. Meng has significantly contributed to understanding the molecular and cellular mechanisms of neurodegenerative diseases, especially Parkinson’s disease and ALS, with a focus on mitochondrial dysfunction, protein aggregation, and innate immunity.

  2. International Academic Background and Collaborations:
    Educated and trained in Japan with active collaborations in both academic and industry sectors (e.g., Longma Pharmaceutical Co., Ltd.), Dr. Meng bridges global perspectives and translational goals effectively.

  3. Strong Publication and Patent Record:
    He has published over a dozen high-impact, peer-reviewed articles (SCI, Scopus indexed) and holds international patents in diagnostic methodology. His research output demonstrates consistency, innovation, and real-world applicability.

  4. Leadership in Research and Lab Management:
    As a full professor and founder of the Laboratory of Molecular Neurology at Soochow University, Dr. Meng leads a dynamic team with successful research grants, including from JSPS, NSFC, and Takeda Foundation.

  5. Interdisciplinary Focus:
    His work integrates behavioral neuroscience, molecular biology, genetics, and technology (e.g., wearable devices), illustrating a forward-looking and solution-oriented approach.

🛠️ Areas for Improvement:

  • Citation Impact (h-index):
    While his Scopus h-index (7) reflects a solid foundation, increased international visibility and broader citation engagement can elevate his standing among global peers.

  • Expanded Global Outreach:
    More international speaking engagements, global consortia leadership, and multi-center trials could further boost Dr. Meng’s influence and accelerate translation of his work.

🎓 Education:

Dr. Hongrui Meng earned his Ph.D. in Behavioral Neuroscience from Hamamatsu University School of Medicine, Japan. His doctoral research focused on neurobiological pathways implicated in behavioral disorders and neurodegenerative processes. Following this, he underwent rigorous postdoctoral training at Juntendo University in Tokyo, where he specialized in molecular neurobiology and human genetics. His interdisciplinary education and training provided him with a strong foundation in genetic, molecular, and cellular neuroscience, particularly as they relate to Parkinson’s disease and ALS. His academic journey was shaped by prestigious institutions known for cutting-edge neuroscience research and helped develop his expertise in mitochondrial dysfunction and protein aggregation mechanisms. Dr. Meng has continued to expand his knowledge through professional development and active engagement with academic societies in both China and Japan. His educational background has prepared him well to lead impactful, translational research in neurodegenerative disease therapy and drug discovery.

🧪 Experience:

Dr. Meng began his academic career in Japan, first as a doctoral researcher and later as a postdoctoral fellow focusing on molecular neurobiology and neurogenetics. He was appointed assistant professor in the Department of Research for Neurodegenerative Diseases and Dementia at Juntendo University. In 2020, he joined the Institute of Neuroscience at Soochow University as a full professor, where he established and currently leads the Laboratory of Molecular Neurology. Over his career, Dr. Meng has managed multiple international and national research projects supported by agencies such as the Japan Society for the Promotion of Science and the Natural Science Foundation of China. His projects span from fundamental mitochondrial research to applied wearable technologies for Parkinson’s monitoring. With over 12 years of research and academic leadership, he also provides consultancy to pharmaceutical companies and reviews for educational institutions. His international experience has made him a key contributor to the neurodegeneration research field.

🔬 Research Focus:

Dr. Meng’s research focuses on uncovering the cellular and molecular mechanisms of neurodegenerative diseases, particularly Parkinson’s disease and ALS. His lab investigates how mitochondrial dysfunction contributes to protein aggregation and neuronal death, with an emphasis on α-synuclein and CHCHD2-related pathways. Using transgenic Drosophila and rodent models, Dr. Meng’s work has identified key genetic mutations and stress response pathways, such as the mitochondrial unfolded protein response (mtUPR), that drive disease progression. His research also extends to glial cell biology, neuroinflammation, and the neuroimmune system’s role in maintaining neuronal integrity. Moreover, he is pioneering in drug discovery, developing plant-derived compounds and wearable technology for disease monitoring. His lab is currently involved in translational research, bridging basic molecular findings with therapeutic applications. Dr. Meng’s studies are multidisciplinary, combining genetics, molecular biology, imaging, and behavioral neuroscience, aiming to transform discoveries into real-world interventions for neurodegenerative conditions.

