Dr. Quanjun Cui is a leading researcher in orthopedic surgery with a strong focus on the pathophysiology and treatment of osteoarthritis (OA). His work integrates clinical insight with advanced molecular and cellular approaches to understand joint degeneration and repair. Dr. Cui’s research has significantly contributed to elucidating the cellular mechanisms underlying cartilage and bone remodeling, macrophage polarization, and the role of extracellular vesicles in joint inflammation. His current studies investigate how M1 macrophage–derived, hyaluronan-coated extracellular vesicles influence OA progression, aiming to identify novel therapeutic targets that modulate immune–cartilage interactions. He has also explored molecular pathways involved in bone regeneration, osteonecrosis, and implant integration, with numerous publications advancing translational strategies in musculoskeletal tissue repair. Through his interdisciplinary approach combining orthopaedic biology, regenerative medicine, and biomaterials science, Dr. Cui continues to advance innovative treatments that address degenerative joint diseases at both cellular and clinical levels.
Featured Publications:
Cui, Q., Mihalko, W. M., Shields, J. S., Ries, M., & Saleh, K. J. (2007). Antibiotic-impregnated cement spacers for the treatment of infection associated with total hip or knee arthroplasty. The Journal of Bone and Joint Surgery (JBJS), 89(4), 871–882.
Zhao, D., Zhang, F., Wang, B., Liu, B., Li, L., Kim, S. Y., Goodman, S. B., Hernigou, P., Cui, Q., … (2020). Guidelines for clinical diagnosis and treatment of osteonecrosis of the femoral head in adults (2019 version). Journal of Orthopaedic Translation, 21, 100–110.
Wu, T. T., Sikes, R. A., Cui, Q., Thalmann, G. N., Kao, C., Murphy, C. F., Yang, H., … (1998). Establishing human prostate cancer cell xenografts in bone: Induction of osteoblastic reaction by prostate-specific antigen-producing tumors in athymic and SCID/bg mice using LNCaP sublines. International Journal of Cancer, 77(6), 887–894.
Wang, G. J., Cui, Q., & Balian, G. (2000). The pathogenesis and prevention of steroid-induced osteonecrosis. Clinical Orthopaedics and Related Research, 370, 295–310.
Cui, Q., Wang, G. J., & Balian, G. (1997). Steroid-induced adipogenesis in a pluripotential cell line from bone marrow. The Journal of Bone and Joint Surgery (JBJS), 79(7), 1054–1063.
Wang, Y., Li, Y., Mao, K., Li, J., Cui, Q., & Wang, G. J. (2003). Alcohol-induced adipogenesis in bone and marrow: A possible mechanism for osteonecrosis.Clinical Orthopaedics and Related Research, 410, 213–224.