Xueru Li | Molecular Mechanisms Signaling | Cell Microenvironment Award

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Ms. Xueru Li | Molecular Mechanisms Signaling | Cell Microenvironment Award

Ms. Xueru Li , Chongqing Medical University , China

Li Xueru is an accomplished researcher and scientist with expertise in clinical laboratory diagnostics. He obtained his Ph.D. in Clinical Laboratory Diagnostics from Chongqing Medical University. Xueru has contributed extensively to scientific research, particularly in the field of cell microenvironment, fibrosis, and oxidative stress. His research has involved collaborations with prestigious organizations, such as the Chongqing Education Commission and Chongqing Natural Science Foundation. Through his academic journey, he has demonstrated a strong commitment to advancing knowledge in biomedical sciences, particularly in the areas of lung fibrosis and cellular response to environmental stress. Li Xueru is an active participant in research projects and has co-authored several influential publications that have contributed to the advancement of molecular biology and clinical diagnostics.

Publication Profile:

Scopus

Strengths for the Award:

Li Xueru’s expertise in clinical laboratory diagnostics, combined with his research in the field of cell microenvironment and fibrosis, positions him as a strong candidate for the Research for Cell Microenvironment Award. His work, especially the study on “Pharmaceutical targeting of succinate dehydrogenase in fibroblasts to control bleomycin-induced lung fibrosis,” highlights his contributions to understanding cellular mechanisms in fibrosis and oxidative stress. His involvement in high-impact research funded by organizations like the Chongqing Education Commission and the Chongqing Natural Science Foundation shows a commitment to advancing scientific knowledge and contributing to both academic and practical advancements in biomedical sciences. Moreover, his ability to bridge fundamental research with clinical applications demonstrates a strength that aligns with the goals of the Research for Cell Microenvironment Award.

Areas for Improvements:

While Li Xueru’s research focus is promising, there is potential to expand his exploration of cellular microenvironment to include other disease models and extend beyond lung fibrosis. Diversifying his research topics could provide a broader understanding of cellular behavior across different tissues and disease states. Additionally, there could be more emphasis on the development of therapeutic interventions, potentially accelerating the translation of his discoveries into clinical practices. Increasing collaboration with international research teams may also offer new perspectives and further enhance the impact of his work.

Education:

Li Xueru earned his Ph.D. degree in Clinical Laboratory Diagnostics from Chongqing Medical University, one of China’s leading medical institutions. His academic background has provided him with in-depth knowledge of diagnostic technologies, clinical pathology, and molecular biology. During his doctoral studies, he developed expertise in understanding cellular behavior and disease mechanisms at the molecular level, with a particular focus on how environmental stress impacts cellular functions. This education laid the foundation for his career in the biomedical field. He has further strengthened his research skills by participating in various projects funded by the Chongqing Education Commission and the Chongqing Natural Science Foundation. His education has been instrumental in shaping his approach to scientific inquiry, fostering a comprehensive understanding of clinical diagnostics, and equipping him to lead innovative research in the cellular microenvironment and disease mechanisms.

Experience:

Li Xueru’s experience spans a wide range of research activities focused on clinical laboratory diagnostics and cell microenvironment. His involvement in multiple high-impact research projects, supported by institutions like the Chongqing Education Commission and the Chongqing Natural Science Foundation, showcases his leadership in advancing scientific knowledge. Xueru has worked closely with interdisciplinary teams to address complex problems in the biomedical field, particularly lung fibrosis and oxidative stress. His research contributions include identifying novel cellular mechanisms involved in disease pathogenesis, improving diagnostic methodologies, and exploring therapeutic strategies for disease management. He has demonstrated a remarkable ability to apply scientific research in real-world contexts, ensuring that his findings have practical applications in medical diagnostics and treatment. His collaborative approach and innovative thinking have positioned him as a key figure in his field, contributing significantly to both academic literature and clinical advancements.