📚 Publications Top Notes:

  1. 🧬 Dicer Is Involved in Cytotoxicity and Motor Impairment Induced by TBPH Deficiency – Current Issues in Molecular Biology, 2025

  2. 🧠 Alpha-Synucleinopathy Disrupts Microglial Homeostasis in Parkinson’s Disease – Cell Communication and Signaling, 2024

  3. 🧪 Transcriptomic Analysis of Lipid Metabolism Genes in Alzheimer’s Disease – Journal of Molecular Neuroscience, 2024

  4. 🔬 CHCHD2 Mutation Alters Ca2+ Homeostasis in ALS – PNAS Nexus, 2024

  5. 🧫 A Simple Technique to Assay Locomotor Activity in Drosophila – Journal of Visualized Experiments, 2023

  6. 🧍‍♂️ MHCI Deficiency Induces ADHD-like Symptoms – Brain Behavior and Immunity, 2021

  7. 🧠 Twin CHCH Proteins in Parkinson’s and ALS – International Journal of Molecular Sciences, 2019

  8. 🧪 CHCHD2 Mutations Cause Alpha-Synuclein Aggregation – Human Molecular Genetics, 2019

  9. 🧬 Monitoring Mitochondrial Changes via Pink1-Parkin Signaling in Drosophila – Methods in Molecular Biology, 2018

  10. 🧪 Loss of CHCHD2 Affects Mitochondrial Cristae and Cytochrome C – Nature Communications, 20

🧾 Conclusion:

Dr. Hongrui Meng exemplifies the qualities of a top-tier neuroscientist: innovation, academic rigor, leadership, and translational vision. His multidisciplinary work contributes directly to unmet clinical needs in Parkinson’s and ALS, backed by strong research funding, publications, and patent activities.

Soumya Basu | RNA Biology Function | Women Researcher Award

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Dr. Soumya Basu | RNA Biology Function | Women Researcher Award

Dr. Soumya Basu , Dr. D. Y. Patil Biotechnology and Bioinformatics Institute , India

Dr. Soumya Basu, an Associate Professor and Principal Investigator at the Cancer and Translational Research Centre, Dr. D.Y. Patil Biotechnology Institute, Pune, boasts 18+ years of experience in life sciences. With a Ph.D. from Jadavpur University and expertise in cell culture, nc-RNA research, small molecule design, and drug-resistant cancer therapy, Dr. Basu is a recognized leader in cancer research. She has contributed extensively to research, scientific writing, and mentoring, with a strong track record in publications, book chapters, and protocols. Her experience spans academic positions, including roles at the Tata Memorial Centre and Chittaranjan National Cancer Institute. Dr. Basu is committed to exploring the molecular mechanisms of cancer and developing innovative therapeutic strategies, with a focus on natural product analogs and drug delivery systems targeting metastatic cancers. Her research continues to impact the understanding and treatment of cancer at a molecular level.

Publication Profile: 

Orcid

Strengths for the Award:

  1. Extensive Research Experience: Dr. Soumya Basu brings over 18 years of research experience in life sciences, with a strong focus on cancer research, small molecule design, nc-RNA research, and drug delivery systems. Her expertise in animal cell culture, cell-based assays, and molecular biology techniques demonstrates her ability to drive impactful research.

  2. Significant Academic Contribution: As a Principal Investigator at the Cancer and Translational Research Centre, Dr. Basu has made notable contributions in the area of targeted cancer therapies. Her involvement in high-impact publications, including recent journal articles and book chapters, highlights her active role in advancing scientific knowledge.

  3. Leadership and Mentorship: As an Associate Professor, Dr. Basu has shown a commitment to leadership, team management, and mentoring students and researchers. Her role as a mentor and ability to manage cross-functional teams demonstrate strong organizational and leadership skills.

  4. Scientific Writing and Publishing: Dr. Basu’s contributions to scientific literature are extensive, with multiple publications in peer-reviewed journals and book chapters. Her work on drug discovery, biomaterials, and the application of AI in drug development further illustrates her versatility and scientific rigor.

  5. Innovative Research Areas: Dr. Basu is involved in cutting-edge research areas, such as the development of natural product analogs targeting the PPAR pathway in lung carcinoma, and the design of drug delivery systems to target metastatic lymph nodes in breast cancer. Her research has the potential for significant clinical impact.

  6. Educational Background: Dr. Basu’s academic qualifications, including a Ph.D. in Life Sciences, an advanced PG course in Artificial Intelligence and Machine Learning, and an advanced diploma in Medical Writing and Regulatory Affairs, showcase her diverse skill set and adaptability to evolving scientific fields.

Areas for Improvement:

  1. Broadening Research Scope: While Dr. Basu’s focus on cancer research and small molecules is impressive, expanding her research into broader therapeutic areas or exploring more interdisciplinary fields could further strengthen her profile as a researcher. Her expertise in AI and machine learning could be leveraged further to address other diseases or health-related issues, potentially opening up new avenues for impactful research.

  2. Increase Collaborative Opportunities: While she has worked with prominent researchers, increasing international collaborations, especially in fields like artificial intelligence in biomedical research, could enhance the global impact of her work and broaden her professional network.

  3. Public Engagement and Outreach: Dr. Basu could focus on increasing public outreach and raising awareness of her research. Given her significant contributions, engaging with non-scientific audiences, through media interviews, science communication platforms, or public talks, could further highlight her as a thought leader.

