Eunhee Lee | Neuronal Cell Biology | Best Research Article Award

Posted on by Cell Biologist

Dr. Eunhee Lee | Neuronal Cell Biology | Best Research Article Award

Dr. Eunhee Lee, Daegu Gyeongbuk Medical Innovation Foundation, K-MEDI hub, South Korea

Dr. Eun-Hee Lee, Ph.D., is a distinguished biomedical researcher with expertise in therapeutic ultrasound and neurobiology. Currently serving as Senior Researcher and Head of the Advanced Technology Department at the Medical Device Development Center, DGMIF, South Korea, she has consistently contributed to the advancement of focused ultrasound applications in neurological disorders. With over a decade of research experience spanning government institutions and clinical collaborations, Dr. Lee has published extensively in peer-reviewed journals on brain delivery mechanisms, neuroinflammation, and neurodegeneration. Her pioneering studies have deepened our understanding of the blood-brain barrier and the therapeutic potential of ultrasound. Her work stands at the forefront of translational neuroscience, aiming to enhance drug delivery and brain repair mechanisms. Dr. Lee’s dedication to impactful and clinically relevant research makes her a strong contender for the Best Research Article Award.

Publication Profile: 

Scopus

✅ Strengths for the Award

  1. Innovative Research Focus:
    Dr. Lee’s work on focused ultrasound (FUS)-mediated blood-brain barrier (BBB) disruption is at the cutting edge of neurotherapeutics and non-invasive brain drug delivery. Her investigations hold promise for treating neurodegenerative disorders like Alzheimer’s disease and traumatic brain injuries.

  2. Extensive Peer-Reviewed Publications:
    With over 15 high-quality, peer-reviewed articles published from 2019 to 2024 in reputable journals like Scientific Reports, Frontiers in Neuroscience, and Biomedicines, her research output reflects consistent and impactful contributions.

  3. Interdisciplinary Approach:
    Her integration of biomedical engineering, imaging, and neurobiology enhances the translational value of her findings. Numerical modeling and simulation studies further strengthen the clinical feasibility of her techniques.

  4. Clinical and Preclinical Impact:
    Dr. Lee’s work bridges preclinical models (rats, skull simulations) with potential human applications, offering real translational pathways for drug delivery across the BBB.

  5. Leadership and Collaboration:
    As the Head of the Advanced Technology Department at DGMIF, she demonstrates leadership in medical innovation and fosters collaboration between academia, hospitals, and research institutes.

⚠️ Areas for Improvement

  1. Greater International Collaboration:
    While her work is deeply embedded in Korean institutions, expanding partnerships internationally could amplify her research reach and global influence.

  2. Clinical Trial Transition:
    Much of her published work is preclinical. Advancing to clinical trials or human pilot studies would significantly increase the translational impact of her findings.

  3. Public Engagement and Visibility:
    Enhanced visibility through global neuroscience or biomedical engineering conferences could further validate and showcase her research excellence.

🎓 Education:

Dr. Eun-Hee Lee received all her academic training from Chonnam National University, Kwangju, South Korea. She earned her Ph.D. (2007–2010) and M.S. (2005–2007) in Biological Sciences and Technology, gaining extensive knowledge in cellular and molecular biology. Her B.S. in Genetic Engineering (2001–2005) laid the groundwork for her interest in biomedical innovations and neurogenetics. During her graduate and doctoral studies, she focused on cellular pathways and gene expression relevant to neurodegenerative diseases and molecular interventions. Her academic journey shaped her multidisciplinary perspective, merging genetics, bioengineering, and neurobiology. These foundations have enabled her to pursue cutting-edge research on the blood-brain barrier, drug delivery systems, and brain stimulation. Dr. Lee’s strong academic background provides her with the theoretical and technical expertise essential for high-impact research.

🧪 Experience:

Dr. Eun-Hee Lee has more than 14 years of progressive research experience. Since 2017, she has led the Advanced Technology Department at DGMIF, where she develops novel medical devices using therapeutic ultrasound. Prior to this, she worked as a Research Scientist at the Korea Atomic Energy Institute’s Advanced Radiation Technology Institute (2015–2017), where she explored radiation-mediated biological responses. Between 2013 and 2015, she contributed to TB and molecular microbiology research at the Korean Institute of Tuberculosis. Her postdoctoral fellowship (2011–2012) at the NIH’s Division of HIV/AIDS and Tumor Viruses expanded her expertise into virology and immunopathology. Dr. Lee’s multidisciplinary roles across leading institutions demonstrate her adaptability, leadership, and commitment to translational science. Her professional trajectory shows strong contributions to national research priorities in healthcare and medical technology.