Research Focus:

Li Xueru’s primary research focus revolves around the molecular mechanisms of diseases, particularly lung fibrosis and cellular responses to environmental stressors. He is dedicated to understanding the impact of oxidative stress on cellular functions and its role in disease progression. His research explores the microenvironment of cells in response to various stimuli, including chemical agents like bleomycin. A significant area of his research is the role of succinate dehydrogenase in fibroblasts and its potential as a pharmaceutical target to control lung fibrosis. Through his work, Xueru has contributed to a better understanding of how cells interact with their microenvironment, which is crucial for developing new diagnostic and therapeutic approaches. His innovative studies on cell signaling pathways, fibrosis, and oxidative stress have the potential to transform treatment strategies for diseases related to chronic inflammation and tissue fibrosis.

Publications Top Notes:

  • Pharmaceutical targeting of succinate dehydrogenase in fibroblasts controls bleomycin-induced lung fibrosis 🧬

  • Corrigendum to “Pharmaceutical targeting of succinate dehydrogenase in fibroblasts controls bleomycin-induced lung fibrosis” 🔬

Conclusion:

Li Xueru is a promising candidate for the Research for Cell Microenvironment Award. His significant contributions to the understanding of cellular mechanisms in fibrosis and oxidative stress have led to valuable insights into the pathophysiology of diseases. By focusing on the cell microenvironment and its role in disease progression, his work is advancing scientific knowledge with important implications for diagnostics and therapy. With further diversification of his research and expanded collaborations, Li Xueru has the potential to make even greater strides in the field, ultimately improving patient outcomes and advancing the application of his findings in clinical settings.

Ranran Li | Signal Transduction Mechanisms | Best Researcher Award

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Dr. Ranran Li | Signal Transduction Mechanisms | Best Researcher Award

Ranran Li , Ruijin Hospital, Shanghai Jiao Tong University School of Medicine , China

Dr. Ranran Li is an associate researcher at Ruijin Hospital, Shanghai Jiao Tong University School of Medicine in Shanghai, China. She earned her Ph.D. from the University Medical Center of Groningen, Netherlands, in 2015, before returning to Shanghai to focus on critical care medicine. Her research centers on sepsis-associated endothelial dysfunction and its underlying molecular mechanisms. Over the years, Dr. Li’s work has provided valuable insights into the role of metabolic disorders and post-translational modifications in regulating endothelial inflammation and coagulation during sepsis. She has published extensively in reputable journals and holds several patents. Her recent findings suggest potential therapeutic targets for the treatment of sepsis and related complications, including endothelial dysfunction and organ injury.

Publication Profile:

Scopus

Strengths for the Award:

Dr. Ranran Li is a distinguished researcher with notable expertise in the mechanisms of sepsis-associated endothelial dysfunction. Her work in identifying the role of metabolic disorders and post-translational modifications in sepsis has been pivotal in advancing the understanding of vascular inflammation and coagulation during critical illness. Her research has led to several high-impact publications and patents, showcasing her contributions to the field. Furthermore, Dr. Li’s interdisciplinary approach, combining metabolic biology, cell signaling, and translational medicine, has provided valuable therapeutic targets for the treatment of sepsis and endothelial dysfunction. Her collaborations with international experts enhance her work’s impact and broaden the scope of her research.

Areas for Improvements:

While Dr. Li’s research has been extensive and groundbreaking, future improvements could include increased collaborations with industry partners to accelerate the translation of her findings into clinical therapies. Expanding her professional network through international collaborations in other areas of critical care medicine could also provide new perspectives and avenues for innovation. Additionally, engaging in larger-scale clinical studies might help further validate her findings in human models.