Education:

Dr. Soumya Basu holds a Ph.D. in Life Sciences from Jadavpur University, where her thesis explored “Reactive oxygen species-mediated targeted therapy in drug-resistant cancer.” She furthered her academic journey with an advanced PG course in Artificial Intelligence and Machine Learning from the University of Texas at Austin, where she earned a 90% score. Dr. Basu also completed an Advanced Diploma in Medical Writing and Regulatory Affairs from Syncorp Educational Institution in Bangalore. She earned her M.Sc. in Microbiology from the University of Kalyani with a 65.6% mark and her B.Sc. (Hons.) in Physics, Chemistry, and Mathematics from the University of Burdwan. Dr. Basu’s educational background showcases a blend of biological sciences and interdisciplinary learning, equipping her with the necessary skills to tackle complex challenges in cancer research and translational medicine.

Experience:

Dr. Soumya Basu has built an illustrious academic and research career. Currently, she is an Associate Professor and Principal Investigator at Dr. D.Y. Patil Biotechnology Institute, Pune, where she has been since 2014. Dr. Basu’s academic journey includes significant roles in research, including her tenure as a Research Associate at the Advanced Centre for Treatment Research and Education in Cancer, Tata Memorial Centre, Navi Mumbai. Her work at Chittaranjan National Cancer Institute, Kolkata, as a Senior Research Fellow (ICMR), honed her skills in cancer biology and cellular chemotherapy. Additionally, she served as a Project Assistant at Jadavpur University and the University of Calcutta, gaining foundational research experience. Her early career also included a position as a Lecturer at Kulti College. Dr. Basu’s multifaceted experience allows her to mentor students, manage cross-functional teams, and spearhead research projects in cancer and drug delivery systems.

Awards and Honors:

Dr. Soumya Basu’s dedication to research excellence has earned her numerous accolades. Her work in cancer research has led to high-impact publications in prestigious journals, with citations exceeding 550 and an H-index of 14. Dr. Basu’s expertise in drug design, nc-RNA research, and cell-based assays has contributed to the development of novel therapeutic approaches in cancer treatment. Her research collaborations have resulted in successful international publications, particularly in drug discovery and cancer genomics. Additionally, she has received recognition from academic and research institutions for her contributions to the field of cancer and biotechnology. Although specific awards are not listed, Dr. Basu’s consistent publication record and leadership in cutting-edge research demonstrate her significant influence in her field. Her recognition among peers and scientific communities highlights her as a key figure in advancing translational medicine and cancer therapy.

Research Focus:

Dr. Soumya Basu’s research primarily focuses on the molecular mechanisms of cancer and the development of innovative therapies. Her work emphasizes the design and synthesis of natural product analogs targeting the PPAR pathway in lung carcinoma and other cancers. Dr. Basu is passionate about advancing drug delivery systems, particularly those targeting metastatic lymph nodes in breast cancer. Her research also delves into non-coding RNAs (ncRNAs), exploring their roles in cancer biology and therapeutic potential. A significant portion of her work is dedicated to studying drug-resistant cancers and designing targeted therapies to overcome resistance. She is involved in both basic and applied research, aiming to develop novel, more effective cancer treatments. Dr. Basu’s interdisciplinary approach integrates artificial intelligence and machine learning techniques with biotechnological applications, positioning her as a forward-thinking scientist at the intersection of computational and experimental cancer research.

Publications Top Notes:

  1. miRVim: Three-dimensional miRNA Structure Database (2024) 🧬📚
  2. Novel insights on oral squamous cell carcinoma management using long non-coding RNAs (2024) 🦷💉
  3. Design, Docking, Synthesis, and In vitro Evaluation of Potent Anti-tubercular Agents Targeting DNA Gyrase (2024) 💊🧪
  4. Identification of Novel PPAR-β/δ Agonists from Kaempferol, Quercetin, and Resveratrol Derivatives by Targeting Cancer (2024) 🍇💥
  5. Exploring binding mode assessment of novel kaempferol, resveratrol, and quercetin derivatives with PPAR-α as potent drug candidates against cancer (2023) 🌿🔬
  6. Design, Synthesis, and Biological Evaluation of Novel Quercetin Derivatives as PPAR‐γ Partial Agonists by Modulating EMT in Lung Cancer (2023) 🍃🫀
  7. Partial Activation of PPAR‐γ by Synthesized Quercetin Derivatives Modulates TGF‐β1‐Induced EMT in Lung Cancer Cells (2023) 💊🧬
  8. Synergistic combination of ritonavir and cisplatin as an efficacious therapy in human cervical cancer cells (2023) 💊🤝
  9. Non-Coding RNAs in Oral Cancer: Emerging Roles and Clinical Applications (2023) 💉🧬

Conclusion:

Dr. Soumya Basu is a highly deserving candidate for the Research for Women Researcher Award. Her substantial research contributions, leadership roles, and innovative work in the cancer research field, particularly in drug discovery and therapeutic design, make her a standout candidate. Dr. Basu’s scientific rigor, ability to manage and mentor, and her commitment to advancing medical science position her as a leader in her field. Despite areas for further growth, particularly in expanding the scope of her research and increasing public engagement, Dr. Basu’s exemplary career trajectory, mentorship, and active research contributions make her an outstanding nominee for this prestigious award.