🔬 Research Focus:

Dr. Eun-Hee Lee’s research centers on focused ultrasound (FUS) as a non-invasive modality for drug delivery and neural repair. Her work explores ultrasound-mediated blood-brain barrier (BBB) disruption to enhance targeted therapeutic access to the brain. She also investigates ultrasound stimulation’s effects on neurogenesis, neuroinflammation, and neuroprotection in various neurological models including Alzheimer’s disease and spinal cord injury. Another significant area of focus includes numerical modeling of skull structures to improve the precision of transcranial FUS applications. Through collaborations with clinicians and physicists, Dr. Lee has produced evidence-based methodologies for safer, more effective BBB modulation. Her integrative approach, combining bioengineering, neuroimmunology, and computational simulation, is impactful in the field of therapeutic neuromodulation and has implications for treating neurodegenerative and cerebrovascular disorders.

📚 Publications Top Notes: 

  • 🧠 Numerical Investigation of Layered Homogeneous Skull Model for Simulations of Transcranial Focused Ultrasound (2024)

  • 🔥 The New Insight into the Inflammatory Response Following Focused Ultrasound-Mediated Blood-Brain Barrier Disruption (2022)

  • 🧪 Methylene Blue Delivery via Focused Ultrasound Reduces Neural Damage and Amyloid-Beta by AQP-4 Upregulation (2022)

  • 🐀 Novel Animal Model of Spontaneous Cerebral Petechial Hemorrhage Using Focused Ultrasound in Rats (2022)

  • ♻️ Ultrasound Stimulation Improves Inflammation Resolution and Functional Recovery After Spinal Cord Injury (2022)

  • 🚑 Relationship Between Treatment Types and BBB Disruption in Acute Ischemic Stroke: Two Case Reports (2022)

  • 🧲 Effects of Transducer Displacement on Focused Ultrasound in the Rat Brain (2022)

  • 📉 BBB Disruption After Syncope: A DCE-MRI Case Report (2021)

  • 🧪 Verification of BBB Disruption Using Rat Model with Human Skull (2021)

  • 💧 Localized Water Molecule Transport Modulation Post-FUS BBB Disruption (2021)

  • 🚨 DCE-MRI for Evaluating BBB Disruption in Traumatic Brain Injury: Review (2021)

  • 🧬 TREM2 Promotes Natural Killer Cell Development in pNK Cells (2021)

  • 🌿 Gintonin Enhances Donepezil Brain Delivery via LPA and VEGF Receptors (2021)

  • 🔄 Cyclophilin A is a Ligand for TREM2 in Myeloid Cells (2021)

  • 🧠 Local Differences in BBB Permeability Induced by Focused Ultrasound (2020)

  • 💉 Advanced FUS Protocol Improves Doxorubicin Delivery in Rat Brain (2019)

  • 🔄 FUS-Induced Diminished P-glycoprotein via JNK Pathway in Cerebral Vessels (2019)

🧾 Conclusion:

Dr. Eun-Hee Lee is a highly suitable candidate for the Best Research Article Award. Her work is scientifically rigorous, clinically relevant, and methodologically innovative. The focus on ultrasound-mediated drug delivery through the BBB is a transformative area in neuroscience and drug delivery technology. Her comprehensive research output, leadership, and translational potential strongly position her among top contenders for recognition. Encouraging clinical application and broader dissemination will only enhance the already substantial value of her contributions.

Ting Wang | Blood brain barrier | Best Researcher Award

Posted on by Cell Biologist

Dr. Ting Wang | Blood brain barrier | Best Researcher Award

Dr. Ting Wang , Guangzhou First People’s Hospital , China

Dr. Wang Ting, born on September 16, 1989, is an accomplished attending physician in the Department of Neurology at Guangzhou First People’s Hospital. She earned her Doctor of Medicine degree and actively mentors master’s students specializing in clinical practice. With a robust background in neurology, Dr. Wang has developed expertise in managing Parkinson’s disease, movement disorders, and cognitive disorders. Her innovative research spans across clinical treatments, including deep brain stimulation, botulinum toxin injections for dystonia, and studying intracranial infections. Dr. Wang is an esteemed member of several key medical committees in Guangdong, focusing on neurological diseases and geriatric healthcare. With a passion for improving patient outcomes and advancing research, Dr. Wang has made significant contributions to the field, with multiple publications in high-impact journals.

Publication Profile:

Google Scholar

Strengths for the Award:

Dr. Wang Ting is highly deserving of the Best Researcher Award due to her significant contributions to the field of neurology. Her extensive expertise in clinical practice and research, particularly related to Parkinson’s disease, movement disorders, cognitive disorders, and deep brain stimulation, places her at the forefront of neurological science. Her work is not only clinically impactful but also academically rigorous, evidenced by multiple high-impact publications in renowned journals. Dr. Wang’s research spans several crucial areas in neurology, including botulinum toxin therapy, brain stimulation, and cognitive disorder treatments. Furthermore, her involvement in prestigious committees and mentorship roles highlights her leadership in the field, as she actively shapes the next generation of neurologists. The depth and breadth of her research, along with her commitment to improving patient outcomes, demonstrate her outstanding qualifications for this award.