Education

Dr. Ranran Li obtained her Ph.D. in Medical Sciences from the University Medical Center of Groningen, Netherlands, from 2011 to 2015. During her doctoral studies, she focused on the molecular mechanisms of sepsis and its impact on vascular endothelial dysfunction. Her Ph.D. research laid the foundation for her ongoing investigations into the pathophysiology of sepsis and endothelial injury. Following her Ph.D., she joined Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, in 2016 as an associate researcher in the Department of Critical Care Medicine. Here, Dr. Li furthered her research into sepsis, vascular inflammation, and metabolic disorders. She has developed an expertise in endothelial dysfunction and coagulation, specifically in the context of sepsis-induced organ injuries. Dr. Li’s comprehensive academic training, both in Europe and China, has significantly contributed to her innovative research work and international collaborations.

Experience:

Dr. Ranran Li has been serving as an associate researcher at Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, since 2016. Prior to this, she earned her Ph.D. from the University Medical Center of Groningen in the Netherlands, where she focused on sepsis and endothelial dysfunction. In her current position, Dr. Li has worked extensively on understanding the mechanisms underlying sepsis-associated endothelial dysfunction, with a particular focus on metabolic disorders and post-translational modifications. Her work has provided critical insights into the role of fatty acid metabolism, insulin resistance, and histone modifications in regulating endothelial inflammation and coagulation activation in sepsis. Dr. Li’s research has led to multiple publications in high-impact journals and the filing of patents for innovative therapeutic approaches. She collaborates with leading researchers in the Netherlands and has contributed significantly to the understanding of vascular injury and its therapeutic targets in sepsis.

Research Focus:

Dr. Ranran Li’s research focuses on the molecular mechanisms of sepsis-associated endothelial dysfunction, with a particular emphasis on metabolic disorders and post-translational modifications. She has been exploring how fatty acid metabolism, glucose-lipid metabolism, and protein acetylation influence endothelial cells during sepsis, leading to organ injury. Her research has highlighted the role of metabolic shifts, including the activation of pathways like AMPK/PKA, in endothelial inflammation and coagulation activation. Dr. Li has also studied the role of histone modifications, including lactylation, in promoting endothelial ferroptosis and dysfunction during sepsis-induced lung injury. She has been pioneering the exploration of metabolic signaling pathways and their potential as therapeutic targets for managing sepsis-related endothelial damage. Her work aims to identify novel strategies to prevent or mitigate vascular injury in septic patients. Dr. Li’s findings have led to both patents and high-impact publications in critical care and translational medicine.

Publications Top Notes:

  1. Shiyuan He et al., Fatty acid synthesis promotes mtDNA release via ETS1-mediated oligomerization of VDAC1 facilitating endothelial dysfunction in sepsis-induced lung injury 🧬🫁 Cell Death and Differentiation, 2025
  2. Ranran Li et al., ATP-citrate lyase controls endothelial gluco-lipogenic metabolism and vascular inflammation in sepsis-associated organ injury 💉🧪 Cell Death and Disease, 2023
  3. Jie Liu et al., Designed microchannel-based lipid nanoparticles encapsulated siRNA targeting gasdermin D for sepsis management via pulmonary delivery 🧬💉 Nano Today, 2025
  4. Fangchen Gong et al., H3K14la drives endothelial dysfunction in sepsis-induced ARDS by promoting SLC40A1/transferrin-mediated ferroptosis 🧬🔥 MedComm, 2025
  5. Jiayin Cui et al., Herbal-based Xuebijing injection ameliorated vascular endothelial dysfunction via inhibiting ACLY/MYB/RIG-I axis in sepsis-associated lung injury 🌱💊 Phytomedicine, 2025
  6. Shasha Lu et al., GDF15 ameliorates sepsis-induced lung injury via AMPK-mediated inhibition of glycolysis in alveolar macrophage 💨🧪 Respiratory Research, 2024
  7. Rui Tian et al., Shenfu injection ameliorates endotoxemia-associated endothelial dysfunction and organ injury via inhibiting PI3K/Akt-mediated glycolysis 💉🫀 Journal of Ethnopharmacology, 2024
  8. Yupeng Zhao et al., H3K18 lactylation-mediated VCAM1 expression promotes gastric cancer progression and metastasis via AKT-mTOR-CXCL1 axis 🎗️🧬 Biochemical Pharmacology, 2024
  9. Rui Tian et al., Metformin ameliorates endotoxemia-induced endothelial pro-inflammatory responses via AMPK-dependent mediation of HDAC5 and KLF2 💊💉 BBA-Molecular basis of disease, 2019
  10. Lei Pei et al., MSCs-derived extracellular vesicles alleviate sepsis-associated liver dysfunction by inhibiting macrophage glycolysis-mediated inflammatory response 🧬🩸 International Immunopharmacology, 2024

