Advanced Center for Treatment and Research in Cancer | India
Dr. Nikhil Gadewal is an accomplished scientist specializing in bioinformatics, molecular modeling, structure-based drug design, and integrative multi-omics analysis. His research portfolio includes 42 peer-reviewed publications spanning computational biology, cancer therapeutics, and systems-level data interpretation. A key focus of his work is the development and application of gene regulatory network analysis using multi-omics datasets to uncover molecular mechanisms underlying disease pathology, particularly in cancer. He has made significant contributions to structure-based drug design, identifying phytochemicals and small molecules with therapeutic potential for integrative cancer treatment strategies. His patented work on biomarkers and therapeutic targets for transformed epithelium in gingivo-buccal cancer reflects his expertise in translational cancer research and precision medicine. In addition to research, he actively contributes to capacity building by conducting workshops and training programs in next-generation sequencing (NGS) data analysis, molecular modeling, and molecular dynamics simulations. His work integrates computational approaches with biological insight to advance drug discovery, biomarker identification, and systems-level understanding of complex diseases.
Featured Publications:
Khare, S. P., Habib, F., Sharma, R., Gadewal, N., Gupta, S., & Galande, S. (2012). HISTome—A relational knowledgebase of human histone proteins and histone modifying enzymes. Nucleic Acids Research, 40(D1), D337–D342.
Chikhale, R., Thorat, S., Choudhary, R. K., Gadewal, N., & Khedekar, P. (2018). Design, synthesis and anticancer studies of novel aminobenzazolyl pyrimidines as tyrosine kinase inhibitors. Bioorganic Chemistry, 77, 84–100.
Singh, S. V., Dakhole, A. N., Deogharkar, A., Kazi, S., Kshirsagar, R., Goel, A., … Gadewal, N. (2017). Restoration of miR-30a expression inhibits growth and tumorigenicity of medulloblastoma cells accompanied by autophagy inhibition. Biochemical and Biophysical Research Communications, 491(4), 946–952.
Bejugam, P. R., Kuppili, R. R., Singh, N., Gadewal, N., Chaganti, L. K., Sastry, G. M., … (2013). Allosteric regulation of serine protease HtrA2 through a novel non-canonical substrate binding pocket. PLOS ONE, 8(2), e55416.
Tokala, R., Sana, S., Lakshmi, U. J., Sankarana, P., Sigalapalli, D. K., Gadewal, N., … (2020). Design and synthesis of thiadiazolo-carboxamide bridged β-carboline-indole hybrids: DNA intercalative topo-IIα inhibition with promising antiproliferative activity. Bioorganic Chemistry, 105, 104357.
Gadewal, N. S., & Zingde, S. M. (2011). Database and interaction network of genes involved in oral cancer: Version II. Bioinformation, 6(4), 169–175.