Areas for Improvement:

While Dr. Wang’s research is already of the highest caliber, there are always opportunities for growth in a dynamic field like neurology. Expanding her collaborative efforts with international research teams could further enhance the global reach and impact of her work. Additionally, Dr. Wang may benefit from increasing her involvement in interdisciplinary studies, particularly exploring the intersection between neuroscience and other emerging fields like genetics, artificial intelligence, and personalized medicine. Integrating cutting-edge technologies such as AI-driven diagnostics or biomarkers could open new avenues for her research, allowing for deeper insights into the complexities of neurological diseases.

Education:

Dr. Wang Ting completed her Doctor of Medicine (MD) degree, showcasing her commitment to advancing medical knowledge and patient care. As a medical professional, she has continually pursued academic excellence and deepened her clinical expertise, particularly in neurology. Over the years, she has balanced clinical practice with research, helping to guide the future of treatments for movement disorders, cognitive impairments, and neurological diseases. In addition to her medical degree, Dr. Wang is actively involved in the mentorship of master’s students specializing in clinical practice. This role allows her to impart her knowledge, inspire the next generation of neurologists, and encourage academic growth within the medical community. Dr. Wang’s continuous educational development and contributions to her field demonstrate a strong dedication to advancing neurology, particularly in complex areas like Parkinson’s disease and deep brain stimulation.

Experience:

Dr. Wang Ting has a well-rounded career in neurology, having served as an attending physician at Guangzhou First People’s Hospital, one of the leading medical institutions in China. Her role includes diagnosing and treating complex neurological conditions such as Parkinson’s disease, movement disorders, and cognitive impairments. With hands-on expertise in deep brain stimulation and botulinum toxin therapy, Dr. Wang has successfully applied her knowledge in clinical settings, directly impacting patient outcomes. She is also a mentor for master’s students, guiding future neurologists in clinical practice and research. Dr. Wang’s extensive involvement in medical committees, such as the Hypertensive Cerebral Hemorrhage Subcommittee and the Parkinson’s Disease Committee of Guangdong, highlights her leadership in advancing the field of neurology. Additionally, her participation in national and international research projects has further bolstered her experience in both clinical and academic domains.

Research Focus:

Dr. Wang Ting’s research spans a variety of crucial areas in neurology, focusing particularly on Parkinson’s disease, movement disorders, and cognitive impairments. One of her key research areas includes the comprehensive management of Parkinson’s disease, including preoperative screening and postoperative programming for deep brain stimulation. She has conducted significant research on botulinum toxin type A injection therapy for focal dystonia. Dr. Wang is also engaged in understanding the pathophysiology of intracranial infections and cognitive disorders, alongside her work in the basic research of neurological diseases. Her research seeks to develop better therapeutic strategies and diagnostics to improve patient outcomes in these areas. Dr. Wang’s work is further exemplified by her involvement in studying vascular, inflammatory, and metabolic risk factors related to dementia in Parkinson’s disease patients with comorbid type 2 diabetes. Through her research, Dr. Wang aims to bridge the gap between clinical practice and scientific advancements in neurology.

Publications Top Notes:

  1. Disease spectrum and prognostic factors in patients treated for tuberculous meningitis in Shaanxi province, China 🧠🔬
  2. Downregulation of platelet-derived growth factor receptor β in pericytes increases blood-brain barrier permeability and significantly enhances α-synuclein in a Parkinson’s Disease 3D cell model 🧪🧑‍🔬
  3. Vascular, inflammatory and metabolic risk factors in relation to dementia in Parkinson’s disease patients with type 2 diabetes mellitus 💔🧠
  4. High rate of drug resistance among tuberculous meningitis cases in Shaanxi province, China 💉🌍
  5. Sub-optimal specificity of modified Ziehl-Neelsen staining for quick identification of tuberculous meningitis 🔬🦠
  6. Contra-Directional Expression of Plasma Superoxide Dismutase with Lipoprotein Cholesterol and High-Sensitivity C-reactive Protein as Important Markers of Parkinson 🧬⚡
  7. Clinical manifestations and changes in cerebrospinal fluid cytology of patients with meningeal carcinomatosis 🧪💀
  8. Pathological Findings in Myasthenia Gravis Patients with Thymic Hyperplasia and Thymoma 🧠🩺
  9. Translation of the headache chapter in the 19th edition of Harrison’s Principles of Internal Medicine 📖👩‍⚕️

Conclusion:

Dr. Wang Ting stands out as an exemplary researcher and clinician in the field of neurology, with a strong track record of groundbreaking research and significant contributions to the understanding and treatment of neurological disorders. Her comprehensive approach to clinical practice, mentorship, and research positions her as an invaluable asset to the field. With her dedication to improving patient care and advancing scientific understanding, Dr. Wang Ting is undoubtedly a strong candidate for the Best Researcher Award.