Conclusion:

Dr. Ranran Li is highly deserving of the Best Researcher Award due to her outstanding contributions to understanding the molecular mechanisms underlying sepsis-related endothelial dysfunction. Her innovative research has not only provided deep insights into the pathophysiology of sepsis but has also uncovered potential therapeutic targets for treating this devastating condition. Her exceptional track record of high-quality publications, patents, and collaborative research, combined with her dedication to advancing critical care medicine, makes her an excellent candidate for this prestigious award.

Sunita Pokhrel Bhattarai | Signal Transduction Mechanisms | Women Researcher Award

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MS. Sunita Pokhrel Bhattarai | Signal Transduction Mechanisms | Women Researcher Award

Ms. Sunita Pokhrel Bhattarai  , Ohio State University , United States

Sunita Pokhrel Bhattarai, PhD, RN, is an accomplished cardiovascular nurse researcher currently pursuing a doctorate at the University of Rochester, New York. Her research focuses on improving the estimation of Left Ventricular Ejection Fraction using ECGs in acute heart failure patients. With a background in emergency and critical care nursing from multiple international institutions, she is committed to advancing healthcare quality, particularly in heart failure care. Dr. Pokhrel Bhattarai’s work is widely published, showcasing expertise in clinical trials, big data analysis, and electrocardiographic assessments in heart failure. She has also contributed significantly to nursing education as a lecturer at Purbanchal University, Nepal. Passionate about reducing healthcare discrepancies, she actively participates in academic and clinical research collaborations, making significant strides in her field.

Publication Profile:

Google Scholar

Strengths for the Award:

Dr. Sunita Pokhrel Bhattarai is an exceptional researcher with a clear commitment to advancing cardiovascular nursing and improving healthcare outcomes for acute heart failure patients. Her research on estimating Left Ventricular Ejection Fraction using ECGs demonstrates innovation and clinical relevance. Her ability to bridge clinical practice with advanced research methodologies, including big data analysis and electrocardiographic assessment, sets her apart. Moreover, her international academic background and diverse professional experience in countries like Nepal, Spain, and the United States highlight her versatility and ability to contribute globally to healthcare solutions. Dr. Pokhrel Bhattarai’s consistent publication record in top-tier journals and her involvement in prestigious research projects further underscores her dedication to advancing nursing knowledge.

Areas for Improvement:

While Dr. Pokhrel Bhattarai has an outstanding academic and research profile, expanding her research to explore broader healthcare disparities, particularly in rural or underserved populations, could enhance the impact of her work. Additionally, pursuing interdisciplinary collaborations with engineers, statisticians, and other healthcare professionals could provide opportunities for more cutting-edge innovations, particularly in ECG-based diagnostic technology and AI integration.

Education:

Dr. Sunita Pokhrel Bhattarai has an extensive academic background. She is currently pursuing a PhD in Health Science and Nursing at the University of Rochester (2020-2024), under the mentorship of Dr. Mary G Carey. Her research explores estimating Left Ventricular Ejection Fraction using ECGs for acute heart failure patients. Dr. Pokhrel Bhattarai earned her MS in Nursing (2015-2017), specializing in Emergency and Critical Care Nursing, from institutions across Spain, Portugal, and Finland. Her research during this time focused on Advanced Cardiac Life Support knowledge among critical care nurses. She completed her BS in Nursing in 2012 from Maharajgunj Nursing Campus, Nepal, with a focus on Community Health Nursing. Throughout her academic career, she has demonstrated a commitment to advancing nursing knowledge and improving healthcare outcomes in cardiovascular care.

Experience:

Dr. Sunita Pokhrel Bhattarai has diverse professional experience across multiple countries. She has worked as a Nursing Lecturer at Purbanchal University in Kathmandu, Nepal (2017-2020), where she educated future nurses in critical care and advanced cardiovascular practices. As a registered nurse at Shahid Gangalal National Heart Centre, Kathmandu, Nepal (2009-2015), she gained hands-on experience in cardiovascular care, particularly in heart failure management. Additionally, she has been involved in research coordination and manuscript review, demonstrating expertise in big data analysis and clinical trials. Dr. Pokhrel Bhattarai has also held positions as a Research Lead Coordinator and Associate, collaborating with international researchers and contributing to advancing healthcare outcomes, particularly in cardiovascular nursing.

Awards and Honors:

Dr. Sunita Pokhrel Bhattarai has received numerous prestigious awards, highlighting her excellence in research and commitment to healthcare. In 2023, she was awarded the Travel Grant by the Council on Cardiovascular and Stroke Nursing Early Career, American Heart Association, and received the Presidential Stronger as One Diversity Award from the University of Rochester. She also secured a research grant from the International Society for Computerized Electrocardiology Conference. Dr. Pokhrel Bhattarai’s accomplishments include the Ireta Neumann Scholarship for International Nurses, providing $5,000 to support her research endeavors. These awards emphasize her leadership and contributions to cardiovascular nursing, both academically and clinically.

Research Focus:

Dr. Sunita Pokhrel Bhattarai’s research focus lies in the intersection of acute heart failure, ECG technology, and cardiovascular nursing. Her PhD dissertation explores estimating Left Ventricular Ejection Fraction using ECGs, aiming to provide accurate, non-invasive diagnostic tools for acute heart failure. She is passionate about identifying self-care strategies for heart failure patients and improving healthcare implementation strategies. Additionally, her work involves big data analysis, electrocardiographic assessment, and clinical trials to better understand heart failure progression and outcomes. Dr. Pokhrel Bhattarai is dedicated to addressing healthcare discrepancies, particularly in global cardiovascular health, and advancing evidence-based nursing practices through innovative research.

Publications Top Notes:

  1. Association Between Increased Serum Albumin and the Length of Hospital Stay among Acute Heart Failure 🏥
  2. Delays in Door-to-Diuretic Time and 1-Year Mortality among Patients with Heart Failure ⏳❤️
  3. Signs and Symptoms Clusters Among Patients With Acute Heart Failure 🔍💓
  4. Integrative Review of Electrocardiographic Characteristics in Patients with Reduced, Mildly Reduced, and Preserved Heart Failure 📊📈
  5. Knowledge and Practices on Prevention of Coronary Artery Diseases in Nepalese Community 🇳🇵💓
  6. Estimating Ejection Fraction from the 12 Lead ECG among Patients with Acute Heart Failure 💖📉
  7. Door-to-Diuretic Time is Related to Length of Hospital Stay Independent of Diuretic Dose ⏰💊
  8. Estimating Very Low Ejection Fraction from the 12 Lead ECG among Patients with Acute Heart Failure ❤️📉
  9. Association Between Serum Albumin and the Length of Hospital Stay Among Patients With Acute Heart Failure 🧑‍⚕️⏱
  10. Estimating Ejection Fraction from the 12 Lead ECG in Acute Heart Failure 💓📝

Conclusion:

Dr. Sunita Pokhrel Bhattarai’s combination of innovative cardiovascular research, global nursing expertise, and dedication to improving patient outcomes makes her an excellent candidate for the Research for Best Researcher Award. Her strong track record in research, awards, and contributions to cardiovascular nursing makes her deserving of this recognition, and her future endeavors hold great potential to further elevate the field of health science and nursing.